雙離子共聚物以光化學接枝抗汙塗層於熱塑型聚氨酯導管

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李培榕(Pei-Rong Li) 查詢紙本館藏

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生物醫學工程研究所

論文名稱

雙離子共聚物以光化學接枝抗汙塗層於熱塑型聚氨酯導管
(Surface Modification of Thermoplastic Polyurethane Catheter by Photografting Zwitterionic Copolymers)

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至系統瀏覽論文 (2025-7-1以後開放)

摘要(中)

熱塑型聚氨酯(Thermoplastic polyurethane, TPU)因具有良好的生物相容性與機械性質，成為生醫器材的重要材料，如:人工血管、透析幫浦、導管等，但是，導管使用容易引起尿道感染與血液感染。歸究其因，TPU 表面的疏水性質使細菌、蛋白容易貼附，讓醫材的使用效率降低、引發發炎反應及感染等問題，同時，放置導管對病人來說是相當不適與疼痛。
兩性雙離子材料磷脂酰膽鹼具有優異的生物相容性、潤滑與抗汙能力，能有效提高表面親水性質，並降低細菌與蛋白質等貼附，可作為醫療器材的抗汙塗層使用。本實驗嘗試開發一種在大氣環境中，透過浸塗與照射 UV 光源的方式，將兩性雙離子聚合物 2-甲基丙烯酰氧乙基磷酸膽鹼-甲基丙烯酸月桂酯 (poly(2-methacryloyloxyethyl phosphorylcholine-co-dodecyl methacrylate), P(MPC-DMA))以共價接枝上 TPU 導管。在吸收 UV 光源的輻射能量後，光引發劑 4-丙烯酰氧基二苯甲酮 (4-benzoylphenyl acrylate, BPA)被激發，會抓取聚合物及 TPU 導管
碳原子上的氫原子，協助雙離子材料 P(MPC-DMA) 與 TPU 導管共價交聯，得到親水潤滑的表面。第一部分我們使用核磁共振光譜儀 (nuclear magnetic resonance ,NMR) 鑑定高分子的化學結構與轉化率，以及使用全反射-傅立葉轉換紅外線光譜儀 (attenuated total reflection-Fourier-transform infrared spectroscopy, ATR-FTIR )來確認導管表面與雙離子材料 P(MPC-DMA) 的鍵結，利用摩擦力測試、抗蛋白
貼附測試、抗菌貼附測試，檢視改質後的 TPU 導管表面的抗汙潤滑特性，並與具潤滑效果的聚乙烯吡咯烷酮 (Poly(N-vinylpyrrolidone), PVP) 塗布導管比較。第二部分討論三種 P(MPC-DMA)不同分子比例的雙離子共聚物，在不同條件下的表面貼附動力學與粒徑大小關係、抗蛋白能力、溶解度及多種材料上的修飾效果差異。本論文，我們使用簡易操作且有效的改質方式，以雙離子聚合物 P(MPCDMA) 共價鍵結於 TPU 表面，使表面具有抗汙且潤滑的性能，並對表面修飾的機制提出見解，期許未來可以更進一步優化配方與製程技術，以滿足於更多的醫療器材應用。

摘要(英)

Thermoplastic polyurethane (TPU) has been widely applied in various medical devices, such as artificial blood vessels, dialysis pumps and catheters, due to its good mechanical and biocompatible properties. However, bacterial infection occurs often in urinary and central venous catheters, which is attributed to the hydrophobic property of TPU, leading to non-specific adsorption of bacteria. Meanwhile, placement of catheters can be uncomfortable and painful for a patient. It has been found that zwitterionic phosphatidylcholine materials possess excellent biocompatible, lubricant and antifouling properties. In this study, we attempt to develop an efficient and facile way to graft zwitterionic polymers on TPU by dip coating and photoreaction in an ambient environment. Amphiphilic copolymers, poly(2-methacryloyloxyethyl phosphorylcholine-co-dodecyl methacrylate), P(MPC-DMA), were covalently grafted onto TPU substrate through photografting of the ketone structure in photoinitiator under UV irradiation. The chemical structures and conversion rate of as-prepared polymers were characterized by nuclear magnetic resonance (NMR) and attenuated total reflection-Fourier-transform infrared spectroscopy (ATR-FTIR). P(MPC-DMA) modified TPU tubes were examined by friction test, UV-Vis spectroscopy, anti-protein adhesion, antibacterial adhesion in comparison with poly(N-vinylpyrrolidone) (PVP) modified tubes. Additionally, we discussed the anti-fouling property and adsorption kinetics of P(MPC-DMA) copolymers with the different molecular ratios to correlate with their colloidal dimensions in solutions with an attempt to explore binding mechanism of polymers. Consequently, we demonstrated a facile and less footprint method to covalently modify P(MPC-DMA) polymeric coatings on TPU surfaces for good lubrication and antifouling capabilities. In the future works, we will dedicate to optimization of the coating process and formulation with an aim to meet the demanded requirements of medical applications.

關鍵字(中)

★ 雙離子材料
★ 2-甲基丙烯酰氧乙基磷酸膽鹼
★ 生醫塗層
★ 抗沾黏塗層
★ 熱塑型聚氨酯

關鍵字(英)

★ zwitterionic materials
★ 2-methacryloyloxyethyl phosphorylcholine (MPC)
★ medical coatings
★ non-specific adsorption
★ thermoplastic polyurethane

論文目次

中文摘要.................................................................................................................i
Abstract................................................................................................................ iii
致謝........................................................................................................................v
目錄.......................................................................................................................vi
圖目錄....................................................................................................................x
表目錄..................................................................................................................xii
化學品名詞簡稱................................................................................................ xiii
一、文獻回顧........................................................................................................1
1-1 生物汙染與醫材設備相關感染 (Device-Associated Infections, DAI）............ 1
1-2 熱塑型聚氨酯的應用與困境............................................................................... 2
1-3 抗菌塗層策略與上市產品回顧........................................................................... 3
1-4 親水塗層的發展性與現有產品........................................................................... 4
1-5 抗沾黏材料........................................................................................................... 5
1-5-1 聚乙二醇材料................................................................................................ 5
1-5-2 乙烯吡咯烷酮 (N-vinylpyrrolidone, NVP) .................................................. 6
1-5-3 雙離子材料.................................................................................................... 7
1-6 表面接枝與光化學接枝..................................................................................... 10
vii
二、研究目的......................................................................................................13
三、實驗藥品與實驗方法..................................................................................14
3-1 實驗藥品與設備................................................................................................. 14
3-1-1 藥品清單...................................................................................................... 14
3-1-2 設備清單...................................................................................................... 15
3-2 材料合成與材料置備......................................................................................... 17
3-2-1 Poly(2-methacryloyloxyethyl phosphorylcholine-co-dodecyl methacrylate),
P(MPC-DMA) 合成 .............................................................................................. 17
3-2-2 聚胺酯導管置備.......................................................................................... 17
3-2-3 鍍金薄片疏水性修飾.................................................................................. 17
3-2-4 玻璃疏水性修飾.......................................................................................... 18
3-2-5 瓊脂平板製備.............................................................................................. 18
3-3 實驗方法............................................................................................................. 19
3-3-1 Poly(2-methacryloyloxyethyl phosphorylcholine-co-dodecyl methacrylate),
P(MPC-DMA) 導管修飾 ...................................................................................... 19
3-3-2 衰減全反射傅立葉轉換紅外線光譜 (Attenuated total reflectance-fourier
transform infrared spectra，ATR-FTIR) 鑑定...................................................... 20
3-3-3 可見光光譜儀 (Ultraviolet–visible spectroscopy，UV-Vis)..................... 20
3-3-4 水下摩擦力測定.......................................................................................... 21
3-3-5 抗蛋白貼附測試.......................................................................................... 21
viii
3-3-6 抗細菌貼附測試.......................................................................................... 22
3-3-7 表面電漿共振抗汙測試.............................................................................. 22
3-3-8 奈米粒徑及介面電位量測儀 (Dynamic light scattering，DLS) .............. 23
3-3-9 水接觸角測定 (Contact angle meter)......................................................... 24
3-3-10 凝膠滲透色譜分析 (Gel Permeation Chromatography，GPC) .............. 24
3-3-11 統計學分析方法........................................................................................ 24
四、結果與討論..................................................................................................25
4-1 氧氣對表面修飾的影響..................................................................................... 25
4-2 除氧劑的選擇..................................................................................................... 28
4-3 Poly(2-methacryloyloxyethyl phosphorylcholine-co-dodecyl methacrylate),
P(MPC-DMA) 鑑定 (
1H NMR) ............................................................................... 31
4-4 Poly(2-methacryloyloxyethyl phosphorylcholine-co-dodecyl methacrylate),
P(MPC-DMA)不同合成比例對聚氨酯導管潤滑度的影響..................................... 32
4-5 Poly(2-methacryloyloxyethyl phosphorylcholine-co-dodecyl methacrylate),
P(MPC-DMA)不同合成比例於 SPR 的抗蛋白貼附效果 ....................................... 34
4-6 空氣烘乾對導管修飾的影響............................................................................. 37
4-7 導管表面 BPA 濃度的重要性 ........................................................................... 38
4-8 輻射波長對 BPA 的使用效率與導管穩定性的影響 ....................................... 40
4-9 導管上聚合物鑑定 (FTIR)................................................................................ 44
4-10 導管於水下的潤滑度測試................................................................................ 46
ix
4-11 導管表面蛋白貼附測試.................................................................................... 48
4-12 導管抗細菌貼附測試........................................................................................ 49
4-13 MD37、MD55、MD73 不同濃度的 SPR 吸附脫附測試............................... 51
4-14 MD37、MD55、MD73 於不同溶劑比例的溶解度........................................ 53
4-15 MD37、MD55、MD73 於 0.5 wt%濃度之 SPR 抗蛋白貼附測試 ................ 54
4-16 MD37、MD55、MD73 修飾於 OTS、PDMS、PET 之接觸角測試 ............ 55
五、結論..............................................................................................................58
六、未來展望......................................................................................................59
七、參考文獻......................................................................................................60

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指導教授

黃俊仁(Chun-Jen Huang)

審核日期

2020-7-14

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