博碩士論文 91224013 詳細資訊




以作者查詢圖書館館藏 以作者查詢臺灣博碩士 以作者查詢全國書目 勘誤回報 、線上人數:7 、訪客IP:54.210.158.163
姓名 陳晏航(Yen-Hung Chen)  查詢紙本館藏   畢業系所 生命科學系
論文名稱 第一型類胰島素生長因子、綠茶唲茶素及雌性素對3T3-L1脂肪細胞中resistin的基因表達有不同的調節效果
(Expression of resistin gene in 3T3-L1 adipocyte is differently regulated by IGF-I, EGCG, and estrogen)
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摘要(中) Resistin (Rstn) 這個新的脂肪細胞激素最近被分離出來,其功能會減少血糖耐受性,且進而造成嚴重的胰島素抗性。進一步的研究顯示Rstn的表達在遺傳以及飲食所造成的肥胖老鼠中會被誘導,而TZD之類用來治療糖尿病的藥物則可以抑制它的表達。基於這些觀察,Rstn被認為可能是介於糖尿病和肥胖之間的關鍵物質,並可以用來解釋TZD改良糖尿病的療效。根據過去的研究指出Rstn的表達量會受到許多影響胰島素敏感性的荷爾蒙與營養物質所調節。本篇研究的第一章則發現Rstn基因會受到第一型類胰島素生長因子藉由刺激某未知蛋白質的合成來抑制其表達。第二章的結果顯示綠茶中的唲茶素則經由加快Rstn mRNA的降解速度來抑制Rstn的表達。相反的,第三章的結果顯示雌性素則是會透過增加轉錄因子C/EBPα和Rstn啟動子的結合而促進Rstn的表達。故本論文的研究成果可以用來釐清第一型類胰島素生長因子、綠茶中的唲茶素及雌性素在胰島素抗性中所扮演的角色。
摘要(英) Recently, the novel adipocytokine resistin (Rstn) had been isolated. This protein hormone functions to impair glucose tolerance. In accordance with this view, Rstn induced severe insulin resistance. Furthermore, it was initially shown that Rstn was up-regulated in both genetic and diet-induced obesity in vivo and down-regulated by TZDs. On the basis of these observations, it had been postulated that Rstn might be both a link between obesity and diabetes, as well as a candidate to explain the anti-diabetic effects of TZDs. It had been clearly shown that Rstn mRNA expression was regulated by various hormones and nutrients which influence insulin sensitivity. In the chapter one of this study, we found that Rstn expression was reduced by insulin-like growth factor I (IGF-I) via an unknown protein synthesis. Chapter two showed that EGCG, the major green tea polyphenol, suppressed Rstn expression through accelerating Rstn mRNA degradation. Contrarily, chapter three showed that estrogen could induce Rstn expression significantly via increasing the association of transcription factor C/EBPα with Rstn promoter. These results might help clarify the roles of IGF-I, EGCG, and estrogen playing in insulin resistance.
關鍵字(中) ★ 第一型類胰島素生長因子
★ 抗素
★ 雌性素
★ 綠茶唲茶素
★ 肥胖
★ 糖尿病
關鍵字(英) ★ obesity
★ Estrogen
★ IGF-I
★ EGCG
★ resistin
★ diabetes
論文目次 Abstract III
中文摘要 IV
Acknowledgements V
List of figures VIII
Abbreviations X
Chapter one Differential regulation of resistin gene expression and protein secretion by insulin-like growth factor I
Abstract 1
Introduction 2
Materials and Methods 5
Results 12
Discussion 17
References 20
Chapter two Modulation of resistin gene expression by green tea epigallocatechin gallate
Abstract 27
Introduction 28
Materials and Methods 31
Results 36
Discussion 40
References 45
Chapter three Up-regulation of resistin gene expression in 3T3-L1 adipocytes by estrogen
Abstract 51
Introduction 53
Materials and Methods 56
Results 63
Discussion 70
References 74
General conclusions 82
Table 1 113
Appendix 114
參考文獻 Chapter 1
1. Steppan CM, Bailey ST, Bhat S, Brown EJ, Banerjee RR, Wright CM, Patel HR, Ahima RS, Lazar MA 2001 The hormone resistin links obesity to diabetes. Nature 409:307-312
2. Kim KH, Lee K, Moon YS, Sul HS 2001 A cysteine-rich adipose tissue-specific secretory factor inhibits adipocyte differentiation. J Biol Chem 276:11252-11256
3. Banerjee RR, Rangwala SM, Shapiro JS, Rich AS, Rhoades B, Qi Y, Wang J, Rajala MW, Pocai A, Scherer PE, Steppan CM, Ahima RS, Obici S, Rossetti L, Lazar MA 2004 Regulation of fasted blood glucose by resistin. Science 303:1195-1198
4. Moon B, Kwan JJ, Duddy N, Sweeney G, Begum N 2003 Resistin inhibits glucose uptake in L6 cells independently of changes in insulin signaling and GLUT4 translocation. Am J Physiol Endocrinol Metab 285:E106-115 (Epub 2003 Mar 04)
5. Verma S, Li SH, Wang CH, Fedak PWM, Li RK, Weisel RD, Mickle DAG 2003 Resistin promotes endothelial cell activation further evidence of adipokine-endothelial interaction. Circulation 108:736-740
6. Degawa-Yamauchi M, Bovenkerk J, Juliar BE, Watson W, Kerr K, Jones R, Zhu Q, Considine RV 2003 Serum resistin (FIZZ3) protein is increased in obese humans. J Clin Endocrinol Metab 88:5452-5455
7. Engert JC, Vohl MC, Williams SM, Lepage P, Loredo-Osti JC, Faith J, Dore C, Renaud Y, Burtt NP, Villeneuve A, Hirschhorn JN, Altshuler D, Groop LC, Despres JP, Gaudet D, Hudson TJ 2002 5’flanking variants of resistin are associated with obesity. Diabetes 51:1629-2002
8. Pizzuti A, Argiolas A, Paola RD, Baratta R, Rausea A, Bozzali M, Vigneri R, Dallapiccola B, Trischitta V, Frittitta L 2002 An ATG repeat in the 3’-untranslated region of the human resistin gene is associated with a decreased risk of insulin resistance. J Clin Endocrinol Metab 87:4403-4406
9. Youn BS, Yu KY, Park HJ, Lee NS, Min SS, Youn MY, Cho YM, Park YJ, Kim SY, Lee HK, Park KS 2004 Plasma resistin concentrations measured by enzyme-linked immunosorbent assay using a newly developed monoclonal antibody are elevated in individuals with type 2 diabetes mellitus. J Clin Endocrinol Metab 89:150-156
10. Ghosh SG, Singh AK, Aruna B, Mukhopadhyay S, Ehtesham NZ 2003 The genomic organization of mouse resistin reveals major differences from the human resistin: functional implications. Gene 305:27-34
11. Cepica S, Rohrer GA, Masopust M, Kubickova S, Musilova P, Rubes J 2002 Partial cloning, cytogenetic and linkage mapping of the porcine resistin (RSTN) gene. Anim Genet 33:381-383
12. Steppan CM, Brown EJ, Wright CM, Bhat S, Banerjee RR, Dai CY, Enders GH, Silberg DG, Wen X, Wu GD, Lazar MA 2001 A family of tissue-specific resistin-like molecules. Proc Natl Acad Sci USA 98:502-506
13. Holcomb IN, Kabakoff RC, Chan B, Baker TW, Gurney A, Henzel W, Nelson C, Lowman HB, Wright BD, Skelton NJ, Frantz GD, Tumas DB, Peale FV, Shelton DL, Hebert CC 2000 FIZZ1, a novel cysteine-rich secreted protein associated with pulmonary inflammation, defines a new gene family. EMBO J 19:4046-4055
14. Fasshauer M, Paschke R 2003 Regulation of adipocytokines and insulin resistance. Diabetologia 46:1594-1603
15. Banerjee RR, Lazar MA 2003 Resistin: molecular history and prognosis. J Mol Med 81: 218-226
16. Oliver P, Pico C, Serra F, Palou A 2003 Resistin expression in different adipose tissue depots during rat development. Mol Cell Biochem 252:397-400
17. Shojima N, Sakoda H, Ogihara T, Fujishiro M, Katagiri H, Anai M, Onishi Y, Ono H, Inukai K, Abe M, Fukushima Y, Kikuchi M, Oka Y, Asano T 2002 Humoral regulation of resistin expression in 3T3-L1 and mouse adipose cells. Diabetes 51:1737-1744
18. Kawashima J, Tsuruzoe K, Motoshima H, Shirakami A, Sakai K, Hirashima Y, Toyonaga T, Araki E 2003 Insulin down-regulates resistin mRNA through the synthesis of protein(s) that could accelerate the degradation of resistin mRNA in 3T3-L1 adipocytes. Diabetologia 46:231-240
19. Haugen F, Jorgensen A, Drevon CA, Trayhurn P 2001 Inhibition by insulin of resistin gene expression in 3T3-L1 adipocytes. FEBS Lett 507:105-108
20. Viengchareun S, Zennaro M, Tallec LP, Lombes M 2002 Brown adipocytes are novel sites of expression and regulation of adiponectin and resistin. FEBS Lett 532:345-350
21. Way JM, Gorgun CZ, Tong Q, Uysal KT, Brown KK, Harrington WW, Oliver WR, Willson TM, Kliewert SA, Hotamisligil GS 2001 Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisome proliferators-activated receptor g agonists. J Biol Chem 276:25651-25653
22. Zhong Q, Lin CY, Clarke KJ, Kemppainen RJ, Schwartz DD, Judd RL 2002 Endothelin-1 inhibits resistin secretion in 3T3-L1 adipocytes. Biochem Biophys Res Commun 16:383-387
23. Rosenfeld RG, Roberts CT 1999 The IGF system: molecular biology, physiology, and clinical applications. Humana Press Inc., Totowa, New Jersey.
24. Fasshauer M, Klein J, Neumann S, Eszlinger M, Paschke R 2001 Tumor necrosis factor a is a negative regulator of resistin gene expression and secretion in 3T3-L1 adipocytes. Biochem Biophys Res Commun 288:1027-1031
25. Delhanty PJ, Mesotten D, Mcdougall F, Baxter RC 2002 Growth hormone rapidly induces resistin gene expression in white adipose tissue of spontaneous dwarf (SDR) rats. Endocrinology 143:2445-24448
26. Kao YH, Hippakka RA, Liao S 2000 Modulation of obesity by a green tea catechin. Am J Clin Nutr 72:1232-1241
27. Ramirez-Zacarias JL, Castro-Munozledo F, Kuri-Harcuch W 1992 Quantitation of adipose conversion and triglycerides by staining intracytoplasmic lipids with Oil red O. Histochemistry 97:493-497
28. Reischl U, Ruger R, Kessler C 1994 Nonradioactive labeling and high sensitive detection of PCR products. Mol Biotechnol 1: 229-240
29. Mathias Fasshauer, Johannes Klein, Susanne Neumann, Markus Eszlinger and Ralf Paschke 2001 Isoproterenol inhibits resistin gene expression through a GS-protein-coupled pathway in 3T3-L1 adipocytes. FEBS Letters 500:60-63
30. Kokontis JM, Hay N, Liao S 1998 Progression of LNCaP prostate tumor cells during androgen deprivation: hormone-independent growth, repression of proliferation by androgen, and role for p27Kip1 in androgen-induced cell cycle arrest. Mol Endocrinol 12:941-953
31. Eilertson CD, Sheridan MA 1995 Pancreatic somatostatin-14 and somatostatin-25 release in rainbow trout is stimulated by glucose and arginine. Am J Physiol 269:R1017-1023
32. Maebuchi M, Machidori M, Urade R, Ogawa T, Moriyama T 2003 Low resistin levels in adipose tissues and serum in high-fat fed mice and genetically obese mice: development of an ELISA system for quantification of resistin. Arch Biochem Biophys 416:164-170
33. Bradford MM 1976 A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254
34. Alessi DR, Cuenda A, Cohen P, Dudley DT, Saltiel AR 1995 PD 98059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J Biol Chem 270:27489-27494
35. Engelman JA, Lisanti MP, Scherer PE 1998 Specific inhibitors of p38mitogen-activated protein kinase block 3T3-L1 adipogenesis. J Biol Chem 273:32111-32120
36. Brunn GJ, Sabers WJ, Wiederrecht G, Lawrence JC, Abraham RT 1996 Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002. EMBO J 15:5256-5267
37. Arco AD, Peralta S, Carrascosa JM, Ros M, Andres A, Arribas C 2003 Alternative splicing generates a novel non-secretable resistin isoform in Wistar rats. FEBS Lett 555:243-249
38. Akeno N, Robins J, Zhang M, Czyzyk-Krzeska MF, Clemens TL 2002 Induction of vascular endothelial growth factor by IGF-I in osteoblast-like cells is mediated by the PI3K signaling pathway through the hypoxia-inducible factor-2alpha. Endocrinology 143:420-425
39. Gutierrez J, Parrizas M, Maestro MA, Navarro I, Plisetskaya EM 1995 Insulin and IGF-I binding and tyrosine kinase activity in fish heart. J Endocrinol 146:35-44
40. Song H, Shojima N, Sakoda H, Ogihara T, Fujishiro M, Katagiri H, Anai M, Onishi Y, Ono H, Inukai K, Fukushima Y, Kikuchi M, Shimano H, Yamada N, Oka Y, Asano T 2002 Resistin is regulated by C/EBPs, PPARs, and signal-transducing molecules. Biochem Biophys Res Commun 299:291-298
41. Gual P, Baron V, Lequoy V, Obberghen EV 1998 Interaction of Janus kinases JAK-1 and JAK-2 with the insulin receptor and the insulin-like growth factor-1 receptor. Endocrinology 139:884-893
42. Boney CM, Sekimoto H, Gruppuso PA, Frackelton AR 2001 Src family tyrosine kinases participate in insulin-like growth factor I mitogenic signaling in 3T3-L1 cells. Cell Growth Different 12:379-386
43. Seo JB, Noh MJ, Yoo EJ, Park SY, Park J, Lee IK, Park SD, Kim JB 2003 Functional characterization of the human resistin promoter with adipocyte determination-and differentiation-dependent factor 1/sterol regulatory element binding protein 1c and CCAAT enhancer binding protein-α. Mol Endocrinol 17:1522-1533
44. Hartman HB, Hu X, Tyler KX, Dalal CK, Lazar MA 2002 Mechanisms regulating adipocyte expression of resistin. J Biol Chem 277:19754-19761
45. Nogueiras R, Gualillo O, Caminos JE, Casanueva FF, Dieguez C 2003 Regulation of resistin by gonadal, thyroid hormone, and nutritional status. Obes Res 11:408-414
46. Felipe F, Bonet ML, Ribot J, Palou A 2004 Modulation of resistin expression by retinoic acid and vitamin a status. Diabetes 53:882-889
47. Lazar DF, Wiese RJ, Brady MJ, Mastick CC, Waters SB, Yamauchi K, Pessin JE, Cuatrecasas P, Saltiel AR 1995 Mitogen-activated protein kinase kinase inhibition does not block the stimulation of glucose utilization by insulin. J Biol Chem 270:20801-20807
48. Hana V, Silha JV, Justova V, Lacinova Z, Stepan JJ, Murphy LJ 2004 The effects of GH replacement in adult GH-deficient patients: changes in body composition without concomitant changes in the adipokines and insulin resistance. Clin Endocrinol 60:442-450
Chapter 2
1. Steppan CM, Bailey ST, Bhat S 2001 The hormone resistin links obesity to diabetes. Nature 409:307-312
2. Kim KH, Lee K, Moon YS, Sul HS 2001 A cysteine-rich adipose tissue-specific secretory factor inhibits adipocyte differentiation. J Biol Chem 276:11252-11256
3. Ghosh SG, Singh AK, Aruna B, Mukhopadhyay S, Ehtesham NZ 2003 The genomic organization of mouse resistin reveals major differences from the human resistin: functional implications. Gene 305:27-34
4. Steppan CM, Brown EJ, Wright CM 2001 A family of tissue-specific resistin-like molecules. Proc Natl Acad Sci USA 98:502-506
5. Banerjee RR, Rangwala SM, Shapiro JS 2004 Regulation of fasted blood glucose by resistin. Science 303:1195-1198
6. Moon B, Kwan JJ, Duddy N, Sweeney G, Begum N 2003 Resistin inhibits glucose uptake in L6 cells independently of changes in insulin signaling and GLUT4 translocation. Am J Physiol Endocrinol Metab 285:E106-115 (Epub 2003 Mar 04)
7. Verma S, Li SH, Wang CH, Fedak PWM, Li RK, Weisel RD, Mickle DAG 2003 Resistin promotes endothelial cell activation further evidence of adipokine-endothelial interaction. Circulation 108:736-740
8. Degawa-Yamauchi M, Bovenkerk J, Juliar BE 2003 Serum resistin (FIZZ3) protein is increased in obese humans. J Clin Endocrinol Metab 88:5452-5455
9. Engert JC, Vohl MC, Williams SM 2002 5’flanking variants of resistin are associated with obesity. Diabetes 51:1629-2002
10. Pizzuti A, Argiolas A, Paola RD 2002 An ATG repeat in the 3’-untranslated region of the human resistin gene is associated with a decreased risk of insulin resistance. J Clin Endocrinol Metab 87:4403-4406
11. Youn BS, Yu KY, Park HJ 2004 Plasma resistin concentrations measured by enzyme-linked immunosorbent assay using a newly developed monoclonal antibody are elevated in individuals with type 2 diabetes mellitus. J Clin Endocrinol Metab 89:150-156
12. Fasshauer M, Paschke R 2003 Regulation of adipocytokines and insulin resistance. Diabetologia 46:1594-1603
13. Banerjee RR, Lazar MA 2003 Resistin: molecular history and prognosis. J Mol Med 81: 218-226
14. Rusznyak S, Szent-Gyorgyi A 1936 Vitamin P: flavanols as vitamins. Nature 138:27
15. Liao S, Kao YH, Hiipakka RA 2001 Green tea: biochemical and biological basis for health benefits. Vitam Horm 62:1-94
16. Yang CS,Wang ZY 1993 Tea and cancer. J Natl Cancer Inst 85:1038-1049
17. Ahmad N, Mukhtar H 1999 Green tea polyphenols and cancer: biologic mechanisms and practical implications. Nutr Rev 57:78-83
18. Haqqi TM, Anthony DD, Gupta S 1999 Prevention of collagen-induced arthritis in mice by a polyphenolic fraction from green tea. Proc Natl Acad Sci USA 96:4524-4529
19. Choi JY, Park CS, Kim DJ 2002 Prevention of nitric acid-mediated 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson’s disease in mice by tea phenolic epigallocatechin 3-gallate. Neurotoxicology 23:367-374
20. Song EK, Hur H, Han MK 2003 Epigallocatechin gallate prevents autoimmune diabetes induced by multiple low doses of streptozotocin in mice. Arch Pharm Res 26: 559-563
21. Kao YH, Hiipakka RA, Liao S 2000 Modulation of endocrine systems and food intake by green tea epigallocatechin gallate. Endocrinology 141:980-987
22. Kao YH, Hippakka RA, Liao S 2000 Modulation of obesity by a green tea catechin. Am J Clin Nutr 72:1232-1241
23. Wu LY, Juan CC, Hwang LS, Hsu YP, Ho PH, Ho LT 2004 Green tea supplementation ameliorates insulin resistance and increases glucose transporter IV content in a fructose-fed rat model. Eur J Nutr 43:116-124
24. Waltner-Law ME, Wang XL, Law BK, Hall RK, Nawano M, Granner DK 2002 Epigallocatechin gallate, a constituent of green tea, represses hepatic glucose production. J Biol Chem 277:34933-34940
25. Dulloo AG, Seydoux J, Girardier L, Chantre P, Vandermander J 2000 Green tea and thermogenesis: interaction between catechin-polyphenols, caffeine and sympathetic activity. Int J Obes Relat Metab Disord 24:252-258
26. Yeh CW, Chen WJ, Chiang CT, Lin-Shiau SY, Lin JK 2003 Suppression of fatty acid synthase in MCF-7 breast cancer cells by tea and tea polyphenols: a possible mechanism for their hypolipidemic effects. Pharmacogenomics J 3:267-276
27. Kobayashi Y, Suzuki M, Satsu H 2000 Green tea polyphenols inhibit the sodium-dependent glucose transporter of intestinal epithelial cells by a competitive mechanism. J Agric Food Chem 48:5618-5623
28. Shojima N, Sakoda H, Ogihara T 2002 Humoral regulation of resistin expression in 3T3-L1 and mouse adipose cells. Diabetes 51:1737-1744
29. Kawashima J, Tsuruzoe K, Motoshima H 2003 Insulin down-regulates resistin mRNA through the synthesis of protein(s) that could accelerate the degradation of resistin mRNA in 3T3-L1 adipocytes. Diabetologia 46:231-240
30. Zhong Q, Lin CY, Clarke KJ, Kemppainen RJ, Schwartz DD, Judd RL 2002 Endothelin-1 inhibits resistin secretion in 3T3-L1 adipocytes. Biochem Biophys Res Commun 16:383-387
31. Ramirez-Zacarias JL, Castro-Munozledo F, Kuri-Harcuch W 1992 Quantitation of adipose conversion and triglycerides by staining intracytoplasmic lipids with Oil red O. Histochemistry 97:493-497
32. Yang LC, Yang SH, Tai KW, Chou MY, Yang JJ 2004 MEK inhibition enhances bleomycin A5-induced apoptosis in an oral cancer cell line: signaling mechanisms and therapeutic opportunities. J Oral Pathol Med 33:37-45
33. Reischl U, Ruger R, Kessler C 1994 Nonradioactive labeling and high sensitive detection of PCR products. Mol Biotechnol 1: 229-240
34. Kokontis JM, Hay N, Liao S 1998 Progression of LNCaP prostate tumor cells during androgen deprivation: hormone-independent growth, repression of proliferation by androgen, and role for p27Kip1 in androgen-induced cell cycle arrest. Mol Endocrinol 12:941-953
35. Bradford MM 1976 A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254
36. Maebuchi M, Machidori M, Urade R, Ogawa T, Moriyama T 2003 Low resistin levels in adipose tissues and serum in high-fat fed mice and genetically obese mice: development of an ELISA system for quantification of resistin. Arch Biochem Biophys 416:164-170
37. Alessi DR, Cuenda A, Cohen P, Dudley DT, Saltiel AR 1995 PD 98059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J Biol Chem 270:27489-27494
38. Tachibana H, Koga K, Fujimura Y, Yamada K 2004 A receptor for green tea polyphenol EGCG. Nature Structural Mol Biol 11:380-381
39. Niimi T, Kumagai C, Okano M, Kitagawa Y 1997 Differentiation-dependent expression of laminin-8 (alpha 4 beta 1 gamma 1) mRNAs in mouse 3T3-L1 adipocytes. Matrix Biol 16:223-230
40. Nam S, Smith DM, Dou QP 2001 Ester bond-containing tea polyphenols potently inhibit proteasome activity in vitro and in vivo. J Biol Chem 276:13322-13330
41. Song H, Shojima N, Sakoda H 2002 Resistin is regulated by C/EBPs, PPARs, and signal-transducing molecules. Biochem Biophys Res Commun 299:291-298
42. Seo JB, Noh MJ, Yoo EJ 2003 Functional characterization of the human resistin promoter with adipocyte determination-and differentiation-dependent factor 1/sterol regulatory element binding protein 1c and CCAAT enhancer binding protein-α. Mol Endocrinol 17:1522-1533
43. Hartman HB, Hu X, Tyler KX, Dalal CK, Lazar MA 2002 Mechanisms regulating adipocyte expression of resistin. J Biol Chem 277:19754-19761
44. Felipe F, Bonet ML, Ribot J, Palou A 2004 Modulation of resistin expression by retinoic acid and vitamin a status. Diabetes 53:882-889
45. Parker JC 2002 Troglitazone: the discovery and development of a novel therapy for the treatment of Type 2 diabetes mellitus. Adv Drug Delivery Rev 54:1173-1197
46. Suetsug M, Su L, Karlsberg K, Yuan YC, Chen S 2003 Flavone and isoflavone phytoestrogens are agonists of estrogen-related receptors. Mol Cancer Res 1:981-991
47. Dulloo AG, Duret C, Rohrer D 1999 Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans. Am J Clin Nutr 70:1040-1045
Chapter 3
1. Steppan CM, Bailey ST, Bhat S, Brown EJ, Banerjee RR, Wright CM, Patel HR, Ahima RS, Lazar MA 2001 The hormone resistin links obesity to diabetes. Nature 409:307-312
2. Ukkola O 2002 Resistin—a mediator of obesity-associated insulin resistance or an innocent bystander? Eur J Endocrinol 147:571–574
3. Steppan CM, Lazar MA 2002 Resistin and obesity-associated insulin resistance. Trends Endocrinol Metab 13:18–23
4. Hotamisligil GS 2003 The irresistible biology of resistin. J Clin Invest 111:173–174
5. Rajala MW, Obici S, Scherer PE, Rossetti L 2003 Adipose-derived resistin and gut-derived resistin-like molecule-beta selectively impair insulin action on glucose production. J Clin Invest 111:225–230
6. Banerjee RR, Rangwala SM, Shapiro JS, Rich AS, Rhoades B, Qi Y, Wang J, Rajala MW, Pocai A, Scherer PE, Steppan CM, Ahima RS, Obici S, Rossetti L, Lazar MA 2004 Regulation of fasted blood glucose by resistin. Science 303:1195-1198
7. Kim KH, Lee K, Moon YS, Sul HS 2001 A cysteine-rich adipose tissue-specific secretory factor inhibits adipocyte differentiation. J Biol Chem 276:11252–11256
8. Song H, Shojima N, Sakoda H, Ogihara T, Fujishiro M, Katagiri H, Anai M, Onishi Y, Ono H, Inukai K, Fukushima Y, Kikuchi M, Shimano H, Yamada N, Oka Y, Asano T 2002 Resistin is regulated by C/EBPs, PPARs, and signal-transducing molecules. Biochem Biophys Res Commun 299:291-298
9. Seo JB, Noh MJ, Yoo EJ, Park SY, Park J, Lee IK, Park SD, Kim JB 2003 Functional characterization of the human resistin promoter with adipocyte determination- and differentiation-dependent factor 1/sterol regulatory element binding protein 1c and CCAAT enhancer binding protein-alpha. Mol Endocrinol. 17(8):1522-33
10. Fasshauer M, Paschke R 2003 Regulation of adipocytokines and insulin resistance. Diabetologia 46:1594-1603
11. Shojima N, Sakoda H, Ogihara T, Fujishiro M, Katagiri H, Anai M, Onishi Y, Ono H, Inukai K, Abe M, Fukushima Y, Kikuchi M, Oka Y, Asano T 2002 Humoral regulation of resistin expression in 3T3-L1 and mouse adipose cells. Diabetes 51:1737-1744
12. Banerjee RR, Lazar MA 2003 Resistin: molecular history and prognosis. J Mol Med 81: 218-226
13. Oliver P, Pico C, Serra F, Palou A 2003 Resistin expression in different adipose tissue depots during rat development. Mol Cell Biochem 252:397-400
14. Viengchareun S, Zennaro M, Tallec LP, Lombes M 2002 Brown adipocytes are novel sites of expression and regulation of adiponectin and resistin. FEBS Lett 532:345-350
15. Way JM, Gorgun CZ, Tong Q, Uysal KT, Brown KK, Harrington WW, Oliver WR, Willson TM, Kliewert SA, Hotamisligil GS 2001 Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisome proliferators-activated receptor g agonists. J Biol Chem 276:25651-25653
16. Kawashima J, Tsuruzoe K, Motoshima H, Shirakami A, Sakai K, Hirashima Y, Toyonaga T, Araki E 2003 Insulin down-regulates resistin mRNA through the synthesis of protein(s) that could accelerate the degradation of resistin mRNA in 3T3-L1 adipocytes. Diabetologia 46:231-240
17. Zhong Q, Lin CY, Clarke KJ, Kemppainen RJ, Schwartz DD, Judd RL 2002 Endothelin-1 inhibits resistin secretion in 3T3-L1 adipocytes. Biochem Biophys Res Commun 16:383-387
18. Delhanty PJ, Mesotten D, Mcdougall F, Baxter RC 2002 Growth hormone rapidly induces resistin gene expression in white adipose tissue of spontaneous dwarf (SDR) rats. Endocrinology 143:2445-24448
19. Nogueiras R, Gualillo O, Caminos JE, Casanueva FF, Dieguez C. 2003 Regulation of resistin by gonadal, thyroid hormone, and nutritional status. Obes Res. 11(3):408-14
20. Katzenellenbogen, B. S. 1996 Estrogen receptors: bioactivities and interactions with cell signaling pathways. Biol. Reprod. 54, 287–293
21. George G. J. M. Kuiper, Eva Enmark, Markku Pelto-Huikko, Stefan Nilsson, and Jan-Åke Gustafsson 1996 Cloning of a novel estrogen receptor expressed in rat prostate and ovary. PNAS 93: 5925-5930
22. Shaun M. Cowley, Susan Hoare, Sietse Mosselman, and Malcolm G. Parker 1997 Estrogen receptors and form heterodimers on DNA. J. Biol. Chem. 272: 19858-19862
23. Ciocca, D. R., and Roig, L. M. V. 1995 Estrogen receptors in human nontarget tissues: biological and clinical implications. Endocr. Rev. 16, 35-62
24. S. J. Lazzarini and G. N. Wade 1991 Role of sympathetic nerves in effects of estradiol on rat white adipose tissue. Am J Physiol Regul Integr Comp Physiol 260: R47-R51
25. Gura T. 1995 Estrogen: key player in heart disease among women. Science 11;269(5225):771-3
26. Wade, G. N., and Gray, J. M. 1978 Cytoplasmic 17 beta-[3H]estradiol binding in rat adipose tissues. Endocrinology 103, 1695-1701
27. Pedersen, S. B., Borglum, J. D., Eriksen, E. F., and Richelsen, B. 1991 Nuclear estradiol binding in rat adipocytes. Regional variations and regulatory influences of hormones. Biochim. Biophys. Acta 1093, 80-86
28. Pedersen, S. B., Borglum, J. D., Moller-Pedersen, T., and Richelsen, B. 1992 Effects of in vivo estrogen treatment on adipose tissue metabolism and nuclear estrogen receptor binding in isolated rat adipocytes. Mol. Cell. Endocrinol. 85, 13-19
29. Naaz A, Zakroczymski M, Heine P, Taylor J, Saunders P, Lubahn D, Cooke PS 2002 Effect of ovariectomy on adipose tissue of mice in the absence of estrogen receptor alpha (ERalpha): a potential role for estrogen receptor beta (ERbeta) Horm Metab Res. 34(11-12):758-63
30. Xie P, Liu ML, Gu YP, Lu J, Xu X, Zeng WM, Song HP 2003 Oestrogen improves glucose metabolism and insulin signal transduction in HepG2 cells. Clin Exp Pharmacol Physiol 30(9):643-8
31. Kumagai S, Holmang A, Bjorntorp P. 1993 The effects of oestrogen and progesterone on insulin sensitivity in female rats. Acta Physiol Scand. 149(1):91-7
32. Kimmerle R, Heinemann L, Heise T, Bender R, Weyer C, Hirschberger S, Berger M 1999 Influence of continuous combined estradiol-norethisterone acetate preparations on insulin sensitivity in postmenopausal nondiabetic women. Menopause 6(1):36-42
33. Lindheim SR, Duffy DM, Kojima T, Vijod MA, Stanczyk FZ, Lobo RA. 1994 The route of administration influences the effect of estrogen on insulin sensitivity in postmenopausal women. Fertil Steril. 62(6):1176-80
34. Louet JF, LeMay C, Mauvais-Jarvis F 2004 Antidiabetic actions of estrogen: insight from human and genetic mouse models. Curr Atheroscler Rep. 6(3):180-5
35. Gonzalez C, Alonso A, Diaz F, Patterson AM. 2003 Dose- and time-dependent effects of 17beta-oestradiol on insulin sensitivity in insulin-dependent tissues of rat: implications of IRS-1. J Endocrinol. 176(3):367-79
36. Kao YH, Hippakka RA, Liao S 2000 Modulation of obesity by a green tea catechin. Am J Clin Nutr 72:1232-1241
37. Ramirez-Zacarias JL, Castro-Munozledo F, Kuri-Harcuch W 1992 Quantitation of adipose conversion and triglycerides by staining intracytoplasmic lipids with Oil red O. Histochemistry 97:493-497
38. Reischl U, Ruger R, Kessler C 1994 Nonradioactive labeling and high sensitive detection of PCR products. Mol Biotechnol 1: 229-240
39. Mathias Fasshauer, Johannes Klein, Susanne Neumann, Markus Eszlinger and Ralf Paschke 2001 Isoproterenol inhibits resistin gene expression through a GS-protein-coupled pathway in 3T3-L1 adipocytes. FEBS Letters 500:60-63
40. Kokontis JM, Hay N, Liao S 1998 Progression of LNCaP prostate tumor cells during androgen deprivation: hormone-independent growth, repression of proliferation by androgen, and role for p27Kip1 in androgen-induced cell cycle arrest. Mol Endocrinol 12:941-953
41. Eilertson CD, Sheridan MA 1995 Pancreatic somatostatin-14 and somatostatin-25 release in rainbow trout is stimulated by glucose and arginine. Am J Physiol 269:R1017-1023
42. Maebuchi M, Machidori M, Urade R, Ogawa T, Moriyama T 2003 Low resistin levels in adipose tissues and serum in high-fat fed mice and genetically obese mice: development of an ELISA system for quantification of resistin. Arch Biochem Biophys 416:164-170
43. Bradford MM 1976 A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254
44. Ulrich Laufs, Oliver Adam, and Georg Nickenig 2003 Down-regulation of Rac-1 GTPase by Estrogen. J Biol Chem 278:5956–5962
45. Florence Machinal, Marie-Noelle Dieudonne, Marie-Christine Leneveu, Rene Pecquery and Yves Giudicelli 1999 In Vivo and in Vitro ob Gene Expression and Leptin secretion in rat adipocytes: Evidence for a regional specific regulation by sex steroid hormones. Endocrinology 140: 1567-1574
46. Robert X. Song, Christopher J. Barnes, Zhenguo Zhang, Yongde Bao, Rakesh Kumar, and Richard J. Santen 2004 The role of Shc and insulin-like growth factor 1 receptor in mediating the translocation of estrogen receptor α to the plasma membrane. PNAS 101:2076-2081
47. Stefan Kahlert, Simone Nuedling, Martin van Eickels, Hans Vetter, Rainer Meyer, and Christian Grohe 2000 Estrogen receptor α rapidly activates the IGF-1 receptor pathway J Biol Chem 275:18447-18453
48. Eing-Mei Tsai, Shao-Chun Wang, Jau-Nan Lee, and Mien-Chie Hung 2001 Akt activation by estrogen in estrogen receptor-negative breast cancer cells. Cancer research 61:8390-8392
49. Eulalia Pozo-Guisado, M. Jesu’s Lorenzo-Benayas, and Pedro M. Ferandez-Salguero 2003 Resveratrol modulates the PI-3K pathway through an estrogen receptor α-dependent mechanism: relevance in cell proliferation. Int. J. Cancer 109: 167–173
50. Mori-Abe A, Tsutsumi S, Takahashi K, Toya M, Yoshida M, Du B, Kawagoe J, Nakahara K, Takahashi T, Ohmichi M, Kurachi H 2003 Estrogen and raloxifene induce apoptosis by activating p38 mitogen-activated protein kinase cascade in synthetic vascular smooth muscle cells. J Endocrinol. 178:417-426
51. Helen B. Hartman, Xiao Hu, Keala X. Tyler, Chiraj K. Dalal, and Mitchell A. Lazar 2002 Mechanisms regulating adipocyte expression of resistin. J. Biol. Chem 277:19754-19761
52. Ling C, Kindblom J, Wennbo H, Billig H 2001 Increased resistin expression in the adipose tissue of male prolactin transgenic mice and in male mice with elevated androgen levels. FEBS Lett. 507:147-50
53. Monika Jakacka, Masafumi Ito, Jeffrey Weiss, Pei-Yu Chien, Barry D. Gehm, and J. Larry Jameson 2001 Estrogen receptor binding to DNA Is not required for its activity through the nonclassical AP1 pathway. J. Biol. Chem 276:13615-13621
54. Venkatesh Krishnan, Xiahong Wang, and Stephen Safe 1994 Estrogen Receptor-Spl Complexes Mediate estrogen-induced cathepsin D gene expression in MCF-7 human breast cancer cells J. Biol. Chem 269:15912-15917
55. Kato, S., Endoh, H., Masuhiro, Y., Kitamoto, T., Uchiyama, S., Sasaki, H., Masushige, S., Gotoh, Y., Nishida, E., Kawashima, H., Metzger, D., and Chambon, P 1995 Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase. Science 270, 1491–1494
56. Francisco Felipe, M. Luisa Bonet, Joan Ribot, and Andreu Palou 2004 Modulation of resistin expression by retinoic acid and vitamin A status. Diabetes 53:882-889
57. Fasshauer M, Klein J, Neumann S, Eszlinger M, Paschke R 2001 Tumor necrosis factor alpha is a negative regulator of resistin gene expression and secretion in 3T3-L1 adipocytes. Biochem Biophys Res Commun. 288:1027-31
58. Imai Y, Tsukahaw S, Asada S, Sugimoto Y 2004 Phytoestrogens/flavonoids reverse breast cancer resistance protein/ABCG2-mediated multidrug resistance. Cancer. Res. 64:4046-52
59. Takahashi M, Nakae D. 2004 Effect of estrogen and metabolites on endometrial carcinogenesis in young adult mice initiated with N-ethyl-N-nitro-N-nitrosoguanidine. Cancer lett. 211:1-9.
60. Zhi-Chao Dang, Vale´rie Audinot, Socrates E. Papapoulos, Jean A. Boutin, and Clemens W. G. M. Lo¨wik 2003 Peroxisome Proliferator-activated Receptorγ (PPARγ) as a Molecular Target for the Soy Phytoestrogen Genistein* J. Biol. Chem 278:962-67
61. Shao-Chun Lu, Wei-Yeong Shieh, Chia-Ying Chen, Shu-Ching Hsu, Hui-Ling Chen 2002 Lipopolysaccharide increases resistin gene expression in vivo and in vitro. FEBS Letters 530:158-62
指導教授 高永旭(Yung-Hsi Kao) 審核日期 2004-7-8
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