| DC 欄位 |
值 |
語言 |
| DC.contributor | 化學學系 | zh_TW |
| DC.creator | 阮氏英虹 | zh_TW |
| DC.creator | NGUYEN THI ANH HONG | en_US |
| dc.date.accessioned | 2021-8-27T07:39:07Z | |
| dc.date.available | 2021-8-27T07:39:07Z | |
| dc.date.issued | 2021 | |
| dc.identifier.uri | http://ir.lib.ncu.edu.tw:88/thesis/view_etd.asp?URN=103283602 | |
| dc.contributor.department | 化學學系 | zh_TW |
| DC.description | 國立中央大學 | zh_TW |
| DC.description | National Central University | en_US |
| dc.description.abstract | 芳烴的乙酰氧基化是重要的反應，也是化學中未滿足的需求。 我們報告了在三氟乙酸、乙酸和乙酸酐的無水環境下使用硝酸鹽進行的無金屬直接乙酰氧基化反應。 芳烴（31 個實例）的氧化電位（Eox，單位為 V vs SCE）低於苯（2.48 V），以良好的產率和區域選擇性被乙酰氧基化。我們 提出了一種逐步的單電子轉移機制。
樅烷二萜 (±)−17−Hydroxymandarone B (3) 的首次具有生物學意義的合成是從 (+)−脫氫樅胺實現的。 乙酰氧基化是簡單合成單乙酸酯 (7)、二乙酸酯 (4) 和三乙酸酯 (5) 的重要步驟。 這些化合物是 (±)−17−Hydroxymandarone B (3) 合成中的關鍵中間體。 在這個關鍵程序之後，精心控制的最終程序被開發出來，導致天然物的完成。 | zh_TW |
| dc.description.abstract | Acetoxylation of arenes is important reaction and an unmet need in chemistry. We report a metal−free, direct acetoxylation reaction using nitrate under an anhydrous environment of trifluoroacetic acid, acetic acid and acetic anhydride. Arenes (31 examples), with oxidation potentials (Eox, in V vs SCE) lower than benzene (2.48 V), were acetoxylated with good yields and regioselectivity. A stepwise, single electron−transfer mechanism is proposed.
The first biologically significant synthesis of abietane diterpene (±)−17−Hydroxymandarone B (3) was achieved from (+)−Dehydroabietylamine. Acetoxylation is an important step for the simple synthesis of monoacetate (7), diacetate (4), and triacetate (5). These compounds are key intermediates in the synthesis of (±)−17−Hydroxymandarone B (3). Following this critical sequence, a meticulously controlled final sequence of events was developed that led to the completion of the product nature.
| en_US |
| DC.subject | 直接乙酰氧基化 | zh_TW |
| DC.subject | 17−羥基曼陀羅 B | zh_TW |
| DC.subject | Direct Acetoxylation | en_US |
| DC.subject | 17−Hydroxymandarone B | en_US |
| DC.title | 芳烴的無金屬直接乙酰氧基化和從(+)−脫氫樅胺全合成17−羥基曼陀羅B | zh_TW |
| dc.language.iso | zh-TW | zh-TW |
| DC.title | Metal−Free, Direct Acetoxylation of Arenes and Total synthesis of 17−Hydroxymandarone B from (+)−Dehydroabietylamine | en_US |
| DC.type | 博碩士論文 | zh_TW |
| DC.type | thesis | en_US |
| DC.publisher | National Central University | en_US |