博碩士論文 104821603 詳細資訊




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姓名 玉思(Azjargal Tumen-Ayush)  查詢紙本館藏   畢業系所 生命科學系
論文名稱 藉由金黃色葡萄球菌增加抗體的產生來對抗痤瘡丙酸桿菌,用以增進痤瘡之治療
(Staphylococcus aureus enhances the production of antibodies to Propionibacterium acnes; Implication for treatment of acne vulgaris)
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摘要(中) 在人體中,存在著許多共生、共存、甚至是治病的微生物族群,尤其,在表皮上存在著極多的痤瘡丙酸桿菌(P. acnes)、以及大多集中於鼻子與呼吸道的少量金黃色葡萄球菌(S. aureus),他們皆為革蘭氏陽性菌、喜愛在厭氧的環境下生長,他們常引起許多的皮膚疾病,如同我們所常聽到的痤瘡即為P. acnes引起的,他也是我們常在青春期時約莫85-100%的青少年有所困擾的症狀,雖然其不會有生命上的威脅,但是卻會在心理上造成嚴重的影響、如同沒有自信去與人群社交。在本篇研究中,我們展示了人體中痤瘡丙酸桿菌的抗體只有非常少量,相較之下在人體中具有及少量的金黃色葡萄球菌卻有著大量的抗體,不論該成人是否有著青春痘的疾病,他們皆有抗痤瘡丙酸桿菌的抗體,在此我們便選用抗金黃色葡萄球菌之抗體來開發抗青春痘的疫苗,我們的數據更顯示了在活體外/活體內實驗中抗金黃色葡萄球菌之抗體的產生,更會來減緩由痤瘡丙酸桿菌所產生的發炎反應、甚至是抑制痤瘡丙酸桿菌的數量。
摘要(英) In the human body, there are much microbiotas, symbiotic and pathogenic microorganisms especially surface of the skin have a lot of P. acnes (on the face) very less number of S. aureus (around of the nose, respiratory tract). They both are a gram-positive human skin commensal that prefers anaerobic growth conditions and the common cause of skin infections. P. acnes mostly played for its role in acne vulgaris, affecting 85-100% of the population at some point in their lives. Although it is not life-threatening, severe acne can greatly burden a patient’s psychological status, thereby reduces their participation in social activities. In this study, we demonstrated their antibody titer. P. acnes produce very less number of production of antibodies, but even with very less number on the skin S. aureus can produce a high number of antibodies. Antibody against P. acnes antigenic determinants are found in the blood of most adults, whether they have had acne or not. Furthermore, in here antibodies produced by S. aureus was selected as antigens for the development of acne vaccines. Our data investigated in vitro/in vivo that the production of antibodies of S. aureus will be suppressed P. acnes – induced inflammation and killed P. acnes.
關鍵字(中) ★ 痤瘡丙酸桿菌
★ 痤瘡
★ 金黃色葡萄球菌
★ 生產抗體
關鍵字(英) ★ Propionibacterium acnes
★ Acne vulgaris
★ Staphylococcus aureus
★ production of antibody
論文目次 Table of contents

Abstract ……………………………………………………………………………. i
Acknowledgments…………………………………………………………………. iii
Table of contents ………………………………………………………………….. iv
List of figures ........………………………………………………………………… v
I. Introduction
1.1. Propionibacterium acnes ………………………………………1
1.2. Staphylococcus aureus …………………………………………2
1.3. Acne vulgaris ………………………………………………2
1.4. Test strip ……………………………………………………3
II. Materials and Methods …………………………………………………4
1. In vitro methods ……………………………………………………6
2. In vivo methods …………………………………………………….7
III. Results ………………………………………………………………….8
IV. Discussions …………………………………………………………….10
V. References ……………………………………………………………..12
VI. Figures …………………………………………………………............14
VII. Appendices …………………………………………………………… 20
參考文獻
1. Propionibacterium acnes and chronic diseases Ajay Bhatia, Ph.D., Jean-Francoise Maisonneuve, Ph.D., and David H. Persing, M.D., Ph.D. Corixa Corporation, Seattle, WA
2. Wang, Y., Zhu, W., et. al., and Huang, C.-M. The Response of Human Skin Commensal Bacteria as a Reflection of UV Radiation: UV-B Decreases Porphyrin Production. PLoS ONE, 2012;7(10):e47798.
3. Wang, Y., Kuo, S., Shu M., Yu, J., Huang, S., Dai, A., Two, A., Gallo, RL., and Huang, C.-M. Staphylococcus epidermidis in the human skin microbiome mediates fermentation to inhibit the growth of Propionibacterium acnes: Implications of probiotics in acne vulgaris. Appl Microbiol Biotechnol., 2014, 98(1):411-24. (S. epidermidis is a probiotic bacterium which can use glycerol fermentation to reduce the overgrowth of P. acnes)
4. Wang Y, Kao MS, Yu J, Huang S, Marito S, Gallo RL, Huang, C.-M. A Precision Microbiome Approach Using Sucrose for Selective Augmentation ofStaphylococcus epidermidis Fermentation against Propionibacterium acnes. Int J Mol Sci. 2016,17(11). pii: E1870. (Sucrose can enhance S. epidermidis fermentation to kill P. acnes).
5. Chih-Wei Lo, Yiu-Kay lai, Yu-Tsueng Liu, Richard L.Gallo and Chun-Ming huang Staphylococcus aureus Hijacks a Skin Commensal to Intensify Its Virulence: Immunization Targeting β-Hemolysin and CAMP Factor
6. Sandrine Henri, David Vremec, Arun Kamath, Jason Waithman et all. The dendritic cell populations of Mouse Lymph nodes
7. Shu, M., Wang, Y., Yu, J., Kuo, S., Coda, A., Jiang, Y., Gallo, R.L., and Huang, C.-M. Fermentation of Propionibacterium acnes, a Commensal Bacterium in the Human Skin Microbiome, as Skin Probiotics Against Methicillin-Resistant Staphylococcus aureus. PLoS ONE, 2013;8(2):e55380
8. Ajay Bhatia, Ph.D., Jean-Francoise Maisonneuve, Ph.D., and David H. Persing, M.D., Ph.D. Propionibacterium acnes and chronic diseases, Corixa Corporation, Seattle, WA
9. Brook, 1., and Frazier.E.H (1991). Infections caused by Propionibacterium species. Rev Infect Dis 13,819-22
10. Brukhart, C.G., Burkhart, C.N., and Lehman., P.F. (1999). Acne: a review of immunology and microbiologic factor. Postgrad Med 75, 328-31
11. Koreck, A., Pivaresi,A., Dobozy, A., and Kemeny, L. (2003). The role of innate immunity in the pathogenesis of acne.
12. Gollnick,H. (2003). Current concepts of the pathogenesis of acne. Implications for drug treatment. Drugs 63. 1579-96
13. Adlam C, Scott MT. Lympho-reticular stimulatory properties of Corynebacterium parvum and related bacteria. Journal of Medical Microbiology. 1973;6:261–274.
14. David A Wrone and Daniel N Sauder., expert review of clinical immunology. (2014) Topical immunotherapy for skin disease.
15. Farzin Khorvash, Fatemeh Abdi, Hessam H. Kashani, Farahnaz Fatemi Naeini, and T.Narimani …Staphylococcus aureus in Acne Pathogenesis: A Case-Control Study (2012)
指導教授 黃俊銘(Chun-Ming Huang Eric Huang) 審核日期 2017-7-26
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