| DC 欄位 |
值 |
語言 |
| DC.contributor | 化學學系 | zh_TW |
| DC.creator | 蔡林松 | zh_TW |
| DC.creator | Li-Si Cai | en_US |
| dc.date.accessioned | 2001-7-17T07:39:07Z | |
| dc.date.available | 2001-7-17T07:39:07Z | |
| dc.date.issued | 2001 | |
| dc.identifier.uri | http://ir.lib.ncu.edu.tw:88/thesis/view_etd.asp?URN= 88223020 | |
| dc.contributor.department | 化學學系 | zh_TW |
| DC.description | 國立中央大學 | zh_TW |
| DC.description | National Central University | en_US |
| dc.description.abstract | 目前已經有許多抑制PTKs的藥物被研究,但關於PTPs的抑制劑非常少,而PTPs的多樣性使得這是藥物研究上值得開發的地方,而CD45是PTPs的一種主要為活化T細胞及B細胞,且對於自動免疫或慢性發炎的疾病,可以對CD45來著手,而天然物Pulchellalactam對CD45有抑制效果,我們發展一系列合成法可控制立體結構並且可任意更換不同取代基.以便尋找更有藥效的藥物 | zh_TW |
| dc.description.abstract | Numerous and specific inhibitors of PTKs have been discovered and tested as therapeutic agents against human disease. Currently, there are few readily available potent inhibitor of CD45 protein tyrosin phosphatase. CD45, has been shown to play crucial roles in activation of B and T cells. CD45 therefore represents a terapeutic target for various auto-immune and chronic anti-inflammatory diseases. We have completed the synthesis of Pulchellalactam, and we can change two different functional group for searching the best inhibitor. | en_US |
| DC.title | 開發單一步驟的簡便的 | zh_TW |
| dc.language.iso | zh-TW | zh-TW |
| DC.type | 博碩士論文 | zh_TW |
| DC.type | thesis | en_US |
| DC.publisher | National Central University | en_US |