選擇性發酵引發劑（SFI）觸發表皮葡萄球菌發酵以緩解UV-B誘導的自由基生成

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普拉索(Prakoso Adi) 查詢紙本館藏

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生醫科學與工程學系

論文名稱

選擇性發酵引發劑（SFI）觸發表皮葡萄球菌發酵以緩解UV-B誘導的自由基生成
(The Selective Fermentation Initiator (SFI) Triggers Fermentation of S. epidermidis to Mitigate UV-B Induced Free-radical Generation)

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摘要(中)

目前已經發現全球輻射水平以驚人的速度增加，來自陽光的UV-B可以直接滲透到皮膚的表皮區域。這就增加了對UV-B輻射的局部補充劑的需求，該補充劑不僅是無毒的而且還不會破壞人類皮膚微生物組。UV-B輻射可以通過增加細胞壓力或在表皮水平上催化增生直接淹沒組織抗氧化劑，甚至長時間暴露也會導致早衰或皮膚癌。人的皮膚內源性抗氧化劑防禦系統有一些局限性，即它們無法對慢性UV-B脅迫起作用。因此，我們的身體需要外部補充劑來防止壓力增加。已經研究了不管是活或死的益生菌細菌可以減輕人類的炎症。有趣的是，局部使用益生菌皮膚細菌表皮葡萄球菌（S. epidermidis）ATCC 12228及其特定的益生元選擇性發酵引髮劑（SFI）稱為椰油辛酸（LCC）可以改善慢性經UV-B照射的小鼠皮膚中自由基的產生。我們的皮膚益生菌具有益生元SFI，經發酵後具有電化學活性。我們的研究成功地證明了添加LCC的表皮葡萄球菌ATCC 12228對UV-B照射的小鼠皮膚的局部光保護作用。此外，我們的實驗模型顯示了該細菌的LCC發酵產生的電子在減輕UV-B誘導的ROS產生中的重要作用。這些研究表明，由於缺乏電子平衡，益生菌細菌可以迅速在自由基位點上釋放電子。將來，我們在這項研究中的整個研究將為解決傳統商業乳液防曬霜的缺點提供一種新穎的替代方法，從而可以克服紫外線對皮膚的不利影響。

摘要(英)

Global radiation levels have been found to increase at an alarming rate. UV-B irradiation from sunlight can directly penetrate up to the epidermal region of skin and can lead to oxidative damage in the skin. This has risen the need for topical supplement against UV-B radiation that not only a non-toxic but also the one which does not disrupt human skin microbiome. UV-B radiation can directly inundate tissue antioxidants by increased cellular stress, catalyzes hyperplasia at the epidermal level, or even lead to premature aging or skin cancer upon prolonged exposure. Human skin endogenous antioxidant defense system has some limitation that they failed to act upon chronic UV-B stress. Therefore our body needs external supplements to protect from augmented stress factors. Probiotic bacteria either live or dead has been studied to reduce inflammation in humans. Interestingly, the topical application of FDA approved live probiotic skin bacteria Staphylococcus epidermidis (S. epidermidis) ATCC 12228 with its specific prebiotic selective fermentation initiator (SFI) named coco-caprylate (LCC) can ameliorate free radical generation in UV-B irradiated mice skin over chronic stress. Our skin probiotic bacteria with prebiotic SFI upon fermentation has been proven electrochemically active. Our study has successfully demonstrated the photo-protective effect of LCC supplemented S. epidermidis ATCC 12228 topical application on the UV-B irradiated mice skin. Moreover, our experimental models have shown the important role of generated electron from LCC fermentation can mitigate the UV-B induced ROS generation. Our study showed that electrobiotic bacteria can promptly donate electrons on the site of free radicals as they are lack of electron balance. In the future, our whole study in this research will provide a novel alternative way to solve the drawbacks of traditional commercial lotion sunscreens, so it can overcome the challenges of UV light exposure over the skin.

關鍵字(中)

★ 電生物學
★ 氧化應激
★ 皮膚發酵引發劑(SFI)
★ 抗氧化劑

關鍵字(英)

★ Electrobiotic
★ Oxidative Stress
★ Selective Fermentation Initiator (SFI)
★ Antioxidants

論文目次

Table of Contents
Abstract I
Acknowledgments II
Table of Contents III
List of Figures V
Abbrevation List VII
Chapter 1 Introduction 1
Chapter 2 Literature review 5
2.1 Electrogenic Bacteria 5
2.2 Bacterial Extracellular Electron Transfer Pathway 5
2.3 Microbial Fuel Cell 6
2.4 Electrogenic S. epidermidis Bacteria 8
2.5 Electron as Antioxidant 10
Chapter 3 Materials and Methods 13
3.1 Ethics statement 13
3.2 Bacterial culture and fermentation 13
3.3 Electricity detection in vitro 13
3.4 Cyclic voltammetry 14
3.5 Extraction of bacterial RNA 14
3.6 Minimum bactericidal concentration (MBC) 15
3.7 Real-time q-PCR 15
3.8 Gas chromatography-mass spectrometry (GC-MS) analysis 16
3.9 UV-B exposure 16
3.10 Western blotting 17
3.11 Haemotoxylin and Eosin (H&E) staining 18
3.12 Ferric iron reductase assay 18
3.13 Statistical analysis 18
Chapter 4 Results 19
4.1 Selective fermentation initiator (SFI) screening by checking the fermentation activity and electricity generation of S. epidermidis ATCC 12228 19
4.2 UV-B induced ROS mitigation and photo-protective effect of LCC supplemented S. epidermidis ATCC 12228 23
4.3 Antioxidant properties of generated electron from LCC fermentation by S. epidermidis ATCC 12228 26
Chapter 5 Conclusion and Discussion 33
References 38

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指導教授

黃俊銘(Chun-Ming Huang)

審核日期

2020-7-15

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