| dc.description.abstract | Common artificial skin is produced in large quantities, and the shape of the artificial skin needs to be trimmed to fit the patient’s wound during the transplantation process, so there is bound to be some residual material.This thesis focuses on making skin objects conforming to the shape of the skin wound, and aims to restore the skin structure to strengthen the stability of the artificial skin structure.Customized production of artificial skin to reduce the loss of modified materials.
This paper will use the technology of 3D bioprinting to make customized artificial skin. However, the skin has a curved structure, and the strength of the printed artificial skin structure will decrease due to its layering method. For this reason, this paper will print artificial skin using the printing method of curve layered path that follows the shape of the wound. This method uses a solid base to match the characteristics of the bottom of the wound, and places the artificial skin to be printed on the base. The hard base can be matched with the texture of the hydrogel, which is easy to collapse like a jelly, and retains the appearance of the wound. Generate the path obtained by cutting in the X direction and the Y direction, combining the two paths to form a network structure. And the user can make fine adjustments to the internal data generated by the path, which has reached the user′s needs. The generated path can be to simulate the skin structure to generate the dermis path and the epidermis path respectively, using a mixture of hydrogel and two kinds of cells to print, and continue the subsequent biological experiments.
The printing results of this experiment can be divided into two, the first is to print the grid-like nose in the horizontal layering method, and the second is to use the curve layering method to print the artificial skin, which proves the printing path of the curved layer base which can be printed successfully on uneven surfaces. Four positioning methods have been developed to facilitate the positioning of the wound support base in the printing coordinates to confirm that the actual printing position of the wound is correct and does not collide. However, the successful case is limited to solid objects, and there may be errors in hollow objects. Because of the unexpected situation that the printing result of the skin layer produces cavities, the path generation method still needs to be improved. | en_US |