| dc.description.abstract | Physiological system models have an important influence on modern medical development, such as the design of medical equipment, clinical research or the test of drugs. Application of physiological system models could be found in all respects of biomedical field. However, it is hard to
see the application in educational learning. The purpose of this study is to develop a simulation platform of three major physiological systems, the cardiovascular, respiratory, and urinary system, used for education. Based
on equivalent analog circuits and mathematical functions, existing physiological system models from the literature were adopted and built in a user-friendly interface that could be used easily to simulate the physiological functions. In addition to normal physiological functions,
two additional clinical symptoms were also simulated with each physiological system model. They were aortic stenosis and aortic insufficiency in cardiovascular system, asthma and emphysema in respiratory system, and hypotension and low sodium concentration in urinary system. Simulation results indicated the cardiovascular system model could simulate normal blood pressure and volume change of the
left atrium and ventricle, and aortic blood pressure and flow change for normal and diseased conditions; the results also showed the respiratory system model could simulate the change of tidal volume, air flow and pleural pressure in normal and pathlogical conditions; and the urinary system model was able to show that reabsorption in nephron could be controlled by urinary hormone. These results implied that physiological system models built in this study could be used for educational purpose.
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