Ahmad, P., M. Ashraf, M. Younis, X. Hu, A. Kumar, N.A. Akram, and F. Al-Qurainy. 2012. Role of transgenic plants in agriculture and biopharming. Biotechnol Adv. 30:524-540.
Akoh, C.C., S.W. Chang, G.C. Lee, and J.F. Shaw. 2008. Biocatalysis for the production of industrial products and functional foods from rice and other agricultural produce. J Agric Food Chem. 56:10445-10451.
Boyd, T.D., S.P. Bennett, T. Mori, N. Governatori, M. Runfeldt, M. Norden, J. Padmanabhan, P. Neame, I. Wefes, J. Sanchez-Ramos, G.W. Arendash, and H. Potter. 2010. GM-CSF upregulated in rheumatoid arthritis reverses cognitive impairment and amyloidosis in alzheimer mice. J Alzheimers Dis. 21:507-518.
Burgess, A.W., J. Camakaris, and D. Metcalf. 1977. Purification and properties of colony-stimulating factor from mouse lung-conditioned medium. J Biol Chem. 252:1998-2003.
Carrier, T., K.L. Jones, and J.D. Keasling. 1998. mRNA stability and plasmid copy number effects on gene expression from an inducible promoter system. Biotechnol Bioeng. 59:666-672.
Chan, M.T., and S.M. Yu. 1998. The 3′ untranslated region of a rice alpha-amylase gene mediates sugar-dependent abundance of mRNA. Plant J. 15:685-695.
Chang S., Puryear J., Cairney J. (1993) A Simple and Efficient Method for Isolating RNA from Pine Trees. Plant Molecular Biology Reporter 11: 113-116.
Chen, P.W., C.A. Lu, T.S. Yu, T.H. Tseng, C.S. Wang, and S.M. Yu. 2002. Rice alpha-amylase transcriptional enhancers direct multiple mode regulation of promoters in transgenic rice. J Biol Chem. 277:13641-13649.
Chen, T.L., Y.L. Lin, Y.L. Lee, N.S. Yang, and M.T. Chan. 2004. Expression of bioactive human interferon-gamma in transgenic rice cell suspension cultures. Transgenic Res. 13:499-510.
Chen, Z., Y. He, B. Shi, and D. Yang. 2013. Human serum albumin from recombinant DNA technology: challenges and strategies. Biochim Biophys Acta. 1830:5515-5525.
Chung, N.D., N.S. Kim, D.V. Giap, S.H. Jang, S.M. Oh, S.H. Jang, T.G. Kim, Y.S. Jang, and M.S. Yang. 2014. Production of functional human vascular endothelial growth factor(165) in transgenic rice cell suspension cultures. Enzyme Microb Tech. 63:58-63.
Dare, A.P., R.J. Schaffer, K. Lin-Wang, A.C. Allan, and R.P. Hellens. 2008. Identification of a cis-regulatory element by transient analysis of co-ordinately regulated genes. Plant Methods. 4:17.
Eager, R., and J. Nemunaitis. 2005. GM-CSF gene-transduced tumor vaccines. Mol Ther. 12:18-27.
Eckardt, N.A. 2000. Sequencing the rice genome. Plant Cell. 12:2011-2017.
Egea, L., C.S. McAllister, O. Lakhdari, I. Minev, S. Shenouda, and M.F. Kagnoff. 2013. GM-CSF Produced by nonhematopoietic cells is required for early epithelial cell proliferation and repair of injured colonic mucosa. J Immunol. 190:1702-1713.
Eubank, T.D., R. Roberts, M. Galloway, Y.J. Wang, D.E. Cohn, and C.B. Marsh. 2004. GM-CSF induces expression of soluble VEGF receptor-1 from human monocytes and inhibits angiogenesis in mice. Immunity. 21:831-842.
Farrar, W.L., A. Harel-Bellan, and D.K. Ferris. 1988. Biochemical and molecular events controlled by lymphokine growth factors. Soc Gen Physiol Ser. 43:371-380.
Fire, A., S. Xu, M.K. Montgomery, S.A. Kostas, S.E. Driver, and C.C. Mello. 1998. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature. 391:806-811.
Fujiwara, Y., Y. Aiki, L. Yang, F. Takaiwa, A. Kosaka, N.M. Tsuji, K. Shiraki, and K. Sekikawa. 2010. Extraction and purification of human interleukin-10 from transgenic rice seeds. Protein Expr Purif. 72:125-130.
Gerasimova, S.V., O.G. Smirnova, A.V. Kochetov, and V.K. Shumnyi. 2016. Production of recombinant proteins in plant cells. Russ J Plant Physl+. 63:26-37.
Gilchrist, R.B., D.B. Rowe, L.J. Ritter, S.A. Robertson, R.J. Norman, and D.T. Armstrong. 2000. Effect of granulocyte-macrophage colony-stimulating factor deficiency on ovarian follicular cell function. J Reprod Fertil. 120:283-292.
Griffin, J.D., S.A. Cannistra, R. Sullivan, G.D. Demetri, T.J. Ernst, and Y. Kanakura. 1990. The biology of GM-CSF: regulation of production and interaction with its receptor. Int J Cell Cloning. 8 Suppl 1:35-44; discussion 44-35.
Guo, S.Y., Q.L. Gu, Z.G. Zhu, H.Q. Hong, and Y.Z. Lin. 2003. TK gene combined with mIL-2 and mGM-CSF genes in treatment of gastric cancer. World J Gastroenterol. 9:233-237.
Gupta, R., and L.A. Emens. 2010. GM-CSF-secreting vaccines for solid tumors: moving forward. Discov Med. 10:52-60.
He, Y., T. Ning, T. Xie, Q. Qiu, L. Zhang, Y. Sun, D. Jiang, K. Fu, F. Yin, W. Zhang, L. Shen, H. Wang, J. Li, Q. Lin, Y. Sun, H. Li, Y. Zhu, and D. Yang. 2011. Large-scale production of functional human serum albumin from transgenic rice seeds. Proc Natl Acad Sci U S A. 108:19078-19083.
Hiatt, A., R. Cafferkey, and K. Bowdish. 1989. Production of antibodies in transgenic plants. Nature. 342:76-78.
Hood, E.E., S.P. Devaiah, G. Fake, E. Egelkrout, K.T. Teoh, D.V. Requesens, C. Hayden, K.R. Hood, K.M. Pappu, J. Carroll, and J.A. Howard. 2012. Manipulating corn germplasm to increase recombinant protein accumulation. Plant Biotechnol J. 10:20-30.
Huang, L.F., Y.K. Liu, C.A. Lu, S.L. Hsieh, and S.M. Yu. 2005. Production of human serum albumin by sugar starvation induced promoter and rice cell culture. Transgenic Res. 14:569-581.
Huang, T.K., and K.A. McDonald. 2012. Bioreactor systems for in vitro production of foreign proteins using plant cell cultures. Biotechnology Advances. 30:398-409.
Hwang, Y.S., E.E. Karrer, B.R. Thomas, L. Chen, and R.L. Rodriguez. 1998. Three cis-elements required for rice alpha-amylase Amy3D expression during sugar starvation. Plant Mol Biol. 36:331-341.
Jung, J.W., N.S. Kim, S.H. Jang, Y.J. Shin, and M.S. Yang. 2016. Production and characterization of recombinant human acid alpha-glucosidase in transgenic rice cell suspension culture. J Biotechnol. 226:44-53.
Karg, S.R., and P.T. Kallio. 2009. The production of biopharmaceuticals in plant systems. Biotechnol Adv. 27:879-894.
Kaufman, H.L., C.E. Ruby, T. Hughes, and C.L. Slingluff, Jr. 2014. Current status of granulocyte-macrophage colony-stimulating factor in the immunotherapy of melanoma. J Immunother Cancer. 2:11.
Khatami, S., E. Brummer, and D.A. Stevens. 2001. Effects of granulocyte-macrophage colony stimulating factor (GM-CSF) in vivo on cytokine production and proliferation by spleen cells. Clin Exp Immunol. 125:198-201.
Kim, B.G., S.H. Kim, N.S. Kim, N.X. Huy, Y.S. Choi, J.Y. Lee, Y.S. Jang, M.S. Yang, and T.G. Kim. 2014. Production of monoclonal antibody against FimA protein from Porphyromonas gingivalis in rice cell suspension culture. Plant Cell Tiss Org. 118:293-304.
Kim, D.I., G.H. Cho, H. Pedersen, and C.K. Chin. 1991. A hybrid bioreactor for high density cultivation of plant cell suspensions. Appl Microbiol Biotechnol. 34:726-729.
Kim, N.S., T.G. Kim, Y.S. Jang, Y.J. Shin, T.H. Kwon, and M.S. Yang. 2008a. Amylase gene silencing by RNA interference improves recombinant hGM-CSF production in rice suspension culture. Plant Mol Biol. 68:369-377.
Kim, N.S., H.Y. Yu, N.D. Chung, Y.J. Shin, T.H. Kwon, and M.S. Yang. 2011. Production of functional recombinant bovine trypsin in transgenic rice cell suspension cultures. Protein Expres Purif. 76:121-126.
Kim, T.G., M.Y. Baek, E.K. Lee, T.H. Kwon, and M.S. Yang. 2008b. Expression of human growth hormone in transgenic rice cell suspension culture. Plant Cell Rep. 27:885-891.
Kim, T.G., M.Y. Baek, E.K. Lee, T.H. Kwon, and M.S. Yang. 2008c. Expression of human growth hormone in transgenic rice cell suspension culture. Plant Cell Reports. 27:885-891.
Kim, T.G., N.Q.D. Tien, M.S. Yang, J.H. Moon, and J.Y. Lee. 2016. Production of monoclonal antibodies against 53-kDa protein of Porphyromonas gingivalis in transgenic rice cell suspension culture. Plant Cell Tiss Org. 126:387-397.
Kingston, D., M.A. Schmid, N. Onai, A. Obata-Onai, D. Baumjohann, and M.G. Manz. 2009. The concerted action of GM-CSF and Flt3-ligand on in vivo dendritic cell homeostasis. Blood. 114:835-843.
Kuo, Y.C., C.C. Tan, J.T. Ku, W.C. Hsu, S.C. Su, C.A. Lu, and L.F. Huang. 2013. Improving pharmaceutical protein production in Oryza sativa. Int J Mol Sci. 14:8719-8739.
Kwon, J.Y., Y.S. Yang, S.H. Cheon, H.J. Nam, G.H. Jin, and D.I. Kim. 2013. Bioreactor engineering using disposable technology for enhanced production of hCTLA4Ig in transgenic rice cell cultures. Biotechnology and Bioengineering. 110:2412-2424.
Kwon, T.H., Y.M. Shin, Y.S. Kim, Y.S. Jang, and M.S. Yang. 2003. Secretory production of hGM-CSF with a high specific biological activity by transgenic plant cell suspension culture. Biotechnol Bioproc E. 8:135-141.
Lau, O.S., and S.S.M. Sun. 2009. Plant seeds as bioreactors for recombinant protein production. Biotechnology Advances. 27:1015-1022.
Lee, S.J., C.I. Park, M.Y. Park, H.S. Jung, W.S. Ryu, S.M. Lim, H.K. Tan, T.H. Kwon, M.S. Yang, and D.I. Kim. 2007. Production and characterization of human CTLA4Ig expressed in transgenic rice cell suspension cultures. Protein Expr Purif. 51:293-302.
Lee, T. H and Lu C. A. 2007. Functional analysis of OsMYBS2 gene in rice.
Li, X., H. Bai, X. Wang, L. Li, Y. Cao, J. Wei, Y. Liu, L. Liu, X. Gong, L. Wu, S. Liu, and G. Liu. 2011. Identification and validation of rice reference proteins for western blotting. J Exp Bot. 62:4763-4772.
Li, Y.H., K.Y. Guo, H. Chen, Y.M. Xie, C.Y. Song, X. Tang, and C.M. Ren. 2001. Oral cytokine gene therapy against murine tumor using attenuated Salmonella typhimurium. Int J Cancer. 94:438-443.
Liu, B.N., W.H. Tan, A. Barsoum, X.G. Gu, K. Chen, W.T. Huang, A. Ramsay, J.K. Kolls, and P. Schwarzenberger. 2010. IL-17 is a potent synergistic factor with GM-CSF in mice in stimulating myelopoiesis, dendritic cell expansion, proliferation, and functional enhancement. Exp Hematol. 38:877-884.
Liu, Y.K., L.F. Huang, S.L. Ho, C.Y. Liao, H.Y. Liu, Y.H. Lai, S.M. Yu, and C.A. Lu. 2012. Production of mouse granulocyte-macrophage colony-stimulating factor by gateway technology and transgenic rice cell culture. Biotechnology and Bioengineering. 109:1239-1247.
Liu, Y.K., Y.T. Li, C.F. Lu, and L.F. Huang. 2015. Enhancement of recombinant human serum albumin in transgenic rice cell culture system by cultivation strategy. N Biotechnol. 32:328-334.
Lu, C.A., T.H. Ho, S.L. Ho, and S.M. Yu. 2002. Three novel MYB proteins with one DNA binding repeat mediate sugar and hormone regulation of alpha-amylase gene expression. Plant Cell. 14:1963-1980.
Lu, C.A., E.K. Lim, and S.M. Yu. 1998. Sugar response sequence in the promoter of a rice alpha-amylase gene serves as a transcriptional enhancer. J Biol Chem. 273:10120-10131.
Lu, C.A., C.C. Lin, K.W. Lee, J.L. Chen, L.F. Huang, S.L. Ho, H.J. Liu, Y.I. Hsing, and S.M. Yu. 2007. The SnRK1A protein kinase plays a key role in sugar signaling during germination and seedling growth of rice. Plant Cell. 19:2484-2499.
Miguel, A., M.J. Herrero, L. Sendra, R. Botella, R. Algas, M. Sanchez, and S.F. Alino. 2012. comparative antitumor effect of preventive versus therapeutic vaccines employing B16 melanoma cells genetically modified to express GM-CSF and B7.2 in a murine model. Toxins. 4:1058-1081.
Murashige, T., and F. Skoog. 1962. A revised medium for rapid growth and bio assays with tobacco tissue cultures. Physiologia Plantarum. 15:473-497.
Rho, C.R., M.Y. Park, and S. Kang. 2015. Effects of granulocyte-macrophage colony-stimulating (GM-CSF) factor on corneal epithelial cells in corneal wound healing model. Plos One. 10.
Sabalza, M., P. Christou, and T. Capell. 2014. Recombinant plant-derived pharmaceutical proteins: current technical and economic bottlenecks. Biotechnol Lett. 36:2367-2379.
Sasaki, T., and B. Burr. 2000. International rice genome sequencing project: the effort to completely sequence the rice genome. Curr Opin Plant Biol. 3:138-141.
Sheu, J.J., T.S. Yu, W.F. Tong, and S.M. Yu. 1996. Carbohydrate starvation stimulates differential expression of rice alpha-amylase genes that is modulated through complicated transcriptional and post-transcriptional processes. J Biol Chem. 271:26998-27004.
Shi, F.S., S. Weber, J. Gan, A.L. Rakhmilevich, and D.M. Mahvi. 1999. Granulocyte-macrophage colony-stimulating factor (GM-CSF) secreted by cDNA-transfected tumor cells induces a more potent antitumor response than exogenous GM-CSF. Cancer Gene Ther. 6:81-88.
Shi, Y.F., C.H. Liu, A.I. Roberts, J.T. Das, G.W. Xu, G.W. Ren, Y.Y. Zhang, L.Y. Zhang, Z.R. Yuan, H.S.W. Tan, G.H. Das, and S. Devadas. 2006. Granulocyte-macrophage colony-stimulating factor (GM-CSF) and T-cell responses: what we do and don′t know. Cell Res. 16:126-133.
Shigemitsu, T., S. Ozaki, Y. Saito, M. Kuroda, S. Morita, S. Satoh, and T. Masumura. 2012. Production of human growth hormone in transgenic rice seeds: co-introduction of RNA interference cassette for suppressing the gene expression of endogenous storage proteins. Plant Cell Rep. 31:539-549.
Shin, Y.J., Y.J. Chong, M.S. Yang, and T.H. Kwon. 2011. Production of recombinant human granulocyte macrophage-colony stimulating factor in rice cell suspension culture with a human-like N-glycan structure. Plant Biotechnol J. 9:1109-1119.
Shin, Y.J., S.Y. Hong, T.H. Kwon, Y.S. Jang, and M.S. Yang. 2003. High level of expression of recombinant human granulocyte-macrophage colony stimulating factor in transgenic rice cell suspension culture. Biotechnol Bioeng. 82:778-783.
Subramaniam, R., Z. Hillberry, H. Chen, Y. Feng, K. Fletcher, P. Neuenschwander, and H. Shams. 2015. Delivery of GM-CSF to protect against Influenza Pneumonia. Plos One. 10:e0124593.
Terashima, M., Y. Ejiri, N. Hashikawa, and H. Yoshida. 1999. Effect of osmotic pressure on human alpha(1)-antitrypsin production by plant cell culture. Biochem Eng J. 4:31-36.
Theoret, J.K., N.M. Jadavji, M. Zhang, and P.D. Smith. 2016. Granulocyte macrophage colony-stimulating factor treatment results in recovery of motor function after white matter damage in mice. Eur J Neurosci. 43:17-24.
Twyman, R.M., E. Stoger, S. Schillberg, P. Christou, and R. Fischer. 2003. Molecular farming in plants: host systems and expression technology. Trends Biotechnol. 21:570-578.
Vamvaka, E., R.M. Twyman, A.M. Murad, S. Melnik, A.Y. Teh, E. Arcalis, F. Altmann, E. Stoger, E. Rech, J.K. Ma, P. Christou, and T. Capell. 2016. Rice endosperm produces an underglycosylated and potent form of the HIV-neutralizing monoclonal antibody 2G12. Plant Biotechnol J. 14:97-108.
Vellenga, E., D.C. Young, K. Wagner, D. Wiper, D. Ostapovicz, and J.D. Griffin. 1987. The effects of GM-CSF and G-CSF in promoting growth of clonogenic cells in acute myeloblastic leukemia. Blood. 69:1771-1776.
Wen, Q., W.J. Xiong, J.C. He, S.M. Zhang, X.L. Du, S.D. Liu, J.J. Wang, M.Q. Zhou, and L. Ma. 2016. Fusion cytokine IL-2-GMCSF enhances anticancer immune responses through promoting cell-cell interactions. J Transl Med. 14.
Whittle, A.T., M. Davis, C.L. Shovlin, P.S. Ganly, C. Haslett, and A.P. Greening. 2001. Alveolar macrophage activity and the pulmonary complications of haematopoietic stem cell transplantation. Thorax. 56:941-946.
Wicks, I.P., and A.W. Roberts. 2016. Targeting GM-CSF in inflammatory diseases. Nat Rev Rheumatol. 12:37-48.
Willinger, T., A. Rongvaux, H. Takizawa, G.D. Yancopoulos, D.M. Valenzuela, A.J. Murphy, W. Auerbach, E.E. Eynon, S. Stevens, M.G. Manz, and R.A. Flavell. 2011. Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung. Proc Natl Acad Sci U S A. 108:2390-2395.
Won, J.H., J.E. Ji, K.H. Ahn, S.K. Kim, J.M. Choi, H.C. Ha, H.M. Kim, C.K. Yun, K. Han, and D.K. Kim. 2013. Effect of rice cell-derived human granulocyte-macrophage colony-stimulating factor on 5-fluorouracil-induced mucositis in hamsters. Biol Pharm Bull. 36:425-431.
Xu, J.F., X.M. Ge, and M.C. Dolan. 2011. Towards high-yield production of pharmaceutical proteins with plant cell suspension cultures. Biotechnology Advances. 29:278-299.
Yang, L.J., T. Kawakatsu, Y. Wakasa, M. Yoine, and F. Takaiwa. 2014. RNA silencing is induced by the expression of foreign recombinant products in transgenic rice. Plant Sci. 225:138-146.
Yoshimura, T., T. Imamichi, J.M. Weiss, M. Sato, L. Li, A. Matsukawa, and J.M. Wang. 2016. Induction of monocyte chemoattractant proteins in macrophages via the production of granulocyte/macrophage colony-stimulating factor by breast cancer cells. Front Immunol. 7:2.
Youngblood, B.A., R. Alfano, S.C. Pettit, D. Zhang, H.G. Dallmann, N. Huang, and C.C. Macdonald. 2014. Application of recombinant human leukemia inhibitory factor (LIF) produced in rice (Oryza sativa L.) for maintenance of mouse embryonic stem cells. J Biotechnol. 172:67-72.