博碩士論文 88224007 詳細資訊




以作者查詢圖書館館藏 以作者查詢臺灣博碩士 以作者查詢全國書目 勘誤回報 、線上人數:80 、訪客IP:3.93.75.30
姓名 楊念忠( Nian-Zhong Yang)  查詢紙本館藏   畢業系所 生命科學系
論文名稱 平滑肌細胞中第一型血紅素氧化
檔案 [Endnote RIS 格式]    [Bibtex 格式]    [相關文章]   [文章引用]   [完整記錄]   [館藏目錄]   [檢視]  [下載]
  1. 本電子論文使用權限為同意立即開放。
  2. 已達開放權限電子全文僅授權使用者為學術研究之目的,進行個人非營利性質之檢索、閱讀、列印。
  3. 請遵守中華民國著作權法之相關規定,切勿任意重製、散佈、改作、轉貼、播送,以免觸法。

關鍵字(中) ★ 一氧化氮合成 關鍵字(英)
論文目次 中文摘要 ------------------------------- 1
英文摘要 ------------------------------- 3
緒 論 ------------------------------- 4
材料與方法 ------------------------------- 11
結 果 ------------------------------- 22
討 論 ------------------------------- 28
圖 表 ------------------------------- 32
參考文獻 ------------------------------- 40
參考文獻 1.Michel, T., and Feron, O. (1997). Perspective series: Nitric oxide and nitric oxide synthases. J. Clin. Invest. 100, 2146-2152.
2.Nathan, C., and Xie, Q.-W. (1994). Nitric oxide synthases: roles, tolls, and controls. Cell 78, 915-918.
3.Dinerman, J. L., Dawson, T. M., Schell, M. J., Snowman, A., and Snyder, S. H. (1994). Endothelial nitric oxide synthase localized to hippocampal pyramidal cells: implication for synaptic plasticity. Proc. Natl. Acad. Sci. USA 91, 4214-4218.
4.Channon, K. M., Qian, H.-S., George, S. E. (2000). Nitric oxide synthase in Atherosclerosis and vascular injury insights from experimental gene therapy. Arterioscler. Thromb. Vasc. Biol. 20, 1873-1881.
5.Leeuwenburgh, C., Hardy, M. M., Hazen, S. L., Wanger, P., Oh-ishi, S., Steinbrecher, U. P., and Heinecke, J. W. (1997). Reactive nitrogen intermediates promote low density lipoprotein oxidation in human atherosclerotic intima. J. Biol. Chem. 272: 1433-1436.
6.Cromheeke, K. M., Kockx, M. M., De Meyer, G. R.Y., Bosmans, J. M., Bult, H., Beelaerts, W. J.F., Vrints, C. J., Herman, A. G. (1999). Inducible nitric oxide synthase colocalizes with signs of lipid oxidation/peroxidation in human atherosclerotic plaques. Cardiovasc. Res. 43, 744-754.
7.Kunz, D., M?hl, H., Walker, G., and Pfeilschifter, J. (1994). Two distinct signaling pathways trigger the expression of inducible nitric oxide synthase in rat renal mesangial cells. Proc. Natl. Acad. Sci. USA 91, 5387-5391.
8.Perrella, J. A., Yoshizumi, M.,Fen Z., Tsai, J.-C., Hsieh, C.-M., Kourembanas, S., and Lee, M.-E. (1994). Transforming growth factor-β1, but not dexamethasone, down-regulates nitric-oxide synthase mRNA after its induction by interleukin-1β in rat smooth muscle cells. J. Biol. Chem. 269, 14595-14600.
9.Lecanu, L., and Plotkine, M. (1999). Contribution of oxidative stress to excitotoxicity-induced deleterious iNOS in the CNS. Drug Discovery Today 4, 292-293.
10.Tenhunen, R., Marver, H. S., and Schmid, R. (1968). The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase. Proc. Natl. Acad. Sci. USA 61, 748-755.
11.Magnusson, S., Ekstrom, J., Elmer, E., Kanje, M., Ny, L., Alm, P. (1999). Heme oxygenase-1, heme oxygenase-2 and biliverdin reductase in peripheral ganglia from rat, expression and plasticity. Neuroscience. 95, 821-829.
12.McCoubrey, W. K., Jr., Huang T. J. and Maines M.D. (1997). Isolation and characterization of cDNA from the rat brain that encodes hemoprotein heme oxygenase-3. Eur. J. Biochem. 247, 725-732.
13.Maines, M. D. (1997). The heme oxygenase system: a regulator of second messenger gases. Annu. Rev. Pharmacol. Toxicol. 37, 5517-554.
14.Choi, A. M. and Alam, J. (1996). Heme oxygenase-1: function, regulation, and implication of a novel stress-inducible protein in oxidant-induced lung injury. Am. J. Respir. Cell Mol. Biol. 15, 9-19.
15.Stocker, R., Yamamoto, Y., McDonagh, A. F., Glazer, A. N. and Ames, B. N. (1987) Bilirubin is an antioxidant of possible physiological importance. Science 235, 1043-1046.
16.Coceani, F. (1993). Carbon monoxide and dialation of blood vessels. Science 260, 739.
17.Leffler, C. W., Nasjletti, A., Yu, C., Johnson, A., Fedinec, A. L., and Walker, N. (1999). Carbon monoxide and cerebral microvascular tone in newborn pigs. Am. J. Physiol. 276, H1641-H1646.
18.Snyder, S. H., Jaffrey, S. R. and zakhary R. (1998). Nitric oxide and carbon monoxide: parallel roles as neural messagers. Brain Res. Rev. 26, 167-175.
19.Balla, G., Jacob, H. S., Balla, J. Rosenbreg, M., Nath, K., Apple, F., Eaton, J. W., and Vercellotti, G. M. (1992). Ferritin: a cytoprotective antioxidant strategem of endothelium J. Biol. Chem. 267 18148-18153.
20.Yachie, A., Niida, Y., Wada. T., Igarashi, N., Kaneda, H., Toma, T., Ohta, K., Kasahara, Y. and Koizumi, S. (1999). Oxidative stress cause enhanced endothelial cell injury in human heme oxygenase-1 deficiency. J. Clin. Invest. 103, 129-135.
21.Dennery, P. A., Wong, H. E., Sridhar, K. J., Rodgers, P. A., Sim, J. E. and Spitz, D. R. (1996). Differences in basal and hyperoxia-associated HO expression in oxidant-resistant hamster fibroblasts. Am. J. Physiol. 271, L672-679.
22.Primiano, T., Kensler, T. W., Kuppusamy, P., Zweier, J. L. and Sutter, T. R. (1996). Induction of hepatic heme oxygenase-1 and ferritin in rats by cancer chemopreventive dithiolethiones. Carcinogenesis 17, 2291-6
23.Neuzil, J., and Stocker, R. (1994). Free and albumin-bound bilirubin are efficient co-antioxidants for alpha-tocopherol, inhibiting plasma and low density lipoprotein lipid peroxidation. J. Biol. Chem. 269, 16712-16719.
24.Abraham, N. G., Lavrovsky, Y., Schwartzman, M. L., Stoltz, R. A., Levere, R. D., Gerritsen, M. E., Shibahara, S., and Kappas, A. (1995). Transfection of the human heme oxygenase gene into rabbit coronary microvessel endothelial cells: protective effect against heme and hemoglobin toxicity. Proc. Natl. Acad. Sci. USA 92, 6798-6802.
25.Yang, L., Quan, S. and Abraham, N. G. (1999). Retrovirus- mediated HO gene transfer into endothelial cells protects against oxidant-induced injury. Am. J. Physiol. 277, L127-133.
26.Lee, P. J., Alam, G., Wiegand, G. W. and Choi, A. M. (1996). Overexpression of heme oxygenase-1 in human pulmonary epithelial cells results in cell growth arrest and increased resistance to hyperoxia. Proc. Natl. Acad. Sci. USA 93, 10393-10398.
27.Suttner, D. M., Sridhar, K., Lee, C. S., Tomura, T., Hansen, T. N. and Dennery, P. A. (1999). Protective effects of transient HO-1 overexpression on susceptibility to oxygen toxicity in lung cells. Am. J. Physiol. 276, L443-451.
28.Shan, Y., Lambrecht, R. W., Hong Lu, T. and Bonkovsky, H. L. Effects of phenylarsine oxide on expression of heme oxygenase-1 reporter constructs in transiently transfected cultures of chick embryo liver cells. Arch. Biochem. Biophys. 372, 224-229.
29.Masuya, Y., Hioki, K., Tokunaga, R., and Taketani, S. (1998). Involvement of the tyrosine phosphorylation pathway in induction of human heme oxygenase-1 by hemin, sodium arsenite, and cadmium chloride. J. Biochem. Tokyo 124, 628-633.
30.Elbirt, K. K., Whitmarsh, A. J., Davis R. J., and Bonkovsky, H. L. (1998). Mechanism of sodium arsenite-mediated induced induction of heme oxygenase-1 in hepatoma cells. Role of mitogen-activated protein kinase. J. Biol. Chem. 273, 8922-8931.
31.Oberly, T. J. Piper, C. E., and McDonald, D. S. (1982). Mutagenicity of metal salts in the L5178Y mouse lymphoma assay. J. Toxicol. Environ. Health. 9, 367-376.
32.Durante, W., Kroll, M. H., Christodoulides, N., Peyton, K. J., and Schafer, A. J. (1997). Nitric oxide induces heme oxygenase-1 gene expression and carbon monoxide production in vascular smooth muscle cells. Circ. Res. 80, 557-564.
33.Terry, C. M., Clikeman, J. A., Hoial, J. R. and Callahan, K. S. (1999). TNF-alpha and IL-1 alpha induce heme oxygenase-1 via protein kinase C, Ca2+, and phospholipase A2 in endothelial cells. Am. J. Physiol. 276, H1493-1501.
34.Kibbe, M., Billiar, T., and Tzeng, E. (1999). Inducible nitric oxide synthase and vascular injury. Cardiovasc. Res. 43, 650-657.
35.Patricia, A. D., Melba, H., John, M., Heide, H., Charlotte, B., Steven, M., Sam, C., Dan, F., Deborah, J. C., JeanMarie, L., Renee, W., James, D. B., Diane, E. S., Anne, H-V., Carl, P. S., Chao, Y.-S., Rader, D. J., Wright, S. D., and Pure, E. (2000). Deficiency in Inducible Nitric Oxide Synthase Results in Reduced Atheroscle- rosis in Apolipoprotein E-Deficient Mice. J. Immunol. 165, 3430-3435.
36.Kitamura, Y., Furukawa, M., Matsuoka, Y., Tooyama, I., Kimura, H., Nomura, Y., and Taniguchi, T. (1998). In vitro and in vivo induction of heme oxygenase-1 in rat glial cells: Possible involvement of nitric oxide production from inducible nitric oxide synthase. Glia. 22, 138-148.
37.Datta, P. K., Koukouritaki, S. B., Hopp K. A., and Elias, Lianos, E. A. (1999). Heme oxygenase-1 induction attenuates inducible nitric oxide synthase expression and proteinuria in glomerulonephritis. J. Am. Soc. Nephrol. 10, 2540-2550.
38.Yamasoba, T., Schacht, J., Shoji, F., and Miller, J. M. (1999). Attenuation of cochlear damage from noise trauma by an iron chelator, a free radical scavenger and glial cell line-derived neurotrophic factor in vivo. Brain Res. 815, 317-325.
39.Otterbein, L. E., Bach, F. H., Alam, J., Soares, M., Lu, H.-T., Wysk, M., Davis, R. J., Flavell, R. A. (2000). Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway. Nature Med. 6, 422-428.
40.Alam, J., Wiks, C., Stewart, D., and Gong, P. (2000). Mechanism of heme oxygenase-1 gene acivation by cadmium in MCF-7 mammary epithelial cells. Role of p38 kinase and Nrf2 transcription factor. J. Biol. Chem. 275, 27694-27697.
41.Clerk, A., and Sugden, P. H. (1998). The p38-MAPK inhibitor, SB203580, inhibits cardiac stress-activated protein kinases/c-Jun N-terminal kinases (SAPKs/JNKs). FEBS Letters 426, 93-96.
42.Cecile, B., and Demple, B. (2000). Nitric oxide-inducible expression of heme oxygenase-1 in human cells. J. Bio. Chem. 275, 32688-32693.
43.Hattori, Y., Nakanishi, N., Gross, S. S., and Kasai, K. (1999). Adrenomedullin augments nitric oxide and tetrahydrobioptein synthesis in cytokine-stimulated vascular smooth muscle cells. Cardiovasc. Res. 44, 207-214.
44.Bradford, M. M. (1976). A rapd and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254.
45.Funakoshi, M., Sonoda, Y., Tago, K., Tominaga, S.-I., Kasahara, T. (2001). Differential involvement of p38 mitogen-activated protein kinase and phosphatidyl inositol 3-kinase in the IL-1-mediated NF-κB and AP-1 activation. Int. J. Immunopharmacol. 1, 595-604.
指導教授 趙麗洋 審核日期 2001-7-18
推文 facebook   plurk   twitter   funp   google   live   udn   HD   myshare   reddit   netvibes   friend   youpush   delicious   baidu   
網路書籤 Google bookmarks   del.icio.us   hemidemi   myshare   

若有論文相關問題,請聯絡國立中央大學圖書館推廣服務組 TEL:(03)422-7151轉57407,或E-mail聯絡  - 隱私權政策聲明