| 摘要(英) |
Due to the prevalence of sports, there is bound to be a risk of sports injuries. Most human tissues damaged by sports injuries are tendons and muscles. If the relationship between muscles, tendons and tension can be known, providing data for medical diagnosis can be more convenient to make accurate judgments. This demand induces scientists to be curious about the relationship between human tissue and tension. Therefore, many methods for measuring human biological tissue have been established, which has enabled biomechanics to flourish. Although more and more attention has been paid to in vivo measurement in recent years, it is not easy to obtain real-time information through traditional measurement methods. Therefore, in order to solve this limitation, more measurement methods combined with imaging systems have been proposed and applied.
Compared with traditional tension measurement methods, the photoacoustic imaging system can obtain real-time information of muscle and tendon tissue more quickly. In this experiment, a 1064 nm laser was used as the excitation light source for the photoacoustic signal to scan the two-dimensional photoacoustic signal. First, an electric translation stage was used to apply different tensions to the muscle and tendon tissue to observe the changes in the photoacoustic signal of the muscle and tendon tissue. However, the translation stage can only indicate the elongation when the tension is applied to the sample. In order to find the relationship between the tension and the elongation, this study uses springs to measure the samples separately and obtains the different elongations under the condition of known spring coefficients. Finally, we use the spring measurement result to compare the relationship between the photoacoustic signal change and the tension.
From the changes in the two-dimensional photoacoustic signal, it can be found that when the translation stage continues to stretch the sample, the photoacoustic signal will gradually decrease, and the signal decline after muscle and tendon stretching is not the same. In order to understand the relationship between tension and elongation, we used springs to do multiple measurements. It can be observed that the relationship between tension and elongation presented by the muscle and tendon samples are different. After measuring the experimental results of the spring, we can know the relationship between the photoacoustic signal and tension. We also do curve fitting of the photoacoustic signal, and we can find that the tendon samples are more consistent with the observations in the past literature However, the muscle sample does not meet the trend, and it is speculated here that there may be a difference in sample preparation. Based on the relationship between tension and photoacoustic signals obtained in this study, it will be possible to obtain real-time muscle and tendon tension information through the observation of photoacoustic images in the future. |
| 參考文獻 |
[1] R. Messier, J. a. Duffy, H. Litchman, P. Paslay, J. Soechting, and P. J. I. J. o. M. S. Stewart,
"The electromyogram as a measure of tension in the human biceps and triceps muscles," 13, 585-598 (1971).
[2] A. Cribb and J. Scott, "Tendon response to tensile stress: an ultrastructural investigation of collagen: proteoglycan interactions in stressed tendon," Journal of anatomy 187, 423 (1995).
[3] Y. Kawakami, K. Nakazawa, T. Fujimoto, D. Nozaki, M. Miyashita, and T. Fukunaga, "Specific tension of elbow flexor and extensor muscles based on magnetic resonance imaging," European journal of applied physiology and occupational physiology 68, 139-147 (1994).
[4] S. Duenwald, H. Kobayashi, K. Frisch, R. Lakes, and R. Vanderby Jr, "Ultrasound echo is related to stress and strain in tendon," Journal of biomechanics 44, 424-429 (2011).
[5] K. A. Hansen, J. K. Barton, and J. A. Weiss, "Optical coherence tomography imaging of collagenous tissue microstructure," in Laser-Tissue Interaction XI: Photochemical, Photothermal, and Photomechanical (International Society for Optics and Photonics2000), pp. 581-587.
[6] H. D. Lee, J. G. Shin, H. Hyun, B.-A. Yu, and T. J. Eom, "Label-free photoacoustic microscopy for in-vivo tendon imaging using a fiber-based pulse laser," Scientific reports 8, 1-9 (2018).
[7] J. R. Crass, G. Van de Vegte, and L. A. Harkavy, "Tendon echogenicity: ex vivo study," Radiology 167, 499-501 (1988).
[8] C. Rashidifard, C. Vercollone, S. Martin, B. Liu, and M. E. Brezinski, "The application of optical coherence tomography in musculoskeletal disease," Arthritis 2013 (2013).
[9] P. Hai, Y. Zhou, L. Gong, and L. V. Wang, "Quantitative photoacoustic elastography in humans," Journal of biomedical optics 21, 066011 (2016).
[10] Y.-S. Chen, D. Yeager, and S. Y. Emelianov, "Photoacoustic Imaging for Cancer Diagnosis and Therapy Guidance," in Cancer Theranostics (Elsevier, 2014), pp. 139-158.
[11] L. V. Wang and H.-i. Wu, Biomedical optics: principles and imaging (John Wiley & Sons, 2012).
[12] C. Hoelen and F. De Mul, "A new theoretical approach to photoacoustic signal generation," The Journal of the Acoustical Society of America 106, 695-706 (1999).
[13] M. W. Sigrist and F. K. Kneubühl, "Laser‐generated stress waves in liquids," The Journal of the Acoustical Society of America 64, 1652-1663 (1978).
[14] "Endomysium, Perimysium and epimysium - definition, histology," http://www.medicinehack.com/2016/12/endomysium-perimysium-and-epimysium.html.
[15] P. P. Purslow, "The structure and functional significance of variations in the connective tissue within muscle," Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology 133, 947-966 (2002).
[16] Y. Gao, T. Y. Kostrominova, J. A. Faulkner, and A. S. Wineman, "Age-related changes in the mechanical properties of the epimysium in skeletal muscles of rats," Journal of biomechanics 41, 465-469 (2008).
[17] L. G. Józsa, "Human tendons: anatomy, physiology and pathology," Human kinetics (1997).
[18] F. H. Silver, J. W. Freeman, and G. P. Seehra, "Collagen self-assembly and the development of tendon mechanical properties," Journal of biomechanics 36, 1529-1553 (2003).
[19] J. Wilmink, A. Wilson, and A. Goodship, "Functional significance of the morphology and micromechanics of collagen fibres in relation to partial rupture of the superficial digital flexor tendon in racehorses," Research in veterinary science 53, 354-359 (1992).
[20] J. H.-C. Wang, "Mechanobiology of tendon," Journal of biomechanics 39, 1563-1582 (2006).
[21] L. David, E. S. Grood, F. R. Noyes, and R. E. Zernicke, "Biomechanics of ligaments and tendons," Exercise and sport sciences reviews 6, 125-182 (1978).
[22] B. Katz, "The relation between force and speed in muscular contraction," The Journal of Physiology 96, 45-64 (1939).
[23] R. B. Svensson, P. Hansen, T. Hassenkam, B. T. Haraldsson, P. Aagaard, V. Kovanen, M. Krogsgaard, M. Kjaer, and S. P. Magnusson, "Mechanical properties of human patellar tendon at the hierarchical levels of tendon and fibril," Journal of Applied Physiology 112, 419-426 (2012).
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