博碩士論文 105826001 詳細資訊




以作者查詢圖書館館藏 以作者查詢臺灣博碩士 以作者查詢全國書目 勘誤回報 、線上人數:8 、訪客IP:3.145.90.226
姓名 邱子洛(Tzu-Lo Chiu)  查詢紙本館藏   畢業系所 系統生物與生物資訊研究所
論文名稱 台北和中壢地區不孕症分佈與共病探討
(Distribution and comorbidities of infertility in Taipei and Zhongli Districts)
相關論文
★ 細菌物種基因體中非編碼小片段核糖核酸之預測★ 從年齡動態網路探討疾病盛行率
★ 藉由比較基因表現資料研究次世代定序與晶片技術分析差異★ 啟動子甲基化與對應之基因表現微陣列資訊整合分析
★ 乾燥綜合症與非病毒型肝炎之相關因子分析★ 氣候變遷對人類疾病網路造成衝擊
★ 探討台灣的門診疾病與環境空氣品質的濃度變化之相關性★ 以地區醫院病例探討桃園之地域族群與疾病之差別
★ 桃園地區之區域與疾病盛行率之關聯★ CyTOF之生物標記篩選與分析
★ 透明細胞腎細胞癌質譜流式細胞儀資料分析與視覺化★ 使用支持向量機預測蛋白質醣基化位置
★ 使用基因表現資料預測基因轉錄調控網路★ RNA Riboswitch搜尋系統之設計與實作
★ 人類疾病差異表現基因與調控網路之整合系統★ 利用赫伯特-黃轉換法辨識酵母菌在呼吸/還原週期中的震盪基因群
檔案 [Endnote RIS 格式]    [Bibtex 格式]    [相關文章]   [文章引用]   [完整記錄]   [館藏目錄]   至系統瀏覽論文 ( 永不開放)
摘要(中) 隨者現在社會型態改變,許多人普遍晚婚,加上心理因素或環境污染等因素,都可能會增加不孕的發生,目前不孕症已成為全球關注的議題。在之前的研究就指出,導致不孕症的原因有女性因素、男性因素或原因不明因素,其中有25~28%不孕症是不明原因導致的。在臨床上,有些疾病之間的共病性是有顯著相關性並互相影響。在此研究中,我們利用國泰醫院和壢新醫院的看診資料,並以健保資料庫為輔助,以男性不孕症 (ICD9-CM : 606.9) 和女性不孕症(ICD9-CM : 628.9)為研究對象,探討不同地區不孕症年齡層分佈和不孕症與其他疾病之間的關聯性,並分析藥物使用是否會提高共病的風險。我們的研究結果顯示,兩家醫院在2008-2014年之間女性盛行率以2014年最高,國泰(0.36%)、壢新(0.52%),女性盛行率比男性高。年齡層分佈顯示在兩家醫院有顯著的差異。在女性患者共病方面,兩家醫院都顯示出與卵巢、子宮內膜異位、陰道炎和泌尿道感染這些疾病有顯著關係,而男性則是與泌尿道感染、生殖器官發炎等疾病相關。這些結果與過去研究相符。特別的是,我們在男女患者皆還發現到接觸性皮膚炎及其他濕疹,這疾病或許是不孕症其他誘導原因,還需進一步探討。
摘要(英) With the current social changes, many people are generally married late, and psychological factors or environmental pollution may increase the incidence of infertility. At present, infertility has become a global concern. In previous studies, it was pointed out that the causes of infertility were female factors, male factors or unexplained factors. Among them, 25-28% of infertility was caused by unexplained factors. Clinically, the comorbidities between some diseases are significantly correlated and affect each other. In this study, male infertility (ICD9-CM: 606.9) and female infertility (ICD9-CM: 628.9) are used be as the main subject. We used clinical data from Cathay General Hospital (CGH), Landseed Hospital (LSH) and supplemented with National Health Insurance Research Database (NHIRD) to investigate the relationship between infertility and the other diseases and age distribution of infertility in different regions. Also, we analyzed whether medicine used will increase the risk of comorbidity. Our research shows that the prevalence of females in the two hospitals was highest in 2014 from 2008 to 2014, with CGH (0.36%) and LSH (0.52%), and the prevalence of females was higher than that of males. Age distribution showed that there were significant differences between the two hospitals. In the comorbidity of female patients, both hospitals have been shown to have a significant relationship with ovarian, endometriosis, vaginitis and urinary tract infections, while men are associated with urinary tract infections, genital inflammation and other diseases. These results are consistent with past studies. In particular, we have also found contact dermatitis and other eczema in both male and female patients. It may be other causes of infertility, and needs further investigation.
關鍵字(中) ★ 不孕症
★ 共病症
關鍵字(英) ★ infertility
★ comorbidity
論文目次 中文摘要 i
English abstract ii
Tables of content iii
List of figures v
List of tables vi
Supplementary Figures vii
Supplementary Tables viii
Chapter 1 Introduction 1
1-1 Background 1
1-2 Related Work 1
1-3 Motivation 2
1-4 Goal 2
Chapter 2 Material and Methods 3
2-1 Collection of clinical data 3
2-2 Data processing 3
2-3 Procedure of research 6
2-3-1 Finding association between infertility patients and the other diseases 6
2-3-2 Identifying comorbidities differ significantly from the different distribution of age 6
2-3-3 Identifying influence between medicines and comorbidities of infertility 6
2-4 Statistics method 7
Chapter3 Result 9
3-1 Statistics of infertility patients 9
3-2 Select association between patients with infertility and the other diseases 12
3-2-1 Comparing significant comorbidities of infertility in LSH with CGH 16
3-2-2 Mapping results from two hospitals 17
3-2-3 The time difference between infertility and comorbidities 17
3-3 Age 26
3-3-1 Age distribution of infertility patients 26
3-3-2 Identify association between infertility and comorbidities depend on specific age groups 27
3-3 Medicine 31
Chapter4 Discussion and Summary 34
References 40
Supplementary 42
參考文獻 1. Ombelet, W. and J. Goossens, Global reproductive health–Why do we persist in neglecting the undeniable problem of childlessness in resource-poor countries? Facts, views & vision in ObGyn, 2017. 9(1): p. 1.
2. Definitions of infertility and recurrent pregnancy loss: a committee opinion. Fertil Steril, 2013. 99(1): p. 63.
3. Larsen, U., Primary and secondary infertility in sub-Saharan Africa. Int J Epidemiol, 2000. 29(2): p. 285-91.
4. Thonneau, P., et al., Incidence and main causes of infertility in a resident population (1 850 000) of three French regions (1988–1989). Human reproduction, 1991. 6(6): p. 811-816.
5. Sharpe, R.M. and S. Franks, Environment, lifestyle and infertility—an inter-generational issue. Nature Medicine, 2002. 8(10s): p. S33.
6. Phipps, W.R., et al., The association between smoking and female infertility as influenced by cause of the infertility. Fertil Steril, 1987. 48(3): p. 377-82.
7. Homan, G., M. Davies, and R. Norman, The impact of lifestyle factors on reproductive performance in the general population and those undergoing infertility treatment: a review. Human reproduction update, 2007. 13(3): p. 209-223.
8. Mascarenhas, M.N., et al., National, regional, and global trends in infertility prevalence since 1990: a systematic analysis of 277 health surveys. PLoS Med, 2012. 9(12): p. e1001356.
9. Diagnostic evaluation of the infertile female: a committee opinion. Fertil Steril, 2012. 98(2): p. 302-7.
10. Wiser, H.J., J. Sandlow, and T.S. Kohler, Causes of male infertility, in Male Infertility. 2012, Springer. p. 3-14.
11. Lindsay, T.J. and K.R. Vitrikas, Evaluation and treatment of infertility. Am Fam Physician, 2015. 91(5): p. 308-14.
12. Lessey, B.A., et al., Integrins as markers of uterine receptivity in women with primary unexplained infertility. Fertility and sterility, 1995. 63(3): p. 535-542.
13. Aitken, R.J., et al., An analysis of sperm function in cases of unexplained infertility: conventional criteria, movement characteristics, and fertilizing capacity. Fertility and Sterility, 1982. 38(2): p. 212-221.
14. Somigliana, E., et al., Age-related infertility and unexplained infertility: an intricate clinical dilemma. Hum Reprod, 2016. 31(7): p. 1390-6.
15. Menken, J., J. Trussell, and U. Larsen, Age and infertility. Science, 1986. 233(4771): p. 1389-1394.
16. Harris, I.D., et al., Fertility and the aging male. Reviews in urology, 2011. 13(4): p. e184.
17. Gunes, S., et al., Effects of aging on the male reproductive system. Journal of assisted reproduction and genetics, 2016. 33(4): p. 441-454.
18. Hassan, M.A. and S.R. Killick, Effect of male age on fertility: evidence for the decline in male fertility with increasing age. Fertility and sterility, 2003. 79: p. 1520-1527.
19. Grimes, D.A. and K.F. Schulz, Compared to what? Finding controls for case-control studies. The Lancet, 2005. 365(9468): p. 1429-1433.
20. Hamajima, N., et al., Case-control studies: matched controls or all available controls? Journal of clinical epidemiology, 1994. 47(9): p. 971-975.
21. Registration, D.o.H. Median age and average age of marriage (according to occurrence). 2010-2016.
22. Mahalingaiah, S., et al., Adult air pollution exposure and risk of infertility in the Nurses′ Health Study II. Human Reproduction, 2016. 31(3): p. 638-647.
23. Lao, X.Q., et al., Exposure to ambient fine particulate matter and semen quality in Taiwan. Occup Environ Med, 2018. 75(2): p. 148-154.
24. Elcin, G., et al., Autoimmune estrogen dermatitis in an infertile female. Cutaneous and ocular toxicology, 2017. 36(2): p. 195-198.
指導教授 吳立青(Li-Ching Wu) 審核日期 2018-7-30
推文 facebook   plurk   twitter   funp   google   live   udn   HD   myshare   reddit   netvibes   friend   youpush   delicious   baidu   
網路書籤 Google bookmarks   del.icio.us   hemidemi   myshare   

若有論文相關問題,請聯絡國立中央大學圖書館推廣服務組 TEL:(03)422-7151轉57407,或E-mail聯絡  - 隱私權政策聲明