博碩士論文 102552007 詳細資訊




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姓名 王孔良(Kung-Liang Wang)  查詢紙本館藏   畢業系所 資訊工程學系在職專班
論文名稱 勃起障礙與缺血性心臟病的雙向研究: 以台灣全人口基礎的世代研究
(A bidirectional study between erectile dysfunction and ischemic heart disease: A population-based cohort study in Taiwan)
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摘要(中) 勃起功能障礙,另又名為陽痿,是一種常見的男性私密疾病,這種疾病是無法勃起或者維持勃起狀況來滿足性活動。此外,勃起障礙已經被指出與缺血性心臟病為相同疾病的不同表現。勃起障礙病患而言,一般認為會受年齡所影響且好發在中老年的男性病患。因此,我們從全民健康保險研究資料庫取出40歲以上的新發勃起障礙病患,然後評估對於缺血性心臟病風險上的影響。之前大多數的研究都是在探討勃起障礙是否會引起缺血性心臟病的風險,本論文的研究提出考量雙向彼此間風險的影響。本論文研究結果顯示,勃起障礙的病患與非勃起障礙病患相比,勃起障礙病患有顯著增加缺血性心臟病風險 (HR =1.58, 95% CI=1.3-1.94),缺血性心臟病的病患與非缺血性心臟病病患相比,缺血性心臟病病患有顯著增加勃起障礙風險(HR =1.72, 95% CI=1.43-2.06)。
摘要(英) Erectile dysfunction, as known as impotence, is a common male and private disorder disease, which is the inability to achieve or sustain an erection for satisfactory sexual activity. In addition, erectile dysfunction has been noted with ischemic heart disease as different manifestations of the same disease. Patients with erectile dysfunction, it is generally believed that male patients will be affected by the age and often occurs in elderly. Therefore, we crawl from the National Health Insurance Research Database 40 years of age patients with new onset of erectile dysfunction, and then the assessment of ischemic heart disease risks. Most previous studies explore whether erectile dysfunction can cause the risk of ischemic heart diseases. In this study, we present the impact of each other between two-way risks. Studies have shown that patients with erectile dysfunction compared to patients without erectile dysfunction, patients with erectile dysfunction have a significant increase in the risk of ischemic heart disease (HR = 1.58, 95% CI = 1.3-1.94), patients with ischemic heart disease compared to patients without ischemic heart disease, patients had a significant increase in the risk of erectile dysfunction (HR = 1.72, 95% CI = 1.43-2.06).
關鍵字(中) ★ 勃起障礙
★ 缺血性心臟病
★ 世代研究
★ 雙向研究
關鍵字(英) ★ erectile dysfunction
★ ischemic heart disease
★ cohort study
★ bidirectional study
論文目次 Table of Contents
摘要 i
ABSTRACT ii
Table of Contents iii
List of Figures v
List of Tables vi
Chapter 1 Introduction 1
1.1 Background. 1
1.2 Related Works 1
1.3 Motivation. 4
1.4 Research Goal 4
Chapter 2 Materials and Methods 6
2.1 Data Sources 6
2.2 Main Disease Definition 6
2.3 Study Cohort Selection 6
2.4 Confounding Factors 11
2.5 Statistical Analysis 11
Chapter 3 Erectile Dysfunction Effects 13
3.1 Demographic Characteristics 13
3.2 Incidence and hazard ratios of Ischemic Heart Disease between two group by demographic characteristics 16
3.3 Incidence and hazard ratios of Ischemic Heart Disease between two group by comorbidity 20
3.4 Sensitive analysis from Erectile Dysfunction exposure 23
3.5 Kaplan-Meier Ischemic Heart Disease-Free Survival Curves 24
Chapter 4 Ischemic Heart Disease Effects 25
4.1 Demographic Characteristics 25
4.2 Incidence and hazard ratios of Erectile Dysfunction between two group by demographic characteristics 28
4.3 Incidence and hazard ratios of Erectile Dysfunction between two group by comorbidity 32
4.4 Sensitive analysis from Ischemic Heart Disease exposure 35
4.5 Kaplan-Meier Erectile Dysfunction-Free Survival Curves 36
Chapter 5 Discussions 37
Chapter 6 Conclusions 42
References 43
Appendix I ICD9 CODES 46
Appendix II Urbanization level 47

List of Figures
Figure 2.1. ED-IHD Flowchart of experimental design 8
Figure 2.2. IHD-ED Flowchart of experimental design 10
Figure 3.1. Probability free of IHD for patients without and with ED 24
Figure 4.1. Probability free of ED for patients without and with IHD 36

List of Tables
Table 1.1. Summary of similar study 3
Table 3.1. Demographic characteristics between patients with or without ED 14
Table 3.2. Incidence rates and adjusted hazard ratios of developing IHD stratified by age and comorbidity, insurance premium, geographic location, urbanization level 17
Table 3.3. Incidence rates and adjusted hazard ratios of IHD by comorbidities 21
Table 3.4. Sensitive anaylysis examining the adjusted hazard ratios of different lag time from
exposure(ED) 23
Table 4.1. Demographic characteristics between patients with or without IHD 26
Table 4.2. Incidence rates and adjusted hazard ratios of developing ED stratified by age and comorbidity, insurance premium, geographic location, urbanization level 29
Table 4.3. Incidence rates and adjusted hazard ratios of ED by comorbidities 33
Table 4.4. Sensitive anaylysis examining the adjusted hazard ratios of different lag time from
exposure(IHD) 35
Table 5.1. Comparison between Table 3.1 and 4.1 40
Table 5.2. Comparison between Table 3.2 and 4.2 41
Table 5.3. Comparison between Table 3.3 and 4.3 41
Table 5.4. Comparison between Table 3.4 and 4.4 42
Table 5.5. Comparison between Figure 3.1 and 4.1 42
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指導教授 洪炯宗(Jorng-Tzong Horng) 審核日期 2016-7-20
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