The Research of Material Deposition Process for Bio-scaffold Fabrication in Tissue Engineering Applications

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范玉海(Ngoc-Hai Pham) 查詢紙本館藏

畢業系所

機械工程學系

論文名稱

(The Research of Material Deposition Process for Bio-scaffold Fabrication in Tissue Engineering Applications)

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摘要(中)

在組織工程技術的最新進展中，已經能讓醫生能夠處理一些先前較難治療的病症。開發這種技術時，也已經製備了具有可控孔徑和孔隙率的支架，以研究細胞相互作用，如細胞增殖和分化。在本研究中，描述使用我們所開發的低溫沉積製造系統所製作出的支架。而該系統使用能夠製造三維微結構的技術並需要多種系統的整合，包括運動卡控制、移動系統、低溫系統、材料分配系統。另一方面，這項研究也通過利用這種低溫沉積製造的方式來研究我們所使用之材料(PLA)的沉積過程，並嘗試用不同方法去做實驗分析，如：梯形移動，片段擠出和可變移動速度的擠出分析以及提高支架寬度均勻的品質，特別是位於轉角處的材料過度堆積。

摘要(英)

Recent developments in tissue-engineering techniques allow physicians to treat a range of previously untreatable conditions. In the development of such techniques, scaffolds with a controllable pore size and porosity have been manufactured to investigate cell interaction effects such as cell proliferation and differentiation. In this study, we describe the fabrication of scaffolds using a low-temperature deposition manufacturing system that we developed. This systems uses technology that enables the manufacture of three-dimensional microstructures and required the combination of several technologies, including motion card control (NI-motion card, National Instruments), movement system (Linmot system), low-temperature system, material dispesing system (Ultimus IV, NORDSON). In the other hand, this research will be researched the material (PLA) deposition process by this low-temperature deposition manufacturing and try to use our method such as: the trapezoidal move, the segment extrusion and the extrusion with variable moving velocities to analysis and improve the quality of the uniform width strands of scaffold and specially the over-accumulation of material located in the corner.

關鍵字(中)

★ 組織工程支架
★ 低溫沉積製造
★ 點膠系統

關鍵字(英)

★ Tissue Engineering Scaffold
★ Low-temperature Depositon Manufacturing
★ Dispensing System

論文目次

ABSTRACT V
Table of contents VIII
List of Figures X
Chapter 1: Introduction 1
1-1 BACKGROUND 1
1-2 LITERATURE REVIEW 2
1-3 RESEARCH PROCESS AND AIMS 15
1-4 THESIS OUTLINE 16
Chapter 2: Research Theory 17
2-1 TISSUE ENGINEERING 17
2-2 ADDITIVE MANUFACTURING FOR TISSUE ENGINEERING 20
2-3 LOW-TEMPERATURE DEPOSITION MANUFACTURING 24
Chapter 3: Research Method 28
3-1 THE INTRODUCTION AND CONFIGURATION OF THE EQUIPMENT IN LOW-TEMPERATURE DEPOSITION METHOD 28
3-2 SCAFFOLD BIO-MATERIAL FOR SCAFFOLD FABRICATION 39
3-3 THE PROCESS OF BIO-SCAFFOLD FABRICATION VIA LOW-TEMPERATURE DEPOSITION METHOD 39
3-4 CONTROL METHOD OF THE SCAFFOLD FABRICATION SCAFFOLD VIA LOW-TEMPERATURE DEPOSITION 51
3-5 INTERFACE AND CODING OF THE PROGRAM 56
Chapter 4: Results and Discussion 72
4-1 THE STRATEGY OF IMPROVING THE QUALITY OF SCAFFOLD 72
4-2 COMPARISION THE EXPERIMENTAL RESULT WITH THE DIFFERENT STRATEGIES 76
4-3 ANALYSIS THE EXPERIMENTAL RESULT WITH DIFFERENT SHAPES 88
4-4 ANALYSIS OF SURFACE MORPHOLOGY 93
Chapter 5: Conclusion and Future work 99
5.1 CONCLUSION 99
5.2 FUTURE WORK 99
References 101

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指導教授

廖昭仰(Chao-Yaug Liao)

審核日期

2017-11-9

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