博碩士論文 91224011 詳細資訊




以作者查詢圖書館館藏 以作者查詢臺灣博碩士 以作者查詢全國書目 勘誤回報 、線上人數:18 、訪客IP:3.233.242.204
姓名 洪珮芳(Pei-Fang Hong)  查詢紙本館藏   畢業系所 生命科學系
論文名稱 綠茶唲茶素透過MAPK相關途徑抑制3T3-L1前脂肪細胞的生長
(Green tea catechins inhibit 3T3-L1 preadipocyte growth via mitogen-activated protein kinase-associated pathway)
相關論文
★ 中華鱉腦垂體甘丙氨激素之研究:cDNA選殖、表現及調控★ 辛基苯酚對3T3-L1脂肪細胞中resistin的調節作用
★ 綠茶表沒食子酸酯型唲茶素酸酯對胰島素刺激前脂肪細胞增生的抑制★ FoxO1 調節抗胰島素激素基因的表現
★ 綠茶表沒食子唲茶素沒食子酸酯受器對於人類乳癌細胞株MCF7生長的影響★ 綠茶表沒食子酸酯型唲茶素酸酯抑制第一型内皮素作用於脂肪細胞上攝入葡萄糖的訊息機制
★ 綠茶表兒茶素藉由microRNA-494路徑改善橫向主動脈繃紮術誘導型小鼠的心臟疾病★ 內皮素誘導前脂肪細胞生長的訊息路徑
★ 綠茶對前脂肪細胞生長的影響★ 綠茶唲茶素對由第一型類胰島素所調節前脂肪細胞生長的影響
★ 綠茶唲茶素對於前脂肪細胞分化的影響★ Cdk2在綠茶唲茶素調節3T3-L1前脂肪細胞的生長和細胞凋亡扮演著必要性的角色
★ 第一型類胰島素生長因子、綠茶唲茶素及雌性素對3T3-L1脂肪細胞中resistin的基因表達有不同的調節效果★ 綠茶唲茶素對前脂肪細胞內活性氧及榖胱甘肽的影響
★ 胰島素接受器受質在綠茶唲茶素對胰島素刺激前脂肪細胞生長作用中扮演的角色★ 賜諾殺穩定性及東方果實蠅費洛蒙之研究
檔案 [Endnote RIS 格式]    [Bibtex 格式]    [相關文章]   [文章引用]   [完整記錄]   [館藏目錄]   [檢視]  [下載]
  1. 本電子論文使用權限為同意立即開放。
  2. 已達開放權限電子全文僅授權使用者為學術研究之目的,進行個人非營利性質之檢索、閱讀、列印。
  3. 請遵守中華民國著作權法之相關規定,切勿任意重製、散佈、改作、轉貼、播送,以免觸法。

摘要(中) 肥胖是脂肪細胞分裂生長和油脂堆積所造成的常見疾病,會增加癌症、糖尿病、高血壓和心血管疾病的發生。許多研究指出綠茶裡的多酚類,特別是唲茶素,有防止肥胖和其他相關疾病的功能,但是其影響脂肪細胞增生的機制仍未清楚。本研究的第一章指出唲茶素能藉由抑制MEK和其下游Cdk2的活性來減少因胎牛血清所造成的3T3-L1前脂肪細胞增生。第二章則發現唲茶素可以藉由減少第二型類胰島素生長因子接受器與Gi-2蛋白質的結合及下游的MEK活性而阻礙第二型類胰島素生長因子所引起的前脂肪細胞生長。這些研究結果可以提供唲茶素調節許多肥胖模式動物體重的機制。
摘要(英) Obesity, a common disease resulting from mitogenesis and lipid accumulation of fat cells, increases the risks of cancers, diabetes, hypertension, and cardiovascular disease. Based on a variety of laboratory studies, green tea polyphenols, especially the catechin, (-)-epigallocatechin gallate (EGCG), have been proposed as an obesity and other disease chemopreventative. But the exact mechanisms of their action on fat cell mitogenesis are still unclear. Chapter one showed that green tea EGCG could reduce fetal bovine serum-induced mitogenesis of 3T3-L1 preadipocytes through inhibiting the activities of MEK and its downstream cyclin-dependent kinase 2. Chapter two demonstrated that EGCG could stop insulin-like growth factor II (IGF-II)-induced mitogenesis of preadipocytes probably via reducing the IGF-II-stimulated the association of IGF-II receptor with Gi-2 protein and their downstream MEK activity. These results of this thesis provide a mechanism by which EGCG modulates the body weight in various animal models of obesity.
關鍵字(中) ★ 第二型類胰島素生長因子
★ 綠茶
★ 肥胖
關鍵字(英) ★ obesity
★ green tea
★ IGF-II
論文目次 Abstract I
中文摘要 II
Acknowledgements III
Contents IV
List of figures V
Abbreviations VII
Chapter one Green tea catechins inhibit FBS-induced preadipocyte growth via mitogen-activated protein kinase-associated pathway
Abstract 1
Introduction 3
Materials and Methods 5
Results 11
Discussion 15
References 18
Chapter two Green tea epigallocatechin gallate inhibits IGF-II-induced mitogenesis of preadipocytes via Gi-2 protein- and mitogen-activated protein kinase-associated pathways
Abstract 23
Introduction 25
Materials and Methods 28
Results 34
Discussion 39
References 43
General conclusion 49
Appendix 73
參考文獻 chapter one
1. Weisburger J H. (1999) Second international scientific symposium on tea and human health: an introduction. Proc Soc Exp Biol Med 220:193-194
2. Liao S, Kao YH, Hiipakka RA. (2001) Green tea: biochemical and biological basis for health benefits. Vitam Horm 62:1-94
3. Yang CS, Wang ZY. (1993) Tea and cancer. J Natl Cancer Inst 85:1038-1049
4. Ahmad N, Mukhtar H. (1999) Green tea polyphenols and cancer: biologic mechanisms and practical implications. Nutr Rev 57:78-83
5. Haqqi TM, Anthony DD, Gupta S. (1999) Prevention of collagen-induced arthritis in mice by a polyphenolic fraction from green tea. Proc Natl Acad Sci USA 96:4524-4529
6. Choi JY, Park CS, Kim DJ. (2002) Prevention of nitric acid-mediated 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson’s disease in mice by tea phenolic epigallocatechin 3-gallate. Neurotoxicology 23:367-374
7. Song EK, Hur H, Han MK. (2003) Epigallocatechin gallate prevents autoimmune diabetes induced by multiple low doses of streptozotocin in mice. Arch Pharm Res 26:559-563
8. Kao YH, Hiipakka RA, Liao S. (2000) Modulation of endocrine systems and food intake by green tea epigallocatechin gallate. Endocrinology 141:980-987
9. Kao YH, Hiipakka RA, Liao S. (2000) Modulation of obesity by a green tea catechin. Am J Clin Nutr 72:1232-1241
10. Hasegawa N, Yamda N, Mori M. (2003) Powdered green tea has antilipogenic effect on Zucker rats fed a high-fat diet. Phytother Res 17:477
11. Liao S. (2001) The medicinal action of androgens and green tea epigallocatechin gallate. Hong Kong Med J 7:369-374
12. Dulloo AG, Duret C, Rohrer D,Girardier L, Mensi N, Fathi M, Chantre P, Vandermander J. (1999) Efficacy of a green tea extract rich in Catechin polyphenols and caffeine in increasing 24-h energy ecpenditure and fat oxidation in humans. Am J Clin Nutr 70:1040-1045
13. Chang L, Karin M. (2001) Mammalian MAP kinase signalling cascades. Nature 410:37-40
14. Chang L, Karin M. (2001) Nature 410:37-40; Widmann C, Gibson S,Jarpe MB, Jorhnson GL.1999 Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human. Physiol Rev 79:143-180
15. Cohen P. (1997) The search for physiological substrates of MAP and SAP kinases in mammalian cells. Trends Cell Biol 7:353-361
16. Cowley S, Paterson H, Kemp P, Marshal CJ. (1994) Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH3T3 cells. Cell 77:841-852
17. Canagarajah BJ, Khokhlatchev A, Cobb MH, Goldsmith EJ. (1997) Activation mechanism of the MAP Kinase ERK2 by dual phosphorylation. Cell 90:859–869
18. Derijard B, Raingeaud J, Barrett T, Wu IH, Han J, Ulevitch RJ, Davis RJ. (1995) Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms. Science 267:682–685
19. Lin JK. (2002) Cancer chemoprevention by tea polyphenols through modulating signal transduction pathways. Arch Pharm Res 25:561-571
20. Bhatia N, Agarwal R. (2001) Detrimental effect of cancer preventive phytochemicals silymarin, genistein and epigallocatechin 3-gallate on epigenetic events in human prostate carcinoma DU145 cells. Prostate 46:98-107
21. Chung JY, Huang C, Meng X, Dong Z, Yang CS. (1999) Inhibition of activator protein 1 activity and cell growth by purified green tea and black tea polyphenols in H-ras-transformed cells: structure-activity relationship and mechanisms involved. Cancer Res 59:4610-4617
22. Vollenweider P, Clodi M, Martin SS, Imamura T, Kavanaugh WM, Olefsky JM. (1999) An SH2 domain-containing 5’ inositolphosphatase inhibits insulin-induced GLUT4 translocation and growth factor-induced actin filament rearrangement. Mol Cell Biol 19:1081-1091
23. Yang LC, Yang SH, Tai KW, Chou MY, Yang JJ (2004) MEK inhibition enhances bleomycin A5-induced apoptosis in an oral cancer cell line: signaling mechanisms and therapeutic opportunities. J Oral Pathol Med 33:37-45
24. Bradford MM. (1976) A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254
25. Kokontis JM, Hay N, Liao S. (1998) Progression of LNCaP prostate tumor cells during androgen deprivation: hormone-independent growth, repression of proliferation by androgen, and role for p27Kip1 in androgen-induced cell cycle arrest. Mol Endocrinol 12:941-953
26. Kong M, Barnes EA, Ollendorff V, Donoghue DJ. (2000) Cyclin F regulates the nuclear localization of cyclin B1 through a cyclin-cyclin interaction. EMBO J 19:1378–1388
27. Gupta S, Hussain T, Mukhtar H. (2003) Molecular pathway for (-)-epigallocatechin-3-gallate-induced cell cycle arrest and apoptosis of human prostate carcinoma cells. Arch Biochem Biophys 410:177-85
28. Liang YC, Lin-Shiau SY, Chen CF, Lin JK. (1999) Inhibition of cyclin-dependent kinases 2 and 4 activities as well as induction of Cdk inhibitors p21 and p27 during growth arrest of human breast carcinoma cells by (-)-epigallocatechin-3-gallate. J Cell Biochem75:1-12
29. Ahmad N, Cheng P, Mukhtar H. (2000) Cell cycle dysregulation by green tea polyphenol epigallocatechin-3-gallate. Biochem Biophys Res Commun 275:328-34
30. Songcang Chen, David G. Gardner. (2004) Suppression of WEE1 and stimulation of cdc25a correlates with endothelin-dependent proliferation of rat aortic smooth muscle cells. J Biol Chem 279:13755-13763
31. Sah JF, Balasubramanian S, Eckert RL, Rorke EA. (2004) Epigallocatechin-3-gallate inhibits epidermal growth factor receptor signaling pathway. Evidence for direct inhibition of ERK1/2 and AKT kinases. J Biol Chem 279:12755-62
32. Nyska A, Suttie A, Bakshi S, Lomnitski L, Grossman S, Bergman M, Ben-Shaul V, Crocket P, Haseman JK, Moser G, Goldsworthy TL, Maronpot RR. (2003) Slowing tumorigenic progression in TRAMP mice and prostatic carcinoma cell lines using natural anti-oxidant from spinach, NAO--a comparative study of three anti-oxidants. Toxicol Pathol 31:39-51
33. Maeda K, Kuzuya M, Cheng XW, Asai T, Kanda S, Tamaya-Mori N, Sasaki T, Shibata T, Iguchi A. (2003) Green tea catechins inhibit the cultured smooth muscle cell invasion through the basement barrier. Atherosclerosis 166:23-30
34. Chen A, Zhang L, Xu J, Tang J. (2002) The antioxidant (-)-epigallocatechin-3-gallate inhibits activated hepatic stellate cell growth and suppresses acetaldehyde-induced gene expression. Biochem J 368:695-704
35. Paschka AG, Butler R, Young CY. (1998) Induction of apoptosis in prostate cancer cell lines by the green tea compound, (-)-epigallocatechin-3-gallate. Cancer Lett 130:1-7
36. Galindo CL, Fadl AA, Sha J, Gutierrez C, Popo VL, Boldogh I, Aggarwal BB, Chopra AK. (2004) Aeromonas hydrophila cytotoxic enterotoxin activates mitogen-activated protein kinases and induces apoptosis in murine macrophages and human intestinal epithelial cells. J Biol chem as manuscript M404641200
37. Lannuzel A, Barnier JV, Hery C, Huynh VT, Guibert B, Gray F, Vincent JD, Tardieu M. (1997) Human immunodeficiency virus type 1 and its coat protein gp120 induce apoptosis and activate JNK and ERK mitogen-activated protein kinase in human neurons. Ann Neurol 42:847-856
38. Tegos G, Stermitz FR, Lomovskaya O, and Lewis K. (2002) Multidrug pump inhibitors uncover remarkable activity of plant antimicrobials. Antimicrob Agents Chemother 46:3133-3141
39. Cao Y, Cao R. (1999) Angiogenesis inhibited by drinking tea. Nature 398:381
40. Nakayama M, Suzuki K, Toda M, Okubo S, and Hara Y. (1993) Inhibition of the infectivity of influenza virus by tea polyphenols. Antivir Res 21:289-299
41. Tang HR, Covington AD, Hancock RA. (2003) Structure-activity relationships in the hydrophobic interactions of polyphenols with cellulose and collagen. Biopolymers 70(3):403-13
42. Tachibana H, Koga K, Fujimura Y, Yamada K. (2004) A receptor for green tea polyphenol EGCG. Nat Struct Mol Biol 11:380-381
chapter two
1. Daughaday WH, Rotwein P. (1989) Insulin-like growth factors I and II. Peptide, messenger ribonucleic acid and gene structures, serum, and tissue concentrations. Endocr Rev 10:68-91
2. Humbel RE. (1990) Insulin-like growth factors I and II. Eur J Biochem 190:445-462
3. Kawamoto K, Onodera H, Kan S, Kondo S, Imamura M. (1999) Possible paracrine mechanism of insulin-like growth factor-2 in the development of liver metastases from colorectal carcinomas. Cancer 85: 18-25
4. Hartmann W, Waha A, Koch A, Albrecht S, Gray SG, Ekstrom TJ, von Schweinitz D, Pietsch T. (2001) Promoter-specific transcription of the IGF-2 gene: a novel rapid,non-radioactive and highly sensitive protofor mRNA analysis. Virchows Arch 439: 803-807
5. Stewart CEH, Rotwein P. (1996) Growth, differentiation, and survival: multiple physiological functions for insulin-like growth factors. Physiol Rev 76:1005-1026
6. Le Roith D. (1997) Seminars in medicine of the beth Israel deaconess medical center: insulin-like growth factors. N Engl J Med 336:633-640
7. Merrinan HL, La Tour D, Linkhard TA, Mohan S, Baylink DJ, Strong DD. (1990) Insulin-like growth factor-I and Insulin-like growth factor-II induce c-fos in mouse osteoblastic cells. Calcif Tissue Int s46:258
8. Baserga R. (2000) The contradictions of the insulin-like growth factor I receptor. Oncogene 19:5574-5581
9. Werner H, LeRoith D. (2000) New concepts in regulation and function of the insulin-like growth factors: implications for understanding normal growth and neoplasia. Cell Mol Life Sci 57:932-942
10. Reiss K, Valentinis B, Tu X, Xu SQ, Baserga R. (1998) Molecular markers of IGF-I-mediated mitogenesis. Experimental Cell Res 242:361-372
11. Petley T, Graff K, Iuang W, Yang H, Florini J. (1999) Variation among cell types in the signalling pathways by which IGF-I stimulates specific cellular responses. Horm Merabol Res 31:70-76
12. Toretsky JA, Helman LJ. (1996) Involvement of IGF-II in human cancer. J Endocrinol 149:367-372
13. Morison I, Becroft DM, Taniguchi T, Woods CG, Reeve AE. (1996) Somatic overgrowth associated with overexpression of insulin-like growth factor II. Nat Med 2:311-316
14. Eggenschwiler J, Ludwig T, Fisher P, Leighton PA, Tilghman SM, Efstradiatis A. (1997) Mouse mutant embryos overexpressing IGF-II exhibit phenotypic features of the Beckwith-Wiedemann and Simpson-Golabi-Behmel syndromes. Genes Dev 11:3128-3142
15. Sperandeo MP, Ungaro P, Vernucci M, Pedone PV, Cerrato F, Perone L, Casola S, Cubellis MV, Bruni CB, Andria G, Sebastio G, Riccio A. (2000) Relaxation of insulin-like growth factor 2 imprinting and discordant methylation at KvDMR1 in two first cousins affected by Beckwith-Wiedemann and Klippel-Trenaunay-Weber syndromes. Am J Hum Genet 66:841-847
16. MacDonald RG, Pfeffer SR, Coussens L, Tepper MA, Brocklebank CM, Mole JE, Anderson JK, Chen E, Czech MP, Ullrich A. (1988) A single receptor binds both insulin-like growth factor II and mannose-6-phosphate. Science 239:1134-1137
17. Morgan DO, Edman JC, Standring DN, Fried VA, Smith MC, Roth RA, Rutter WJ. (1987) Insulin-like growth factor II receptor as a multifunctional binding protein. Nature 329:301-307
18. Oshima A, Nolan CM, Kyle JW, Grubb JH, Sly WS. (1988) The human cation-independent mannose 6-phosphate receptor: cloning and sequence of the full-length cDNA and expression of functional receptor in COS cells. J Biol Chem 263:2553-2562
19. Lobel P, Dahms NM, Kornfeld S. (1988) Cloning and sequence analysis of the cation-independent mannose 6-phosphate receptor. J Biol Chem 263:2563–2570
20. Okamoto T, Nishimoto I. (1991) Analysis of stimulation-G protein subunit coupling by using active insulin-like growth factor II receptor peptide. PNAS 88:8020-8023
21. Schmidt B, Kiecke-Siemsen C, Waheed A, Braulke T, von Figura K. (1995) Localization of the insulin-like growth factor II binding site to amino acids 1508–1566 in repeat 11 of the mannose 6-phosphate/insulin-like growth factor II receptor. J Biol Chem 270:14975–14982
22. Dahms NM, Rose PA, Molkentin JD, Zhang Y, Brzycki MA. (1993) The bovine mannose 6-phosphate/insulin-like growth factor II receptor. The role of arginine residues in mannose 6-phosphate binding. J Biol Chem, 268, 5457–5463
23. Goda Y, Pfeffer SR. (1988) Selective recycling of the mannose 6-phosphate/IGF-II receptor to the trans golgi network in vitro. Cell 55:309-320
24. Griffiths G, Hoflack B, Simons K, Mellman I, Kornfield S. (1988) The mannose 6-phosphate receptor and the biogenesis of lysosomes. Cell 52:329-341
25. Braulke T, Tippmer S, Nether E, von Figura K. (1989) Regulation of the mannose 6-phosphate/IGF-II receptor expression at the cell surface by mannose 6-phasphate and insulin-like growth factors and epidermal growth factor. EMBO J 8:681-686
26. Perdue JF, Chan JK, Thibault C, Radaj P, Mills B, Daughaday, WH. (1983) The biochemical characterization of detergent-solubilized insulin-like growth factor II receptors from rat placenta. J Biol Chem 258:7800-7811
27. Thibault C, Chan JK, Perdue JF, Daughaday WH. (1984) Insulin-like growth factor II receptors. Molecular radius and molecular weight determination using quantitative polyacrylamide gel electrophoresis. J Biol Chem 259:3361-3367
28. York SJ, Arneson LS, Gregory WT, Dahms NM, Kornfeld S. (1999) The rate of internalization of the mannose 6-phosphate/insulin-like growth factor II receptor is enhanced by multivalent ligand binding. J Biol Chem 274:1164-1171
29. Byrd JC, Park JH, Schaffer BS, Garmroudi F, MacDonald RG. (2000) Dimerization of the insulin-like growth factor II/mannose 6-phosphate receptor. J Biol Chem 275:18647-18656
30. Byrd JC, MacDonald RG. (2000) Mechanisms for high affinity mannose 6-phosphate ligand binding to the insulin-like growth factor II/mannose 6-phosphate receptor. J Biol Chem 275:18638-18646
31. Rechler MM, Nissley SP. (1985) The nature and regulation of the receptors for insulin-like growth factors. Annu Rev PHysiol 47:425-442
32. Jones IJ, Clemmons DR. (1995) Insulin-like growth factors and their binding proteins: biological actions. Endocr Rev 16:3-34
33. Le Roith D, Werner H, beitner-Johnson D, Roberts CT Jr. (1995) Molecular and cellular aspects of the insulin-like growth factor I receptor. Endocr Rev 16:143-163
34. Nissley SP, Kiess W, Sklar MM. (1991) The insulin-like growth factor-II/mannose-6-phosphate receptor. In: LeRoith D (eds) Insulin-like Growth Factors: Cellular and Molecular Aspects. CRC Press, Boca Roton. p111-150
35. Czech MP. (1989) Signaling transmission by the insulin-like growth factors. Cell 59:235-238
36. DeChiara TM, Efstradiatis A, Robertson EJ. (1990) A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting. Nature 345:78-80
37. Kao YH, Hippakka RA, Liao S. (2000) Modulation of obesity by a green tea catechin. Am J Clin Nutr 72:1232-1241
38. Vollenweider P, Clodi M, Martin SS, Imamura T, Kavanaugh WM, and Olefsky JM. (1999) An SH2 domain-containing 5’ inositolphosphatase inhibits insulin-induced GLUT4 translocation and growth factor-induced actin filament rearrangement. Mol Cell Biol 19:1081-1091
39. Pipper, RC, Hess LJ, James DE. (1991) Differential sorting of two glucose transporters expressed in insulin-sensitive cells. Am J Physiol 260:570-580
40. Aikawa T, Segre GV, Lee K 2001 Fibroblast growth factor inhibits chondrocytic growth through induction nof p21 and subsequent inactivation of cyclin E-Cdk2. J Biol Chem 276:29347-29352
41. Yang LC, Yang SH, Tai KW, Chou MY, Yang JJ (2004) MEK inhibition enhances bleomycin A5-induced apoptosis in an oral cancer cell line: signaling mechanisms and therapeutic opportunities. J Oral Pathol Med 33:37-45
42. Bradford MM. (1976) A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254
43. Kokontis JM, Hay N, Liao S. (1998) Progression of LNCaP prostate tumor cells during androgen deprivation: hormone-independent growth, repression of proliferation by androgen, and role for p27Kip1 in androgen-induced cell cycle arrest. Mol Endocrinol 12:941-953
44. Murayama Y, Okamoto T, Ogata E, Asano T, Iiri T, Katada T, Ui M, Grubb JH, Sly WS, Nishimoto I. (1990) Distinctive regulation of the functional linkage between the human cation-independent mannose 6-phosphate receptor and GTP-binding proteins by insulin-like growth factor II and mannose 6-phosphate. J Biol Chem 265:17456-17462
45. Hanahan D. (1985) Heritable formation of pancreatic beta - cell tumors in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. Nature 315:115 – 122
46. Nishimoto I, Hata Y, Ogata E, Kojima I. (1987) Insulin-like growth factor II stimulates calcium influx in competent BALB/c 3T3 cells primed with epidermal growth factor. Characteristics of calcium influx and involvement of GTP-binding protein. J Biol Chem 262:12120-12126
47. Nishimoto I, Murayama Y, Katada T, Ui M, Ogata E. (1989) Possible direct linkage of insulin-like growth factor-II receptor with guanine nucleotide-binding proteins. J Biol Chem 264:14029-14038
48. Okamoto T, Katada T, Murayama Y, Ui M, Ogata E, Nishimoto I. (1990) A simple structure encodes G protein-activating function of the IGF-II/mannose 6-phosphate receptor. Cell 62:709-717
49. Dhanasekaran N, Prasad MV. (1998) G protein subunits and cell proliferation. Biol Signals Recept 7:109-117
50. Alblas J, van Corven EJ, Hordijk PL, Milligan G, Moolenaar WH. (1993) Gi-mediated activation of the p21ras-mitogen-activated protein kinase pathway by α2-adrenergic receptors expressed in fibroblasts. J Biol Chem 268:22235-22238
51. Pace AM, Faure M, Bourne HR. (1995) Gi2-mediated activation of the MAP kinase cascade. Mol Biol Cell 6:1685-1695
52. Gutkind JS. (1998) Cell growth control by G protein-coupled receptors: from signal transduction to signal integration. Oncogene 17:1331-1342
53. Kojima I, Matsunaga H, Kurokawa K, Ogata E, Nishimoto I. (1988) Calcium influx: an intracellular message of the mitogenic action of insulin-like growth factor-I. J Biol Chem 263:16561-16567
54. Kojima I, Nishimoto I, Iiri T, Ogata E, Rosenfeld RG. (1988) Evidence that type II IGF receptor is coupled to calcium gating system. Biochem Biophys Re. Commun. 154:9-19
55. Tegos G, Stermitz FR, Lomovskaya O, Lewis K. (2002) Multidrug pump inhibitors uncover remarkable activity of plant antimicrobials. Antimicrob Agents Chemother 46:3133-3141
56. Cao Y, Cao R. (1999) Angiogenesis inhibited by drinking tea. nature 398:381
57. Nakayama M, Suzuki K, Toda M, Okubo S, Hara Y. (1993) Inhibition of the infectivity of influenza virus by tea polyphenols. Antivir. Res 21:289-299
58. Tang HR, Covington AD, Hancock RA. (2003) Structure-activity relationships in the hydrophobic interactions of polyphenols with cellulose and collagen. Biopolymers. 70(3):403-13
59. Tachibana H, Koga K, Fujimura Y, Yamada K. (2004) A receptor for green tea polyphenol EGCG. Nat Struct Mol Biol 11:380-381
指導教授 高永旭(Yung-Hsi Kao) 審核日期 2004-7-8
推文 facebook   plurk   twitter   funp   google   live   udn   HD   myshare   reddit   netvibes   friend   youpush   delicious   baidu   
網路書籤 Google bookmarks   del.icio.us   hemidemi   myshare   

若有論文相關問題,請聯絡國立中央大學圖書館推廣服務組 TEL:(03)422-7151轉57407,或E-mail聯絡  - 隱私權政策聲明