| dc.description.abstract | The occurrence of bone marrow suppression will reduce the number of blood cells. The
Mmost common reason is that chemical drugs slow down the division and reproduction of stem cells and specialized offspring, causing the hematopoietic function to fail to function properly., Wwhen the number of neutrophils decreases, cancer patients are more likely to suffer systemic infections. The current treatment methods include preventive antibacterial drugs and hematopoietic growth factor supplements, and . Tthe need to reduce the dose of chemotherapy,
thus limiting the treatment efficacyefficacy of treatment, infecting repeatedly will lead to prolonged hospital stays and delayed treatment.
In my research, a blood analyzer was established using the principle of Fresnel digital holography(FDH). We simplify the optical imaging equipment by scalar diffraction theory, and no large and complex optical components are needed. Without the lens to limit the field of view(FOV) size, it can simultaneously have a wide field of view (30mm^2 ) and reach a high spatial resolution close to the diffraction limit. We recorded the diffraction image on the sensor by controlling the spatial coherence of the light source, and the diffraction image of the blood cell is classified and counted by Deep Neural Network(DNN), and the microcomputer is used as the control center of the system. The system is a high-throughput microscopy system without field-limited, and it can analyze blood in real-time.
In this paper, we use the whole blood cell analysis to monitor the number of blood cells, ; coupled with the self-designed microfluidic chip and deep learning network, the accuracy of red blood and white blood cell counts can reach 9281% to 7583% . The experimental verification results confirm that the system can perform rapid and large-area blood cell characterization analysis and complete blood count function with only a small amount of blood, which can respond to various indications caused by abnormal blood counts. In the future, we will further count various types of white blood cells to achieve real-time detection of neutropenia, which greatly reduces the risk of systemic infection in patients, thereby reducing the needs ofneed for hospitalization and avoiding delays in treatment. | en_US |