| DC 欄位 |
值 |
語言 |
| DC.contributor | 化學學系 | zh_TW |
| DC.creator | 鍾政宇 | zh_TW |
| DC.creator | Cheng-Yu Chung | en_US |
| dc.date.accessioned | 2016-1-8T07:39:07Z | |
| dc.date.available | 2016-1-8T07:39:07Z | |
| dc.date.issued | 2016 | |
| dc.identifier.uri | http://ir.lib.ncu.edu.tw:88/thesis/view_etd.asp?URN=102223035 | |
| dc.contributor.department | 化學學系 | zh_TW |
| DC.description | 國立中央大學 | zh_TW |
| DC.description | National Central University | en_US |
| dc.description.abstract | 本篇研究是以D-Ribose作為起始物合成目標天然物(+)-Pericosine A, (-)-Pericosine C和(+)-Pericosine E。主要的反應有Wittig反應和Swern氧化反應。以[α-(Alkoxycarbonyl)vinyl]aluminium作為具有非鏡像選擇性的羰基加成反應可得到重要的中間產物8a和8b。(+)-Pericosine A可在化合物8a進行環合置換(Ring-Closing Metathesis)反應後，參考Stevenson教授的合成方法而得。化合物8a經由環合置換反應合環、鈀催化的allylic substitution後可得到(-)-Pericosine C。(+)-Pericosine E應亦可藉由鈀催化的allylic substitution而得，然而尚在進行中。 | zh_TW |
| dc.description.abstract | Successfully synthesizing natural product (+)-Pericosine A, (-)-Periciosine C,(+)-Pericosine E was the aim. The main reactions we used are Wittig reaction, Swern oxidation, [α-(Alkoxycarbonyl)-vinyl]aluminum reaction and Palladium-catalyzed allylic substitution. Diastereomeric intermediate 8a and 8b can be synthesized via [α-(Alkoxycarbonyl)-vinyl]aluminum reaction which the ratio is 4 to 1. (+)-Pericosine A was obtained by compound 8a through Ring-Closing metathesis then directly referring to Prof. Stevenson’s method. (-)-Pericosine C was obtained by compound 8a via Ring-Closing Metathesis and Palladium-catalyzed allylic substitution successfully. (+)-Pericosine E might can be synthesized by Palladium-catalyzed allylic substitution, but still doing effort right now. | en_US |
| DC.subject | 非鏡像選擇性 | zh_TW |
| DC.subject | 鈀催化 | zh_TW |
| DC.subject | [α-(Alkoxycarbonyl)vinyl]aluminium reaction | en_US |
| DC.subject | allylic substitution | en_US |
| DC.title | 天然物(+)-Pericosine A, (-)-Pericosine C, (+)-Pericosine E的合成研究 | zh_TW |
| dc.language.iso | zh-TW | zh-TW |
| DC.type | 博碩士論文 | zh_TW |
| DC.type | thesis | en_US |
| DC.publisher | National Central University | en_US |