博碩士論文 108223004 詳細資訊




以作者查詢圖書館館藏 以作者查詢臺灣博碩士 以作者查詢全國書目 勘誤回報 、線上人數:39 、訪客IP:18.118.138.10
姓名 趙惠群(Hui-Qun Zhao)  查詢紙本館藏   畢業系所 化學學系
論文名稱 利用深共熔溶劑結合超音波輔助液液微萃取法檢測茶樣中防曬乳成分之殘留
相關論文
★ 以質譜技術探討非共價鍵結蛋白質聚合物之結構★ 以液相層析質譜儀檢測水樣與生物檢體中 全氟界面活性劑之濃度
★ 利用液相層析串聯質譜技術檢測水環境中藥物殘留物之方法開發與應用★ 直鏈式烷基苯基二甲基銨鹽類陽離子型界面活性劑在水環境中微量檢測方法的研究
★ 芳香族磺酸鹽類有機污染物在水環境中的分析與研究★ 以固相萃取及氣相層析質譜儀對水環境中壬基苯酚類 持久性有機污染物之分析與研究
★ 以固相萃取法及氣相層析質譜儀對水環境中動情激素類有機污染物之分析與研究★ 利用熱裂解直接高溫衍生化法快速分析直鏈式烷基三甲基銨鹽之方法建立與探討
★ 利用感應偶合電漿質譜儀檢測半導體製程用化學品中微量金屬不純物之分析研究★ 應用毛細管電泳間接偵測方法分離四級銨鹽界面活性劑
★ 利用毛細管電泳結合線上濃縮方法分離奈磺酸鹽之機制探討★ 快速分析水環境中醫療藥品殘留物之研究與探討
★ 以毛細管電泳法與電灑游離質譜法探討內包錯合物之研究★ 以氣相及液相層析質譜儀分析具荷爾蒙效應物質之方法開發
★ 以離子配對高效液相層析儀檢測螢光增白劑在不同基質中之研究★ 以氣相層析質譜儀檢測具荷爾蒙效應添加劑之方法開發與研究
檔案 [Endnote RIS 格式]    [Bibtex 格式]    [相關文章]   [文章引用]   [完整記錄]   [館藏目錄]   [檢視]  [下載]
  1. 本電子論文使用權限為同意立即開放。
  2. 已達開放權限電子全文僅授權使用者為學術研究之目的,進行個人非營利性質之檢索、閱讀、列印。
  3. 請遵守中華民國著作權法之相關規定,切勿任意重製、散佈、改作、轉貼、播送,以免觸法。

摘要(中) 本研究開發一種簡易快速、符合綠色化學的方法檢測茶樣中六種防曬乳成分- 二苯基甲酮 b enzophenones 簡稱 BPs) 的殘留。 深共熔溶劑 為一種新興綠色化學溶劑, 具有原料便宜且對環境友善、合成簡單等優點, 因此本研究 以疏水性深共熔溶劑取代傳統毒性較高的有機溶劑作為萃取劑,選擇 氯化膽鹼及對氯苯酚以 莫耳比 1 :2 進行合成,並結合超音波輔助液液萃取法 (Deep eutectic solvent based ultrasonic assisted liquid liquid microextraction, 簡稱 DES USALLME) 從茶樣萃取待測物 ,接著 利用 超高效液相層析儀
串聯電 灑游離法 四極桿飛行時間質譜儀 U HPLC ESI(+) QTOF MS) 進行測定。實驗數據以 多變量 實驗設計法中的 M in run screen 及 Central composite design(CCD)中反應曲面法和多變量分析 ( 進行各項因子最佳化。所得 最佳條件為:於玻璃離心管 中 加入 5 mL 茶樣和 70 m g MgSO 4 並 vortex 數秒使鹽類完全溶解,再加入 700 μL DES ,以 vortex 約 10 秒使茶樣和 DES 稍微混合,放入 30 ℃ 的超音波水浴 槽震盪 5 分鐘,接著以 3000 rpm 離心 10 分鐘,取出約 440 μL DES 層 下層 並以 甲醇稀釋至 1 m L 。最後將 2 μ L 提取物直接注入 U H PLC QTOF MS 進行檢測分析。所開發方法的定量極限 ( 為 1.8 至 10 ng/mL 。在 i ntra day 及 inter day 的測試中,相對標準偏差 RSD) 皆小於 15 % %,回收率在 74 % 至 127 % 之間,顯示其方法有良好穩定性及再現性。 最後 以 DES USALLME 結合高選擇性和高靈敏度的 U HPLC ESI(+) QTOF MS 成功 應 用於 真實茶樣 的檢測 中,包含紅茶、綠茶及烏龍茶,來源分別有茶包、一般手搖店及便利商店中的罐裝茶,其中 有 檢測出 2OH BP 的微量殘留。
摘要(英) In this study, a simple, efficient, and environmental friendly method for the determination of the presence of six benzophenone type (BPs) UV filters in tea beverages was develops. Due to fulfill the requirements of green analytical chemistry and sustai nable development, a novel “green” solvent, deep eutectic solvent (DES), was replaced traditional halogenated organic solvents using as the extracting solvent. This DES was based on the mixture of choline chloride and 4 chlorophenol at molar ratio of 1:2. The target analytes were effectively extracted from tea beverages using a d eep eutectic solvents based ultrasonic assisted liquid liquid micro extraction (DES USALLME), and their determination were then performed by the combination of ultrahigh performance liquid chromatography and electrospray
ionization(+) quadrupole time of f light mass spectrometry (UHPLC ESI(+) QTOF MS). The parameters for the DES USALLME were screened and optimized by multivariate experimental design based on Min run screen and Central composite design (CCD) plus with response surface design and analysis of variance (ANOVA), respectively. The optimal conditions were: a 5 mL of tea beverage mixed with 70 mg of MgSO4 in a glass centrifuge tube.After MgSO4 completely dissolved, a 700 μ L of DES was added and sonicated for 5 min in ultrasonic bath at 30 ℃℃. Then the sample was centrifuged at 3000 rpm for 1 0 min, the DES(about 440 μL) was collected and diluted with methanol to 1 mL. The extract 2 μL was then directly injected into UHPLC QTOF MS for detection. After optimization, the method was validated an d shown to possess low limits of quantification (L OQs) ranged from 1 to 3.2 ng/mL . High precisions and reproducibility (i.e., the relative standard deviations (RSDs) were all less than 15 %) were obtained for both intra and inter day analysis. Satisfact ory average spiked recovery ranged from 74 to 127 %. The developed method was then successfully applied for the analysis of some selected BPs in tea beverages.
關鍵字(中) ★ 深共熔溶劑
★ 茶樣
關鍵字(英) ★ Deep eutectic solvent
★ tea beverages
論文目次 摘要 ............................................................................................................................................. i
Abstract ...................................................................................................................................... iii
圖目錄 ....................................................................................................................................... ix
表目錄 ....................................................................................................................................... xi
第一章 前言 ............................................................................................................................ 1
1-1 研究源起 ....................................................................................................................... 1
1-2 研究目標 ....................................................................................................................... 2
第二章 文獻回顧 .................................................................................................................... 3
2-1 綠色化學溶劑 ............................................................................................................... 3
2-1-1 離子液體(Ionic liquid, 簡稱IL) ........................................................................... 3
2-1-2 深共熔溶劑(Deep eutectic solvents, 簡稱DESs) ................................................ 4
2
1 2 1 深共熔溶劑製備 6
2
1 2 2 深共熔溶劑的應用 6
2-2 Core-shell 管柱 ............................................................................................................ 7
2-3 液液微萃取法 ............................................................................................................... 8
2-3-1 前言 ........................................................................................................................ 8
2-3-2 原理 ........................................................................................................................ 8
2-3-3 DLLME流程 ......................................................................................................... 9
2-3-4 影響因素 .............................................................................................................. 10
2-3-5 DLLME的後續發展 ........................................................................................... 11
2-4 超音波輔助深共熔溶劑液液微萃取法 ..................................................................... 12
vi
2-5 實驗設計(Experiment design) .................................................................................... 13
2-5-1 單因子及多因子實驗設計法 .............................................................................. 13
2-5-2 反應曲面法(Response surface methodology, 簡稱RSM) ................................. 13
2-5-3 中心合成設計(Central composite design, 簡稱CCD) ....................................... 14
2-6 防曬乳成分(UV filters) .............................................................................................. 15
2-6-1 二苯基甲酮(Benzophenone, 簡稱BPs) ............................................................. 15
2-6-2 對環境及人類的影響 .......................................................................................... 16
2-6-3 毒性研究 .............................................................................................................. 18
2-6-4 每日暴露量 .......................................................................................................... 19
2-6-5 相關法規 .............................................................................................................. 19
2-7 茶品市場 ..................................................................................................................... 20
2-8 相關文獻 ..................................................................................................................... 21
第三章 實驗步驟與樣品分析 .............................................................................................. 25
3-1 實驗藥品與設備 ......................................................................................................... 25
3-1-1 實驗藥品 .............................................................................................................. 25
3-1-2 儀器設備 .............................................................................................................. 26
3-2 實驗步驟 ..................................................................................................................... 26
3-2-1 標準品配製 .......................................................................................................... 26
3-2-2 超高效液相層析串聯質譜儀參數設定 .............................................................. 27
3-2-3 質量校正 .............................................................................................................. 29
3-2-4 深共熔溶劑(DES)合成 ........................................................................................ 29
3-2-5 超音波輔助深共熔溶劑液液微萃取法 .............................................................. 30
vii
3-2-6 樣品來源 .............................................................................................................. 31
第四章 結果與討論 .............................................................................................................. 33
4-1 UHPLC-QTOF-MS對待測物之測定 ........................................................................ 33
4-1-1 待測物分析及其層析圖 ...................................................................................... 33
4-1-2 待測物及之質譜圖 .............................................................................................. 34
4-2 超音波輔助深共熔溶劑液液微萃取法最佳化條件探討 ......................................... 35
4-2-1 單因子最佳化探討 .............................................................................................. 35
4
4--22--11--11 深共熔溶劑深共熔溶劑((萃取劑萃取劑))比例比例................................................................................................................................ 3535
4
4--22--11--22 萃取劑體積萃取劑體積 ............................................................................................................................................................................ 3636
4
4--22--11--33 超音波震盪溫度超音波震盪溫度 ............................................................................................................................................................ 3737
4
4--22--11--44 超音波震盪時間超音波震盪時間 ............................................................................................................................................................ 3838
4
4--22--11--66 鹽的種類鹽的種類 .................................................................................................................................................................................... 3939
4
4--22--11--77 加入加入MgSOMgSO44的量的量 ........................................................................................................................................................ 4040
4-2-2 Experiment Design ............................................................................................... 41
4
4--22--22--11 MinMin--run screeningrun screening ........................................................................................................................................................ 4141
4
4--22--22--11--11 MinMin--run screeningrun screening與結果與結果 ........................................................................................................ 4141
4
4--22--22--11--22 顯著因子探討顯著因子探討 .............................................................................................................................................. 4343
4
4--22--22--11--33 殘差分布圖殘差分布圖 ...................................................................................................................................................... 4545
4
4--22--22--22 CentralCentral--composite designcomposite design .................................................................................................................................. 4747
4
4--22--22--22--11 CCD optimizationCCD optimization與結果與結果 ........................................................................................................ 4747
4
4--22--22--22--22 因子間交互作用力探討因子間交互作用力探討 .............................................................................................................................. 4949
4
4--22--22--22--33 殘差分布圖殘差分布圖 ...................................................................................................................................................... 5151
4
4--22--22--22--44 最佳化結果最佳化結果 ...................................................................................................................................................... 5151
4-3 深共熔溶劑性質 ......................................................................................................... 52
viii
4-3-1 物理性質 .............................................................................................................. 52
4-3-2 紅外線光譜圖(Infrared spectrometry,IR) ......................................................... 53
4-3-3 核磁共振光譜圖(NMR) ...................................................................................... 54
4
4--33--33--11 11HH--NMRNMR ...................................................................................................................................................................................... 5454
4
4--33--33--22 1313CC--NMRNMR .................................................................................................................................................................................... 5555
4-4 檢量線與偵測極限 ..................................................................................................... 56
4-5 方法準確度與精密度 ................................................................................................. 57
4-6 真實樣品檢測 ............................................................................................................. 58
4-7 茶葉中汙染物之相關文獻整理 ................................................................................. 61
4-8 Analytical Eco-Scale ................................................................................................... 65
第五章 結論 .......................................................................................................................... 67
第六章 參考文獻 .................................................................................................................. 69
參考文獻  台灣質譜學會, 質譜分析技術原理與應用 2015
 衛生福利部,衛授食字第 1071608162 號, 2018
 蘇朝墩 六標準差 2009
 凌永健 環境荷爾蒙與新興污染物 2013
http://liukovsky.niu.edu.tw/%E5%AE%9C%E5%A4%A7%E6%95%99%E6%9D%90/C
hapter07(%E7%92%B0%E5%A2%83%E8%8D%B7%E7%88%BE%E8%92%99)_2%2
0Slides.pdf
 友和電子報, 2017/5/31 ,第 29 期, http://www.uni onward.com.tw/uniEDM/201705
2.htm
 Core shell technology https://www.chromservis.eu/i/core shell technology/c/stationary
phases overview
 Abbott, A.P.; Capper, G.; Davies, D.L.; Rasheed, R.K.; Tambyrajah , V., Novel solvent
properties of choline chloride/urea mixtures , C h emical Communications 2003 , 1 , 70 71
 Anadón , A.; Bell, D.; Binderup, M. Bursch, W .; Castle, L.; Crebelli, R.; Engel, K.H.;
Franz, R.; Gontard, N.; Haertlé, T.; Husøy, T.; Jany, K.D.; Leclercq, C.; Lhuguenot, J.C.;
Mennes, W.; Milana, M.R.; Pfaff, K.; Svensson, K.; Toldrá, F.; Waring, R.; Wölfle, D.,
Toxicological evaluation of benzophenone, The EFSA Journal 2009 , 1104, 1 30
 Anderson, W.A.C.; Castle, L., Benzophenone in cartonboard packaging materials and the
factors that influence its migration into food . Food Additives & Contaminants 2015 , 20(6)
607 618.
 Asimakopoulos , A G.G.; Thomaidis N.S.; K. Widespread occurrence of bisphenol
A diglycidyl ethers, p hydroxybenzoic acid esters (parabens), benzophenone type UV
filters, triclosan, and triclocarban in human urine from Athens, Greece . Science of the Total
Environment 2014 a 470, 1243 1249.
70
 AsimAsimakopoulos, A.G.; akopoulos, A.G.; WangaWanga, L.; Thomaidis, L.; Thomaidis,, N.S.; N.S.; Kannan, K.Kannan, K.,, A multiA multi--class class bioanalytical methodology for the determination ofbioanalytical methodology for the determination of bisphenol A diglycidyl ethers, pbisphenol A diglycidyl ethers, p--hydroxybenzoic acid esters,hydroxybenzoic acid esters, benzophenonebenzophenone--type ultraviolet filters, triclosan, and type ultraviolet filters, triclosan, and triclocarban intriclocarban in humhuman urine by liquid chromatographyan urine by liquid chromatography––tandem mass spectrometrytandem mass spectrometry, , Journal of Chromatography AJournal of Chromatography A 20142014bb,, 1324, 1324, 141141--148.148.
 Balázs, A.;Balázs, A.; Krifaton,Krifaton, C.;C.; Orosz, I.; Szoboszlay, S.;Orosz, I.; Szoboszlay, S.; KKovács, ovács, RR.; Csenki, Z.;.; Csenki, Z.; Urbányi, B.;Urbányi, B.; Kriszt Kriszt B.B., , Hormonal activity,Hormonal activity, cytotoxicitycytotoxicity andand developmentaldevelopmental toxicitytoxicity ofof UV filtersUV filters, , Ecotoxicology and Environmental SafetyEcotoxicology and Environmental Safety 20162016, , 131, 131, 4545--53.53.
 Bideau, J.L.; Viaub, L.; Bideau, J.L.; Viaub, L.; ViouxVioux, A., , A., Ionogels, ioniIonogels, ionic liquid based hybrid materials, c liquid based hybrid materials, Chemical Chemical Society ReviewsSociety Reviews 20112011,, 40, 90740, 907--925.925.
 ChungChung, W.H.;, W.H.; TzingTzing, S.H.;, S.H.; DingDing, W.H., , W.H., Optimization of dispersive micro solidOptimization of dispersive micro solid--phase phase extractionextraction for the rapid determination of benzophenonefor the rapid determination of benzophenone--type UVtype UV absorbers in aqueous absorbers in aqueous samplessamples, , Journal of Chromatography AJournal of Chromatography A 20152015, 1411(15), 12, 1411(15), 12--17.17.
 CoradaCorada--Fernández, C.; Candela, L.; Fernández, C.; Candela, L.; TorresTorres--FuenteFuentes,s, N.; PintN.; Pintadoado--Herrera, M.G.; Herrera, M.G.; PaniwPaniw,, M.;M.; GonzálezGonzález--MazoMazo, E., , E., Effects of extreme rainfall events on the distribution of selected Effects of extreme rainfall events on the distribution of selected emergingemerging contaminants in surface and groundwater: The Guadalete River basincontaminants in surface and groundwater: The Guadalete River basin (SW, (SW, Spain)Spain), , Science of the Total EnvironmentScience of the Total Environment 20172017, , 605, 605, 770770--783.783.
 Coronado, Coronado, M.;M.; Haro, Haro, H.D.;H.D.; Deng, Deng, X.;X.; Rempel,Rempel, M.A.; M.A.; Lavado, Lavado, R.;R.; SchlenkSchlenk,, D., D., Estrogenic Estrogenic activity and reproductive effects of the UVactivity and reproductive effects of the UV--filter oxybenzone(2filter oxybenzone(2--hydroxyhydroxy--44--methoxyphenylmethoxyphenyl--methanone) in fishmethanone) in fish, , Aquatic ToxicologyAquatic Toxicology 20082008, , 90(3), 90(3), 182182--187.187.
 CunhaCunha, S., S.C.C.; FernandesFernandes, J., , J., Extraction techniques with deep eutectic solventsExtraction techniques with deep eutectic solvents, , Trends in Trends in Analytical ChemistryAnalytical Chemistry 20182018, 105, 225, 105, 225--239.239.
 Delso, I.; Lafuente, C.; MuñozDelso, I.; Lafuente, C.; Muñoz--Embid, J.; Artal,Embid, J.; Artal, M., M., NMR study of choline chlorideNMR study of choline chloride--based based deep eutectic solventsdeep eutectic solvents, , Journal of Molecular Journal of Molecular LiquidsLiquids 20192019, , 290, 290, 111236.111236.
 Farajzadeh, M.A.;Farajzadeh, M.A.; Abbaspour, Abbaspour, MM..; Kazemian, R.; ..; Kazemian, R.; MogaddamMogaddam, M.R.A., , M.R.A., Preparation of a Preparation of a new threenew three--component deepcomponent deep eutectic solvent and its use as an extractioneutectic solvent and its use as an extraction solvent in solvent in
71
dispersive liquid
dispersive liquid––liquidliquid microextraction of pesticides in green microextraction of pesticides in green teatea and herbal distillatesand herbal distillates, , Journal of the Science of Food and AgricultureJournal of the Science of Food and Agriculture 20202020, 100, 1904, 100, 1904--1912.1912.
 Farajzadeh, M.A.; Hojaghan, A.S.; Farajzadeh, M.A.; Hojaghan, A.S.; MogaddamMogaddam, M.R.A., , M.R.A., Development of a new Development of a new temperaturetemperature--controlled liquidcontrolled liquid phase microextraction using deep eutectic solvent forphase microextraction using deep eutectic solvent for extraction and preconcentration of diazinon, metalaxyl,extraction and preconcentration of diazinon, metalaxyl, bromopropylate, oxadiazon, and bromopropylate, oxadiazon, and fenazaquin pesticides fromfenazaquin pesticides from fruit juice and vegetable samples followed by gasfruit juice and vegetable samples followed by gas chromatographychromatography--flame ionization detectionflame ionization detection, , Journal of Food Composition and AnalysisJournal of Food Composition and Analysis 20182018, 66, 66, 90, 90--97.97.
 Francisco, M.; Bruinhorst, A.V.D.; Kroon, M.C., Francisco, M.; Bruinhorst, A.V.D.; Kroon, M.C., LowLow--TransitionTransition--Temperature Mixtures Temperature Mixtures (LTTMs): A New(LTTMs): A New Generation of Designer SolventsGeneration of Designer Solvents, , Angewandte ChemieAngewandte Chemie 20132013,, 52, 307452, 3074--3085.3085.
 Gałuszka, A.;Gałuszka, A.; KoKonieczka, P.; Migaszewski, Z.M..; nieczka, P.; Migaszewski, Z.M..; Namies´nikNamies´nik, J., , J., Analytical Analytical EcoEco--Scale Scale for assessingfor assessing the greenness of analyticalthe greenness of analytical proceduresprocedures, , Trends in Analytical ChemistryTrends in Analytical Chemistry 20122012, , 37, 6137, 61--72.72.
 Gao, L.; Liu, L.;Gao, L.; Liu, L.; Sun, Y.; Zhao, W.;Sun, Y.; Zhao, W.; HeHe, L., , L., Fabrication of a novel azamacrocycleFabrication of a novel azamacrocycle--based based adsorbent foradsorbent for solidsolid--phase extraction of organophosphorusphase extraction of organophosphorus pesticides in tea drinkspesticides in tea drinks, , Microchemical JournalMicrochemical Journal 20202020, 153, 104364., 153, 104364.
 Ge, D.; Zhang, Y.; Dai, Y.;Ge, D.; Zhang, Y.; Dai, Y.; YangYang, S., , S., AirAir--assisted dispersive liquidassisted dispersive liquid––liquid microextraction liquid microextraction based on a new hydrophobic deepbased on a new hydrophobic deep eutectic solvent for the preconcentration of eutectic solvent for the preconcentration of benzophenonebenzophenone--type type UV filters from aqueousUV filters from aqueous samplessamples, , Journal of Separation ScienceJournal of Separation Science 20172017, , 41(7), 163541(7), 1635--1643.1643.
 Ghazipura, M.; McGowan, R.; Arslan, A.; Hossain, T., Ghazipura, M.; McGowan, R.; Arslan, A.; Hossain, T., Exposure to benzophenoneExposure to benzophenone--3 and 3 and reproductive toxicity: A systematicreproductive toxicity: A systematic review of human and animal studiesreview of human and animal studies, , Reproductive Reproductive ToxicologyToxicology 20172017, , 73, 73, 175175--183.183.
 GiokasGiokas, D.L, D.L..; SalvadorSalvador, A.;, A.; Alberto ChisvertAlberto Chisvert., ., UV filters: From sunscreens toUV filters: From sunscreens to human body human body and the environmentand the environment, , Trends in Analytical ChemistryTrends in Analytical Chemistry 20072007, 26(5), 360, 26(5), 360--374.374.
72
 Gonzalez, H.; Jacobson, C.E.; Wennberg, A.M.; Larkö, O.; Farbrot, A., Gonzalez, H.; Jacobson, C.E.; Wennberg, A.M.; Larkö, O.; Farbrot, A., SolidSolid--Phase Phase Extraction and ReverseExtraction and Reverse--Phase HPLC: ApplicationPhase HPLC: Application to Study the Urinary Excretion Pattern to Study the Urinary Excretion Pattern of Benzophenoneof Benzophenone--33 and its Metabolite 2,4and its Metabolite 2,4--Dihydroxybenzophenone in Human UrineDihydroxybenzophenone in Human Urine, , AnalyticaAnalytical Chemistry Insightsl Chemistry Insights 20082008, , 3, 3, 11--7.7.
 Ho, Y.C.; Ho, Y.C.; DingDing, W.H., , W.H., SolidSolid--phase Extraction Coupled Simple Onphase Extraction Coupled Simple On--line Derivatization Gas line Derivatization Gas ChromatoChromatography graphy Tandem Mass Spectrometry for the Determination of BenzophenoneTandem Mass Spectrometry for the Determination of Benzophenone--type UV Filters intype UV Filters in Aqueous SamplesAqueous Samples, , Journal of the ChineJournal of the Chinese Chemical Societyse Chemical Society 20122012, 59, , 59, 107107--113.113.
 Jeon, H.K.; Sarma, S.N.; Kim, Y.J.;Jeon, H.K.; Sarma, S.N.; Kim, Y.J.; RyuRyu, J.C., , J.C., Toxicokinetics and metabolisms of Toxicokinetics and metabolisms of benzophenonebenzophenone--type UV filters in ratstype UV filters in rats, , ToxicologyToxicology 20082008, , 248, 248, 8989--95.95.
 Jeon, H.K.; Chung, Y.;Jeon, H.K.; Chung, Y.; RyuaRyua, J.C., , J.C., Simultaneous determination of Simultaneous determination of benzophenonebenzophenone--type UV type UV filters infilters in water and soil by gas chromatographywater and soil by gas chromatography––mass spectrometrymass spectrometry, , Journal of Journal of Chromatography AChromatography A 20062006,, 1131, 1921131, 192--202.202.
 JhongJhong,, H.RH.R.; Wong.; Wong, S.H, S.H.; Wan.; Wan, C.C, C.C.; Wang.; Wang, Y.Y, Y.Y.; Wei.; Wei, T.C, T.C., A novel deep eutectic solvent., A novel deep eutectic solvent--based ionic liquid used as electrolyte for dyebased ionic liquid used as electrolyte for dye--sensitized solar cells, sensitized solar cells, Electrochemistry Electrochemistry CommunicationsCommunications 20092009, 11, 209, 11, 209--211.211.
 JohnsonJohnson, K., K.E.E., , What’s an Ionic Liquid?What’s an Ionic Liquid?, , The Electrochemical Society InterfaceThe Electrochemical Society Interface 20072007, , 16(1), 16(1), 3838--41.41.
 KawKawaguchi, M.;aguchi, M.; ItoIto, R, R.;.; EndoEndo, N, N.; Sakui.; Sakui, N, N.; Okanouchi.; Okanouchi, N, N.; Saito.; Saito, K, K.; Sato.; Sato, N, N.,., Shiozaki, Shiozaki, T.;T.; NakazawaNakazawa, H., , H., Stir bar sorptive extraction and thermal desorptionStir bar sorptive extraction and thermal desorption--gasgas chromatographychromatography--mass spectrometry for trace analysismass spectrometry for trace analysis of benzophenone and its derivatives in of benzophenone and its derivatives in water samplewater sample, , Analytica Chimica ActaAnalytica Chimica Acta 20062006, 557, 272, 557, 272--277.277.
 Kim, S.;Kim, S.; Jung, Jung, DD.; Kho Y.; Choi, K., .; Kho Y.; Choi, K., Effects of benzophenoneEffects of benzophenone--3 exposure on endocrine 3 exposure on endocrine disruptionand reproduction of Japanese medaka (Oryzias latipes)disruptionand reproduction of Japanese medaka (Oryzias latipes)——A tA twogeneration wogeneration exposure study, exposure study, Aquatic ToxicologyAquatic Toxicology 20142014, 155, 244, 155, 244--252.252.
 Kotnik, K.; Kosjek, T.; Krajnc, U.;Kotnik, K.; Kosjek, T.; Krajnc, U.; HeathHeath, E., , E., Trace analysis of benzophenoneTrace analysis of benzophenone--derived derived
73
compounds
compounds in surface waters and sediments using solidin surface waters and sediments using solid--phase extractionphase extraction and microwaveand microwave--assisted extraction followed by gasassisted extraction followed by gas chromatographychromatography––mass mass spectrometryspectrometry, , Analytical and Analytical and Bioanalytical Chemistry Bioanalytical Chemistry 20142014, 406, 3179, 406, 3179--3190.3190.
 KraševecKraševec,, I.; I.; ProsenProsen, H., , H., Development of a Dispersive LiquidDevelopment of a Dispersive Liquid--LiquidLiquid Microextraction Microextraction Followed by LCFollowed by LC--MS/MS for DeterminationMS/MS for Determination of Benzotriazoles in Environmental Watersof Benzotriazoles in Environmental Waters,, Acta Chimica SlActa Chimica Slovenicaovenica 20192019, 66, 247, 66, 247--254.254.
 KunisueKunisue, T, T.; Chen.; Chen, Z, Z.;.; LLouis, G.M.B.; Sundaram, R.;ouis, G.M.B.; Sundaram, R.; HedigerHediger, M.L., M.L..; Sun.; Sun, L, L.; .; KannanKannan, K, K.,., Urinary Concentrations of BenzophenoneUrinary Concentrations of Benzophenone--type UV Filters in U.S.type UV Filters in U.S. Women and Their Women and Their Association with EndometriosisAssociation with Endometriosis, , Environmental Science & Environmental Science & TechnologyTechnology 20122012, 46, 4624, 46, 4624--4632.4632.
 Leong, M.I.;Leong, M.I.; HuangHuang, S.D., , S.D., Dispersive liquidDispersive liquid––liquid microextraction method based on liquid microextraction method based on solidification ofsolidification of floating organic drop combined with gas chromatography with electronfloating organic drop combined with gas chromatography with electron--capturecapture or mass spectrometry detectionor mass spectrometry detection, , Journal of ChrJournal of Chromatography A omatography A 20082008, 1211, 8, 1211, 8--12.12.
 Liao, C.; Liao, C.; KannanKannan, K., , K., Widespread Occurrence of BenzophenoneWidespread Occurrence of Benzophenone--Type UV Light Filters inType UV Light Filters in Personal Care Products from China and the United States: AnPersonal Care Products from China and the United States: An Assessment of Human Assessment of Human ExposureExposure, , Environmental Science & TechnologyEnvironmental Science & Technology 20142014, 48, 4103, 48, 4103--4109.4109.
 Lin, D.; Zhu, L., Lin, D.; Zhu, L., Polycyclic Aromatic Hydrocarbons: Pollution and SourcePolycyclic Aromatic Hydrocarbons: Pollution and Source Analysis of a Analysis of a Black TeaBlack Tea, , Journal of Agricultural and Food ChemistryJournal of Agricultural and Food Chemistry 20042004, 52, 8268, 52, 8268--8271.8271.
 LiuLiu, X.;, X.; Chen, Chen, M.; Meng, Z.; Qian, H.; Zhang,M.; Meng, Z.; Qian, H.; Zhang, S.; Lu, R.; Gao, H.; S.; Lu, R.; Gao, H.; ZhouZhou, W., , W., ExtractionExtraction of benzoylurea pesticides from tea and fruit juices using deepof benzoylurea pesticides from tea and fruit juices using deep eutectic solventseutectic solvents, , Journal of Journal of Chromatography BChromatography B 20202020, 1140, 1, 1140, 1--8.8.
 MaoMao, F.; You, L.; Reinhard, M.; He, Y.; , F.; You, L.; Reinhard, M.; He, Y.; GinGin, K.Y.H., , K.Y.H., Occurrence and Fate of Occurrence and Fate of BenzophenoneBenzophenone--Type UV Filters in a Tropical Urban WatType UV Filters in a Tropical Urban Watershedershed, , Environmental Science & Environmental Science & TechnologyTechnology 20182018, 52(7), 3960, 52(7), 3960--3967.3967.
 MarshMarsh, K.N.; Boxall, J.A..; Lichtenthaler, R., , K.N.; Boxall, J.A..; Lichtenthaler, R., Room temperature ionic liquids and their Room temperature ionic liquids and their mixturesmixtures——a reviewa review, , Fluid Phase EquilibriaFluid Phase Equilibria 20042004, 219, 93, 219, 93--98.98.
74
 Matkovich, C.E..; Christian, G.D., Matkovich, C.E..; Christian, G.D., SaltingSalting--Out of Acetone from WaterOut of Acetone from Water--Basis of a New Basis of a New Solvent Extraction SystemSolvent Extraction System, , Analytical chemistryAnalytical chemistry 19731973, 45(11), 1915, 45(11), 1915--1921.1921.
 MoinfaraMoinfara, S., S., Hosseini, Hosseini, M.R.M., , M.R.M., Development of dispersive liquidDevelopment of dispersive liquid––liquid microextraction liquid microextraction method formethod for the analysis of organophosphorus pethe analysis of organophosphorus pesticides in teasticides in tea, , Journal of Hazardous Journal of Hazardous MaterialsMaterials 20092009, 169, 907, 169, 907--911.911.
 Negreira, N.; Rodríguez, I.;Negreira, N.; Rodríguez, I.; RamilRamil, , M.M.; RubíRubí, , E.E.; CelaCela, R., , R., SolidSolid--phase extraction followed phase extraction followed by liquid chromatographyby liquid chromatography––tandem masstandem mass spectrometry for the determination of spectrometry for the determination of hydroxylated hydroxylated benzophenonebenzophenone UV absorbers in environmental water samplesUV absorbers in environmental water samples, , Analytica Analytica Chimica ActaChimica Acta 20092009, 654, 162, 654, 162--170.170.
 Philippat, C.; Mortamais, M.; Chevrier, C.; Petit, C.; Calafat, A.M.; Ye, X.; Silva, M.J.; Philippat, C.; Mortamais, M.; Chevrier, C.; Petit, C.; Calafat, A.M.; Ye, X.; Silva, M.J.; Brambilla, C.; Pin, I.; Charles, M.A.; Cordier, S.; Slama, R., Brambilla, C.; Pin, I.; Charles, M.A.; Cordier, S.; Slama, R., Exposure to Phthalates and Exposure to Phthalates and Phenols during Pregnancy and Offspring SizePhenols during Pregnancy and Offspring Size at Birthat Birth, , Environmental Health PerspectivesEnvironmental Health Perspectives 20122012, 120(3), 464, 120(3), 464--470.470.
 Rezaee, M.; Assadi, Y.;Rezaee, M.; Assadi, Y.; Hosseini, M.R.MHosseini, M.R.M..; Aghaee, E.; Ahmadia, F.; Aghaee, E.; Ahmadia, F.; BerijaniBerijani, S., , S., Determination of organic compounds inDetermination of organic compounds in water usingwater using dispersive liquiddispersive liquid––liquid liquid microextractionmicroextraction, , Journal of Chromatography AJournal of Chromatography A 20062006, 1116, 1, 1116, 1--9.9.
 RodríguezRodríguez--Gómez, R.; ZafraGómez, R.; Zafra--Gómez, A.; DorivalGómez, A.; Dorival--García, N.; Ballesteros, O.; García, N.; Ballesteros, O.; NavalónNavalón, , A.A.; ; DeterminationDetermination ofof benzophenonebenzophenone--UV filtersUV filters inin humanhuman milkmilk samplessamples usingusing ultrasoundultrasound--assistedassisted extractionextraction andand cleanclean--upup withwith dispersivedispersive sorbents followedsorbents followed byby UHPLCUHPLC––MS/MS MS/MS analysisanalysis, , TalantaTalanta 20142014, 134, 657, 134, 657--664.664.
 Rogers, R.D.; Rogers, R.D.; SeddonSeddon, K.R., , K.R., Ionic LiquidsIonic Liquids——Solvents of the Future?Solvents of the Future?, , ScienceScience 20032003, 302, , 302, 792792--793.793.
 Sajida., M;Sajida., M; AlhooshaniAlhooshani, K., , K., UltrasoundUltrasound--assisted solvent extraction of organochlorine assisted solvent extraction of organochlorine pesticides frompesticides from porous membrane packed tea samples followed by GCporous membrane packed tea samples followed by GC––MS analysisMS analysis, , Microchemical JournalMicrochemical Journal 20202020, 152, 104464., 152, 104464.
 SánchezSánchez--BruneteBrunete, C, C.; Miguel.; Miguel, E, E.; Albero.; Albero, B, B.;.; TadeoTadeo, J.L, J.L.,., Analysis of salicylate and Analysis of salicylate and
75
benzophenone
benzophenone--type UV filters in soils and sediments bytype UV filters in soils and sediments by simultaneous extraction cleanup simultaneous extraction cleanup and gas chromatographyand gas chromatography––mass spectrometrymass spectrometry, , Journal of Chromatography AJournal of Chromatography A 20112011, 1218, , 1218, 42914291--4298.4298.
 Shishov, A.; Bulatov, A.; Locatelli, M.; CarradorShishov, A.; Bulatov, A.; Locatelli, M.; Carradori, S.;i, S.; AndruchAndruch, V., , V., Application of deep Application of deep eutectic solvents in analytical chemistry. A revieweutectic solvents in analytical chemistry. A review, , Microchemical JournalMicrochemical Journal 20201717,, 135, 33135, 33--38.38.
 Tang, R.; Chen, M.J.; Ding, G.D.; Chen, X.J.; Han, X.M.; Zhou, K.; Chen, L.M.; Xia, Y.K.; Tang, R.; Chen, M.J.; Ding, G.D.; Chen, X.J.; Han, X.M.; Zhou, K.; Chen, L.M.; Xia, Y.K.; Tian, Y.;Tian, Y.; WangWang, X.R., , X.R., Associations of prenatal exposure to phenols with birth outcomesAssociations of prenatal exposure to phenols with birth outcomes, , Environmental PollutionEnvironmental Pollution 20132013, 178, 115, 178, 115--120.120.
 Touitou, E.; Godin, B., Touitou, E.; Godin, B., Skin nonpenetrating sunscreens for cosmetic andSkin nonpenetrating sunscreens for cosmetic and pharmaceutical pharmaceutical formulationsformulations, , Clinics in DermatologyClinics in Dermatology 20082008, 26, 375, 26, 375--379.379.
 TorTorimotoimoto, T, T.; .; Tsuda, T.;Tsuda, T.; Okazaki, K.I.;Okazaki, K.I.; KuwabataKuwabata, S., , S., New Frontiers in Materials Science New Frontiers in Materials Science Opened by IonicOpened by Ionic LiquidsLiquids, , Advanced MaterialsAdvanced Materials 20102010, 22(11), 1196, 22(11), 1196--1221.1221.
 VelaVela--Soria, F..; Ballesteros, O.; ZafraSoria, F..; Ballesteros, O.; Zafra--Gómez, A.; Ballesteros, L.; Gómez, A.; Ballesteros, L.; NavalónNavalón, , A.A., , A newA new methodmethod forfor thethe determinationdetermination ofof benzophenonebenzophenone--UV filtersUV filters inin human serumhuman serum samplessamples byby dispersivedispersive liquidliquid––liquidliquid microextractionmicroextraction with liquidwith liquid chromatographychromatography––tandem masstandem mass spectrometryspectrometry, , TalantaTalanta 20142014, 121, 97, 121, 97--104.104.
 VelaVela--Soria, F.; JiménezSoria, F.; Jiménez--Díaz,Díaz, I.; RodríguezI.; Rodríguez--Gómeza, R.; ZafraGómeza, R.; Zafra--GómezGómeza,a, A.; Ballesterosa, A.; Ballesterosa, O.; Navalóna,O.; Navalóna, A.; Vílcheza, J.L.; Fernándezb, M.F.;A.; Vílcheza, J.L.; Fernándezb, M.F.; OleaOlea, N., , N., Determination of Determination of benzophenones in human placental tissue samples by liquidbenzophenones in human placental tissue samples by liquid chromatographychromatography––tandem mass tandem mass spectrometryspectrometry, , TalantaTalanta 20112011, 85, 1848, 85, 1848--1855.1855.
 Wang, T.E.; Guo,Wang, T.E.; Guo, M.; Song, M.; Song, W.W.LL.; Zhang, Y.D.;.; Zhang, Y.D.; DuDu, , X.ZX.Z.,., A new nitrogenA new nitrogen--containing containing carbon nanoparticles coated stainless steelcarbon nanoparticles coated stainless steel fiber for selective solidfiber for selective solid--phase microextraction phase microextraction of ultraviolet filtersof ultraviolet filters, , Analytical MethodsAnalytical Methods 20152015, 7, 3385, 7, 3385--3394.3394.
 Watanabe, Y.; Kojima, H.; Takeuchi, S.; UramarWatanabe, Y.; Kojima, H.; Takeuchi, S.; Uramaru, N.; Sanoh, S.; Sugihara, K.; Shigeyuki u, N.; Sanoh, S.; Sugihara, K.; Shigeyuki Kitamura.;Kitamura.; Shigeru OhtaShigeru Ohta., ., Metabolism of UVMetabolism of UV--filter benzophenonefilter benzophenone--3 by rat and human 3 by rat and human
76
liver
liver microsomes and its effect on endocrinemicrosomes and its effect on endocrine--disrupting activitydisrupting activity, , Toxicology and Applied Toxicology and Applied PharmacologyPharmacology 20152015, 282, 119, 282, 119--128.128.
 Weisbrod, Weisbrod, C.J.; KunzC.J.; Kunz, P.Y, P.Y.; Zenker.; Zenker, A.K, A.K.;.; FentFent, K, K.,., Effects of the UV filter benzophenoneEffects of the UV filter benzophenone--2 on reproduction in fish2 on reproduction in fish, , Toxicology and Applied PharmacologyToxicology and Applied Pharmacology 20072007, 225, 255, 225, 255--266.266.
 Wolff, M.S.; Engel, S.M.; Berkowitz, G.S.; Ye, X.; Silva, M.J.; Zhu, C.; Wetmur, J.; Wolff, M.S.; Engel, S.M.; Berkowitz, G.S.; Ye, X.; Silva, M.J.; Zhu, C.; Wetmur, J.; CalafatCalafat, A.M., , A.M., Prenatal Phenol and Phthalate Exposures and Birth OutcomesPrenatal Phenol and Phthalate Exposures and Birth Outcomes, , Environmental Health PerspectivesEnvironmental Health Perspectives 20082008, 116(8), 1092, 116(8), 1092--1097.1097.
 Wu, L.Wu, L.; Hu, M.Hu, M.; Li, Z.Li, Z.; Song, Y.Song, Y.; ZhangZhang, H., H.; Yu, A.Yu, A.; Ma,Ma, Q.Q.; WangWang, Z., Z.,, Dynamic Dynamic microwavemicrowave--assisted extraction online coupled with assisted extraction online coupled with single drop microextraction of single drop microextraction of organophosphorus pesticides in tea samplesorganophosphorus pesticides in tea samples, , Journal of Chromatography AJournal of Chromatography A 20152015, , 1407(14), 421407(14), 42--51.51.
 WypychWypych, A.;, A.; WypychWypych, G., , G., Databook of UV StabilizersDatabook of UV Stabilizers, , 22ndnd, , ChemTec PublishingChemTec Publishing 20202020..
 YeYe, L.; , L.; LiuLiu, J.; , J.; YangYang, X., , X., PengPeng, Y.; , Y.; XuXu, L., , L., Orthogonal array design for the optimizationOrthogonal array design for the optimization of of ionic liquidionic liquid--based dispersive liquidbased dispersive liquid––liquid microextraction of benzophenoneliquid microextraction of benzophenone--type UV type UV filtersfilters, , Journal of Separation ScienceJournal of Separation Science 20112011, 34, 700, 34, 700--706.706.
 Zhang, Z.; Ren, N.; YiZhang, Z.; Ren, N.; Yi--Fan Li.; Kunisue, T.; Gao, D.; Kannan, K., Fan Li.; Kunisue, T.; Gao, D.; Kannan, K., Determination of Determination of Benzotriazole and Benzophenone UV Filters inBenzotriazole and Benzophenone UV Filters in Sediment and Sewage SludgeSediment and Sewage Sludge, , Environmental Science & TechnologyEnvironmental Science & Technology 20112011, 45, 3909, 45, 3909--3916.3916.
指導教授 丁望賢(Wang-Hsien) 審核日期 2021-7-1
推文 facebook   plurk   twitter   funp   google   live   udn   HD   myshare   reddit   netvibes   friend   youpush   delicious   baidu   
網路書籤 Google bookmarks   del.icio.us   hemidemi   myshare   

若有論文相關問題,請聯絡國立中央大學圖書館推廣服務組 TEL:(03)422-7151轉57407,或E-mail聯絡  - 隱私權政策聲明