鈀金屬催化含氮炔類的合環反應之探討

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姓名

詹詠翔(Yung-Hsiang Chan) 查詢紙本館藏

畢業系所

化學學系

論文名稱

鈀金屬催化含氮炔類的合環反應之探討
(Palladium catalyzed intramolecular cyclization of N-(2-ethynylcyclopentyl)sulfonamide)

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摘要(中)

我們成功以鈀金屬催化含氮炔類化合物進行分子內合環形成環戊
烷取代吡咯衍生物，且使用微波反應器輔助可以有效提升產率，最高可
達92%。此方法可應用於合成藥物Ramipril 中的重要結構。

摘要(英)

Hydroamination of N-(2-ethynylcyclopentyl)sulfonamide to
give non-aromatic 2,3-dihydropyrroles was achieved by using
PdCl2 as the catalyst. With microwave-assisted heating, up to 92%
isolated yield was obtained from this intramolecular 5-endodig
cyclization. The cyclopentane-fused 2,3-dihydropyrroles were
transformed into the corresponding N-tosyl-pyrrolidine-2-
carboxylic acids.

關鍵字(中)

★ 鈀金屬催化含氮炔類的合環反應之探討

關鍵字(英)

論文目次

總目錄
中文摘要 I
英文摘要 II
總目錄 III
圖目錄 V
流程圖目錄 VI
表目錄 VII
附圖目錄 VIII
第一章序論 1
1-1 前言 1
1-2 含氮雜環的合成 2
1-3 研究動機 8
第二章結果與討論 9
2-1 起始物的製備 9
2-2 金屬催化合環反應的結果 14
2-2-1 最佳反應條件 14
2-2-2鈀金屬催化環戊烷取代含氮炔類的合環反應 16
2-2-3合成cyclopentane-fused N-tosyl-pyrrolidine-2-carboxylic acid 19
2-2-4合成具高共軛系統吡咯衍生物 20
第三章結論 24
第四章實驗部分 25
4-1溶媒及處理過程 25
4-2實驗器材與儀器 26
4-3實驗步驟 29
第五章參考文獻 88

參考文獻

第五章參考文獻
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指導教授

侯敦仁

審核日期

2017-8-23

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