〔2〕Willett WC, Hennekens CH, Bain C, Rosner B and Speizer FE. “Cigarette smoking and non-fetal myocardial infarction in women”, American Journal of Epidemiology, Vol 113, pp.575-582, September 1981.
〔3〕Prescott E, Osler M, Andersen PK, Hein HO, Borch-Johnsen K, Lange P, Schnohr P and Vestbo J. “Mortality in women and men in relation to smoking”, International Journal of Epidemiology, Vol 27, pp. 27-32, May 1997.
〔4〕Anderson AE Jr and Foraker AG. “Smoking, mortality, and sex in a community hospital necropsy population”, Southern Medical Journal, Vol 74, pp. 1097-1100, September 1981.
〔5〕Yogesh C. Patel, Dankward Kodlin and Jack P. Strong. “On the interpretation of smoking risks in atherosclerosis”, Journal of Chronic Diseases, Vol 33, pp. 147-155, January 1979.
〔6〕Russell Ross. “The pathogenesis of atherosclerosis: a perspective for the 1990s”, Nature, Vol 362, pp. 801-809, April 1993.
〔7〕Glass CK and Witztum JL. “Atherosclerosis. The road ahead”, Cell, Vol 104, pp.503-516, February 2001.
〔8〕Benowitz NL. “Cigarette smoking and cardiovascular disease: phathophysiology and implications for treatment”, Progress in Cardiovascular Diseases, Vol 44-45, pp. 724-738, August 2003.
〔9〕Glantz SA and Parmley WW. “Passive smoking and heart disease; mechanisms and risk”, Journal of the American Medical Association, Vol 273, pp. 1047-1053. April 1995.
〔10〕Cornel Pater. “The current status of primary prevention in coronary heart disease”, Current Controlled Trials in Cardiovascular Medicine ,Vol 2, pp. 24-37, January 2001.
〔11〕Prefonatine D, Morin A, Jumarie C and Porter A. “In vitro bioactivity of combustion products from 12 tobacco constituents”, Food and Chemical Toxicology,Vol 44-45, pp. 724-738, May 2006.
〔12〕Crigui MH, Browner D, Fronek A, Klauber MR, Coughlin SS, Barrett-Connor E and Gabriel S. “Peripheral arterial disease in large vessels is epidemiologically distinct from small vessel disease. An analysis of risk factors”, American Journal of Epidemiology, Vol 129, pp. 1110-1119, June 1989.
〔13〕Ambrose JA and Barua RS. “The pathophysiology of cigarette smoking and cardiovascular disease: an update”, Journal of the American College of Cardiology, Vol 43, pp. 1731-1737, May 2004.
〔14〕Haltmayer, M., Mueller T, Horvath W, Luft C, Poelz W and Haidinger D. “Impact of atherosclerotic risk factors on the anatomical distribution of peripheral arterial disease”, International Angiology, Vol 20, pp. 200-207, Septemper 2001.
〔15〕Park HS, Cho K, Park YJ and Lee T. “Chronic nicotine exposure attenuates proangiogenic activity on human umbilical vein endothelial cells”, Journal of Cardiovascular Pharmacology, Vol 57, pp. 287-293, March 2011.
〔16〕Edirisinghe I and Rahman I. “Cigarette smoke-mediated oxidative stress, shear stress, and endothelial dysfunction: role of VEGFR2”, Annals of the New York Academy of Sciences, Vol 1203, pp. 66-72, August 2010.
〔17〕Lee J and Cooke JP. “The role of nicotine in the pathogenesis of atherosclerosis”, Atherosclerosis, Vol 215, pp. 281-283, April 2011.
〔18〕Benowitz NL, Jacob P 3rd, Jones RT and Rosenberg J. “Interindividual variability in the metabolism and cardiovascular effects of nicotine in man”, Journal of Pharmacology and Experimental Therapeutics, Vol 221, pp. 368-72, May 1982.
〔19〕Russell MA, Jarvis M, Iyer R and Feyerabend C. “Relation of nicotine yield of cigarettes to blood nicotine concentrations in smokers”, British Medical Journal, Vol 280, pp. 972-76, April 1980.
〔20〕Cucina A, Sapienza P, Borrelli V, Corvino V, Foresi G, Randone B, Cavallaro A and Santoro-D’Angelo L. “Nicotine reorganizes cytoskeleton of vascular endothelial cell through platelet-derived growth factor BB”, Journal of Surgical Research, Vol 92, pp. 233-238, August 2000.
〔21〕Park YJ, Lee T, Ha J, Jung IM, Chung JK and Kim SJ. “Effect of nicotine on human umbilical vein endothelial cells (HUVECs) migration and angiogenesis”, Vascular Pharmacology, Vol 49, pp. 32-36, July 2008.
〔22〕Conklin BS, Surowiec SM, Ren Z, Li JS, Zhong DS, Lumsden AB and Chen C. “Effects of nicotine and continine on porcine arterial endothelial cell function”, Journal of Surgical Research, Vol 95, pp. 23-31, January 2001.
〔23〕Cucina A, Corvino V, Sapienza P, Borrelli V, Lucarelli M, Scarpa S, Strom R, Santoro-D’Angelo L and Cavallaro A. “Nicotine regulates basic fibroblastic growth factor and transforming growth factor betal production in endothelial cells”, Biochemical and Biophysical Research Communications, Vol 257, pp. 306-312, April 1999.
〔24〕Janet T Powell. “Vascular damage from smoking: disease mechanisms at the arterial wall”, Vascular Medicine, Vol 3, pp. 21-28, February 1998.
〔25〕Yang YM and Liu GT. ‘Damaging effect of cigarette smoke extract on primary cultured human umbilical vein endothelial cells and its mechanism”, Biomedical and Environmental Sciences, Vol 17, pp.121-34, June 2004.
〔26〕Devasagayam TP, Tilak JC, Boloor KK, Sane KS, Ghaskadbi SS and Lele RD. “Free radicals and antioxidants in human health: current status and future prospects”, Journal of the Association of Physicians of India, Vol 52, pp. 794-804, October 2004.
〔27〕Rahman I and Macnee W. “Role of oxidants/antioxidant in smoking-induced lung disease”, Free Radical Biology and Medicine, Vol 21, pp. 669-681, March 1996.
〔28〕E. L. Wynder, A. Lupberger and Carol Grener, “Experimental production of cancer with cigarette tar: strain differences”, British Journal of Cancer, Vol 10, pp. 507-509, September 1956.
〔29〕Abraham SK, Goswami V and Kesavan PC. “A preliminary assessment of possible mutagenicity of betel nut and ingredients of the betel guid when administered alone or in combinations to larvae of Drosophila melanogaster”, Mutation Research, Vol 66, pp. 261-266, March 1979.
〔30〕Mahapatra SK, Das S, Bhattachariee S, Gautam N, Majumdar S and Roy S. “In vitro nicotine-induced oxidative stress in mice peritoneal macrophages: a dose-dependent approach”, Toxicology Mechanisms and Methods, Vol 19, pp. 100-108, February 2009.
〔31〕Papaharalambus CA and Griendling KK. “Basic mechanisms of oxidative stress and reactive oxygen species in cardiovascular injury”, Trends in Cardiovascular Medicine, Vol 17, pp. 48-54, February 2007.
〔32〕Zhou L, Li Y and Yue BY. “Oxidative stress affects cytoskeletal structure and cell-matrix interactions in cells from an ocular tissue: the trabecular meshwork”, Journal of Cellular Physiology, Vol 180, pp. 182-189, August 1999.
〔33〕Davies PF. “Flow-mediated endothelial mechanotransduction”, Physiological Reviews, Vol 75, pp. 519-560, July 1995.
〔34〕C. G. Caro, J. M. Fitz-Gerald and R. C. Schroter. “Atheroma and arterial wall shear observation, correlation and proposal of a shear dependent mass transfer mechanism for atherogenesis”, Proceedings of the Royal Society B: Biological Sciences, Vol 77, pp. 109-159, February 1971.
〔35〕Peter F. Davies, Denise C. Polacek, Congzhu Shi and Brian P. Helmke. “The convergence of haemodynamics, genomics, and endothelial structure in studies of the focal origin of atherosclerosis”, Biorheology, Vol 39, pp. 299-306, January 2002.
〔36〕Kristopher S Cunningham and Avrum I Gotlieb. “The role of shear stress in the pathogenesis of atherosclerosis”, Laboratory Investigation, Vol 85, pp. 9-23, November 2004.
〔37〕P. F. Davies, A Remuzzi, E. J. Gordon, C. F. Dewey, Jr and M. A. Gimbrone, Jr. “Turbulent fluid shear stress induces vascular endothelial cell turnover in vitro”, Proceedings of the National Academy of Sciences USA, Vol 83, pp. 2114-2117, April 1986.
〔38〕DePaola N, Gimbrone MA Jr, Davies PF and Dewey CF Jr. “Vascular endothelium responds to fluid shear stress gradients”, Arteriosclerosis, Thrombosis, and Vascular Biology,Vol 12, pp. 1254-1257, November 1992.
〔39〕Barbee KA, Davies PF and Lal R. “Shear stress-induced reorganization of the surface topography of living endothelial cells imaged by atomic force microscopy”, Circulation Research, Vol 74, pp. 163-171, January 1994.
〔40〕Potter CM, Lundberg MH, Harrington LS, Warboys CM, Warner TD, Berson RE, Moshkov AV, Gorelik J, Weinberg PD and Mitchell JA. “Role of shear stress in endothelial cell morphology and expression of cyclooxygenase isoforms”, Arteriosclerosis, Thrombosis, and Vascular Biology, Vol 31, pp. 384-391, December 2010.
〔41〕Galbraith CG, Skalak R and Chien S. “Shear stress induces spatial reorganization of the endothelial cell cytoskeleton”, Cell Motility and Cytoskeleton , Vol 40, pp. 317-330, December 1998.
〔42〕Geoffrey B. “Release of vasoactive substances from endothelial cells by shear stress and purinergic mechanosensory transduction”, Journal of Anatomy, Vol 194, pp. 335-342, April 1999.
〔43〕Wang W, Ha CH, Jhun BS, Wong C, Jain MK and Jin ZG. “Fluid shear stress stimulates phosphorylation-dependent nuclear export of HDAC5 and mediates expression of KLF2 and eNOS”, Blood, Vol 115, pp. 2971-2979, April 2010.
〔44〕Choy JC, Granville DJ, Hunt DW and McManus BM. “Endothelial cell apoptosis: biochemical characteristics and potential implications for atherosclerosis”, Journal Molecular and Cellular Cardiology, Vol 33, pp. 1673-1690, September 2001.
〔45〕Tan J, Kuang W, Jin Z, Jin F, Xu L, Yu Q, Kong L, Zeng G, Yuan X and Duan Y. “Inhibition of NFKappaB by activated c-Jun NH2 terminal kinase 1 acts as a switch for C2C12 cell death under excessive stretch”, Apoptosis, Vol 14, pp. 764-770, August 2009.
〔46〕Leytin V, Allen DJ, Mykhaylov S, Mis L, Lyubimov EV, Garvey B and Freedman J. “Pathologic high shear stress induces apoptosis events in human platelets”, Biochemical and Biophysical Research Communications, Vol 320, pp. 303-310, July 2004.
〔47〕Jeremy B. Bower, Jerome H. Targovnik, Benjamin P. Bowen, Michaei. R. Caplan and Stephen P. Massia. “Elevated glucose impairs the endothelial cell response to shear stress”, Cellular and Molecular Bioengineering, Vol 4, pp. 533-543, December 2009.
〔48〕Kerr JF, Wyllie AH and Currie AR. “Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics”, British Journal of Cancer, Vol 26, pp. 239-257, August 1972.
〔49〕Conti-Tronconi BM, McLane KE, Raftery MA, Grando SA and Protti MP. “The nicotinic acetylcholine receptor: structure and autoimmune pathology”, Critical Reviews in Biochemistry and Molecular Biology, Vol 29, pp. 69-123, 1994.
〔50〕Kawashima K and Fujii T. “The lymphocytic cholinergic system and its contribution to the regulation of immune activity”, Life Sciences, Vol 74, pp. 675-696, December 2003.
〔51〕Zeidler R, Albermann K and Lang S. “Nicotine and apoptosis”, Apoptosis, Vol 11-12, pp. 1927-1943, November 2007.
〔52〕Machaalani R, Waters KA, Tinworth KD. “Effects ofpostnatal nicotine exposure on apoptotic markers in the developing piglet brain”, Neuroscience, Vol 132, pp. 325-333, March 2005.
〔53〕Suzuki J, Bayna E, Dalle Molle E and Lew WY. “Nicotine inhibits cardiac apoptosis induced by lipopolysaccharide in rats”, Journal of the American College of Cardiology, Vol 41, pp. 482-488, February 2003.
〔54〕Wright SC, Zhong J, Zheng H and Larrick JW. “Nicotine inhibition of apoptosis suggests a role in tumor promotion”, Federation of American Societies for Experimental Biology, Vol 7, pp. 1045-1051, August 1993.
〔55〕Imperial College London: Apoptosis Research Group。2013年7月5日，取自https://www1.imperial.ac.uk/departmentofmedicine/divisions/experimentalmedicine/pharmacologyandtherapeutics/pharmacology/apoptosis/
〔56〕Villablanca AC. “Nicotine stimulates DNA synthesis and proliferation in vascular endothelial cells in vitro”, Journal of Applied Physiology, Vol 84, pp. 2089-2098, June 1998.
〔57〕Takabe W, Warabi E and Noquch N. “Anti-atherogenic effect of laminar shear stress via Nrf2 activation”, Antioxidants & Redox Signaling, Vol 15, pp. 1415-1426, September 2011.
〔58〕Zarins CK, Zatina MA, Giddens DP, Ku DN and Glagov S. “Shear stress regulation of artery lumen diameter in experimental atherogenesis”, Journal of Vascular Surgery, Vol 5, pp. 413-420, March 1987.
〔59〕林松洲, 應用藥理學, 四版, 生韻出版社, 台北市, 1984.
〔60〕Russell MA, Jarvis M, Iyer R and Feyerabend C. “Relation of nicotine yield of cigarettes to blood nicotine concentrations in smokers”, British Medical Journal, Vol 280, pp. 972-976, April 1980.
〔61〕Flasherty JT, Pierce JE, Ferrans VJ, Patel DJ, Tucker WK and Fry DL. “Endothelial nuclear patterns in the canine arterial tree with particular reference to hemodynamic events”, Circulation Research, Vol 30, pp. 23-33, Jane 1972.
〔62〕Dewey CF Jr, Bussolari SR, Gimbrone MA Jr and Davies PF. “The dynamic-response of vascular endothelial-cells to fluid shear-stress”, Journal of Biomechanical Engineering Transactions of the ASME, Vol 103, pp. 177-185, August 1981.
〔63〕Smith FB, Lee AJ, Fowkes FG, Rumley A and Lowe GD. “Smoking, haemostatic factors and the severity of aorto-iliac and femoro-popliteal disease”, Journal of Thrombosis and Haemostasis, Vol 75, pp. 19-24, January 1996.
〔64〕Wu CC, Li YS, Haga JH, Kaunas R, Chiu JJ, Su FC, Usami S and Chien S. “Directional shear flow and Rho activation prevent the endothelial cell apoptosis induced by micropatterned anisotropic geometry”, Proceedings of the National Academy of Sciences, Vol 104, pp. 1254-1259, November 2007.
〔65〕Barbee KA, Mundel T, Lal R and Davies PF. “Subcellular distribution of shear stress at the surface of flow-aligned and nonaligned endothelial monolayers”, American Journal of Physiology, Vol 268, pp. H1765-H1772, April 1995.
〔66〕Chen CS, Tan J and Tien J. “Mechanotransduction at cell-matrix and cell-cell contacts”, Annual Review of Biomedical Engineering, Vol 6, pp. 275-302, July 2004.
〔67〕Ma Z, Liu Z, Myers DP and Terada LS. “Mechanotrasductin and anoikis: death and the homeless cell” Cell Cycle, Vol 7, pp. 2462-2465, August 2008.
〔68〕Shyu, K.G. “Cellular and molecular effects of mechanical stretch on vascular cells and cardiac myocytes”, Clinical Science, Vol 116, pp. 377-389, March 2009.
〔69〕Siasos G, Tousolis D, Siasou Z, Stefanadis C and Papavassiliou AG. “Shear stress, protein kinases and atherosclerosis”, Current Medicinal Chemistry, Vol 14, pp.1567-1572, June 2007.
〔70〕Padayatty S, Katz A, Wang Y, Eck P, Kwon O, Lee JH, Chen S, Corpe C, Dutta A, Dutta SK and Levine M. “Vitamin C as an antioxidant: evaluation of its role in disease prevention”, Journal of the American College of Nutrition, Vol 22, pp. 18-35, May 2002.
〔71〕Booyse FM, Osikowicz G and Quarfoot AJ. “Effects of chronic oral consumption of nicotine on the rabbit aortic endothelium”, The American Journal of Pathology, Vol 102, pp. 229-238, February 1981.