DC 欄位 值 語言 DC.contributor 生醫科學與工程學系 zh_TW DC.creator 吳氏蘭香 zh_TW DC.creator Ngo Thi Lan Huong en_US dc.date.accessioned 2021-1-18T07:39:07Z dc.date.available 2021-1-18T07:39:07Z dc.date.issued 2021 dc.identifier.uri http://ir.lib.ncu.edu.tw:88/thesis/view_etd.asp?URN=107827605 dc.contributor.department 生醫科學與工程學系 zh_TW DC.description 國立中央大學 zh_TW DC.description National Central University en_US dc.description.abstract 水凝膠是一種三維聚合物結構，具有高含水量、柔軟性、柔韌性、與生物相容性等特殊性質，因此水凝膠成為一種有潛力的生醫材料。水凝膠適合應用於藥物傳遞系統、生醫感測器、組織工程支架、生物膜、人工器官、傷口癒合敷料、隱形眼鏡等。[1] 其中，在控制釋放藥物系統及植入式醫療器材的應用中，水凝膠的生物降解能力是一項重要的性質。[3] 因此，我們展示一項新型生物可降解的雙離子交聯劑，藉由合成2-[2-{2-(methacryloyloxy)ethyldimethylammonium}ethyl phosphate] 2-ethyl disulfide (MPCSS)，以提供可經由還原而降解的雙硫鍵結。經由結合2-甲基丙烯酰氧基乙基磷酰膽鹼(MPC)及MPCSS交聯劑，以形成完全磷酸膽鹼的雙離子水凝膠，而此水凝膠展現生物可相容及生物可降解的特性。我們深入探討完全磷酸膽鹼的雙離子水凝膠，了解其機械性質、生物相容性及抗汙貼附的能力。此外，我們探討MPCSS交聯劑水凝膠的重量損失，以衡量其可降解的特性。在這項研究中，我們初步探討了磷酸膽鹼水凝膠的注射應用. zh_TW dc.description.abstract Hydrogel, a three-dimensional polymer structure, has been discovered as a good biomaterial with specific properties, such as high water content, softness, flexibility, and biocompatibility. The hydrogels are great candidates for drug delivery systems, biosensors, tissue engineering scaffolds, physiological membranes, artificial organs, wound healing dress, and contact lenses. [1] Moreover, with applications for control drug delivery or implantable medical devices, the biodegradable property is in high demand. Hence, a novel zwitterionic degradable crosslinker, 2-[2-{2-(methacryloyloxy)ethyldimethylammonium}ethyl phosphate] 2-ethyl disulfide (MPCSS) was synthesized to provide a disulfide linkage for degradation via reduction. A full zwitterionic phosphorylcholine (PC) hydrogel, which is phospholipid-inspired, biocompatible and biodegradable, was created by combining zwitterionic monomer 2-Methacryloyloxyethyl phosphorylcholine (MPC) and MPCSS crosslinker. Herein, the mechanical, biocompatible and antifouling properties of the full zwitterionic PC hydrogels were investigated. Besides, the degradation characteristic of MPCSS-crosslinked hydrogel was evaluated through their weight loss. In this research, the injectable application of PC hydrogel is preliminarily explored. en_US DC.subject 雙離子交聯劑 zh_TW DC.subject 磷酸膽鹼 zh_TW DC.subject 水凝膠 zh_TW DC.subject 可降解 zh_TW DC.subject Zwitterionic crosslinker en_US DC.subject phosphorylcholine en_US DC.subject hydrogel en_US DC.subject degradable en_US DC.title 開發可生物降解的完全磷酸膽鹼水凝膠 zh_TW dc.language.iso zh-TW zh-TW DC.title Development of Biodegradable Complete Phosphorylcholine Hydrogel en_US DC.type 博碩士論文 zh_TW DC.type thesis en_US DC.publisher National Central University en_US