慢性阻塞性肺疾病病患服用吸入式類固醇或茶鹼的白內障,青光眼,黃斑部病變之風險:以台灣人口為基礎的回溯性巢式病例對照研究

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姓名

林繼群(Chi-Chun Lin) 查詢紙本館藏

畢業系所

資訊工程學系

論文名稱

慢性阻塞性肺疾病病患服用吸入式類固醇或茶鹼的白內障,青光眼,黃斑部病變之風險:以台灣人口為基礎的回溯性巢式病例對照研究
(Use of inhaled corticosteroids or theophylline and risk of cataract, glaucoma and age-related macular degeneration among chronic obstructive pulmonary disease patients: A population-based retrospective nested case-control study in Taiwan)

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摘要(中)

慢性阻塞性肺疾病是不可逆的肺部疾病，在我國的十大死因中排名第七，在治療上進入到中期開始就會建議使用吸入式類固醇來醫治，茶鹼也是病患的建議服用藥物之一。在我國的慢性阻塞性肺疾病病患的藥物使用中佔有最高的比例，此藥物對眼睛的影響目前尚未有明確的結果。白內障、青光眼、黃斑部病變都是常見之眼睛疾病。白內障影響了許多老年人的眼睛造成他們視力上的傷害影響深遠，而截至目前為止文獻對於吸入式類固醇的使用與罹患白內障的風險看法不一致；青光眼則是造成失明的一大主因，而吸入式類固醇對其影響目前的研究不多且缺乏大型的資料庫研究。黃斑部病變亦為好發於年長者，若輕忽則亦會造成失明。本研究中採用回顧性巢式病例對照設計。尋找慢性阻塞性肺部疾病的患者在使用吸入糖皮質激素/茶鹼與不同藥物組合後與眼睛疾病之間的關係。

摘要(英)

Chronic obstructive pulmonary disease is an irreversible lung disease. The leading cause of death ranked seventh in Taiwan. According to COPD guideline when patient enter into the third stage. They recommend using inhaled corticosteroids to heal, theophylline is also recommended that patients taking one of the medicines. Theophylline occupies the highest proportion of drug use in Taiwan. The effect of theophylline on eyes doesn’t have clearly results yet. Cataracts, glaucoma, age-related macular degeneration are all common eye diseases on elder. Cataract affects a lot of elder patients’ eyes and hurt a profound impact on their vision, however the published literature for inhaled corticosteroids using and the risk of cataracts is inconsistent until now. Glaucoma is the major culprit of cause blindness, and inhaled corticosteroids impacts on glaucoma in the current research is sparse and lacking large database research. Age-related macular degeneration is also a common eye disease in elder patients. Age-related macular degeneration will also cause blindness. This study is using retrospective nested case control to design. Searching the relation of eye diseases after using inhaled corticosteroids /theophylline with different drug combination among chronic obstructive pulmonary disease patients.

關鍵字(中)

★ 慢性阻塞性肺疾病
★ 吸入式類固醇
★ 白內障
★ 青光眼
★ 黃斑部病變
★ 巢式病例對照研究

關鍵字(英)

★ COPD
★ ICS
★ cataract
★ glaucoma
★ AMD
★ nested case-control study

論文目次

摘要 i
ABSTRACT ii
Table of Contents iii
List of Tables iv
List of Figures v
Chapter 1 Introduction 1
1.1 Background 1
1.2 Motivation 2
1.3 Research Goal 2
Chapter 2 Related Works 3
2.1 COPD and ICS 3
2.2 Eye diseases and ICS 3
2.3 COPD and theophylline 4
Chapter 3 Materials and Methods 5
3.1 Data Source 5
3.2 Study Design and Cohort Selection 5
3.3 Case definition and Controls Selection 7
3.4 Exposure measurement 7
3.5 Statistical Analysis 7
Chapter 4 Results 11
4.1 Baseline Characteristics 11
4.2 Eye diseases and ICS used 14
4.3 Eye diseases and theophylline used 25
Chapter 5 Discussion and Conclusion 34
References 37

參考文獻

1. Rabe KF, Hurd S, Anzueto A, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med 2007; 176:532-55.
2. Fabbri LM, Hurd SS. Global Strategy for the Diagnosis, Management and Prevention of COPD: 2003 update. Eur Respir J. 2003;22:1-2.
3. Anthonisen NR, Connett JE, Murray RP. Smoking and lung function of Lung Health Study participants after 11 years. Am J Respir Crit Care Med. 2002;166:675-679.
4. Lee CH, Lee MC, Shu CC, Lim CS, Wang JY, Lee LN, Chao KM. Risk factors for pulmonary tuberculosis in patients with chronic obstructive airway disease in Taiwan: a nationwide cohort study. BMC Infect Dis 13(1): 194.
5. David Price, Barbara Yawn, Guy Brusselle, Andrea Rossi. Risk-to-benefit ratio of inhaled corticosteroids in patients with COPD. Prim Care Respir J 2013; 22(1): 92-100
6. Congdon N, Vingerling J R, Klein B E. et al Eye Diseases Prevalence Research Group. Prevalence of cataract and pseudophakia/aphakia among adults in the United States. Arch Ophthalmol 2004. 122487–494.494
7. Cumming RG, Mitchell P, Leeder SR. Use of inhaled corticosteroids and the risk of cataracts. N Engl J Med 1997; 337: 8–14.
8. Garbe E, Suissa S, LeLorier J. Association of inhaled corticosteroid use with cataract extraction in elderly patients. JAMA 1998; 280: 539–543.
9. P. Ernst, M. Baltzan, J. Descheˆnes and S. Suissa. Low-dose inhaled and nasal corticosteroid use and the risk of cataracts. Eur Respir J 2006; 27: 1168–1174 DOI: 10.1183/09031936.06.00043005.
10. Weinreb RN, Khaw PT. Primary open-angle glaucoma. Lancet 2004 May 22;363(9422):1711–20.
11. Quigley HA. Number of people with glaucoma worldwide. Br J Ophthalmol 1996 May;80(5):389–93
12. Anne V. Gonzalez , Gisele Li , Samy Suissa , Pierre Ernst. Risk of glaucoma in elderly patients treated with inhaled corticosteroids for chronic airflow obstruction. Pulmonary Pharmacology & Therapeutics 23 (2010) 65–70.
13. Ryskulova A, Turczyn K, Makuc DM, Cotch MF, Klein RJ, Janiszewski R. Self-reported age-related eye diseases and visual impairment in the United States: results of the 2002 national health interview survey. Am J Public Health. 2008;98:454–461.
14. Etminan M, Brophy JM, Maberley D. Use of statins and angiotensin converting enzyme inhibitors (ACE-Is) and the risk of age-related macular degeneration: nested case-control study. Curr Drug Saf. 2008;3:24–26.
15. Nowak J.Z. Age-related macular degeneration (AMD): pathogenesis and therapy. Pharmacol. Rep. 2006;58:353-363.
16. Elin Drivenes, Anders Østrem and Hasse Melbye. Predictors of ICS/LABA prescribing in COPD patients: a study from general practice. BMC Family Practice 2014, 15:42.
17. Caramori G, Chung KF, Adcock IM. Profile of fluticasone furoate/vilanterol dry powder inhaler combination therapy as a potential treatment for COPD.Int J Chron Obstruct Pulmon Dis. 2014 Feb 24;9:249-56.
18. Jick SS, Vasilakis-Scaramozza C, Maier WC. The risk of cataract among users of inhaled steroids. Epidemiology 2001; 12: 229–234.
19. David P Miller, Stephanie E Watkins, Tim Sampson, Kourtney J Davis. Long-term use of fluticasone propionate salmeterol fixed-dose combination and incidence of cataracts and glaucoma among chronic obstructive pulmonary disease patients in the UK General Practice Research Database. International Journal of COPD 2011:6 467–476.
20. Weatherall M, Clay J, James K, Perrin K, Shirtcliffe P, et al. (2009) Dose-response relationship of inhaled corticosteroids and cataracts: a systematic review and meta-analysis. Respirology 14: 983–990.
21. Gartlehner G, Hansen RA, Carson SS, Lohr KN. The efficacy and safety of inhaled corticosteroids in patients with COPD: a systematic review and meta-analysis of health outcomes. Ann Fam Med 2006;4:253–262.
22. Smeeth L, Boulis M, Hubbard R, Fletcher AE. A population based case-control study of cataract and inhaled corticosteroids. Br J Ophthalmol. 2003;87:1247–1251.
23. Uboweja A, Malhotra S, Pandhi P. Effect of inhaled corticosteroids on risk of development of cataract: a meta-analysis development of cataract: a meta-analysis. Fundam Clin Pharmacol. 2006;20(3):305–309.
24. Vogelmeier, C F. Possible Harms of Theophylline in Chronic Obstructive Pulmonary Disease. Dtsch Arztebl Int 2014; 111(17): 291-2.
25. WU Jun-ping, WU Qi, SUN Xin and SUN Hong-fen. Corticosteroid resistance in chronic obstructive pulmonary disease: new uses of theophylline.Chinese Medical Journal 2013;126 (5)
26. Meng-Ting Wang, Cheng-Liang Tsai, Yu-Wen Lo, Jun-Ting Liou, Wan-Ju Lee, I-Ching Lai. Risk of stroke associated with inhaled ipratropium bromide in chronic obstructive pulmonary disease: A population-based nested case–control study. International Journal of Cardiology 158 (2012) 279–284.
27. Manuela M. Bergmann, Tim Byers, David S. Freedman, and Ali Mokdad . Validity of Self-reported Diagnoses Leading to Hospitalization: A Comparison of Self-reports with Hospital Records in a Prospective Study of American Adults. Am. J. Epidemiol. (1998) 147(10): 969-977.
28. Duanping Liao, Jingping Mo, Yinkang Duan, Ronald Klein, Ingrid U. Scott, Kui A. Huang and Haibo Zhou. Is Age-Related Macular Degeneration Associated with Stroke Among Elderly Americans? The Open Ophthalmology Journal, 2008, 2, 37-42
29. Deyo RA, Cherkin DC, Ciol MA. Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. J Clin Epidemiol.1992;45:613-619.
30. Wang CY, Lin YS, Tzao C, et al. Comparison of Charlson comorbidity index and Kaplan-Feinstein index in patients with stage I lung cancer after surgical resection. Eur J Cardiothorac Surg 2007;32:877–881.
31. Global Initiative for Chronic Obstructive Lung Disease. Global Strategy for Diagnosis Management and Prevention of COPD 2014 update.
32. Cazzola M, Bettoncelli G, Sessa E, Cricelli C, Biscione G. Prevalence of Comorbidities in Patients with Chronic Obstructive Pulmonary Disease. Respiration. 2010;80(2):112-9.
33. F Abuekteish, J N Kirkpatrick, G Russell. Posterior subcapsular cataract and inhaled corticosteroid therapy.Thorax 1995;50:674-676.

指導教授

洪炯宗(Jorng-Tzong Horng)

審核日期

2014-7-30

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