| dc.description.abstract | Chemical sensor is generally defined as a detector with high sensitive, small size, and highly selective to special organic matter, inorganic substance, or biomedical substance. All the chemical sensors are composed by molecular recognition unit and signal transduction unit. Chemical sensing material must select the wanted analyte as specific as possible. Furthermore, the signal output that caused by binding with the analyte have to be distinguishable and stable. Therefore, the synthesis and design of the chemical sensing material are the significant challenges in chemical research.
Riboflavin has the polydentate ligand to form the complexes with different metals. Moreover, it also can form the supramolecule with salicylic acid, 3,5-dihydroxybenzoic acid, acetoguanamine, and melamine through the hydrogen bonding formation. Therefore, our research uses visible-light emitting metal-organic frameworks (MOFs) as a sensing platform, and riboflavin molecules are grafted on the framework structures by chelation to form the (MOFs)-(riboflavin) chelating crystals. Besides, liquid-assisted grinding can help to check the interactions between the sensing molecule (i.e. riboflavin) and target analytes (i.e. salicylic acid, 3,5-dihydroxybenzoic acid, acetoguanamine, and melamine), then, to predict the possibility of forming (MOFs)-(sensing molecule)-(analyte) binding system. Finally, the detecting light signal will further translate to the chromaticity coordinates to quantify the sensing results.
The (MOFs)-(sensing molecule)-(analyte) sensing system is a novel concept, it can overcome the limitation of size exclusion of MOFs sensors, and strengthen the binding interaction with analyte. On the other hand, the search for the candidate of sensing molecule can be easily and rapidly achieved by liquid-assisted grinding to develop a complete sensing system. Afterwards, we expect to construct more possible chemical sensing systems using this strategy.
Apart from this, this thesis also investigates the fundamental crystallized properties of riboflavin, and collects information about riboflavin from different patents. In these patents, we find that six polymorphs of riboflavin have already been published, including three types of hydrates. Furthermore, to summarize the significant data, the polymorph transformation diagram, manufacturing procedures, and characterized principles are provided as well. We hope these data we offer in this thesis will aid the related research about riboflavin in the future.
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