DC 欄位 |
值 |
語言 |
DC.contributor | 化學學系 | zh_TW |
DC.creator | 劉駿威 | zh_TW |
DC.creator | Jun-Wei Liu | en_US |
dc.date.accessioned | 2012-7-23T07:39:07Z | |
dc.date.available | 2012-7-23T07:39:07Z | |
dc.date.issued | 2012 | |
dc.identifier.uri | http://ir.lib.ncu.edu.tw:88/thesis/view_etd.asp?URN=992203048 | |
dc.contributor.department | 化學學系 | zh_TW |
DC.description | 國立中央大學 | zh_TW |
DC.description | National Central University | en_US |
dc.description.abstract | 本篇論文利用掌性雙烯雙醇化合物1當作起始物合成番荔枝科乙醯化合物(annonaceous acetogenins)中含有相鄰兩個四氫呋喃(adjacent bis-tetrahydrofurans)中心結構的天然物的差向異構物(14S,21S)-bis-epi-Squamocin-K (18),藉此發展具有相鄰兩個四氫呋喃的番荔枝科化合物之合成方法。本篇利用亞甲基繫繩以及環閉合
置換反應建構其中心結構,之後利用交叉置換反應建構兩端的長碳鏈結構,接著使用環內酯15a做為親核試劑,反應得到關鍵產物。最後轉換官能基得到最終產物天然物的差向異構物(14S,21S)-bis-epi-Squamocin-K (18)。
| zh_TW |
dc.description.abstract | To develop a new and efficient synthetic methodology for annonaceous acetogenins, a large family of natural products containing adjacent bis-tetrahydrofurans as the core structure, we
chose bis-epimer (14S,21S)-bis-epi-Squamocin-K (18) as our target molecules. The adjacent bis-tetrahydrofurans cores was constructed by using chiral dienediol 1 as the starting material. Methylene acetal was used as the linker to connect dienediol 1, and then ring-closing-metathesis reaction was applied to provide the precursor of the adjacent bis-tetrahydrofurans structure. The cross-metathesis reaction was used to extend the carbon skeleton. The lactone 15a was used as nucleophile and the total synthesis of 14S,21S-bis-epi-Squamocin-K (18) was achieved.
| en_US |
DC.subject | 番荔枝科 | zh_TW |
DC.subject | 亞甲基繫繩 | zh_TW |
DC.subject | 置換反應 | zh_TW |
DC.subject | annonaceous acetogenins | en_US |
DC.subject | Squamocin-K | en_US |
DC.subject | CM | en_US |
DC.title | 含雙呋喃天然物Squamocin-K之全合成研究 | zh_TW |
dc.language.iso | zh-TW | zh-TW |
DC.title | Total Synthesis of Bis-THF Containing Natural Product Squamocin-K | en_US |
DC.type | 博碩士論文 | zh_TW |
DC.type | thesis | en_US |
DC.publisher | National Central University | en_US |