博碩士論文 992203048 完整後設資料紀錄

DC 欄位	值	語言
DC.contributor	化學學系	zh_TW
DC.creator	劉駿威	zh_TW
DC.creator	Jun-Wei Liu	en_US
dc.date.accessioned	2012-7-23T07:39:07Z
dc.date.available	2012-7-23T07:39:07Z
dc.date.issued	2012
dc.identifier.uri	http://ir.lib.ncu.edu.tw:88/thesis/view_etd.asp?URN=992203048
dc.contributor.department	化學學系	zh_TW
DC.description	國立中央大學	zh_TW
DC.description	National Central University	en_US
dc.description.abstract	本篇論文利用掌性雙烯雙醇化合物1當作起始物合成番荔枝科乙醯化合物(annonaceous acetogenins)中含有相鄰兩個四氫呋喃(adjacent bis-tetrahydrofurans)中心結構的天然物的差向異構物(14S,21S)-bis-epi-Squamocin-K (18)，藉此發展具有相鄰兩個四氫呋喃的番荔枝科化合物之合成方法。本篇利用亞甲基繫繩以及環閉合 置換反應建構其中心結構，之後利用交叉置換反應建構兩端的長碳鏈結構，接著使用環內酯15a做為親核試劑，反應得到關鍵產物。最後轉換官能基得到最終產物天然物的差向異構物(14S,21S)-bis-epi-Squamocin-K (18)。	zh_TW
dc.description.abstract	To develop a new and efficient synthetic methodology for annonaceous acetogenins, a large family of natural products containing adjacent bis-tetrahydrofurans as the core structure, we chose bis-epimer (14S,21S)-bis-epi-Squamocin-K (18) as our target molecules. The adjacent bis-tetrahydrofurans cores was constructed by using chiral dienediol 1 as the starting material. Methylene acetal was used as the linker to connect dienediol 1, and then ring-closing-metathesis reaction was applied to provide the precursor of the adjacent bis-tetrahydrofurans structure. The cross-metathesis reaction was used to extend the carbon skeleton. The lactone 15a was used as nucleophile and the total synthesis of 14S,21S-bis-epi-Squamocin-K (18) was achieved.	en_US
DC.subject	番荔枝科	zh_TW
DC.subject	亞甲基繫繩	zh_TW
DC.subject	置換反應	zh_TW
DC.subject	annonaceous acetogenins	en_US
DC.subject	Squamocin-K	en_US
DC.subject	CM	en_US
DC.title	含雙呋喃天然物Squamocin-K之全合成研究	zh_TW
dc.language.iso	zh-TW	zh-TW
DC.title	Total Synthesis of Bis-THF Containing Natural Product Squamocin-K	en_US
DC.type	博碩士論文	zh_TW
DC.type	thesis	en_US
DC.publisher	National Central University	en_US