DC 欄位 值 語言 DC.contributor 資訊工程學系 zh_TW DC.creator 陳柏傑 zh_TW DC.creator Po-Chieh Chen en_US dc.date.accessioned 2018-8-7T07:39:07Z dc.date.available 2018-8-7T07:39:07Z dc.date.issued 2018 dc.identifier.uri http://ir.lib.ncu.edu.tw:88/thesis/view_etd.asp?URN=105522047 dc.contributor.department 資訊工程學系 zh_TW DC.description 國立中央大學 zh_TW DC.description National Central University en_US dc.description.abstract 深度類神經網路(DNN)在各個不同的領域，舉凡聲音，影像等領域中皆有不凡的表現，而目前在生醫工程方面也陸續有深度學習方法的應用，而本論文中，我們使用來自The Cancer Genome Atlas(TCGA)上，針對DNA去做次世代定序而得出的RNA-seq資料，因其通量數高，且背景雜質低的特性，所以能最正確的偵測基因表現量。 在本篇論文裡，主要大方向為三： 1. 使用基因表現來判定癌症種類之預測 2. 分別對肺癌、乳癌、腦癌之存活，死亡分析其分類 3. 分別對肺癌、乳癌、腦癌之治癒，復發分析其分類 在本篇論文裡，實驗了一部份機器學習之方法，如決策樹(Decision Tree)，以及支援向量機(Support Vector Machine)，XGBoost(Extreme Gradient Boost)，也加入深度學習之方法，深度神經網路(Deep Neural Network)、自編碼器(Auto-encoder)及變異型自編碼器(Variational Auto-encoder)，去比較各個方法的辨識率。 zh_TW dc.description.abstract Deep neural networks (DNN) have extraordinary performances in various of fields such as sound and image processing. Recently, deep learning methods are applied in the field of biomedical engineering. In this paper, we use the RNA-sequencing data from TCGA (The Cancer Genome Atlas), which is sequenced from RNA data and generated by NGS (Next Generation Sequencing). Due to its high flux number and low background impurities, the most accurate detection of gene expression become possible. In this paper, we have tree main directions: 1. Classification of cancer types based on RNA- sequencing data. 2. To predict the OS (Overall Survival) of lung, breast, and brain cancer. 3. To predict the DFS (Disease Free Survival) of lung, breast, and brain cancer. In this paper, we have experimented with a number of methods of machine learning, such as Decision tree, Support Vector Machine and XGBoost (Extreme gradient boost), as well as deep learning methods, including DNN (Deep neural network), autoencoder and VAE (Variational Autoencoder). Our goal is to perform all of these methods and compare the recognition rate of each method. en_US DC.subject 機器學習 zh_TW DC.subject 癌症 zh_TW DC.subject 醫學預測 zh_TW DC.subject 深度學習 zh_TW DC.subject Maching Learning en_US DC.subject Cancer en_US DC.subject Medical prediction en_US DC.subject Deep learning en_US DC.title 運用深度學習方法預測癌症種類及存活死亡與治癒復發 zh_TW dc.language.iso zh-TW zh-TW DC.title Deep learning in predicting outcomes of cancer type, overall survival and disease free survival en_US DC.type 博碩士論文 zh_TW DC.type thesis en_US DC.publisher National Central University en_US