| DC 欄位 |
值 |
語言 |
| DC.contributor | 化學學系 | zh_TW |
| DC.creator | 陳慶濃 | zh_TW |
| DC.creator | Ching-Nung Chen | en_US |
| dc.date.accessioned | 2016-8-15T07:39:07Z | |
| dc.date.available | 2016-8-15T07:39:07Z | |
| dc.date.issued | 2016 | |
| dc.identifier.uri | http://ir.lib.ncu.edu.tw:88/thesis/view_etd.asp?URN=103223052 | |
| dc.contributor.department | 化學學系 | zh_TW |
| DC.description | 國立中央大學 | zh_TW |
| DC.description | National Central University | en_US |
| dc.description.abstract | 本篇論文是以對稱的雙烯醇化合物2作為起始物，利用Sharpless不對稱環氧化反應，合成高鏡像選擇性的兩個不對稱中心。將兩鏡像化合物修飾後，經由交叉置換反應連接成主要骨架8，經多步反應包括環氧三環的開環、酯化反應、環烷化反應、氧化反應、環閉合置換反應等官能基化，成功合成天然物(+)-brevipolide H及其家族成員(+)-brevipolide G。 | zh_TW |
| dc.description.abstract | By way of Sharpless epoxidation of enta-1,4-dien-3-ol, both enantiomerically pure epoxides were converted to the corresponding olefins for cross metathesis. Subsequent transformations, including epoxide ring opening, esterifications,cyclopropanation, oxidation and ring-closing metathesis, provided the target molecule. This
synthesis successfully addresses previous shortcomings in preparing brevipolides. | en_US |
| DC.subject | 有機化學 | zh_TW |
| DC.subject | 天然物合成 | zh_TW |
| DC.subject | 全合成 | zh_TW |
| DC.subject | 抗癌藥物 | zh_TW |
| DC.subject | organic chemistry | en_US |
| DC.subject | natural product synthesis | en_US |
| DC.subject | total synthesis | en_US |
| DC.subject | anti cancer | en_US |
| DC.title | 具鏡像選擇性合成(+)-brevipolide H | zh_TW |
| dc.language.iso | zh-TW | zh-TW |
| DC.type | 博碩士論文 | zh_TW |
| DC.type | thesis | en_US |
| DC.publisher | National Central University | en_US |