一次性多角度漫射光譜量測系統

以作者查詢圖書館館藏

、以作者查詢臺灣博碩士

、以作者查詢全國書目

、勘誤回報

、線上人數：25

、訪客IP：3.15.17.60

姓名

陳虹伶(Hong-Ling Chen) 查詢紙本館藏

畢業系所

光電科學與工程學系

論文名稱

一次性多角度漫射光譜量測系統
(One-snap multi-angle diffused reflection spectrum measuring system)

相關論文

★ 非反掃描式平行接收之雙光子螢光超光譜顯微術	★ 以二次通過成像量測架構及降低誤差迭代演算法重建人眼之點擴散函數
★ LASER光源暨LED在老鼠毛生長的低能量光治療比較分析	★ 應用線狀結構照明提升雙光子顯微鏡解析度
★ 以同調結構照明顯微術進行散射樣本解析度之提升	★ 掃描式二倍頻結構照明顯微術
★ 小貓自泵相位共軛鏡於數位光學相位共軛與時間微分之研究	★ 鏡像輔助斷層掃描相位顯微鏡
★ 以數位全像術重建多波長環狀光束之研究	★ 相位共軛反射鏡用於散射介質中光學聚焦之研究
★ 雙光子螢光超光譜顯微術於多螢光生物樣本之研究	★ 倍頻非螢光基態耗損超解析之顯微成像方法
★ 葉綠素雙光子螢光超光譜影像於光合作用研究之應用	★ 雙光子掃描結構照明顯微術
★ 微投影光學切片超光譜顯微術	★ 使用結構照明顯微術觀察活體小鼠毛囊生長週期之變化

檔案

[Endnote RIS 格式]

[Bibtex 格式]

[相關文章]

[文章引用]

[完整記錄]

[館藏目錄]

[檢視]

[下載]

本電子論文使用權限為同意立即開放。
已達開放權限電子全文僅授權使用者為學術研究之目的，進行個人非營利性質之檢索、閱讀、列印。
請遵守中華民國著作權法之相關規定，切勿任意重製、散佈、改作、轉貼、播送，以免觸法。

摘要(中)

在醫學上非侵入式檢測生物的方式逐漸成為重要的檢測方式，所以光譜的檢測開始被應用在醫學疾病的研究上。而皮膚的病變常因病徵的相似而容易有誤判的狀況，所以我們想透過不同角度的光譜量測來探討是否能由角度與光譜的關係來進行疾病的診斷。
為了得到更多的光譜資訊，來達到更精準的判斷，本實驗將研究樣本不同角度的漫射光譜。為了達到這個目的，本實驗將建立一個量測光譜的系統，它可以一次收取不同角度的光譜資訊，並且不用擔心樣本在量測不同角度之光譜資訊的過程中因實驗時間過久而量測失準。
首先，使用臺灣青銅金龜當樣本做研究，觀察金龜子的背殼在不同角度的光譜結構。隨著接收到的反射角度越大光譜的峰值會逐漸往短波長移動，。0度對應的顏色是橘黃色而60度對應的顏色是黃綠色。再來研究人類皮膚的光譜資訊，分析不同角度的情況下，皮膚光譜內帶有的黑色素、血紅素以及帶氧血紅素濃度比例，隨接收到的反射角越大，其濃度隨角度變小。再使用另一個分析方法，分析皮膚散射光經過系統的光學量測幾何特性。根據這個方法發現皮膚組織內吸收和散射對反射光譜貢獻程度的差異，以及樣本正負角度範圍的對稱性。

摘要(英)

The biological detection using non-invasive way in medicine is becoming an important detected method, so spectral detection began to be applied in medical disease research. The pathological changes of human skin are easy to be misjudged owing to that the symptoms are too similar, so we want to use the spectrum at different angles to study the disease diagnosis.
In order to obtain more spectral information to achieve more exact judgments, we will research the spectral structure at different angles. To realize this target, we set up a system to measure spectrum, which collects the spectral information of multi-angle in one time, and we do not concern about that it will take too long to measure multi-angle spectral information and causing inaccurate.
First of all, we take a Taiwanese bronze scarab as a sample and observe the result of this sample in multi-angle spectral measurement. As the received reflection angle is larger, the peaks of the spectrum gradually move to the short wavelength. 0 degree corresponding to the color is yellow and 60 degree corresponding to the color is green. Next, we research the spectrum information of human skin. In different angles spectrum, we analyze the skin spectrum with melanin, hemoglobin and oxyhemoglobin concentration ratio. As the received reflection angle is larger, the concentration decreases. And then we use another method to analyze the skin scattered light through the system with geometrical characteristics. According to this method, we find the difference in the contribution of absorption and scattering to the reflection spectrum in the skin tissue and the symmetry of the angle in positive and negative.

關鍵字(中)

★ 光譜
★ 漫射
★ 皮膚

關鍵字(英)

★ spectrum
★ diffused reflection
★ skin

論文目次

中文摘要 ................................................................................................................ I
Abstract ................................................................................................................. II
目錄 ..................................................................................................................... IV
圖目錄 ................................................................................................................. VI
表目錄 ................................................................................................................. XI
第一章緒論 ......................................................................................................... 1
1.1 研究動機與目的 .......................................................................................... 1
1.2 光譜學介紹 ................................................................................................. 2
第二章實驗原理與分析 ..................................................................................... 8
2.1 光與介質之間的交互作用.......................................................................... 8
2.2 人體皮膚之漫反射光譜 ............................................................................. 9
第三章一次性多角度漫射光譜量測系統 ....................................................... 18
3.1 一次性多角度漫射光譜量測系統之架構介紹 ....................................... 18
3.2 光譜維度的計算 ........................................................................................ 20
3.3 角度維度的設計 ....................................................................................... 22
3.4 量測系統的校正 ........................................................................................ 24
3.4.1 光譜校正 ............................................................................................. 24
3.4.2 角度校正 ............................................................................................. 27
3.5 白平衡校正 ............................................................................................... 28
第四章系統量測結果 ....................................................................................... 31
4.1 光柵量測 .................................................................................................... 31
4.2 金龜子背殼之反射光譜 ............................................................................ 33
4.3 人體皮膚之反射光譜 ................................................................................ 39
第五章結論與未來展望 ................................................................................... 52
5.1 結論 ............................................................................................................ 52
5.2 未來展望 .................................................................................................... 53
參考文獻 ............................................................................................................. 54

參考文獻

[1] M. Zaharna and R. T. Brodell. "It’s time for a “change” in our approach to early detection of malignant melanoma." Clinics in dermatology 21.5 : 456-458, 2003.
[2] K. S. Bersha. "Spectral imaging and analysis of human skin. " Diss. University of Eastern Finland, 2010.
[3] H. Cen and Y. He. "Theory and application of near infrared reflectance spectroscopy in determination of food quality." Trends in Food Science & Technology 18.2 : 72-83, 2007.
[4] E. Angelopoulou. "Understanding the color of human skin." Photonics West 2001-Electronic Imaging. International Society for Optics and Photonics, 2001.
[5] E. Angelopoulou. "The reflectance spectrum of human skin." Technical Reports (CIS) : 584, 1999.
[6] M. Sydor and L. Gloege. "Angular distribution of spectral reflectance from live human skin in the 400-850 nm region of the spectrum."
[7] H. Zeng, C. MacAulay, B. Palcic and D. I. McLean. "A computerized autofluorescence and diffuse reflectance spectroanalyser system for in vivo skin studies." Physics in medicine and biology 38.2 : 231, 1993.
[8]http://oddwiring.com/archive/websites/mndev/MSB/AD100/colorwheel.htm
[9]https://theideagirlsays.wordpress.com/2012/08/17/higgs-boson-particle-speed-of-light-msw-effect-wavelength-electromagnetic-spectrum-5g-wow-seti/increasing-energy-wavelength-visible-light-diagram/
[10] S. Juds. "Photoelectric sensors and controls: selection and application." Vol. 63. CRC Press, 1988.
[11] J. Reeves, G. McCarty and T. Mimmo. "The potential of diffuse reflectance spectroscopy for the determination of carbon inventories in soils." Environmental Pollution 116 : S277-S284, 2002.
[12] B. Torrent and V. Barron. "Diffuse reflectance spectroscopy." Methods of soil analysis. Part 5 : 367-385, 2008.
[13] P. Connes and G. Michel. "Astronomical Fourier spectrometer." Applied Optics 14.9 : 2067-2084, 1975.
[14] D. J. Schroeder. "An echelle spectrometer–spectrograph for astronomical use." Applied optics 6.11 : 1976-1980, 1967.
[15] R. Washington, M. Todd, N. J. Middleton and A. S. Goudie. "Dust-storm source areas determined by the total ozone monitoring spectrometer and surface observations." Annals of the Association of American Geographers 93.2 : 297-313, 2003.
[16] H. Zeng, H. Lui, C. MacAulay, B. Palcic and D. I. McLean. "Spectrometer system for diagnosis of skin disease." U.S. Patent No. 6,008,889. 28 Dec. 1999.
[17] G. Gauglitz. "UV/visible-spectrometry." Trends in Analytical Chemistry 2.10, 1983.
[18] D. Barcelo, G. Durand, V. Bouvot and M. Nielen. "Use of extraction disks for trace enrichment of various pesticides from river water and simulated seawater samples followed by liquid chromatography-rapid-scanning UV-visible and thermospray-mass spectrometry detection." Environmental science & technology 27.2 : 271-277, 1993.
[19] X. Jiang , J. Jiang , Y. Jin , E. Wang and S. Dong. "Effect of colloidal gold size on the conformational changes of adsorbed cytochrome c: probing by circular dichroism, UV-visible, and infrared spectroscopy." Biomacromolecules 6.1 : 46-53, 2005.
[20] D. F. Malley, C. McClure, P. D. Martin, K. Buckley and W. P. McCaughey. "Compositional analysis of cattle manure during composting using a field?portable near?infrared spectrometer." Communications in Soil Science and Plant Analysis 36.4-6 : 455-475, 2005.
[21] B. G. Osborne and T. Fearn. "Near infrared spectroscopy in food analysis. " Longman, 1986.
[22] P. G. Al-Rawi, P. Smielewski and P. J. Kirkpatrick. "Evaluation of a near-infrared spectrometer (NIRO 300) for the detection of intracranial oxygenation changes in the adult head." Stroke 32.11 : 2492-2500, 2001.
[23] F. M. Flasar, et al. "Exploring the Saturn system in the thermal infrared: The composite infrared spectrometer." The Cassini-Huygens Mission. Springer Netherlands. 169-297, 2004.
[24] Y. Garini, I. T. Young and G. McNamara. "Spectral imaging: principles and applications." Cytometry Part A 69.8 : 735-747, 2006.
[25] Q. Li, X. He, Y. Wang, H. Liu, D. Xu, and F. Guo. "Review of spectral imaging technology in biomedical engineering: achievements and challenges." Journal of biomedical optics 18.10 : 100901, 2013.
[26] K. Fuwa and B. L. Valle. "The Physical Basis of Analytical Atomic Absorption Spectrometry. The Pertinence of the Beer-Lambert Law." Analytical Chemistry 35.8 : 942-946, 1963.
[27] A. Fournell, L. A. Schwarte, T. W. L. Scheeren, D. Kindgen-Milles, P. Feindt, and S. A. Loer. "Clinical evaluation of reflectance spectrophotometry for the measurement of gastric microvascular oxygen saturation in patients undergoing cardiopulmonary bypass." Journal of Cardiothoracic and Vascular Anesthesia 16.5 : 576-581, 2002.
[28] N. Sato, N. Hayashi, S. Kawano, T. Kamada and H. Abe. "Hepatic hemodynamics in patients with chronic hepatitis or cirrhosis as assessed by organ-reflectance spectrophotometry." Gastroenterology 84.3 : 611-616, 1983.
[29] J. Hoffmann, D. W. Lubbers and H. M. Heise. "Applicability of the Kubelka-Munk theory for the evaluation of reflectance spectra demonstrated for haemoglobin-free perfused heart tissue." Physics in Medicine and Biology 43.12 : 3571, 1998.
[30] J. D. Hardy, H. T. Hammel and D. Murgatroyd. "Spectral transmittance and reflectance of excised human skin." Journal of Applied Physiology 9.2 : 257-264, 1956.
[31] R. R. Anderson and J. A. Parrish. "The optics of human skin." Journal of Investigative Dermatology 77.1 : 13-19, 1981.
[32] http://slideplayer.com/slide/5695405/
[33] W. Montagna. "The Structure and Function of Skin." Elsevier, 2012.
[34] A. Haake, G. A. Scott and K. A. Holbrook. "Structure and function of the skin: overview of the epidermis and dermis." The Biology of the Skin 2001 : 19-20, 2001.
[35]http://pharmaxchange.info/press/2011/03/the-ageing-skin-part-1-structure-of-skin-and-introduction/
[36] K. S. Bersha. "Spectral imaging and analysis of human skin. " Diss. University of Eastern Finland, p16, 2010.
[37]https://en.wikipedia.org/wiki/Epidermis#/media/File:Epidermal_layers.png
[38] E. Bastonini, D. Kovacs and M. Picardo. "Skin Pigmentation and Pigmentary Disorders: Focus on Epidermal/Dermal Cross-Talk." Annals of dermatology 28.3 : 279-289, 2016.
[39] S. L. Jacques, Skin optics, Oregon Medical Laser Center, 1998. http://omlc.ogi.edu/news/jan98/skinoptics.html
[40] http://omlc.org/spectra/index.html
[41] T. Igarashi, K. Nishino and S. K. Nayar. "The appearance of human skin: A survey." Foundations and TrendsR in Computer Graphics and Vision 3.1 : 15, 2007.
[42] A. J. Vogel. "Noninvasive Optical Imaging Techniques as a Quantitative Analysis of Kaposi′s Sarcoma Skin Lesions." Doctoral dissertation, 2007.
[43] R. Casiday and R. Frey. "Hemoglobin and the heme group: Metal complexes in the blood for oxygen transport." Retrieved March 28 : 2008, 1998.
[44] T. J. Farrell, M. S. Patterson and B. Wilson. "A diffusion theory model of spatially resolved, steady?state diffuse reflectance for the noninvasive determination of tissue optical properties in vivo." Medical physics 19.4 : 879-888, 1992.
[45] M. Born and E. Wolf. "Principles of Optics." Pergamon Press, 1975.
[46] W. J. Wiscombe. "Mie scattering calculations: Advances in technique and fast, vector-speed computer codes." Atmospheric Analysis and Prediction Division, National Center for Atmospheric Research, 1979.
[47] G. Zonios, J. Bykowski and N. Kollias. "Skin melanin, hemoglobin, and light scattering properties can be quantitatively assessed in vivo using diffuse reflectance spectroscopy." Journal of Investigative Dermatology 117.6 : 1452-1457, 2001.
[48] G. Zonios and A. Dimou. "Modeling diffuse reflectance from semi-infinite turbid media: application to the study of skin optical properties." Optics express 14.19 : 8661-8674, 2006.
[49] T. J. Farrell, M. S. Patterson and B. Wilson. "A diffusion theory model of spatially resolved, steady?state diffuse reflectance for the noninvasive determination of tissue optical properties invivo." Medical physics 19.4 : 879-888, 1992.
[50] C. H. Ko, and M. F. R. Lee. "Design and fabrication of a microspectrometer based on silicon concave micrograting." Optical Engineering 50.8 : 084401-084401, 2011.
[51] R. J. Woodham, Y. Iwahori, R. A. Barman and S. K. Gokiso-cho. "Photometric stereo: Lambertian reflectance and light sources with unknown direction and strength. " University of British Columbia. Department of Computer Science, 1991.
[52] H. E. Hinton and D. F. Gibbs. "An electron microscope study of the diffraction gratings of some carabid beetles." Journal of Insect Physiology 15.6 : 959IN7961-960IN11962, 1969.
[53] V. Sharma, M. Crne, J. O. Park and M. Srinivasarao. "Structural origin of circularly polarized iridescence in jeweled beetles." science 325.5939 : 449-451, 2009.
[54] S. Yoshioka and S. Kinoshita. "Direct determination of the refractive index of natural multilayer systems." Physical Review E 83.5 : 051917, 2011.
[55] http://taibif.tw/zh/namecode/334456?page=8
[56] M. N. Wu, C. Y. Chen and W. Pan. "Coloration and structure of Taiwanese bronze scarab (Anomala expansa)." AIP Advances 5.12 : 127227, 2015.
[57] M. Xu, A. E. Seago, T. D. Sutherland and S. Weisman. "Dual structural color mechanisms in a scarab beetle." Journal of morphology 271.11 : 1300-1305, 2010.
[58] A. R. Young. "Chromophores in human skin." Physics in Medicine and Biology 42.5 : 789, 1997.

指導教授

陳思妤

審核日期

2017-3-17

推文