博碩士論文 88321008 詳細資訊




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姓名 吳怡靜( Jing-Yi Wu)  查詢紙本館藏   畢業系所 化學工程與材料工程學系
論文名稱 PU橡膠血液相容性之探討
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摘要(中) 嵌段式聚胺基甲酸酯(Segment polyurethane,SPU)具有良好的血液相容性與機械性質,因此在生醫材料上的應用日漸廣泛。但是在SPU表面與血液之間的反應,直至目前為止仍無法對單一表面因子提供明確的關係。由於材料表面與血液間的反應,除了涉及血小板和凝血因子之間的作用外,也會受到材料表面的性質、結構所影響。且在使用不同的鑄膜溶劑之下,亦會產生不同的結果。
本論文利用PTMO與polyester為polyols,設計出一系列不同polyol分子量、不同MDI含量的過氧化物交聯之PU系統;又因為此一系列PU之機械性質並不佳,所以又設計了添加促進劑與filler的系統。使用ATR-FTIR、靜態接觸角測量儀以及血小板吸附測試進行血液相容性的研究。實驗結果顯示:在PTMO系列中,低polyol分子量、高MDI含量下,具有較佳的結果。又在加入促進劑與filler之後,發現不但對於機械性質改善甚多,且對於血液相容性並無不當的影響,甚至發現接觸時間愈久,血小板吸附量愈少的情況。
關鍵字(中) ★ 血液相容性
★ 彈性體
關鍵字(英) ★ polyurethane elastomer
★ blood compatibility
論文目次 目錄
摘要
目錄----------------------------------------------------I
圖目錄--------------------------------------------------VI
表目錄--------------------------------------------------XI
第一章序論 ------------------------------------------1
第二章文獻回顧 -------------------------------------3
2.1PU彈性體簡介---------------------------------------3
2.1-1 Casting------------------------------------------4
2.1-2 Millable Urethane Gums---------------------------4
2.1-3 Thermoplastic------------------------------------4
2.2Millable Urethane Gums的合成與加工-----------------5
2.2-1 Millable Urethane Gums的合成---------------------5
2.2-1-1 Polyesters-based彈性體-----------------------6
2.2-1-2 Polyethers-based彈性體-----------------------6
2.2-2 Millable Urethane Gums的交聯---------------------8
2.2-2-1 硫化交聯--------------------------------------8
2.2-2-2 過氧化物交聯----------------------------------8
2.2-2-3 異氫酸鹽交聯---------------------------------11
2.2-3 塑化---------------------------------------------11
2.2-4 填充料之補強-------------------------------------12
2.3Millable Urethane Gums的性質-----------------------12
2.3-1 硬度---------------------------------------------13
2.3-2 拉伸強度與伸長量---------------------------------13
2.3-3 壓縮與剪切力-------------------------------------13
2.3-4 撕裂強度-----------------------------------------14
2.3-5 抗摩擦與摩擦係數---------------------------------14
2.3-6 彈性---------------------------------------------15
2.4血液與材料表面的反應--------------------------------15
2.4-1 血液的組成---------------------------------------16
2.4-2 凝血酵素 (thrombin)的形成------------------------16
2.4-2-1 內在途徑 (Intrinsic Pathway)-----------------16
2.4-2-2 外在途徑 (Extrinsic Pathway)-----------------17
2.4-3 血小板的活化-------------------------------------18
2.4-4 血栓的形成---------------------------------------21
2.5PU在血液相容性研究上的文獻回顧---------------------21
2.5-1 表面軟、硬質段比例的影響-------------------------22
2.5-2 表面親、疏水性的影響-----------------------------23
2.5-3 表面結晶性---------------------------------------24
2.5-4 表面微相分離程度---------------------------------25
2.5-5 軟質段polyol、diisocyanate、chain extender and
casting solvent-----------------------------------26
2.5-6 蛋白質層的影響-----------------------------------28
第三章實驗--------------------------------------------29
3.1化學藥品-------------------------------------------29
3.2儀器設備-------------------------------------------30
3.3Polyurethane Gum之製備----------------------------32
3.3-1 Polyol除水--------------------------------------32
3.3-2 Polyurethane Gum之合成--------------------------32
3.3-3 Polyurethane Gum之成膜--------------------------33
3.4Millable Urethane Gum sample 的鑑定----------------33
3.4-1 靜態接觸角 (Contact Angle,CA)測試與表面能的
評估:表面親、疏水性之測定------------------------33
3.4-2 多重式全反射紅外線光譜分析 (Attenuated Total
Reflection Fourier Transformed Infrared Spec
-troscopy,ATR-FTIR)------------------------------36
3.4-3 吸水性測試----------------------------------------36
3.4-4拉伸測試------------------------------------------37
3.4-5撕裂測試------------------------------------------37
3.4-6耐磨測試------------------------------------------37
3.4-7硬度測試------------------------------------------38
3.4-8熱重分析------------------------------------------38
3.4-9流變儀分析----------------------------------------38
3.4-10血小板吸附測試:血液相容性分析--------------------38
第四章結果與討論---------------------------------------41
4.1 靜態接觸角測試與表面張力之評估-----------------------41
4.2 ATR-FTIR測試-----------------------------------------45
4.3 吸水性測試-------------------------------------------53
4.4 拉伸測試---------------------------------------------57
4.5 撕裂測試---------------------------------------------58
4.6 耐磨測試---------------------------------------------59
4.7 硬度測試---------------------------------------------59
4.8 熱重分析---------------------------------------------70
4.9 流變儀分析-------------------------------------------77
4.10 血小板吸附測試--------------------------------------80
第五章結論---------------------------------------------91
參考文獻-------------------------------------------------93
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指導教授 陳登科(Teng-Ko Chen) 審核日期 2001-7-5
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