博碩士論文 86341002 詳細資訊

姓名 蘇富湖( Fu-Hu Su)  查詢紙本館藏   畢業系所 化學工程與材料工程學系
論文名稱 聚二甲基矽氧高分子膠體溶液之研究:NMR顯影劑、NMR訊號及流變性質等探討
(On NMR Signal and Rheology Properties of Crosslinked PDMS colloidal solution and its application to NMR Contrast Agent)
檔案 [Endnote RIS 格式]    [Bibtex 格式]    [檢視]  [下載]
  1. 本電子論文使用權限為同意立即開放。
  2. 已達開放權限電子全文僅授權使用者為學術研究之目的,進行個人非營利性質之檢索、閱讀、列印。
  3. 請遵守中華民國著作權法之相關規定,切勿任意重製、散佈、改作、轉貼、播送,以免觸法。

摘要(中) 就腸胃道用顯影劑而言,其主要需求有(1)較低毒性、(2)較低黏度及(3)能增進影像的晰度。本文主要在探討交鏈型(crosslinked)聚二甲基矽氧高分子(PDMS)應用在核磁共振造影(NMRI)之顯影劑(contrast agent)上的可適性,透過乳化技術與hydrosilylation反應可將crosslinked PDMS均勻地分散在水中而形成膠體溶液(colloidal solution),並對這些膠體溶液作FTIR、MTT、NMRI、粒徑、穩態流變性質、動態流變性質、NMR光譜、NMR T1鬆弛及NMR T2鬆弛等特性分析。經MTT實驗證實這種膠體溶液有很低之毒性,NMRI影像亦顯示這種膠體溶液可增進影像的對比效果。在NMR特性分析中發現:crosslinked PDMS的T2鬆弛、水的T2鬆弛、-(CH2CH2O)-的T1鬆弛與T2鬆弛等數據均不符合傳統上描述T1鬆弛與T2鬆弛之公式(如方程式(2-4)與(2-5))。在流變性質研究中發現:當PDMS的體積分率大於或小於某關鍵值(φc)時,其流變性質有很大不同。因此,本研究對這些特殊現象作了深入分析與討論。此外,本研究亦發現:就crosslinked PDMS膠體溶液而言,ψ
摘要(英) The objective of this study is to research the application of crosslinked PDMS (polydimethylsiloxane) to contrast agent of NMRI (nuclear magnetic resonance imaging) for gastro-intestine. With emulsification and hydrosilylation, the crosslinked PDMS can be homogeneously dispersed in water to form colloidal solutions. The characters of these colloidal solutions are ascertained by FTIR spectra, MTT assay, NMR images, laser light scattering, steady-shear rheology, dynamic-shear rheology, NMR spectra, T1 relaxation and T2 relaxation. MTT assay indicates these colloidal solutions have low toxicity and NMR images illustrate they can intensify contrast in in-vitro gastrointestinal images. Regarding the NMR properties of the crosslinked PDMS colloidal solutions and the linear PDMS emulsions, the conventional equations for T1 relaxation and T2 relaxation (eqn.(2-4) and eqn.(2-5)) do not agree with some of experimental results such as T1 relaxation of -(CH2CH2O)- segments and T2 relaxation of crosslinked PDMS, water as well as -(CH2CH2O)- segments. For the rheology behaviors, there is a peculiar difference between the volume fraction (ψ) greater than and smaller than a critical value (ψc). These specific NMR properties and rheology behaviors are discussed in detail in chapters 4 and 5 respectively. However, ψ
關鍵字(中) ★ NMR顯影劑
★ 高分子膠體溶液
★ 聚二甲基矽氧高分子
★ NMR訊號
★ 流變性質
關鍵字(英) ★ NMR contrast agent
★ colloidal solution
論文目次 封面
第一章 緒綸
第二章 文獻回顧
1. 前言
2. NMRI及其顯影劑
3. 聚二甲基矽氧高分子(PDMS)之NMR性質
4. 流變性質
第三章 顯影劑之製備與特性分析
1. 前言
2. 實驗
3. 結果與討論
4. 結論
第四章 顯影劑之NMR性質研究
1. 前言
2. 理論
3. 結果與討論
4. 結論
第五章 顯影劑之流變性質研究
1. 前言
2. 理論
3. 結果與討論
4. 結論
第六章 總結
參考文獻 [1] 楊美惠教授,官能性有機聚矽氧之合成與應用,830208M002097,1993
[2] 楊美惠教授,結晶性含苯基聚矽氧之特性與其製造方法之研究(I),842113M002004,1994
[3] 楊美惠教授,結晶性含苯基聚矽氧之特性與其製造方法之研究(II),852113M002015,1995
[4] 楊美惠教授,結晶性聚二苯基矽氧嵌段之介相結構研究,862113M002003,1996
[5] 楊美惠教授,結晶性聚二苯基矽氧嵌段之介相結構研究,872113M002008,1997
[6] 胡紀如教授,新矽化學及高分子科技之研發,830208M007101,1993
[7] 胡紀如教授,新合成與矽化學之研究(I),862113M007028,1996
[8] 胡紀如教授,新合成與矽化學之研究(II),872113M007023,1997
[9] 蘇富湖、劉泰康、陳省三,「矽橡膠之市場與發展」,新新雙月刊,1998
[10] S. W. Young, , Magnetic Resonance Imaging: Basic Principles, 2nd, New York
[11] M. A. Foster and J. M. S. Hutchison, Practical NMR Inaging, IRL Prrss, UK
[12] S. B. Petersen, R. N. Muller and P.A. Rinck, An Introduction to Biomedical Nuclear Magnetic Resonance, Jhieme Inc. New York, 1985
[13] R. C. Brasch, New directions in the development of MR imaging contrast media, Radiology, 183, p1-11, 1992
[14] H. J. Weinmann., R.C. Brasch, W. R. Press and G. E. Wesbey, Am. J. Roentg., 142, p916, 1984
[15] R. B. Lauffer, Paramagnetic metal complexes as water proton relaxation agents for NMR imaging: theory and design, Chem. Rev., 87, p901-927, 1987
[16] P. Sabine, R. Reszka, S. Wagner, K.-J. Wolf, H.-J. Buhr and G. Berger, Liposome-encapsulated superparamagnetic iron oxide particles as makers in as MRI-guided search for tumor-specific drug carriers, Anti-Cancer Drug Des., 12(2), p125-135, 1997
[17] B. Hamm, A.-E. Mahfouz, M. Taupitz, D. G. Mitchell, r. Nelson, E. Haopern, A. Speidel, K.-J. Wolf and S. Saini, Liver metastases: improved detedtion with dynamic gasolinium-enhanced MR imaging?, Radiology, 202(3), p677-682, 1997
[18] J.-P. Vallee, H. D. Sostman, J. R. MacFall and Rl E. Coleman, Quantification of myocarfdial perfusion with MRI and exogenous contrast agents, Cardiology, 88, p90-105, 1997
[19] J. P. Kuhtz-buschbeck, K. Ehrhardt, S. Koehnlein, W. Radtke and P. Heintzen, Gadopentetate dimeglumine and iodinated contrast media. Hemodynamic side effects after bolus injections in pigs, Invest. Radiol., 32(2), p111-119, 1997
[20] M. F. Wendland, M. Saeed, K. Lauerma, N. Derugin, J. Mintorovitch, F. M. Cavagna and C. B. Higgins, Alteration in T1 of normal and reperfused infarcted myocardium after Gd-BOPTA versus Gd-DTPA on inversion recovery EPI, Magnetic Resonance in Medicine, 37, p448-456, 1997
[21] K. G. Toft, G. A. Friisk and T. Skotland, mangafodipir trisodium injection, a new contrast medium for magnetic resonance imaging: detection and quantitation of the parent compound MnDPDP and metabolites in human plasma by high performance liquid chromatography, J. of Pharmaceutical and Biomedical Analysis, 15, p973-981, 1997
[22] V. P. Torchilin and V. S. trubetskoy, Amphiphilic polyethylene glycol derivatives: long-circulating micellar carriers for therapeutic and diagnostic agents, Polym. Prepr., v38(1), p545-546, 1997
[23] V. Montembault, J.-C. Soutif, J.-C. Brosse, F. Hindre and J.-J. L. Jeune, Synthesis of chelating molecules as agents for magnetic resonance imaging, 41.complexing properties of polycondensates prepared from diethylenetriaminepentaacetic acid bisanhydride, Reactive & Functional Polymer, 32, p43-52, 1997
[24] B. Gallez, C. Baudelet, J. Adline, M. Geurts and N. Delzenne, Accumulation of manganese in the brain of mice after intravenous injection of manganese-based contrast agents, Chem. Res. Toxicol., 10(4), p360-363, 1997
[25] E. M. Georgiev and D. M. Roundhill, An assessment of calixarene amides as potential magnetic resonance imaging enhancement agents for gadolinium(III), Inorg. Chim. Acta, 258(1), p93-96, 1997
[26] K. Kumar, Macrocyclic polyaminocarboxylate complexes of Gd(III) as magnetic resonance imaging contrast agents, J. Alloys Compd., 249(1-2), p163-172, 1997
[27] S. Aime, M. Botta, S. G. Crich, G. B. biovenzana, G. Jommi, R. Pagliarin and M. Sisti, Synthesis and NMR studies of three pyridine-containing triaza macrocyclic ligands and their complexes with lanthanide ions, Inorg. Chem., 36(14), p2992-3000, 1997
[28] R.-S. Sheu, G>-C. Liu, U. M. Wang, T.-S. Jaw, H.-M. Chen and Y.-T. Kuo, Evaluation of Fe-(5-C2H5-EHPG) as a contrast agent in MR imaging of hepatobiliary system, Kaohsiung J. Med. Sci., 13(2), p75-85, 1997
[29] Y.-M. Wang, T.-H. Cheng, G.-C. Liu and R.-S. Sheu, Synthesis of some N,N’-bis(amide) derivatives of diethylenetriaminepentaacetic acid and the stabilities of their complexes with Gd+3, Ca+3, Cu+2 and Zn+2, J. Chem. Soc., Dalton Trans., 5, p833-837, 1997
[30] R. X.Zhuo, U. J. Fu and J. Liao, Synthesis, relaxivity and biodistribution of novel magnetic resonance imaging (MRI) contrast agents: polylysine (Gd-DTPA/DOTA) with pendent galactose moieties as hepatocyte-targeting groups, Chin. Chem. Lett. 8(2), p157-160, 1997
[31] R. B. Lauffer and S. K. Larsen, Hydroxy-aryl metal chelates for diagnostic NMR imaging, U. S. Patent 5,527,522, 1996
[32] G. A. Elgavish and S. K. Kim, Lipophilic contrast agents for diagnostic image analysis, U. S. Patent 5,460,799, 1995
[33] J. P. Sadler and C.. T. Harding, NMR contrast agents, U. S. Patent 5,401,491, 1995
[34] B. Raduchel, H. Schmitt-Willich, H. Gries, G. Schuhmann-Giampieri. H. Vogler and J. Conrad, Use of amide complex compounds, U. S. Patent 5,399,340, 1995
[35] R.. D. Waigh, S. J. Anie and B. Wood, Method for magnetic resonance imaging of internal body tissues using polysiloxanes, U. S. Patent 5,380,514, 1995
[36] A. Sachse, G. Roessling, J. Platzek, B. Misselwitz and A. Muehler, Contrast agent-loaded liposomes for use in MRI lymphography, Ger. Offen. DE 19,529,922, 1997
[37] A. Muehler, Y. Frenzel, B. Misselwitz, H.-J. Weinmann and A. Sachse, Contrast agents for ventilation imaging of lung, Ger. Offen. DE 19,529,921, 1997
[38] H. Schmitt-Willich, J. Platzek, A. Muehler, G. Adam and R. Guenther, Ger. Offen., Use of polymeric contrast agents of medium molecular weight for differentiation of benign and malignant tumors by modern imaging techniques, Ger. Offen. DE 19,518,222, 1996
[39] D. Meyer, O. Russeaux, M. Schaefer and C. Simonot, Preparation of gadolinium poly(amino acid) complexes as MRI contrast agents, Fr. Demande FR 2,736,051, 1997
[40] H. Takayanagi, Preparation of 2,2-difluorolevulinic acid derivatives as contrast agents for magnetic resonance imaging (MRI), JP 09,067,323, 1997
[41] P. Podieser, E. Schober, K. Hittmair, J. Kettenbach, J. Naude, F. Herbst, J. Karner-Hanusch, R. Segel H. Imhof and J. Kramer, Vegetable oil as an MR contrast agent for rectal applications, Magnetic Resonance Imaging, 32(7), p979-984, 1995
[42] J. P. Ballee, H. D. Sostman, J. R. MacFall and R. E. Coleman, Quantification of myocardial perfusion with MRI and exogenous contrast agents, Cardiology, 88, p90-105, 1997
[43] Jerome Bibette and Fernando Leal-Calderon, Surfactant-stabilized emulsions, Current Opinion in Colloid & Interface Science, 1, p746-751, 1996
[44] F. Bloch, W.W. Hansen and M. Packark, Phys. Rev. 70, p474, 1948
[45] N. Bloembergen, E.M. Purcell and R.V. Pound, Phys. Rev. 73, p678, 1948
[46] R. Kubo and K. Tomita, J. Phys. Soc. Jpn., 9, p888, 1954
[47] I. Solomon, Phys. Rev., 99, p559, 1955
[48] J. Eisinger, R.G. Shulman and W.E. blumberg, Nature (London), New Biol., 192, p963, 1961
[49] R.A. Dwek, In Nuclear Magnetic Resonance in Biochemistry, Appllication to Enzyme Systems; Clarendon: Oxford, Chapter 9-11, 1973
[50] A.S. Mildvan, Annu. Rev. Biochem., 43, 357, 1974
[51] D.R. burton, S. Forse , G. Karlstrom and R.A. Dwek, A. Prog. Nucl. Magn. Reson. Spectrosc., 13, p1, 1979
[52] P.C. Lauterbur, Nature (London), New Biol., 242, p190, 1973
[53] W.S. Hinshaw, P.A. Bottomley and G.N. Holland, Nature (London), 270, p722, 1977
[54] T.J. Brady, et al., Radiology, 144, p343, 1982
[55] M.R. Goldman, et al., Circulation, 66, p1012, 1982
[56] I.R. Young, et al., Comput. Tomogr., 5, p534, 1981
[57] D.H. Carr et al., Lancet, 1, p484, 1984
[58] D. R. Thomas, Cross-Linking of Polydimethylsiloxanes, edited by S. J. Clarson and J. A. Semlyen, Siloxane Polymers, PTR Prentice Hall.
[59] B. Arkles, Look what you can make out of silicones, Chemtech, 13, p542-555, 1983
[60] J.G. Powles and A. Hartland, Nature, 186, p26, 1960
[61] J.G. Powles., A. Hartland and J.S.E. Kail, J. Polym. Sci., 55, p361, 1961
[62] D.w. McCall, et al., J. Polym. Sci., 59, p301, 1962
[63] R. Folland, J.H. Steven and A. Charlesby, J. Polym. Sci., Polymer Physics Ed., 16, p1041, 1978
[64] H.H. Grapengeter, b. Alefeld and R. Kosfeld, Colloid & Polymer Sci., 265, p226, 1987
[65] A. Nuts and B. Approach, Experimental pulse NMR, Addison-Wesley Pub. Co., 1981
[66] J.W. Hennel and J. Klinowski, Fundamentals of nuclear magnetic resonance, Longman Sci. & Tech., 1993
[67] P.T. Callaghan, Principles of nuclear magnetic resonance microscopy, Oxford, 1991
[68] B. Blumich and W. Kuhn, Magnetic resonance microscopy, VCH, 1992
[69] T. C. Farrar, Introduction to pulse NMR spectroscopy, the Farragut press Chiago, Madison, 1989
[70] R. Kimmich, M.Kopf and P. Callaghan, J. Polym. Sci.: Part B: Polym. Physics, 29, p1025, 1991
[71] T. Crogrove, P. C. Griffiths, J. Hollingshurst, R. D. C. Richards and J. A. Semlyen, Macromolecules, 25, p6761, 1992
[72] T. Cosgrove, et al., Polymer, 37, p1535, 1996
[73] V.M. Litvinov and A.A. Zhdanov, Dokl. Phys. Chem., 283, p811, 1984
[74] V.M. Litvinov, Organosilicon Chem. II, 2nd, Ed. by A. Norbert, VCH, Germany, 1994
[75] T.P. Lulagina, V.M. Litvinov and K.T. Summanen, J. Polym. Sci.: Part B: Polym. Phys., 31, p241, 1993
[76] M. Appel and G. Fleischer, Macromolecules, 26, p5520, 1993
[77] S. Pahi, G. Fleischer, J. Jujara and B. Geil, Macromolecules, 30, p1414, 1997
[78] G. Fleischer, Polym. Bull., 11, p75, 1984
[79] D. W. Vankrevelen, Properties of Polymers, 2nd ed., Chap. 15, p. 331 and Chap. 18, p. 403, Elsevier Scientific Pub. Co., NY, 1976
[80] M. Doi and S. F. Edwards, The Theory of Polymer Dynamics, 1st ed., Chap. 6, p. 188., Clarendon, Oxford, U.K., 1986
[81] M. G. Brereton: Macromolecules, 23, 1119, 1990
[82] M.G. Brereton, I.M. Ward, N. Boden and P. Wright: Macromolecules, 24, p2068, 1991
[83] P.J. Carreau, C.R. De Kee and R.P. Chhabra, Rheology of polymeric systems, Chap. 8, Hanser/Gardner Publications Inc., 1996
[84] R.J. Hunter, Introduction to modern colloid science, Chap. 4, Oxford University Press Inc., 1993
[85] R.J. Hunter, Foundations of colloid science, Chap. 9?, Oxford University Press Inc., 1989
[86] A. Einstein, Ann. Physik, 19, p289, 1906
[87] G.I., Proc. Roy. Soc. A, 138, p41, 1932
[88] D.A.RJ., Jones, B. Leary and D.V. Boger, Journal of colloid and interface science, 147, p479, 1991
[89] W.R. Schwalter, C.E. Chaffey and H. Brenner, J. Cjoll. Interface Sci., 26, p152, 1968
[90] W.R. Schwalter, Mechanics of non-Newtonian fluid, Paergamon Press, New York, NY, 1978
[91] J.G. Oldroyd, Proc. Roy. Soc. London, A218, p122, 1953
[92] J.G. Oldroyd, Proc. Roy. Soc. London, A232, p567, 1955
[93] J.F. Palierne, Rheol. Acta, 29, p204, 1990
[94] M. Bousmina, P.B. Bataille, S. Sapieha and H.P, Schreiber, J. Rheol., 39, p499, 1995
[95] K. Lakdawala and R. Salovey, Polym. Eng. Sci., 27, p1035, 1987
[96] Y. Otsubo, J. Colloid and Interf. Sci., 112, p380, 1986
[97] D. Graebling, R. Muller and J.F. Palierne, Macromolecules, 26, p320, 1993
[98] P.J. Carreau and P. Guerin, Can. J. Chem. Eng., 72, p966, 1994
[99] M. Bousmina and R. Muller, J. Rheol., 37, p663, 1993
[100] P. C. Hiemenz, Principles of Colloid and Surface Chemistry, 2nd ed., Dekker, New York, 1986
[101] S. T.Clarson and J. A.Semlyen, Siloxane Polymers, Ptr Prentice Hall, 1995
[102] M. Bousmina and R. Muller, J. Rheol., 37, 663, 1993
[103] H. Vahidi, D.R. Berry and L.M. Harvey, Toxicology Letters, 95, 159, 1998
[104] D. Lobner, Journal of Neuroscience Methods, 96(2), 147, 2000
[105] B. Baras, M.A. Benoit, O. Poulain-Godefroy, A.M. schacht, A. Capron, J. Gillark and G. R. Riveau, Vaccine, 18, 1495, 2000
[106] G. Socrates, Infrared Characteristic Group Frequencies, John Wiley & Sons, LTd., (1980)
[107] D.B. Yang, Journal of Polymer Science: Part A: Polymer Chemistry, 31, 199, 1993
[108] G. I. Sandakov, L. P. Smirnov, A. I. Sosikov, K. T.Summanen and N. N. Volkova, J. Polym. Sci.: Part B: Polym. Phys., 32, 1585 (1994)
[109] E. VON Meerwall and T. Stone, J. Polym. Sci., Part B: Polym. Phys., 27, 503 (1989)
[110] V. M. Litvinov and H. W. Spiess, Makromol. Chem., 192, 3005 (1991)
[111] H. Feng, L. Shi and Z. Feng, Makromol. Chem., 194, 2257 (1993)
[112] J. P. Cohen-Addad, Polymer, 24, 1128 (1983)
[113] Kimmich R., Schnur, G., Kopf, M. Prog. NMR Spectroscopy., 20, 385, (1988)
[114] Schnur, G. and Kimmich, R., Chem. Phys. Lett., 144, 333 (1988)
[115] Fatkullin, N.: Kimmich, R. Phys. Rev. E, ,52, 3273 (1995)
[116] D. W. Vankrevelen: Properties of Polymers, Elsevier Scientific Pub. Co., NY, 2nd ed., Chap. 15, p. 331 and Chap. 18, p. 403, (1976)
[117] P. T. Callaghan: Polymer, 29, 1951, (1988)
[118] M.H. Levitt and R. Freeman, J. Magn. Reson. 43, 65, (1981)
[119] Bloembergen, N., Purcell, E. M. and Pound, R. V., Phys. Rev., 73, 679 (1948)
[120] A. Abragam, The principles of nuclear magnetism, Ch. VIII, (1961)
[121] I. Solomon, Physical Review, July 15, 559, (1955)
[122] I. Solomon and N. Bloembergen, The Journal of Chemical Physics, 25(2), 261, (1956)
[123] N. Aomari, R. Gaudu, F. Cabioch and A. Omari, Colloids and Surfaces A, 139, 13, (1998)
[124] T. G. Mason and J. Bibette, Physical Review Letters, 16, 3481, (1996)
[125] T. G. Mason, J. Bibette andD. A. Weitz, Physical Review Letters, 10, 2051, (1995)
[126] T. G. Mason, J. Bibette andD. A. Weitz, J. Colloid and Interface Sci., 179, 439, (1996)
[127] H. M. Princen and A. D. Kiss, J. Colloid and Interface Sci., 128(1), 176, (1989)
[128] H. M. Princen and A. D. Kiss, J. Colloid and Interface Sci., 112(2), 427, (1986)
[129] J. P. Hsu and B. T. Liu, J. Colloid and Interface Sci., 198, 186, (1998)
[130] R. Pal, Chemical Engineering J., 70, 173, (1998)
[131] R. Pal, Chemical Engineering J., 67, 37, (1997)
[132] C. Chang, R. and L. Powell, J. Fluid Mech., 253, 1, (1993)
[133] J. S. Chong, E. B. Christiansen and A. D. Baer, J. Appl. Poly. Sci., 15 (1971)
[134] D. C. Morse and T. A. Witten, Europhys. Lett., 22(7), 549, (1993)
[135] J. W. Adams, Paintindia, Oct., 31, (1996)
[136] C. lacroix, M. Bousmina, P. J. Carreau, B. D. Favis and A. Michel, Polymer, 37, 2939, (1996)
[137] P.J. Carreau, M. Bousmina and A. Ajji, in Progress in Pacific Polymer Science 3. K.P. Ghiggin (Ed.), Springer-Verlag, New York, NY, p.25, (1994)
[138] D. M. Buzza, C. Y. D. Lu and M. E. Cates, J. Phys. II, 5, 37, (1995)
[139] T.P.L. roberts, N. Chuang and H.C. Robert, European J. of Radiology, 34(3), p166-178, (2000)
[140] A. Y. Louie and T. J. Meade, A Trends Guide, 2000(12), p7-11, (2000)
[141] Y. O:duhata, Advanced drug Delivery Reviews, 37(1-3), p121-137, (1999)
[142] R. Passariello and M. De Santis, The American Journal of Cardiology, 81(12), p68g-73g, (1998)
指導教授 徐新興(Shin-Shing Shyu) 審核日期 2001-6-15
推文 facebook   plurk   twitter   funp   google   live   udn   HD   myshare   reddit   netvibes   friend   youpush   delicious   baidu   

若有論文相關問題,請聯絡國立中央大學圖書館推廣服務組 TEL:(03)422-7151轉57407,或E-mail聯絡