| dc.description.abstract | It is well-known that crystalline materials obtain their fundamental physical properties from the molecular arrangement within the solid, and altering the placement and/or interactions between these molecules. Most studies were interested in the formation and structure of co-crystal/salt compound, the hydrogen bonding played an important role to affect physical properties.
In crystal engineering for screening co-crystals/salts, this thesis focused on relating the physical properties such as the heat of fusion, the enthalpy of dissolution, the entropy of dissolution, and the solubility in water. Common laboratory analytical tools such as PXRD, DSC, TGA, FT-IR, OM, and SXD were used to understand the supramolecular architectures and to ensure the quality of co-crystals. 2:1 co-crystal of cytosine-fumaric acid, 2:1 co-crystal of cytosine-acetylenedicarboxylic acid, and 2:1 salt of cytosine-tartaric acid were manufactured. The significance of our research is to offer concept to study the solid state hydrogen bonding.
In the experimental process, we used hydrogen bonding number in the solid-state to attempt to explain the co-crystal solubility in the liquid state, rather than using the solubility product in the liquid state to explain the co-crystal solubility in the liquid state.
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