| DC 欄位 |
值 |
語言 |
| DC.contributor | 化學學系 | zh_TW |
| DC.creator | 包慧彥 | zh_TW |
| DC.creator | Hui-Yen Pao | en_US |
| dc.date.accessioned | 2021-1-13T07:39:07Z | |
| dc.date.available | 2021-1-13T07:39:07Z | |
| dc.date.issued | 2021 | |
| dc.identifier.uri | http://ir.lib.ncu.edu.tw:88/thesis/view_etd.asp?URN=107223045 | |
| dc.contributor.department | 化學學系 | zh_TW |
| DC.description | 國立中央大學 | zh_TW |
| DC.description | National Central University | en_US |
| dc.description.abstract | 在天然物與藥物中經常出現五員環結構，因此[4+1]環化反應受到了重視。在[4+1]環化反應中，起始物大多為,-不飽和化合物，而硫偶極體(sulfur ylide)與,-不飽和化合物大多進行[2+1]環化反應，故想要利用硫偶極體進行反應，得到五員環產物是有很大的挑戰性。
本研究主要目標為利用實驗室開發的手性硫化物(S)-1作為不對稱環丙烷化反應催化劑，合成三員環化合物，再添加路易士酸進行擴環反應得到五員環吡咯類產物。起始物使用1-氮雜二烯(1-azadienes)，透過2-羥基苯乙酮經過四步驟合成得到。我們也探討反應如何獲得良好的鏡像超越值。 | zh_TW |
| dc.description.abstract | Five-membered ring is an important structure in natural product and medicinal chemistry, and therefore [4+1] annulation has attracted much attention from organic chemists. While most of the [4+1] annulations were based on ,-unsaturated starting materials, using sulfur ylides and ,-unsaturated compounds to construct five-membered rings still remains a challenge.
The main goal of this thesis is to use sulfur catalyst (S)-1 for developing asymmetric cyclopropanations of 1-azadienes. The resulting cyclopropanes were the treated with Lewis acid for ring-expansion to give five-membered rings. The starting material, 1-azadienes, was synthesized through a 4-step process from 1-(2-hydroxyphenyl)ethan-1-one. | en_US |
| DC.subject | 不對稱環丙烷化反應 | zh_TW |
| DC.subject | 合成吡咯類化合物 | zh_TW |
| DC.subject | 手性有機硫催化劑 | zh_TW |
| DC.subject | Asymmetric Cyclopropanation | en_US |
| DC.subject | Synthesis of Pyrrole Derivatives | en_US |
| DC.subject | chiral sulfur catalyst | en_US |
| DC.title | 以手性有機硫催化劑進行不對稱環丙烷化反應並應用於合成吡咯類化合物之研究 | zh_TW |
| dc.language.iso | zh-TW | zh-TW |
| DC.title | (Thiolan-2-yl)diphenylmethanol Benzyl Ether-catalyzed Asymmetric Cyclopropanation and Its Application to the Synthesis of Pyrrole Derivatives | en_US |
| DC.type | 博碩士論文 | zh_TW |
| DC.type | thesis | en_US |
| DC.publisher | National Central University | en_US |