博碩士論文 103522099 詳細資訊




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姓名 洪子為(Tzu-Wei Hung)  查詢紙本館藏   畢業系所 資訊工程學系
論文名稱 藥物與疾病關聯性自動化分析平台設計與實作
(Design and Implementation of an Automated Analysis System to Analyze Correlations between a Drug and Diseases)
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摘要(中) 隨著全民健保資料庫(NHIRD)相關研究的成長, 開發一個能進行世代分析研究的自動化平台是有必要的,本論文設計與實作一平台來分析疾病與藥物之間的關聯性,探討當罹患某種疾病進而服用某種藥物時, 會不會提高另外一種疾病發生的風險。我們蒐集了對此關聯性進行相關討論的研究論文,以驗證我們自動化平台的可行性。經過驗證後, 可發現我們所實作的平台確實可達到與驗證的論文結果有一致的方向性。
摘要(英) Objective: Currently none of analysis systems have considered the correlations between a drug and diseases. With the growth in number of data in the NHIRD (National Health Insurance Research Database), similar procedures, which have been used in previous cohort studies are performed again and again when carrying out similar cohort research and do the same procedures repeatedly is inefficient. In such circumstances an automatic analysis system ought to be able to reduce the laborious repeated procedures used in such circumstances. The aim of this study is to design and implement an automatic analysis system to analyze the correlations between a drug and diseases.
Method: Based on NHIRD of the registration files and original claim data, we design and implement an automatic analysis system to analyze the correlations between a drug and diseases using cohort study design. We build a website to let users to enter their query. After each query is performed, our system transforms the query into corresponding SAS codes and then executes the SAS file by the statistical software until. Finally, our system converts the SAS output files into result tables and displays them on website.
Results: We collect some cohort study researches from journals so as to verify the feasibility of our system, and input parameters by follow the previous researches parameters as equally as possible.
Conclusion: Our system does make research more efficiently in using cohort study design to analyze correlations between a drug and diseases and save much more time for researchers.
關鍵字(中) ★ 全民健保資料庫
★ 世代研究
★ 自動化分析平台
關鍵字(英) ★ NHIRD
★ Cohort study
★ Analysis system
論文目次 Table of Contents
摘要 …………………………………………………………………………………...…... i
ABSTRACT ……………………………………………………………….……..….……...ii
List of Figures …………………………………………………..………….…….….……...v
List of Tables …………………………………………………….……………..……..……vi
Chapter 1 Introduction ……………………………………….………………………..……1
1.1 Background ……………………………………………………….…..….…………..…….1
1.2 Motivation …………………………………………………………..……….……….…….1
1.3 Research Goal ………………………………………………………………….…………..2
Chapter 2 Related Works…………………………………………..………………………...3
Chapter 3 Materials and Methods …………………………..............4
3.1 Data Sources ………………………………………………………………..…….....……...4
3.2 Cohort Study Design ………………………………………………………………..……...4
3.3 System Design ………………………………………………………………...………........7
3.4 Website of System ……………………………………………………..................................8
3.5 Data Converter …………………………………………………………………...………..11
3.6 Statistical Software ………………………………………………………………………..14
3.7 Website Display …………………………………………………………………………..14
Chapter 4 Results …………………………………………………………………………..17
4.1 A Verification of Analysis System……………………………………………....17
4.2 Results of the Verification …………………………….……..……..….17
Chapter 5 Discussions and Conclusions ……………………..……...…...28
5.1 Discussions ...……………………………………………………………………….….28
5.2 Conclusions…………………………………………………………...………………..30
References ………………………………………………………………………….….…31
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3. SAS ( Accessed at http://www.sas.com/en_us/company-information.html#stats )
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6. Chia-Ling Lin, et al. “Risk of Type 2 Diabetes in Patients With Nonapnea Sleep Disorders in Using Different Types of Hypnotics” Medicine Volume 94(2015): 1-8
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10. National Health Insurance Research Database (Accessed at
http://nhird.nhri.org.tw/.).
11. Data subsets of National Health Insurance Research Database. (Accessed at http://nhird.nhri.org.tw/en/Data_Subsets.html.)
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17. J. B. Andersen, et al. “Total drug treatment and comorbidity in myasthenia gravis: a population-based cohort study” European Journal of Neurology(2014): 948-955
18. Maria Gustafsson, et al. “Psychotropic drug use among people with dementia – a six-month follow-up study” BMC Pharmacology and Toxicology(2013): 1-9
19. Tony Antoniou, et al. “Statins and the Risk of Herpes Zoster: A Population-Based Cohort Study” CID(2014): 350-356
20. Jui-Ming Chen, et al. “Acarbose Treatment anf the Risk of Cardiovascular Disease in Type 2 Diabetic Patients: A Nationwide Seven-Year Follow-Up Study” Journal of Diabetes Research (2014): 1-6
21. Lars Vedel Kessing, Julie Lyng Forman and Per Kragh Andersen, “Does lithium protect against dementia” Bipolar Disorders (2010): 87-94
22. R. E. Aubert, et al. “Rosiglitazone and pioglitazone increase fracture risk in women and men with type 2 diabetes” Diabetes, Obesity and Metabolism (2010): 716-721
指導教授 洪炯宗(Jorng-Tzong Horng) 審核日期 2016-7-22
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