| dc.description.abstract | In recent years, many researchers have paid attention to health problem in the
world. Non-invasive measurement methods were applied to detect health prob
lems. Laser Doppler flowmetry (LDF), a non-invasive method, is used to measure
red blood cells in a tissue. Researchers used LDF to do research in medicine,
and they found that the microcirculation and health condition are closely related.
Therefore, LDF is very applicable to healthcare. However, the commercial LDF
machines are very expensive and hard to obtain, which lead to very few relevant
application and popularization. In this thesis, continuing previous researches, a
LDF Prototype was built by electronic materials which can be purchased com
mercially; Further, we design an accurate mathematical regression analysis model
to calibrate feature of LDF prototype, and we hope to match with business LDF
feature.
On verification and calibration of the LDF signal feature, we compared the
data obtained by business LDF model and LDF prototype to establish a model
for calibrating error. We took the center of forefinger as the measure point and
measured the signal layer and feature layer. The result of the experiment showed
that before calibration, the correlation coefficient of physiological feature is about
0.7, and after we used our Regression Model to calibrate physiological feature, the
correlation coefficient reached nearly 0.9999, which was close to a perfect positive
correlation. The overall evaluation results showed that the proposed method can
verify and insure the correctness of the LDF prototype. Also, LDF prototype can
obtain high correlation with business LDF after calibration.
The results of this thesis that can help LDF prototype into the commercial
ization stage. Since the LDF prototype only cost about fifty thousand NTD, and
the estimated cost can be further reduced after the mass production. This price is
highly competitive comparing to business LDF. Through regression model to cal
ibrate it in this thesis, the applications of all business LDF can be directly applied
in the LDF prototype. Therefore, the result of this thesis, the LDF prototype can
significantly reduce the cost, and promote popularization to use in medical insti
tutions, fitness centers, etc. In addition, the application on the wearable device is
also promising. The LDF prototype can be built into integrated circuits that can
reduce the size to a single IC. If it is successfully implemented, the LDF prototype
IC can be plugged in wearable device. For instance, smart glasses, smart watch,
smart clothing and smart pants, etc. The LDF application can be more popular
ized, and it has a positive contribution to the action care, remote medical, aging
society. | en_US |