博碩士論文 102223034 詳細資訊




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姓名 鐘紹恩(Shao-En Chung)  查詢紙本館藏   畢業系所 化學學系
論文名稱 含硫官能基之內環狀中孔洞矽材合成與反 丁烯二酸金屬骨架材料之酵素催化應用
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摘要(中) 本篇論文分成兩個部分:

第一部分為合成具有硫醇官能基之內環裝中孔洞材料,其是利用直接合成法得到具有硫醇官能基的中孔洞材料SBA-15-thiol,且進一步利用具有雙異氰酸酯官能基之化合物進行合環反應,達到在中孔洞材料上修飾上內環狀之結構,而合成條件在經過最佳化後反應時間進需2 小時且反應在室溫下即可進行。新合成之內環狀中孔洞材料其體表面積高達600m2/g,且孔徑大小約在60 Å ,而此材料依舊保有中孔洞矽材的高熱穩定性的特性。因此在材料擁有眾多的優勢下將其去對金屬離子做吸附實驗,期望會有相較於同類型材料有更好的的吸附能力及選擇性。

第二部分是利用水相合成反丁烯二酸金屬骨架材料 (Zr-fum MOF) 將碳酸酐酶 (Carbonic Anhydrase, CA) 以原位反應的方式包裹在材料當中,來進行碳酸酐酶催化。因材料的合成環境較酸低於蛋白可容忍的範圍,所以我們利用縮短合成時間的方式提前結束反應以保留蛋白的活性,而經由X光繞射圖及掃描式電子顯微鏡的影像可以得知在提前結束反應的材料依舊保留完好的結構與外型。在酵素活性測試中,由CA@Zr-fum MOF 可加速4-硝基苯乙酸酯的水解速度可看出,包覆在Zr-fum MOF 中的碳酸酐酶依然保有活性。
摘要(英) This research is divided into two parts which are majorly focusing on the synthesis of annulated mesoporous silica and microporous material of Zr-Fumarate MOF. In the first part, a series of annulated mesoporous silica (SBA-15) with mercapto functional groups are successfully synthesized under room temperature condition. In this study, we adjust the annulated design with several diisocyanate derivatives. The as-synthesized particles were characterized by X-ray diffraction, 13C NMR, FT-IR spectra, thermogravimetric analysis, nitrogen sorption isothermal, electron microscopy. Notably, these synthesis

conditions are also moderate that the modified SBA-15 materials remain merely no change in their chemical and physical property. Moreover, we also utilized these materials as sorbents for the removal of mercury ion under aqueous solutions, and the results also reveal the exceptional consequence.

In the second part, we developed an aqueous system to synthesize Zr-Fumarate MOF and an in-situ procedure to encapsulate biomolecules such as protein. In order to limit the impact of the acidity and harshness of the synthetic environment on carbonic anhydrase, the synthesis duration was reduced from 2 hours to 15 minutes. According to the result from powder X-ray diffraction patterns (XRD) and scanning electron microscope (SEM), enzyme-encapsulated Zr-fum MOF are still with well morphology. Furthermore, the enzyme activity test showed that enzyme-encapsulated Zr-fum MOF still maintained its activity after the synthetic procedure.
關鍵字(中) ★ 中孔洞矽材
★ 環狀結構
★ 重金屬吸附
★ 金屬有機骨架材料
★ 固定化酵素
關鍵字(英)
論文目次 中文摘要 I

Abstract II

謝誌 III

目錄 IV

圖目錄 VI

表目錄 VII

Part I 1

第1章 緒論 1

1.1 中孔洞分子篩材料介紹 1

1.1.1 簡介 1

1.1.2 發展史 2

1.2 界面活性劑 5

1.2.1 簡介 5

1.2.2 界面活性劑分類 6

1.2.3 微胞的形成與結構 7

1.3 合成中孔洞材料 9

1.3.1 中孔洞材料合成條件 9

1.3.2 界面活性劑和矽氧化物的交互作用 10

1.3.3 合成中孔洞材料 11

1.3.4 中孔洞材料表面修飾官能基 12

1.4 中孔洞材料的應用 14

1.5 研究動機與目的 16

第2章 實驗 18

2.1 實驗藥品 18

2.2 實驗步驟 19

2.2.1 合成具硫醇官能基的SBA-15 19

2.2.2 移除中孔洞分子篩中的模板 20

2.2.3 合成具環狀結構的Annulatd-SBA-15 系列 20

2.3 實驗設備 21

2.3.1 實驗合成設備 21

2.3.2 實驗鑑定儀器 21

2.4 鑑定儀器之原理 22

2.4.1 X射線粉末繞射儀 (PXRD) 22

2.4.2 傅立葉傳換紅外線吸收光譜儀 (FT-IR) 24

2.4.3 固態核磁共振儀 (Solid-State NMR) 25

2.4.4 掃描式電子顯微鏡 (SEM) 29

2.4.5 等溫氮氣吸/脫附儀 (ASAP) 30

2.4.6 熱重分析儀 (TGA) 32

第3章 結果與討論 34

3.1 結構鑑定 34

3.1.1 PXRD鑑定結果 34

3.1.1 SEM影像. 35

3.1.2 29Si MAS NMR 鑑定結果 36

3.1.3 FT-IR 鑑定結果 37

3.1.4 13C CP/MAS NMR 鑑定結果 40

3.1.5 等溫氮氣吸脫附鑑定結果 42

3.1.6 熱重分析 44

3.2 環狀結構Annulatd-SBA-15系列吸附汞金屬實驗結果 45

第4章 結論 47

第5章 緒論 48

5.1 金屬有機骨架材料 48

5.2 反丁烯二酸金屬骨架材料 (Zr-fum MOF) 49

5.3 固定化酵素 (Immobilized Enzyme) 50

5.4 碳酸酐酶 (Carbonic Anhydrase, CA) 53

5.5 研究動機 55

第6章 實驗部分 57

6.1 實驗藥品 57

6.2 實驗儀器與方法 58

6.2.1 紫外光可見光分光光譜儀 (UV/VIS Spectrophotometer) 58

6.2.2 反丁烯二酸金屬骨架包覆碳酸酐酶材料 (CA@Zr-fum MOF) 的合成 58

6.2.3 反丁烯二酸金屬骨架包覆碳酸酐酶材料 (CA@Zr-fum MOF)的活性測試 59

第7章 結果與討論 62

7.1 反丁烯二酸金屬骨架包覆碳酸酐酶材料 (CA@Zr-fum MOF)的鑑定 62

7.2 反丁烯二酸金屬骨架包覆碳酸酐酶材料 (CA@Zr-fum MOF)的活性 62

第8章 結論與未來展望 64

參考文獻 65

第9章 附錄 72

9.1 類沸石咪唑骨架材料 ( Zeolitic Imidazolate Frameworks) 72

9.2 類沸石咪唑骨架材料-61 74

9.3 利用醇水混和合成類沸石咪唑骨架材料-61 74

9.4 結果與討論 75

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指導教授 謝發坤(Fa-KuenShieh) 審核日期 2015-8-26
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