| dc.description.abstract | This paper presents a non-invasive, non-contact system to measure Parkinson’’s disease patient dorsum manus vibration waveforms of artery via applying laser line method to detect dorsum manus vibration. The proposed Parkinson’’s disease measurement system chiefly consists of a laser diode and a low cost complementary metal-oxide semiconductor (CMOS) image sensor. Laser line and centroid method are combined with the Fast Fourier Transform (FFT) in this study. The shape and frequency of the dorsum manus vibration waveforms can be detected rapidly by using our Parkinson’’s disease measurement system. The relative variation of the Parkinson’’s disease patient dorsum manus vibration waveforms at laser line near wrist joint is used as testing points. An extensive series of experiments was conducted to evaluate the performance of the designed Parkinson’’s disease measurement system.
Experimental design is divided into two groups for that control group normal human and Parkinson’’s patients. From the experimental results show that Parkinson’’s disease patients dorsum manus at rest, two patients left dorsum manus existence 4.1-4.3 Hertz of resting tremor frequency and the average frequency is 4.2 hertz. In addition the four patients with right dorsum manus 4.3-4.7 hertz of resting tremor frequency and the average frequency is 4.5 Hertz. Six patients dorsum manus postural action tremor frequency range from 0.29 to 1.52 hertz, and the average frequency is 0.905 Hertz. The control group normal human dorsum manus resting tremor frequency range from 0.09 to 0.53 hertz and the average frequency is 0.31 hertz, and postural action tremor frequency range from 0.71 to 0.82 hertz and the average frequency is 0.77 hertz. According to the results, six patients dorsum manus resting tremor frequency in descending order, 4.5 Hz (course of 5 years), 4.3 Hz (duration 2 years of disease), 4.1 Hz (duration 3 years of disease), 4.7 Hz (duration 7 years of disease), 4.5 Hz (duration 2 years of disease) and 4.3 Hz (duration 7 years of disease). If we rule out the sixth patient samples, dorsum manus tremor frequency is proportional to the duration of disease. On the other hand, we are laser line can detect two different situations simultaneously, for example the frequencies of postural action tremor left hand and the resting right hand by one laser line across both hand and get two frequencies dorsum manus simultaneously. By calculated their difference △f = f resting - f postural action. We get the preliminary data. △f = 3.495 Hertz which is almost ten times than the control group (△f = 0.46). This method can get rid of the environment and the psychological influence to the hand’s vibration. In our method, we can measure the micro vibration of human hand as high as 10μm resolution. This research demonstrates that applying a CMOS image sensor in designing a non-contact, portable, easy-to-use, low cost Parkinson’’s disease measurement system is feasible. Also, the designed Parkinson’’s disease measurement system is well suited for evaluating and pre-diagnosing the health of a human being.
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