| dc.description.abstract | Surface properties are one of determinants for the successful outcome of biomedical devices. Indeed, the high friction and insufficient lubrication in indwelling catheters or medical implants directly affect health situation of each patient. The hydrophobic surface also causes the bacterial attachment and protein adsorption, leading to the long-term instability then the failure of biomaterials. In this study, random copolymers, poly (2-methacryloyloxyethyl phosphorylcholine (MPC) -r- 3-(tris(trimethylsiloxy)silyl)propyl methacrylate (TSM) are synthesized to modify thermoplastic polyurethane (TPU) catheter, a common artificial implantable material in biomedical fields, via a simple and quick dip-coating method. The bio-inspired polymer containing 2-methacryloyloxyethyl phosphorylcholine (MPC) can provide the outstanding biocompatibility and the high resistance to unfavorable reactions. In addition, TSM in the copolymer with hydrophobic domain served as attachment material with a strong physical affinity to TPU surface. Poly vinylpyrrolidone (PVP) and 4-benzoylphenyl acrylate (BPA) were also added into the coating solution to induce the stability and form a tight network for surface membrane. Attenuated total reflection-Fourier-transform infrared (ATR-FTIR) results indicated the successfully uniform coating layer on TPU surface after modification with the significant decrease of roughness measured by Profilometer, Profilm3D (P3D). Regarding to a friction test in deionization water environment, the dynamic friction coefficient decreased over 10 times with the high stability during testing time after modification with a coating solution including MPC7-TSM5, PVP and BPA (CsMT75). Moreover, TPU tubes with CsMT75-coated membrane can be durable in PBS in one month. The anti-fouling assay also showed the significant decrease of bacterial and protein adhesion on the surface for the long period of time. Therefore, modifying TPU with coating solution including random copolymer MPC-TSM, PVP and BPA (CsMT) is potentially promising for stable lubricant coating material as well as repelling of nonspecific absorption on surface for the long term, then prevention of implant failure. Via Surface Plasmon Resonance (SPR) and Dynamic light scattering (DLS) testing as well as viscosity and surface tension measurement, the key factors such as suitable ratio of monomers in copolymer, solvents and drying time/condition were investigated to acknowledge deeply about the coating mechanism. Nevertheless, in this process, the polymer concentration is quite high up to (5 wt%), the aim to continuously decrease the concentration of polymer but still keep the similar coating efficiency has led to the newly released three-random copolymer (MPC-TSM-BPA). When photo crosslinkers were introduced into the copolymer, not only does the antifouling lubricant stable surface remain, but the main copolymer concentration was also down to only 1 wt%. After adjustment of components and factors, in addition to the 5-time decrease of polymer concentration, the UV time also reduced 3 times to 5 min compared to 15 min in the previous coating process thanks to the enhancement of crosslinking and formation of covalent bonds. Therefore, due to simple process and cost efficiency, the coating process can be applied to manufacturing and potentially used for various substrates of medical devices. | en_US |