||Precise neural firing is important in the transferring of information. However, we still do not fully understand the mechanism that allows neurons to generate a spike within a narrow temporal regime in the order of a few millisecond. To study the spike timing in a neuron, we perform two types of experiment. Firstly, we stimulate the neuron with different temporal correlated stimuli using patch clamp, and analyze the statistics of corresponding firing patterns; secondly, we apply the stochastic optimal control to manipulate the spiking time. Our samples are from the primary cortical culture. Our result indicates that precision of spike timing is optimal when the correlation times of stimuli are from 2 to 10 ms. In the ramp stimuli experiment, the higher slope of ramp stimuli result in higher precision of spike timing. Obviously, the precision of spike timing depends on stimulus transients. In the stochastic optimal control experiment, the spike timing can be controlled within a few millisecond(1~5ms).|
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