博碩士論文 104881606 詳細資訊




以作者查詢圖書館館藏 以作者查詢臺灣博碩士 以作者查詢全國書目 勘誤回報 、線上人數:5 、訪客IP:3.235.105.97
姓名 蘇妮塔(Sunita Keshari)  查詢紙本館藏   畢業系所 生命科學系
論文名稱 皮膚微生物基因組群揭示益生菌/益生質/後生元對搔癢症與紫外線輻射誘導產生的發炎反應之作用機制
(Skin Microbiome Reveals Mechanisms of Pro/Pre/Postbiotics on Inflammation by Pruritus and UV Radiation)
檔案 [Endnote RIS 格式]    [Bibtex 格式]    [相關文章]   [文章引用]   [完整記錄]   [館藏目錄]   至系統瀏覽論文 ( 永不開放)
摘要(中) 微生物基因組群 (microbiome) 在人類健康和疾病發病機制中扮演重要的角色。我們現有的數據是基於皮膚微生物基因組群 (skin microbiome) 在皮膚病學的顯現例如瘙癢或發炎反應,尤其著重在尿毒性瘙癢與慢性紫外線 ((UV)-B) 引起的皮膚發炎反應之中的益生菌作用。尿毒性搔癢伴隨皮膚中磷酸鈣 (calcium phosphate; CaP) 濃度的升高是慢性腎臟病 (chronic kidney disease; CKD) 患者常見的症狀。在這項研究中我們證明,皮內注射到小鼠的磷酸鈣所引起的老鼠抓癢行為,隨著注射劑量的增加而增加,是透過正向調控在皮膚中的IL-6的表現量與背根神經節(dorsal root ganglion; DRG)中ERK的磷酸化程度。在IL-6基因剔除小鼠的背根神經節中,磷酸鈣誘導的ERK磷酸化 (p-ERK) 的正向調控程度大幅減少,因此IL-6是不可缺少的。磷酸鈣注射後,微陣列分析加上即時聚合酶鏈鎖反應分析顯示,在背根神經節中布魯頓氏酪氨酸激酶 (Bruton’s tyrosine kinase; BTK) 基因的mRNA表現量更高。透過Ibrutinib將BTK抑制後明顯地減少磷酸鈣誘導的IL-6表現量與ERK磷酸化的正向調控程度。在慢性腎臟病患者的搔癢皮膚與血液中檢測到 較高量的IL-6。經過IL-6重組蛋白處理後,DRG初代細胞中的p-BTK與p-ERK的表現量分別在第1分鐘與第10分鐘達到最高程度,並且兩者的表現量在細胞同時處理IL-6重組蛋白與Ibrutinib之後顯著地降低。磷酸鈣誘導的搔癢機制是透過IL-6/p-BTK/p-ERK訊息傳導路徑所介導的。

皮膚共生益生菌在磷酸鈣誘導的尿毒性搔癢和發炎反應中的作用尚未被鑑定與揭露。在這項研究中我們證實皮膚共生菌,痤瘡嗜酸桿菌 (Cutibacterium acnes) 透過葡萄糖發酵產生的短鏈脂肪酸 (short-chain fatty acids; SCFAs),例如丁酸,溶解磷酸鈣。像丁酸一樣,N-[2-(2-Butyrylamino-ethoxy)-ethyl]-butyramide (BA-NH-NH-BA),一種丁酸的衍生物,在角質細胞中顯著地誘導組織蛋白H3離胺酸 (histone H3 lysine 9; AcH3K9) 的乙醯化。在小鼠皮膚上局部施用發酵的痤瘡丙酸桿菌、丁酸或BA-NH-NH-BA可以有效地改善磷酸鈣誘導的皮膚搔癢 角質細胞中白介素IL-6的正向調控程度,以及背根神經節中p-BTK和p-ERK表現程度。在IL-6基因剔除小鼠中,磷酸鈣誘導的p-BTK和p-ERK正向調控明顯減少。在慢性腎臟病患者的搔癢皮膚中量測到的角質屬細菌含量相對較低。我們的結果確定了皮膚發酵的痤瘡丙酸桿菌能夠改善磷酸鈣誘導的IL-6/p-BTK/p-ERK訊息傳導路徑的活化並造成發炎反應的作用。此外,我們更提供BA-NH-NH-BA作為一種後抗生素治療尿毒性瘙癢症的潛在治療功效的證據。
我們還檢測到皮膚共生益生菌,表皮葡萄球菌(Staphylococcus epidermidis) 對慢性紫外線輻射的抗發炎作用是透過甘油發酵產生例如丁酸的短鏈脂肪酸來進行的。我們檢測到皮膚微生物基因組群中的表皮葡萄球菌在體外以毫摩爾範圍的濃度產生丁酸。小鼠背側皮膚暴露於UVB光引起顯著的IL-6產量增加。局部單獨施用丁酸或表皮葡萄球菌與甘油一起施用可顯著改善UVB誘導的IL-6產生。小鼠皮膚中2的短鏈脂肪酸受體2 (short-chain fatty acid receptor 2; FFAR2) 的體內剔除明顯地阻斷了表皮葡萄球菌對於抑制UVB誘導的IL-6產生的益生作用。這些結果表明,發酵中的皮膚益生菌的代謝產物中的丁酸介導FFAR2來調節UVB誘導的促炎性細胞因子的產生。總體而言,我們已經闡明了尿毒性搔癢症和UVB誘導的皮膚發炎反應的分子信號傳導路徑,並且驗證了丁酸的抗發炎作用。丁酸是痤瘡丙酸桿菌和表皮葡萄球菌皮膚益生菌透過發酵碳源產生的主要代謝產物,可提供預防和治療尿毒性瘙癢和UVB引起的皮膚慢性發炎的治療方法。
摘要(英) Microbiome plays a significant role in human health and disease pathogenesis. Our current data based on the probiotic role of the skin microbiome in dermatological manifestations like pruritus or inflammation with a special emphasis on uremic pruritus and chronic ultraviolet (UV)-B induced skin inflammation. Uremic pruritus with elevated levels of calcium phosphate (CaP) in skin is a common symptom in patients with chronic kidney disease (CKD). In this study, we demonstrate that intradermal injection of CaP into mice triggered scratching by up-regulating the IL-6 in skin and phosphorylation of ERK in dorsal root ganglion (DRG) in a dose-dependent manner. IL-6 is essential because the CaP-induced up-regulation of phosphorylated (p)-ERK in DRG was considerably reduced in the IL-6 knockout mice. Microarray analysis in conjunction with real-time PCR revealed higher mRNA expression of Bruton’s tyrosine kinase (BTK) gene in DRG after CaP injection. The inhibition of BTK by ibrutinib noticeably decreased the CaP-induced up-regulation of IL-6 and p-ERK in mice. A high amount of IL-6 was detected in itchy skin and blood of patients with CKD. The expressions of p-BTK and p-ERK in DRG primary cells reached maximum levels at 1 and 10 min, respectively, after treatment of recombinant IL-6 and were significantly reduced by treatment of IL-6 along with ibrutinib. The mechanism by which the CaP-induced pruritus mediated by the IL-6/p-BTK/p-ERK signaling was revealed.
The role of skin commensal microbiota in the CaP-induced uremic pruritus and inflammation remains uncharacterized. In this study, we have shown that skin commensal, Cutibacterium acnes (C. acnes) can solubilize CaP by the production of short-chain fatty acids (SCFAs), such as butyric acid, through glucose fermentation. Like butyric acid, the N-[2-(2-Butyrylamino-ethoxy)-ethyl]-butyramide (BA-NH-NH-BA), a butyric acid derivative, remarkably induced acetylation of histone H3 lysine 9 (AcH3K9) in keratinocytes. Topical application of fermenting C. acnes and its metabolite, butyric acid or BA-NH-NH-BA onto mouse skin effectively ameliorated CaP-induced skin itching, interleukin IL-6 up-regulation in keratinocytes, p-BTK and p-ERK in DRG. The upregulation of p-BTK and p-ERK by CaP was markedly reduced in IL-6 knockout (KO) mice. Genus Cutibacterium was detected in relatively low abundance in itchy skin of patients with CKD. Our results identify a role for the skin fermenting C. acnes in ameliorating CaP-induced activation of IL-6/p-BTK/p-ERK signaling and resulting skin inflammation. Moreover, we provide evidence for the potential therapeutic efficacy of BA-NH-NH-BA as a postbiotic for the treatment of uremic pruritus.
We have also detected the anti-inflammatory effect of skin commensal, Staphylococcus epidermidis (S. epidermidis) against chronic ultraviolet B (UVB) radiation by the production of SCFAs, such as butyric acid, through glycerol fermentation. We detected that S. epidermidis in the skin microbiome produced butyric acid in vitro at concentrations in the millimolar (mM) range. The exposure of the dorsal skin of mice to UVB light provoked a significant increase in IL-6 production. Topical application of S. epidermidis with glycerol or butyric acid alone remarkably ameliorated the UVB-induced IL-6 production. In vivo knockdown of short-chain fatty acid receptor 2 (FFAR2) in mouse skin considerably blocked the probiotic effect of S. epidermidis on suppression of UVB-induced IL-6 production. These results demonstrate that butyric acid in the metabolites of fermenting skin probiotic bacteria mediates FFAR2 to modulate the production of pro-inflammatory cytokines induced by UVB. Overall, we have unraveled the molecular signaling in uremic pruritus and UVB induced skin inflammation and validated the anti-inflammatory role of butyric acid, a major metabolite from the fermentation of carbon source by C. acnes and S. epidermidis skin probiotic bacteria could provide a therapeutic approach for the prevention and treatment of uremic pruritus and UVB induced chronic inflammation in skin.
關鍵字(中) ★ 酪氨酸激酶
★ 磷酸鈣
★ 慢性腎病
★ 痤瘡桿菌
★ 丁酸類似物
★ 發酵
關鍵字(英) ★ Bruton’s tyrosine kinase
★ CaP
★ CKD
★ C. acnes
★ BA‐NH‐NH‐BA
★ fermentation
論文目次 Abstract………………………………………………………………………………………… ii
Acknowledgments………………………………………………..……………….……. vi
Table of contents………………………………………………………………………. ix
List of tables……………………………………………………………………….…… xv
List of figures………………………………………………………………………….. xvi
Abbreviations………………………………………………………………………….. xix
Chapter 1
Literature Review……………………………………………………..… 1
Chapter 2
The IL-6/p-BTK/p-ERK signaling mediates
the calcium phosphate–induced pruritus……………………………… 13
Chapter 3
Skin Cutibacterium acnes Mediates
Fermentation to Suppress the Calcium Phosphate
‐Induced Itching: A Butyric Acid Derivative with Potential for Uremic Pruritus………………………………………………… 35
Chapter 4
Butyric acid from probiotic Staphylococcus
epidermidis in the skin microbiome down-regulates
the ultraviolet-induced pro-inflammatory IL-6
Cytokine via short-chain fatty acid receptor……………………59
Chapter 5
Summary, conclusions and future study……………………..…….. 81
參考文獻 Abdallah, F., Mijouin, L., & Pichon, C. (2017). Skin Immune Landscape: Inside and Outside the Organism. Mediators Inflamm, 2017, 5095293. doi:10.1155/2017/5095293
Acker, T., Fandrey, J., & Acker, H. (2006). The good, the bad and the ugly in oxygen-sensing: ROS, cytochromes and prolyl-hydroxylases. Cardiovasc Res, 71(2), 195-207. doi:10.1016/j.cardiores.2006.04.008
Afsar, B., & Elsurer Afsar, R. (2012). HbA1c is related with uremic pruritus in diabetic and nondiabetic hemodialysis patients. Ren Fail, 34(10), 1264-1269. doi:10.3109/0886022X.2011.560401
Akiyama, T., Carstens, M. I., Piecha, D., Steppan, S., & Carstens, E. (2015). Nalfurafine suppresses pruritogen- and touch-evoked scratching behavior in models of acute and chronic itch in mice. Acta Derm Venereol, 95(2), 147-150. doi:10.2340/00015555-1879
Amdur, R. L., Mukherjee, M., Go, A., Barrows, I. R., Ramezani, A., Shoji, J., Reilly, M. P., Gnanaraj, J., Deo, R., Roas, S., Keane, M., Master, S., Teal, V., Soliman, E. Z., Yang, P., Feldman, H., Kusek, J. W., Tracy, C. M., Raj, D. S., & Investigators, C. S. (2016). Interleukin-6 Is a Risk Factor for Atrial Fibrillation in Chronic Kidney Disease: Findings from the CRIC Study. PLoS One, 11(2), e0148189. doi:10.1371/journal.pone.0148189
Ansel, J. C., Luger, T. A., & Green, I. (1983). The effect of in vitro and in vivo UV irradiation on the production of ETAF activity by human and murine keratinocytes. J Invest Dermatol, 81(6), 519-523. doi:10.1111/1523-1747.ep12522862
Armstrong, B. K., & Kricker, A. (2001). The epidemiology of UV induced skin cancer. J Photochem Photobiol B, 63(1-3), 8-18. doi:10.1016/s1011-1344(01)00198-1
Atalan, G., Demirkan, I., Yaman, H., Cihan, M., Önder, F., & Sözmen, M. (2003). Effect of topical kefir application on open wound healing: An in vivo study. KAFKAS ÜNİVERSİTESİ VETERİNER FAKÜLTESİ DERGİSİ, 9(1).
Banasiewicz, T., Krokowicz, L., Stojcev, Z., Kaczmarek, B. F., Kaczmarek, E., Maik, J., Marciniak, R., Krokowicz, P., Walkowiak, J., & Drews, M. (2013). Microencapsulated sodium butyrate reduces the frequency of abdominal pain in patients with irritable bowel syndrome. Colorectal Dis, 15(2), 204-209. doi:10.1111/j.1463-1318.2012.03152.x
Barnard, E., Shi, B., Kang, D., Craft, N., & Li, H. (2016). The balance of metagenomic elements shapes the skin microbiome in acne and health. Scientific Reports, 6(1), 39491. doi:10.1038/srep39491
Barreto, D. V., Barreto, F. C., Liabeuf, S., Temmar, M., Lemke, H. D., Tribouilloy, C., Choukroun, G., Vanholder, R., Massy, Z. A., & European Uremic Toxin Work, G. (2010). Plasma interleukin-6 is independently associated with mortality in both hemodialysis and pre-dialysis patients with chronic kidney disease. Kidney Int, 77(6), 550-556. doi:10.1038/ki.2009.503
Bassetti, M., Vena, A., Croxatto, A., Righi, E., & Guery, B. (2018). How to manage Pseudomonas aeruginosa infections. Drugs in context, 7.
Bautista, D. M., Wilson, S. R., & Hoon, M. A. (2014). Why we scratch an itch: the molecules, cells and circuits of itch. Nat Neurosci, 17(2), 175-182. doi:10.1038/nn.3619
Bek-Thomsen, M., Lomholt, H. B., & Kilian, M. (2008). Acne is not associated with yet-uncultured bacteria. J Clin Microbiol, 46(10), 3355-3360. doi:10.1128/JCM.00799-08
Block, G., & Port, F. K. (2003). Calcium phosphate metabolism and cardiovascular disease in patients with chronic kidney disease. Semin Dial, 16(2), 140-147. doi:10.1046/j.1525-139x.2003.160301.x
Bottoni, A., Rizzotto, L., Lai, T. H., Liu, C., Smith, L. L., Mantel, R., Reiff, S., El-Gamal, D., Larkin, K., Johnson, A. J., Lapalombella, R., Lehman, A., Plunkett, W., Byrd, J. C., Blachly, J. S., Woyach, J. A., & Sampath, D. (2016). Targeting BTK through microRNA in chronic lymphocytic leukemia. Blood, 128(26), 3101-3112. doi:10.1182/blood-2016-07-727750
Brancaccio, D., Tetta, C., Gallieni, M., & Panichi, V. (2002). Inflammation, CRP, calcium overload and a high calcium–phosphate product: a ‘liaison dangereuse’. Nephrology Dialysis Transplantation, 17(2), 201-203. doi:10.1093/ndt/17.2.201
Brouwer, M., Wolt‐Plompen, S., Dubois, A., Van der Heide, S., Jansen, D., Hoijer, M., Kauffman, H., & Duiverman, E. (2006). No effects of probiotics on atopic dermatitis in infancy: a randomized placebo‐controlled trial. Clinical & Experimental Allergy, 36(7), 899-906.
Bruggemann, H., Henne, A., Hoster, F., Liesegang, H., Wiezer, A., Strittmatter, A., Hujer, S., Durre, P., & Gottschalk, G. (2004). The complete genome sequence of Propionibacterium acnes, a commensal of human skin. Science, 305(5684), 671-673. doi:10.1126/science.1100330
Caporaso, J. G., Lauber, C. L., Walters, W. A., Berg-Lyons, D., Lozupone, C. A., Turnbaugh, P. J., Fierer, N., & Knight, R. (2011). Global patterns of 16S rRNA diversity at a depth of millions of sequences per sample. Proc Natl Acad Sci U S A, 108 Suppl 1, 4516-4522. doi:10.1073/pnas.1000080107
Carvalho, S. M., de Jong, A., Kloosterman, T. G., Kuipers, O. P., & Saraiva, L. M. (2017). The Staphylococcus aureus alpha-Acetolactate Synthase ALS Confers Resistance to Nitrosative Stress. Front Microbiol, 8, 1273. doi:10.3389/fmicb.2017.01273
Cavallo, J., & DeLeo, V. A. (1986). Sunburn. Dermatol Clin, 4(2), 181-187. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/3955890
Chalmers, S. A., Doerner, J., Bosanac, T., Khalil, S., Smith, D., Harcken, C., Dimock, J., Der, E., Herlitz, L., Webb, D., Seccareccia, E., Feng, D., Fine, J. S., Ramanujam, M., Klein, E., & Putterman, C. (2016). Therapeutic Blockade of Immune Complex-Mediated Glomerulonephritis by Highly Selective Inhibition of Bruton’s Tyrosine Kinase. Scientific Reports, 6(1), 26164. doi:10.1038/srep26164
Chalmers, S. A., Wen, J., Doerner, J., Stock, A., Cuda, C. M., Makinde, H. M., Perlman, H., Bosanac, T., Webb, D., Nabozny, G., Fine, J. S., Klein, E., Ramanujam, M., & Putterman, C. (2018). Highly selective inhibition of Bruton′s tyrosine kinase attenuates skin and brain disease in murine lupus. Arthritis Res Ther, 20(1), 10. doi:10.1186/s13075-017-1500-0
Chang, B. Y., Huang, M. M., Francesco, M., Chen, J., Sokolove, J., Magadala, P., Robinson, W. H., & Buggy, J. J. (2011). The Bruton tyrosine kinase inhibitor PCI-32765 ameliorates autoimmune arthritis by inhibition of multiple effector cells. Arthritis Res Ther, 13(4), R115. doi:10.1186/ar3400
Chang, H. W., Yan, D., Singh, R., Liu, J., Lu, X., Ucmak, D., Lee, K., Afifi, L., Fadrosh, D., Leech, J., Vasquez, K. S., Lowe, M. M., Rosenblum, M. D., Scharschmidt, T. C., Lynch, S. V., & Liao, W. (2018). Alteration of the cutaneous microbiome in psoriasis and potential role in Th17 polarization. Microbiome, 6(1), 154. doi:10.1186/s40168-018-0533-1
Che, Q., Liu, B. Y., Liao, Y., Zhang, H. J., Yang, T. T., He, Y. Y., Xia, Y. H., Lu, W., He, X. Y., Chen, Z., Wang, F. Y., & Wan, X. P. (2014). Activation of a positive feedback loop involving IL-6 and aromatase promotes intratumoral 17beta-estradiol biosynthesis in endometrial carcinoma microenvironment. Int J Cancer, 135(2), 282-294. doi:10.1002/ijc.28679
Chen, Y., Rekha, P., Arun, A., Shen, F., Lai, W.-A., & Young, C. (2006). Phosphate solubilizing bacteria from subtropical soil and their tricalcium phosphate solubilizing abilities. Applied soil ecology, 34(1), 33-41.
Chen, Y., Willcockson, H. H., & Valtschanoff, J. G. (2009). Vanilloid receptor TRPV1-mediated phosphorylation of ERK in murine adjuvant arthritis. Osteoarthritis Cartilage, 17(2), 244-251. doi:10.1016/j.joca.2008.06.015
Chen, Z. X., & Breitman, T. R. (1994). Tributyrin: a prodrug of butyric acid for potential clinical application in differentiation therapy. Cancer Res, 54(13), 3494-3499. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/8012972
Clydesdale, G. J., Dandie, G. W., & Muller, H. K. (2001). Ultraviolet light induced injury: immunological and inflammatory effects. Immunol Cell Biol, 79(6), 547-568. doi:10.1046/j.1440-1711.2001.01047.x
Cogan, T. M., Fitzgerald, R. J., & Doonan, S. (2009). Acetolactate synthase of Leuconostoc lactis and its regulation of acetoin production. Journal of Dairy Research, 51(4), 597-604. doi:10.1017/S002202990003291X
Cogen, A. L., Yamasaki, K., Sanchez, K. M., Dorschner, R. A., Lai, Y., MacLeod, D. T., Torpey, J. W., Otto, M., Nizet, V., Kim, J. E., & Gallo, R. L. (2010). Selective antimicrobial action is provided by phenol-soluble modulins derived from Staphylococcus epidermidis, a normal resident of the skin. J Invest Dermatol, 130(1), 192-200. doi:10.1038/jid.2009.243
Collier, C. N., Harper, J. C., Cafardi, J. A., Cantrell, W. C., Wang, W., Foster, K. W., & Elewski, B. E. (2008). The prevalence of acne in adults 20 years and older. J Am Acad Dermatol, 58(1), 56-59. doi:10.1016/j.jaad.2007.06.045
Collins, A. J., Foley, R. N., Gilbertson, D. T., & Chen, S. C. (2015). United States Renal Data System public health surveillance of chronic kidney disease and end-stage renal disease. Kidney Int Suppl (2011), 5(1), 2-7. doi:10.1038/kisup.2015.2
Cope, E. K., & Lynch, S. V. (2015). Novel microbiome-based therapeutics for chronic rhinosinusitis. Curr Allergy Asthma Rep, 15(3), 504. doi:10.1007/s11882-014-0504-y
De Fabo, E. C., & Noonan, F. P. (1983). Mechanism of immune suppression by ultraviolet irradiation in vivo. I. Evidence for the existence of a unique photoreceptor in skin and its role in photoimmunology. J Exp Med, 158(1), 84-98. doi:10.1084/jem.158.1.84
DeSantis, T. Z., Hugenholtz, P., Larsen, N., Rojas, M., Brodie, E. L., Keller, K., Huber, T., Dalevi, D., Hu, P., & Andersen, G. L. (2006). Greengenes, a chimera-checked 16S rRNA gene database and workbench compatible with ARB. Appl Environ Microbiol, 72(7), 5069-5072. doi:10.1128/AEM.03006-05
Dou, S., Yao, Y. D., Yang, X. Z., Sun, T. M., Mao, C. Q., Song, E. W., & Wang, J. (2012). Anti-Her2 single-chain antibody mediated DNMTs-siRNA delivery for targeted breast cancer therapy. J Control Release, 161(3), 875-883. doi:10.1016/j.jconrel.2012.05.015
Eddington, H., & Heaf, J. G. (2009). Clinical management of disturbances of calcium and phosphate metabolism in dialysis patients. NDT Plus, 2(4), 267-272. doi:10.1093/ndtplus/sfp044
Eddington, H., Hoefield, R., Sinha, S., Chrysochou, C., Lane, B., Foley, R. N., Hegarty, J., New, J., O′Donoghue, D. J., Middleton, R. J., & Kalra, P. A. (2010). Serum phosphate and mortality in patients with chronic kidney disease. Clin J Am Soc Nephrol, 5(12), 2251-2257. doi:10.2215/CJN.00810110
Elmariah, S. B., & Lerner, E. A. (2011). Topical therapies for pruritus. Semin Cutan Med Surg, 30(2), 118-126. doi:10.1016/j.sder.2011.04.008
Falagas, M. E., Rafailidis, P. I., & Makris, G. C. (2008). Bacterial interference for the prevention and treatment of infections. Int J Antimicrob Agents, 31(6), 518-522. doi:10.1016/j.ijantimicag.2008.01.024
Finnin, M. S., Donigian, J. R., Cohen, A., Richon, V. M., Rifkind, R. A., Marks, P. A., Breslow, R., & Pavletich, N. P. (1999). Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors. Nature, 401(6749), 188-193. doi:10.1038/43710
Francuzik, W., Franke, K., Schumann, R. R., Heine, G., & Worm, M. (2018). Propionibacterium acnes Abundance Correlates Inversely with Staphylococcus aureus: Data from Atopic Dermatitis Skin Microbiome. Acta Derm Venereol, 98(5), 490-495. doi:10.2340/00015555-2896
Fyhrquist, N., Muirhead, G., Prast-Nielsen, S., Jeanmougin, M., Olah, P., Skoog, T., Jules-Clement, G., Feld, M., Barrientos-Somarribas, M., Sinkko, H., van den Bogaard, E. H., Zeeuwen, P., Rikken, G., Schalkwijk, J., Niehues, H., Daubener, W., Eller, S. K., Alexander, H., Pennino, D., Suomela, S., Tessas, I., Lybeck, E., Baran, A. M., Darban, H., Gangwar, R. S., Gerstel, U., Jahn, K., Karisola, P., Yan, L., Hansmann, B., Katayama, S., Meller, S., Bylesjo, M., Hupe, P., Levi-Schaffer, F., Greco, D., Ranki, A., Schroder, J. M., Barker, J., Kere, J., Tsoka, S., Lauerma, A., Soumelis, V., Nestle, F. O., Homey, B., Andersson, B., & Alenius, H. (2019). Microbe-host interplay in atopic dermatitis and psoriasis. Nat Commun, 10(1), 4703. doi:10.1038/s41467-019-12253-y
Galperin, T. A., Cronin, A. J., & Leslie, K. S. (2014). Cutaneous manifestations of ESRD. Clin J Am Soc Nephrol, 9(1), 201-218. doi:10.2215/CJN.05900513
Gannesen, A. V., Borrel, V., Lefeuvre, L., Netrusov, A. I., Plakunov, V. K., & Feuilloley, M. G. J. (2019). Effect of two cosmetic compounds on the growth, biofilm formation activity, and surface properties of acneic strains of Cutibacterium acnes and Staphylococcus aureus. Microbiologyopen, 8(3), e00659. doi:10.1002/mbo3.659
Gao, Z., Tseng, C.-h., Strober, B. E., Pei, Z., & Blaser, M. J. (2008). Substantial Alterations of the Cutaneous Bacterial Biota in Psoriatic Lesions. PLoS One, 3(7), e2719. doi:10.1371/journal.pone.0002719
Grice, E. A., Kong, H. H., Renaud, G., Young, A. C., Program, N. C. S., Bouffard, G. G., Blakesley, R. W., Wolfsberg, T. G., Turner, M. L., & Segre, J. A. (2008). A diversity profile of the human skin microbiota. Genome Res, 18(7), 1043-1050. doi:10.1101/gr.075549.107
Gröne, A. (2002). Keratinocytes and cytokines. Veterinary Immunology and Immunopathology, 88(1), 1-12. doi:https://doi.org/10.1016/S0165-2427(02)00136-8
Gueniche, A., Benyacoub, J., Buetler, T. M., Smola, H., & Blum, S. (2006). Supplementation with oral probiotic bacteria maintains cutaneous immune homeostasis after UV exposure. Eur J Dermatol, 16(5), 511-517. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/17101471
Hamer, H. M., Jonkers, D., Venema, K., Vanhoutvin, S., Troost, F. J., & Brummer, R. J. (2008). Review article: the role of butyrate on colonic function. Alimentary Pharmacology & Therapeutics, 27(2), 104-119. doi:10.1111/j.1365-2036.2007.03562.x
Hartig, E., & Jahn, D. (2012). Regulation of the anaerobic metabolism in Bacillus subtilis. Adv Microb Physiol, 61, 195-216. doi:10.1016/B978-0-12-394423-8.00005-6
Heisig, M., Reich, A., & Szepietowski, J. C. (2016). Is uremic pruritus still an important clinical problem in maintenance hemodialysis patients? J Eur Acad Dermatol Venereol, 30(12), e198-e199. doi:10.1111/jdv.13524
Higaki, S., Nakamura, M., Morohashi, M., & Yamagishi, T. (2004). Propionibacterium acnes biotypes and susceptibility to minocycline and Keigai-rengyo-to. Int J Dermatol, 43(2), 103-107. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/15125499
Huang, C., Lu, F., Li, P., Cao, C., & Liu, Z. (2017). Tlx3 Function in the Dorsal Root Ganglion is Pivotal to Itch and Pain Sensations. Front Mol Neurosci, 10, 205. doi:10.3389/fnmol.2017.00205
Ingram, L. O., & Buttke, T. M. (1984). Effects of alcohols on micro-organisms. Adv Microb Physiol, 25, 253-300. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/6398622
Ishida, T., & Sakaguchi, I. (2007). Protection of human keratinocytes from UVB-induced inflammation using root extract of Lithospermum erythrorhizon. Biol Pharm Bull, 30(5), 928-934. doi:10.1248/bpb.30.928
Jeayeng, S., Wongkajornsilp, A., Slominski, A. T., Jirawatnotai, S., Sampattavanich, S., & Panich, U. (2017). Nrf2 in keratinocytes modulates UVB-induced DNA damage and apoptosis in melanocytes through MAPK signaling. Free Radical Biology and Medicine, 108, 918-928. doi:https://doi.org/10.1016/j.freeradbiomed.2017.05.009
Jebur, M. S. (2010). Therapeutic efficacy of Lactobacillus acidophilus against bacterial isolates from burn wounds. North American journal of medical sciences, 2(12), 586.
Jeffry, J., Kim, S., & Chen, Z. F. (2011). Itch signaling in the nervous system. Physiology (Bethesda), 26(4), 286-292. doi:10.1152/physiol.00007.2011
Ji, R. R., Baba, H., Brenner, G. J., & Woolf, C. J. (1999). Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity. Nat Neurosci, 2(12), 1114-1119. doi:10.1038/16040
Ji, R. R., Kawasaki, Y., Zhuang, Z. Y., Wen, Y. R., & Zhang, Y. Q. (2007). Protein kinases as potential targets for the treatment of pathological pain. Handb Exp Pharmacol(177), 359-389. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/17087130
Jikare, A., & Chavan, M. (2013). Siderophore produced by Bacillus shackletonii. Gn-09 and showed its plant growth promoting activity. Int. J. Pharm. Biol. Sci, 3(2), 198-202.
Kalliomäki, M., Salminen, S., Poussa, T., & Isolauri, E. (2007). Probiotics during the first 7 years of life: a cumulative risk reduction of eczema in a randomized, placebo-controlled trial. Journal of Allergy and Clinical Immunology, 119(4), 1019.
Kamo, A., Tominaga, M., Kamata, Y., & Takamori, K. (2017). Mechanisms and treatments of dry skin-induced itch. J Clin Cosmet Dermatol, 1(1).
Kao, M. S., Huang, S., Chang, W. L., Hsieh, M. F., Huang, C. J., Gallo, R. L., & Huang, C. M. (2017). Microbiome precision editing: Using PEG as a selective fermentation initiator against methicillin-resistant Staphylococcus aureus. Biotechnol J, 12(4). doi:10.1002/biot.201600399
Karaki, S., Mitsui, R., Hayashi, H., Kato, I., Sugiya, H., Iwanaga, T., Furness, J. B., & Kuwahara, A. (2006). Short-chain fatty acid receptor, GPR43, is expressed by enteroendocrine cells and mucosal mast cells in rat intestine. Cell Tissue Res, 324(3), 353-360. doi:10.1007/s00441-005-0140-x
Keshari, S., Balasubramaniam, A., Myagmardoloonjin, B., Herr, D. R., Negari, I. P., & Huang, C. M. (2019). Butyric Acid from Probiotic Staphylococcus epidermidis in the Skin Microbiome Down-Regulates the Ultraviolet-Induced Pro-Inflammatory IL-6 Cytokine via Short-Chain Fatty Acid Receptor. Int J Mol Sci, 20(18). doi:10.3390/ijms20184477
Keshari, S., Sipayung, A. D., Hsieh, C. C., Su, L. J., Chiang, Y. R., Chang, H. C., Yang, W. C., Chuang, T. H., Chen, C. L., & Huang, C. M. (2019). IL-6/p-BTK/p-ERK signaling mediates calcium phosphate-induced pruritus. FASEB J, 33(11), 12036-12046. doi:10.1096/fj.201900016RR
Keshari, S., Wang, Y., Herr, D. R., Wang, S. M., Yang, W. C., Chuang, T. H., Chen, C. L., & Huang, C. M. (2020). Skin Cutibacterium acnes Mediates Fermentation to Suppress the Calcium Phosphate-Induced Itching: A Butyric Acid Derivative with Potential for Uremic Pruritus. J Clin Med, 9(2). doi:10.3390/jcm9020312
Kim, J. Y., Kwon, J. H., Ahn, S. H., Lee, S. I., Han, Y. S., Choi, Y. O., Lee, S. Y., Ahn, K. M., & Ji, G. E. (2010). Effect of probiotic mix (Bifidobacterium bifidum, Bifidobacterium lactis, Lactobacillus acidophilus) in the primary prevention of eczema: a double‐blind, randomized, placebo‐controlled trial. Pediatric Allergy and Immunology, 21(2p2), e386-e393.
Kimmel, M., Alscher, D. M., Dunst, R., Braun, N., Machleidt, C., Kiefer, T., Stulten, C., van der Kuip, H., Pauli-Magnus, C., Raub, U., Kuhlmann, U., & Mettang, T. (2006). The role of micro-inflammation in the pathogenesis of uraemic pruritus in haemodialysis patients. Nephrol Dial Transplant, 21(3), 749-755. doi:10.1093/ndt/gfi204
Kimura, K., Saika, Y., Otani, H., Fujii, R., Mune, M., & Yukawa, S. (1999). Factors associated with calcification of the abdominal aorta in hemodialysis patients. Kidney Int Suppl, 71, S238-241. doi:10.1046/j.1523-1755.1999.07163.x
Kirnbauer, R., Kock, A., Neuner, P., Forster, E., Krutmann, J., Urbanski, A., Schauer, E., Ansel, J. C., Schwarz, T., & Luger, T. A. (1991). Regulation of epidermal cell interleukin-6 production by UV light and corticosteroids. J Invest Dermatol, 96(4), 484-489. doi:10.1111/1523-1747.ep12470181
Kloos, W. E., & Musselwhite, M. S. (1975). Distribution and persistence of Staphylococcus and Micrococcus species and other aerobic bacteria on human skin. Appl Microbiol, 30(3), 381-385. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/810086
Kober, M. M., & Bowe, W. P. (2015). The effect of probiotics on immune regulation, acne, and photoaging. Int J Womens Dermatol, 1(2), 85-89. doi:10.1016/j.ijwd.2015.02.001
Kong, H. H., Oh, J., Deming, C., Conlan, S., Grice, E. A., Beatson, M. A., Nomicos, E., Polley, E. C., Komarow, H. D., Program, N. C. S., Murray, P. R., Turner, M. L., & Segre, J. A. (2012). Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis. Genome Res, 22(5), 850-859. doi:10.1101/gr.131029.111
Kong, W., Deng, W., Sun, Y., Huang, S., Zhang, Z., Shi, B., Chen, W., Tang, X., Yao, G., Feng, X., & Sun, L. (2018). Increased expression of Bruton′s tyrosine kinase in peripheral blood is associated with lupus nephritis. Clin Rheumatol, 37(1), 43-49. doi:10.1007/s10067-017-3717-3
Kumar, M., Myagmardoloonjin, B., Keshari, S., Negari, I. P., & Huang, C. M. (2019). 5-methyl Furfural Reduces the Production of Malodors by Inhibiting Sodium l-lactate Fermentation of Staphylococcus epidermidis: Implication for Deodorants Targeting the Fermenting Skin Microbiome. Microorganisms, 7(8). doi:10.3390/microorganisms7080239
Kurban, M. S., Boueiz, A., & Kibbi, A. G. (2008). Cutaneous manifestations of chronic kidney disease. Clin Dermatol, 26(3), 255-264. doi:10.1016/j.clindermatol.2007.10.017
Kuvandik, G., Çetin, M., Genctoy, G., Horoz, M., Duru, M., Akcali, C., Satar, S., Kiykim, A. A., & Kaya, H. (2007). The prevalance, epidemiology and risk factors for onychomycosis in hemodialysis patients. BMC Infectious Diseases, 7(1), 102. doi:10.1186/1471-2334-7-102
Kuypers, D. R. (2009). Skin problems in chronic kidney disease. Nat Clin Pract Nephrol, 5(3), 157-170. doi:10.1038/ncpneph1040
Lau, W. L., Kalantar-Zadeh, K., & Vaziri, N. D. (2015). The Gut as a Source of Inflammation in Chronic Kidney Disease. Nephron, 130(2), 92-98. doi:10.1159/000381990
Lavery, M. J., Stull, C., Kinney, M. O., & Yosipovitch, G. (2016). Nocturnal Pruritus: The Battle for a Peaceful Night′s Sleep. Int J Mol Sci, 17(3), 425. doi:10.3390/ijms17030425
Lee, S.-J., Lee, K. B., Son, Y. H., Shin, J., Lee, J.-H., Kim, H.-J., Hong, A.-Y., Bae, H. W., Kwon, M.-a., Lee, W. J., Kim, J.-H., Lee, D. H., Jeong, E. M., & Kim, I.-G. (2017). Transglutaminase 2 mediates UV-induced skin inflammation by enhancing inflammatory cytokine production. Cell Death & Disease, 8(10), e3148-e3148. doi:10.1038/cddis.2017.550
Li, S., Bao, X., Wang, D., You, L., Li, X., Yang, H., Bian, J., Wang, Y., & Yang, Y. (2017). APOBEC3B and IL-6 form a positive feedback loop in hepatocellular carcinoma cells. Sci China Life Sci, 60(6), 617-626. doi:10.1007/s11427-016-9058-6
Linnskog, R., Mohapatra, P., Moradi, F., Prasad, C. P., & Andersson, T. (2016). Demonstration of a WNT5A-IL-6 positive feedback loop in melanoma cells: Dual interference of this loop more effectively impairs melanoma cell invasion. Oncotarget, 7(25), 37790-37802. doi:10.18632/oncotarget.9332
Lisiero, D. N., Soto, H., Everson, R. G., Liau, L. M., & Prins, R. M. (2014). The histone deacetylase inhibitor, LBH589, promotes the systemic cytokine and effector responses of adoptively transferred CD8+ T cells. J Immunother Cancer, 2, 8. doi:10.1186/2051-1426-2-8
Liu, B., Tai, Y., Achanta, S., Kaelberer, M. M., Caceres, A. I., Shao, X., Fang, J., & Jordt, S. E. (2016). IL-33/ST2 signaling excites sensory neurons and mediates itch response in a mouse model of poison ivy contact allergy. Proc Natl Acad Sci U S A, 113(47), E7572-E7579. doi:10.1073/pnas.1606608113
Liu, N., & Zhuang, S. (2015). Treatment of chronic kidney diseases with histone deacetylase inhibitors. Frontiers in Physiology, 6(121). doi:10.3389/fphys.2015.00121
Liu, Q., & Dong, X. (2015). The role of the Mrgpr receptor family in itch. Handb Exp Pharmacol, 226, 71-88. doi:10.1007/978-3-662-44605-8_5
Locatelli, F., Pozzoni, P., Tentori, F., & del Vecchio, L. (2003). Epidemiology of cardiovascular risk in patients with chronic kidney disease. Nephrol Dial Transplant, 18 Suppl 7, vii2-9. doi:10.1093/ndt/gfg1072
Lopez-Camarillo, C., Ocampo, E. A., Casamichana, M. L., Perez-Plasencia, C., Alvarez-Sanchez, E., & Marchat, L. A. (2012). Protein kinases and transcription factors activation in response to UV-radiation of skin: implications for carcinogenesis. Int J Mol Sci, 13(1), 142-172. doi:10.3390/ijms13010142
Lopez-Herrera, G., Vargas-Hernandez, A., Gonzalez-Serrano, M. E., Berron-Ruiz, L., Rodriguez-Alba, J. C., Espinosa-Rosales, F., & Santos-Argumedo, L. (2014). Bruton′s tyrosine kinase--an integral protein of B cell development that also has an essential role in the innate immune system. J Leukoc Biol, 95(2), 243-250. doi:10.1189/jlb.0513307
Ma, T. K., McAdoo, S. P., & Tam, F. W. (2017). Targeting the tyrosine kinase signalling pathways for treatment of immune-mediated glomerulonephritis: from bench to bedside and beyond. Nephrol Dial Transplant, 32(suppl_1), i129-i138. doi:10.1093/ndt/gfw336
Malav, M. K., Prasad, S., Kharia, S. K., Kumar, S., Sheetal, K., & Kannojiya, S. (2017). Furfural and 5-HMF: Potent fermentation inhibitors and their removal techniques. International Journal of Current Microbiology and Applied Sciences, 6(3), 2060-2066.
Masui, R., Sasaki, M., Funaki, Y., Ogasawara, N., Mizuno, M., Iida, A., Izawa, S., Kondo, Y., Ito, Y., Tamura, Y., Yanamoto, K., Noda, H., Tanabe, A., Okaniwa, N., Yamaguchi, Y., Iwamoto, T., & Kasugai, K. (2013). G protein-coupled receptor 43 moderates gut inflammation through cytokine regulation from mononuclear cells. Inflamm Bowel Dis, 19(13), 2848-2856. doi:10.1097/01.MIB.0000435444.14860.ea
McLaughlin, J., Watterson, S., Layton, A. M., Bjourson, A. J., Barnard, E., & McDowell, A. (2019). Propionibacterium acnes and Acne Vulgaris: New Insights from the Integration of Population Genetic, Multi-Omic, Biochemical and Host-Microbe Studies. Microorganisms, 7(5). doi:10.3390/microorganisms7050128
Meijer, K., de Vos, P., & Priebe, M. G. (2010). Butyrate and other short-chain fatty acids as modulators of immunity: what relevance for health? Curr Opin Clin Nutr Metab Care, 13(6), 715-721. doi:10.1097/MCO.0b013e32833eebe5
Middendorp, S., Dingjan, G. M., Maas, A., Dahlenborg, K., & Hendriks, R. W. (2003). Function of Bruton′s tyrosine kinase during B cell development is partially independent of its catalytic activity. J Immunol, 171(11), 5988-5996. doi:10.4049/jimmunol.171.11.5988
Moe, S., Drueke, T., Cunningham, J., Goodman, W., Martin, K., Olgaard, K., Ott, S., Sprague, S., Lameire, N., Eknoyan, G., & Kidney Disease: Improving Global, O. (2006). Definition, evaluation, and classification of renal osteodystrophy: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO). Kidney Int, 69(11), 1945-1953. doi:10.1038/sj.ki.5000414
Mohamed, A. J., Yu, L., Backesjo, C. M., Vargas, L., Faryal, R., Aints, A., Christensson, B., Berglof, A., Vihinen, M., Nore, B. F., & Smith, C. I. (2009). Bruton′s tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain. Immunol Rev, 228(1), 58-73. doi:10.1111/j.1600-065X.2008.00741.x
Mohan, C., & Putterman, C. (2015). Genetics and pathogenesis of systemic lupus erythematosus and lupus nephritis. Nat Rev Nephrol, 11(6), 329-341. doi:10.1038/nrneph.2015.33
Morton, C. A., Lafferty, M., Hau, C., Henderson, I., Jones, M., & Lowe, J. G. (1996). Pruritus and skin hydration during dialysis. Nephrol Dial Transplant, 11(10), 2031-2036. doi:10.1093/oxfordjournals.ndt.a027092
Nadra, I., Mason, J. C., Philippidis, P., Florey, O., Smythe, C. D., McCarthy, G. M., Landis, R. C., & Haskard, D. O. (2005). Proinflammatory activation of macrophages by basic calcium phosphate crystals via protein kinase C and MAP kinase pathways: a vicious cycle of inflammation and arterial calcification? Circ Res, 96(12), 1248-1256. doi:10.1161/01.RES.0000171451.88616.c2
Nakatsuji, T., Chen, T. H., Butcher, A. M., Trzoss, L. L., Nam, S. J., Shirakawa, K. T., Zhou, W., Oh, J., Otto, M., Fenical, W., & Gallo, R. L. (2018). A commensal strain of Staphylococcus epidermidis protects against skin neoplasia. Sci Adv, 4(2), eaao4502. doi:10.1126/sciadv.aao4502
Narita, I., Alchi, B., Omori, K., Sato, F., Ajiro, J., Saga, D., Kondo, D., Skatsume, M., Maruyama, S., Kazama, J. J., Akazawa, K., & Gejyo, F. (2006). Etiology and prognostic significance of severe uremic pruritus in chronic hemodialysis patients. Kidney Int, 69(9), 1626-1632. doi:10.1038/sj.ki.5000251
National Kidney, F. (2002). K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis, 39(2 Suppl 1), S1-266. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/11904577
Nattkemper, L. A., Tey, H. L., Valdes-Rodriguez, R., Lee, H., Mollanazar, N. K., Albornoz, C., Sanders, K. M., & Yosipovitch, G. (2018). The Genetics of Chronic Itch: Gene Expression in the Skin of Patients with Atopic Dermatitis and Psoriasis with Severe Itch. J Invest Dermatol, 138(6), 1311-1317. doi:10.1016/j.jid.2017.12.029
Nechemia-Arbely, Y., Barkan, D., Pizov, G., Shriki, A., Rose-John, S., Galun, E., & Axelrod, J. H. (2008). IL-6/IL-6R Axis Plays a Critical Role in Acute Kidney Injury. Journal of the American Society of Nephrology, 19(6), 1106. doi:10.1681/ASN.2007070744
Olaru, F., & Jensen, L. E. (2010). Chemokine expression by human keratinocyte cell lines after activation of Toll-like receptors. Exp Dermatol, 19(8), e314-316. doi:10.1111/j.1600-0625.2009.01026.x
Omori, S., Hida, M., Fujita, H., Takahashi, H., Tanimura, S., Kohno, M., & Awazu, M. (2006). Extracellular signal-regulated kinase inhibition slows disease progression in mice with polycystic kidney disease. J Am Soc Nephrol, 17(6), 1604-1614. doi:10.1681/ASN.2004090800
Pace, B. S., White, G. L., Dover, G. J., Boosalis, M. S., Faller, D. V., & Perrine, S. P. (2002). Short-chain fatty acid derivatives induce fetal globin expression and erythropoiesis in vivo. Blood, 100(13), 4640-4648. doi:10.1182/blood-2002-02-0353
Pal Singh, S., Dammeijer, F., & Hendriks, R. W. (2018). Role of Bruton′s tyrosine kinase in B cells and malignancies. Mol Cancer, 17(1), 57. doi:10.1186/s12943-018-0779-z
Palmqvist, E., & Hahn-Hägerdal, B. (2000). Fermentation of lignocellulosic hydrolysates. II: inhibitors and mechanisms of inhibition. Bioresource Technology, 74(1), 25-33. doi:https://doi.org/10.1016/S0960-8524(99)00161-3
Pan, J., Ruan, W., Qin, M., Long, Y., Wan, T., Yu, K., Zhai, Y., Wu, C., & Xu, Y. (2018). Intradermal delivery of STAT3 siRNA to treat melanoma via dissolving microneedles. Scientific Reports, 8(1), 1117. doi:10.1038/s41598-018-19463-2
Park, H., Wahl, M. I., Afar, D. E., Turck, C. W., Rawlings, D. J., Tam, C., Scharenberg, A. M., Kinet, J. P., & Witte, O. N. (1996). Regulation of Btk function by a major autophosphorylation site within the SH3 domain. Immunity, 4(5), 515-525. doi:10.1016/s1074-7613(00)80417-3
Pecoits-Filho, R., Barany, P., Lindholm, B., Heimburger, O., & Stenvinkel, P. (2002). Interleukin-6 is an independent predictor of mortality in patients starting dialysis treatment. Nephrol Dial Transplant, 17(9), 1684-1688. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/12198224
Perkins, A. C., Maglione, J., Hillebrand, G. G., Miyamoto, K., & Kimball, A. B. (2012). Acne vulgaris in women: prevalence across the life span. J Womens Health (Larchmt), 21(2), 223-230. doi:10.1089/jwh.2010.2722
Petit-FrèrePeter, C., Clingen, P. H., Arlett, C. F., Green, M. H. L., Grewe, M., Krutmann, J., & Roza, L. (1998). Induction of Interleukin-6 Production by Ultraviolet Radiation in Normal Human Epidermal Keratinocytes and in a Human Keratinocyte Cell Line is Mediated by DNA Damage. Journal of Investigative Dermatology, 111(3), 354-359. doi:https://doi.org/10.1038/sj.jid.5602962
Pirozzi, C., Francisco, V., Guida, F. D., Gomez, R., Lago, F., Pino, J., Meli, R., & Gualillo, O. (2018). Butyrate Modulates Inflammation in Chondrocytes via GPR43 Receptor. Cell Physiol Biochem, 51(1), 228-243. doi:10.1159/000495203
Pisoni, R. L., Wikstrom, B., Elder, S. J., Akizawa, T., Asano, Y., Keen, M. L., Saran, R., Mendelssohn, D. C., Young, E. W., & Port, F. K. (2006). Pruritus in haemodialysis patients: International results from the Dialysis Outcomes and Practice Patterns Study (DOPPS). Nephrol Dial Transplant, 21(12), 3495-3505. doi:10.1093/ndt/gfl461
Pituch, A., Walkowiak, J., & Banaszkiewicz, A. (2013). Butyric acid in functional constipation. Prz Gastroenterol, 8(5), 295-298. doi:10.5114/pg.2013.38731
Pizzonero, M., Dupont, S., Babel, M., Beaumont, S., Bienvenu, N., Blanque, R., Cherel, L., Christophe, T., Crescenzi, B., De Lemos, E., Delerive, P., Deprez, P., De Vos, S., Djata, F., Fletcher, S., Kopiejewski, S., L′Ebraly, C., Lefrancois, J. M., Lavazais, S., Manioc, M., Nelles, L., Oste, L., Polancec, D., Quenehen, V., Soulas, F., Triballeau, N., van der Aar, E. M., Vandeghinste, N., Wakselman, E., Brys, R., & Saniere, L. (2014). Discovery and optimization of an azetidine chemical series as a free fatty acid receptor 2 (FFA2) antagonist: from hit to clinic. J Med Chem, 57(23), 10044-10057. doi:10.1021/jm5012885
Pradhan, A. K., Ivanek, R., Grohn, Y. T., Geornaras, I., Sofos, J. N., & Wiedmann, M. (2009). Quantitative risk assessment for Listeria monocytogenes in selected categories of deli meats: impact of lactate and diacetate on listeriosis cases and deaths. J Food Prot, 72(5), 978-989. doi:10.4315/0362-028x-72.5.978
RATHORE, P. (2014). Chelation effect on phosphate solubilizing activity by Citrobacter Freund II MTCC 6738. International Journal of Applied and Natural Sciences, 3, 103-108.
Regna, N. L., Chafin, C. B., Hammond, S. E., Puthiyaveetil, A. G., Caudell, D. L., & Reilly, C. M. (2014). Class I and II histone deacetylase inhibition by ITF2357 reduces SLE pathogenesis in vivo. Clinical Immunology, 151(1), 29-42. doi:https://doi.org/10.1016/j.clim.2014.01.002
Saeid, A., Prochownik, E., & Dobrowolska-Iwanek, J. (2018). Phosphorus Solubilization by Bacillus Species. Molecules, 23(11). doi:10.3390/molecules23112897
Sanford, J. A., & Gallo, R. L. (2013). Functions of the skin microbiota in health and disease. Semin Immunol, 25(5), 370-377. doi:10.1016/j.smim.2013.09.005
Scholz, C. F. P., & Kilian, M. (2016). The natural history of cutaneous propionibacteria, and reclassification of selected species within the genus Propionibacterium to the proposed novel genera Acidipropionibacterium gen. nov., Cutibacterium gen. nov. and Pseudopropionibacterium gen. nov. Int J Syst Evol Microbiol, 66(11), 4422-4432. doi:10.1099/ijsem.0.001367
Schwarz, A., Bruhs, A., & Schwarz, T. (2016). The Short-Chain Fatty Acid Sodium Butyrate Functions as a Regulator of the Skin Immune System. Journal of Investigative Dermatology, 137. doi:10.1016/j.jid.2016.11.014
Shanahan, C. M., Crouthamel, M. H., Kapustin, A., & Giachelli, C. M. (2011). Arterial calcification in chronic kidney disease: key roles for calcium and phosphate. Circ Res, 109(6), 697-711. doi:10.1161/CIRCRESAHA.110.234914
Sharma, S., Orlowski, G., & Song, W. (2009). Btk regulates B cell receptor-mediated antigen processing and presentation by controlling actin cytoskeleton dynamics in B cells. J Immunol, 182(1), 329-339. doi:10.4049/jimmunol.182.1.329
Shi, B., Bangayan, N. J., Curd, E., Taylor, P. A., Gallo, R. L., Leung, D. Y. M., & Li, H. (2016). The skin microbiome is different in pediatric versus adult atopic dermatitis. J Allergy Clin Immunol, 138(4), 1233-1236. doi:10.1016/j.jaci.2016.04.053
Shirazian, S., Aina, O., Park, Y., Chowdhury, N., Leger, K., Hou, L., Miyawaki, N., & Mathur, V. S. (2017). Chronic kidney disease-associated pruritus: impact on quality of life and current management challenges. Int J Nephrol Renovasc Dis, 10, 11-26. doi:10.2147/IJNRD.S108045
Shu, M., Wang, Y., Yu, J., Kuo, S., Coda, A., Jiang, Y., Gallo, R. L., & Huang, C.-M. (2013). Fermentation of Propionibacterium acnes, a Commensal Bacterium in the Human Skin Microbiome, as Skin Probiotics against Methicillin-Resistant Staphylococcus aureus. PLoS One, 8(2), e55380. doi:10.1371/journal.pone.0055380
Slee, A. D. (2012). Exploring metabolic dysfunction in chronic kidney disease. Nutr Metab (Lond), 9(1), 36. doi:10.1186/1743-7075-9-36
Smerdon, M. J., Lan, S. Y., Calza, R. E., & Reeves, R. (1982). Sodium butyrate stimulates DNA repair in UV-irradiated normal and xeroderma pigmentosum human fibroblasts. J Biol Chem, 257(22), 13441-13447. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/7142158
Smith, C. I., Baskin, B., Humire-Greiff, P., Zhou, J. N., Olsson, P. G., Maniar, H. S., Kjellen, P., Lambris, J. D., Christensson, B., Hammarstrom, L., & et al. (1994). Expression of Bruton′s agammaglobulinemia tyrosine kinase gene, BTK, is selectively down-regulated in T lymphocytes and plasma cells. J Immunol, 152(2), 557-565. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/8283037
Solak, B., Acikgoz, S. B., Sipahi, S., & Erdem, T. (2016). Epidemiology and determinants of pruritus in pre-dialysis chronic kidney disease patients. Int Urol Nephrol, 48(4), 585-591. doi:10.1007/s11255-015-1208-5
Spoto, B., Mattace-Raso, F., Sijbrands, E., Leonardis, D., Testa, A., Pisano, A., Pizzini, P., Cutrupi, S., Parlongo, R. M., D’Arrigo, G., Tripepi, G., Mallamaci, F., & Zoccali, C. (2015). Association of IL-6 and a Functional Polymorphism in the IL-6 Gene with Cardiovascular Events in Patients with CKD. Clinical Journal of the American Society of Nephrology, 10(2), 232. doi:10.2215/CJN.07000714
Sun, J., Axelsson, J., Machowska, A., Heimburger, O., Barany, P., Lindholm, B., Lindstrom, K., Stenvinkel, P., & Qureshi, A. R. (2016). Biomarkers of Cardiovascular Disease and Mortality Risk in Patients with Advanced CKD. Clin J Am Soc Nephrol, 11(7), 1163-1172. doi:10.2215/CJN.10441015
Sun, Y. G., & Chen, Z. F. (2007). A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord. Nature, 448(7154), 700-703. doi:10.1038/nature06029
Sun, Y. G., Zhao, Z. Q., Meng, X. L., Yin, J., Liu, X. Y., & Chen, Z. F. (2009). Cellular basis of itch sensation. Science, 325(5947), 1531-1534. doi:10.1126/science.1174868
Szepietowski, J. C., Sikora, M., Kusztal, M., Salomon, J., Magott, M., & Szepietowski, T. (2002). Uremic pruritus: a clinical study of maintenance hemodialysis patients. J Dermatol, 29(10), 621-627. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/12432992
Takahashi-Tezuka, M., Hibi, M., Fujitani, Y., Fukada, T., Yamaguchi, T., & Hirano, T. (1997). Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK. Oncogene, 14(19), 2273-2282. doi:10.1038/sj.onc.1201071
Traisaeng, S., Herr, D. R., Kao, H. J., Chuang, T. H., & Huang, C. M. (2019). A Derivative of Butyric Acid, the Fermentation Metabolite of Staphylococcus epidermidis, Inhibits the Growth of a Staphylococcus aureus Strain Isolated from Atopic Dermatitis Patients. Toxins (Basel), 11(6). doi:10.3390/toxins11060311
Turan, M., Ataoğlu, N., & Şahιn, F. (2006). Evaluation of the Capacity of Phosphate Solubilizing Bacteria and Fungi on Different Forms of Phosphorus in Liquid Culture. Journal of Sustainable Agriculture, 28(3), 99-108. doi:10.1300/J064v28n03_08
Vandecasteele, S. J., Boelaert, J. R., & De Vriese, A. S. (2009). Staphylococcus aureus infections in hemodialysis: what a nephrologist should know. Clin J Am Soc Nephrol, 4(8), 1388-1400. doi:10.2215/CJN.01590309
Vaziri, N. D. (2006). Dyslipidemia of chronic renal failure: the nature, mechanisms, and potential consequences. Am J Physiol Renal Physiol, 290(2), F262-272. doi:10.1152/ajprenal.00099.2005
Viegas, C., Araujo, N., Marreiros, C., & Simes, D. (2019). The interplay between mineral metabolism, vascular calcification and inflammation in Chronic Kidney Disease (CKD): challenging old concepts with new facts. Aging (Albany NY), 11(12), 4274-4299. doi:10.18632/aging.102046
Wagner Mackenzie, B., Waite, D. W., & Taylor, M. W. (2015). Evaluating variation in human gut microbiota profiles due to DNA extraction method and inter-subject differences. Front Microbiol, 6, 130. doi:10.3389/fmicb.2015.00130
Wang, Y., Kuo, S., Shu, M., Yu, J., Huang, S., Dai, A., Two, A., Gallo, R. L., & Huang, C. M. (2014). Staphylococcus epidermidis in the human skin microbiome mediates fermentation to inhibit the growth of Propionibacterium acnes: implications of probiotics in acne vulgaris. Appl Microbiol Biotechnol, 98(1), 411-424. doi:10.1007/s00253-013-5394-8
Wang, Y., Wu, Y., Wang, Y., Xu, H., Mei, X., Yu, D., Wang, Y., & Li, W. (2017). Antioxidant Properties of Probiotic Bacteria. Nutrients, 9(5). doi:10.3390/nu9050521
Wang, Y., Zhang, L., Yu, J., Huang, S., Wang, Z., Chun, K. A., Lee, T. L., Chen, Y.-T., Gallo, R. L., & Huang, C.-M. (2017). A Co-Drug of Butyric Acid Derived from Fermentation Metabolites of the Human Skin Microbiome Stimulates Adipogenic Differentiation of Adipose-Derived Stem Cells: Implications in Tissue Augmentation. Journal of Investigative Dermatology, 137(1), 46-56. doi:https://doi.org/10.1016/j.jid.2016.07.030
Weiss, M., Mettang, T., Tschulena, U., Passlick-Deetjen, J., & Weisshaar, E. (2015). Prevalence of chronic itch and associated factors in haemodialysis patients: a representative cross-sectional study. Acta Derm Venereol, 95(7), 816-821. doi:10.2340/00015555-2087
Weston, S., Halbert, A., Richmond, P., & Prescott, S. L. (2005). Effects of probiotics on atopic dermatitis: a randomised controlled trial. Archives of disease in childhood, 90(9), 892-897.
Wong, J., Piceno, Y. M., DeSantis, T. Z., Pahl, M., Andersen, G. L., & Vaziri, N. D. (2014). Expansion of urease- and uricase-containing, indole- and p-cresol-forming and contraction of short-chain fatty acid-producing intestinal microbiota in ESRD. Am J Nephrol, 39(3), 230-237. doi:10.1159/000360010
Xia, J., Song, X., Bi, Z., Chu, W., & Wan, Y. (2005). UV-induced NF-kappaB activation and expression of IL-6 is attenuated by (-)-epigallocatechin-3-gallate in cultured human keratinocytes in vitro. Int J Mol Med, 16(5), 943-950. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/16211268
Yang, A. J., Marito, S., Yang, J. J., Keshari, S., Chew, C. H., Chen, C. C., & Huang, C. M. (2018). A Microtube Array Membrane (MTAM) Encapsulated Live Fermenting Staphylococcus epidermidis as a Skin Probiotic Patch against Cutibacterium acnes. Int J Mol Sci, 20(1). doi:10.3390/ijms20010014
Yang, X. O., Panopoulos, A. D., Nurieva, R., Chang, S. H., Wang, D., Watowich, S. S., & Dong, C. (2007). STAT3 regulates cytokine-mediated generation of inflammatory helper T cells. J Biol Chem, 282(13), 9358-9363. doi:10.1074/jbc.C600321200
Yoshizumi, M., Nakamura, T., Kato, M., Ishioka, T., Kozawa, K., Wakamatsu, K., & Kimura, H. (2008). Release of cytokines/chemokines and cell death in UVB-irradiated human keratinocytes, HaCaT. Cell Biol Int, 32(11), 1405-1411. doi:10.1016/j.cellbi.2008.08.011
Yosipovitch, G., Greaves, M. W., & Schmelz, M. (2003). Itch. The Lancet, 361(9358), 690-694.
Zhang, L., Jiang, G. Y., Song, N. J., Huang, Y., Chen, J. Y., Wang, Q. X., & Ding, Y. Q. (2014). Extracellular signal-regulated kinase (ERK) activation is required for itch sensation in the spinal cord. Mol Brain, 7, 25. doi:10.1186/1756-6606-7-25
Zoccali, C., Tripepi, G., & Mallamaci, F. (2006). Dissecting inflammation in ESRD: do cytokines and C-reactive protein have a complementary prognostic value for mortality in dialysis patients? J Am Soc Nephrol, 17(12 Suppl 3), S169-173. doi:10.1681/ASN.2006080910
指導教授 黃俊銘 莊宗顯(Chun-Ming Huang Tsung-Hsien Chuang) 審核日期 2020-2-27
推文 facebook   plurk   twitter   funp   google   live   udn   HD   myshare   reddit   netvibes   friend   youpush   delicious   baidu   
網路書籤 Google bookmarks   del.icio.us   hemidemi   myshare   

若有論文相關問題,請聯絡國立中央大學圖書館推廣服務組 TEL:(03)422-7151轉57407,或E-mail聯絡  - 隱私權政策聲明