| dc.description.abstract | Polydimethylsiloxane (PDMS) is a silicone material that has excellent elasticity, optical transparency, chemical and biological inertness, permeability to oxygen, and ease of fabrication. Therefore, PDMS has been used for biomedical applications such as catheters, vascular grafts, contact lenses, and intraocular lenses. However, it has some problems in the development of medical applications because the hydrophobic surface of PDMS, leading to non-specific adsorption of protein. Poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) is well known as its hydrophilicity, biocompatibility, lubrication, and anti-protein adsorption. In our study, the zwitterionic copolymers, poly(2-methacryloyloxyethyl phosphorylcholine-co-methacryloxypropyl terminated polydimethylsiloxane (poly(MPC-MTP))and(2-methacryloyloxyethyl phosphorylcholine-co-methacryloxypropyl functional polydimethylsiloxane (poly(MPC-MFP)), were deposited on PDMS by dip coating and spray coating in an ambient environment, and polymers will adsorbed on the surface by hydrophobic interaction between the hydrophobic segment on the copolymer and surface of PDMS to improve its hydrophilicity and antifouling properties. The nuclear magnetic resonance was used to measure the conversion rate and identification of the chemical structure of copolymer. The surface chemical composition and elemental ratios were measured by the X-ray photoelectron spectroscopy (XPS). The surface morphology was measured by atomic force microscope (AFM) and optical microscope. The hydrophilicity was determined by sessile drop water contact angle measurements. The lubrication and, antifouling property were measured by friction test, and bacteria adhesion tests, respectively. We used simple and low toxic process for modification of PDMS by poly(MPC-co-MTP) and poly(MPC-co-MFP) to improve hydrophilicity , lubrication, anti-fouling property, oxygen permeability and biocompatibility. In future work, we will extend to various types of silicone surface modification. | en_US |