| dc.description.abstract | Non-invasive brain stimulation (NIBS) has been widely used in clinical treaments. In some studies, NIBS is demonstrated as a posssible substitution for drug therapy. According to the stimulation types, NIBS has two main categories. One is the transcranial magnetic stimulation (TMS), and the the other one is the transcranial electrical stimulation (TES). Comparing the TMS with the TES system, though the TMS has been widely accepted in clinical use owing to its advantage of focal stimulation, however, the poor penetration depth of TMS limits its clinical applications and the TES is usually chosen in case of the need for deep brain stimulation.
Due to the aforementioned reasons, we have designed a portable NIBS device, which contains the dual functitons of the repetitive TMS (rTMS) and the TES. Our NIBS device has the features of small, portable and low cost which can be triggered throgh bluetooth connection. Users can conveniently adjust the stimulation parameters, such as stimulation frequency, pulse width, stimulation duration, stimulation interval, etc., on mobile phone or computer. Demonstration of the proposed NIBS has been done in a preliminary human study and an animal study on piggy. For rTMS part, subjects were requested to receive rTMS, 1Hz repetitive rate, for fifteen minutes. EEG signals from left and right sensorimotor area (C3 and C4 position) were recorded and the Mu rhythms were enhanced after stimulation.
For TES part, we developed time-interfering transcranial alternative current stimulation (TI-tACS) for sizure suppression on a piggy animal model. Two six-channel SEEG electrodes were placed in the left/right hippocampus regions to see the efficacy of seizure suppression using TI-tACS. The biopsy of the piggy’s brain has shown that no tissue damage resulted from TI-tACS was found and the seizure in piggy’s brain was successfully supressed. Our experimental results have shown the safety and effectiveness of our NIBS system. | en_US |