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姓名 丁挺洲(Ting-Jou Ding)  查詢紙本館藏   畢業系所 光電科學與工程學系
論文名稱 以EWOD為基礎的長鏈高分子原位合成器
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摘要(中) 本文探討二維介電質電濕式(electrowetting on dielectric, EWOD)微流體系統的設計與製作,並利用此微流體系統來做胜肽合成(Peptide Synthesis)反應的應用。利用立體結構將表面控制電極與底層的外接電路隔開,可以有效解決介電質電濕式微流體元件在增加控制電極數目成為二維陣列時,內部控制電極無法布線的問題。使用立體結構的方法製作的二維EWOD元件,在大氣環境下的操作電壓約為30伏特。其次,利用self-assembly monolayer(SAM) FTS分子鍵結的成膜方式來取代傳統使用Teflon spin-coating 方式來製作的疏水層。以此方法製作的疏水層可以防止疏水層在物理碰觸或外加高電壓時產生疏水膜破裂的現象。因此可使微流體元件更加穩固、容易清洗、耐用、亦可重複使用。
另外,利用介電質電濕式微流體元件進行胜肽合成(Peptide synthesis)反應,分別以Wang resin 和Au@Fe奈米粒子作為固體基材,分別進行兩種胺基酸的接合反應,並研究胺基酸接合情形。藉此提出以EWOD為基礎的長鏈高分子原位合成器。
關鍵字(中) ★ 胜肽合成
★ 胺基酸
★ 介電質電濕式
關鍵字(英) ★ peptide synthesis
★ Amino Acid
★ EWOD
論文目次 論文摘要 i
目錄 ii
圖索引 iv
表索引 viii
第一章 導論 1
第二章 微流體的驅動 11
2.1 微流體驅動的原理 11
2.2 表面張力 12
2.3 使用表面張力的微驅動器 15
2.3.1 電毛細管作用 15
2.3.2 Continuous Electrowetting 16
2.3.3 Electrowetting 18
2.3.4 Electrowetting on Dielectric(EWOD) 20
2.4 微流體的裝置 22
第三章 設計與製造 23
3.1 EWOD 元件 23
3.2 Self-assembly monolayer 25
3.3 以EWOD 為基礎的微流體系統設計 28
3.4 總結 42
第四章 測試 43
4.1 實驗裝置 43
4.2 SAM(FTS)接觸角的量測 46
4.3 表面FTS 物理吸附之測試 51
4.4 SAM(FTS)成長時間之測試 53
4.5 二維系統操控測試 56
4.6 總結 63
第五章 應用 64
5.1 胜肽合成 65
5.2 胜肽合成實驗流程 70
5.3 胜肽合成實驗測試 78
第六章 結論 87
參考資料 89
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指導教授 楊宗勳(Tsung-Hsun Yang) 審核日期 2005-7-13
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