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姓名 陳鑫昌(Hsin-Chang Chen) 查詢紙本館藏 畢業系所 化學學系 論文名稱 液相層析串聯質譜技術針對新興污染物微量分析之方法開發與應用
(Liquid chromatography-tandem mass spectrometryin trace analysis of selected emerging contaminants-Method development and applications)相關論文 檔案 [Endnote RIS 格式]
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摘要(中) 近年來在環境檢測方面，科學家對於新興污染物(emerging contaminants, ECs)已產生
濃厚的興趣與關注。新興污染物定義為“新認定”或“之前未定確認”的污染物，包含日常
生活用品如：界面活性劑及其殘留物、個人護理用品、汽油添加劑、塑化劑及各種工業
添加劑等。由於新興污染物的蹤跡、風險評估及其生物毒性資訊均難以獲得，對於人體
及水中生物體所造成的影響亦是難以預估的。而造成資訊難以獲得的主要因素之一則是
因為欠缺適當的微量方析分法，以致無法對於環境中新興污染物進行有效的監測與評
估。由於環境樣品中基質複雜且濃度微量，偵測此類新興污染物需以最適當分析方法檢
測，並搭配有效的前處理方式將待測物濃縮淨化，以避免在偵測時產生干擾。常用檢測
方式是以層析方法搭配質譜儀以達到分離及質量與結構鑑定之定性與定量目的。本研究
將以液相層析串聯質譜技術(liquid chromatography/tandem mass spectrometry, LC-MS-MS)
在微量分析上的方法開法與應用，並根據待測物的極性程度及酸鹼性質找尋適當的游離
源，結合串聯質譜技術 (MS-MS) 對待測物進行結構鑑定並有效提升靈敏度。
本研究首先針對四個苯二乙烯類及一個二苯乙烯聯苯類之強離子性螢光增白劑
(fluorescent whitening agents, FWAs)，發展出一套穩定且可靠的微量檢測技術，藉由探討
兩種不同固相萃取管柱對回收率及離子抑制效應之影響，尋找出一套較佳之樣品前處理
方法，偵測水環境中之螢光增白劑含量。利用揮發性離子配對-液相層析，以電灑游離
法(electrospray ionization, ESI)結合離子阱二次質譜技術對待測物在複雜基質中進行定
性以確定分析物結構，並選定特徵斷裂離子作為定量，藉此亦可提高靈敏度及降低偵測
極限。在最佳之樣品前處理方法搭配層析分離方法與最佳之游離條件下，偵測極限可達
4 – 18 ng/L，檢量線r2值均大於0.995。在分析方法之精密度與準確度分別小於13%及
11%，且平均回收率為68% – 97%。將此方法應用至廢污水處理廠放流水與河流水樣中，
皆可偵測到五種螢光增白劑的存在，濃度為n.d. – 1580 ng/L。
藉由上述方法之開發，進而將樣品類別延伸至餐巾紙、嬰幼兒衣物等商業化產品
上。樣品先經由熱水萃取法(hot-water extraction)萃取固體樣品中之螢光增白劑，將萃取
濾液以Oasis WAX固相萃取管柱萃取，再以揮發性離子配對LC-MS-MS 檢測之。回收
率為42 – 95%，相對標準偏差均小於11%。初步結果顯示螢光增白劑在餐巾紙中的含量
為n.d. – 4.2 mg/g、在衛生紙中含量為n.d. – 7.0 ng/g、在嬰幼兒衣物中之含量為n.d. – 118
mg/g。檢測出之主要物質為兩種苯二乙烯類螢光增白劑。
由於研究強陰離子型化合物之概念已成型，因此在研究的第三部份，則是探討弱酸
鹼性等極性化合物的檢測方法開發，在此方法中選擇新興污染物中漸受重視的藥物殘留
物(pharmaceuticals residues)作為研究對象。此部份主要是發展一套快速、可靠且穩定的
分析方法，研究這類藥物殘留物在台灣水環境中的流布與含量。藉由最佳的層析分離與
游離化條件，搭配良好的固相萃取方法(solid-phase extraction, SPE)，可達到濃縮及移除
干擾物質之目的。實驗結果顯示LC流速設定為0.2 mL/min，搭配ESI並結合MS-MS
可得到較佳的感度。其偵測極限可達0.5 – 20 ng/L。利用此方法針對民生廢污水及河流
水樣進行檢測，發現在民生廢污水及河流水樣均可測得藥物殘留物的存在，且最高濃度
可達960 ng/L。
在本研究的最後部份則是針對非離子性的雌激素化合物(estrogenic compounds)以三
種不同離子源游離偵測，探討游離效率及基質干擾在分析含有複雜基質的真實樣品過程
中所造成的影響，試以較適當的離子源搭配MS-MS，降低基質所造成的離子抑制現象。
研究結果顯示，ESI及摻雜劑輔助之大氣壓力光游離法(dopant-assisted atmospheric
pressure photoionzation, DA-APPI)對雌激素化合物具較好的游離效率及感度。以去鹽萃
取法(de-salting extraction)結合SPE，針對含有複雜基質的廢污水樣進行樣品前處理，再
以LC-MS-MS搭配ESI及DA-APPI，探討基質干擾所造成之離子抑制現象，並利用此
兩種游離法之互補的特性，以補足單一游離法在複雜基質水樣中雌激素化合物的定量。
ESI的平均離子抑制因子為52 ± 5%；而DA-APPI之平均離子抑制因子為27 ± 7%。在
LC-ESI-MS-MS 的系統中，當水樣為含有複雜基質之廢污水進流水(influent)時，其感度
與游離效率均明顯降低。廢污水進流水與放流水中均可測得雌激素化合物的存在，在進
流水中之濃度為n.d. – 230 ng/L，而在放流水中之濃度為 n.d. – 28.5 ng/L。此部份的研究
結果顯示，利用具有較低偵測極限之ESI方法輔以具有較高基質容忍度之DA-APPI游
離技術，對於複雜基質中之雌激素化合物之定量可達相輔相成的作用。
由本論文中之結果可得知新興污染物的檢測不易，尤其在利用LC-MS 時，具有不
同官能基性質之新興污染物對質譜游離方式亦有不同的感度與限制，因此檢測方法的開
發與最佳化需要投入更多的研究才能獲得高品質的結果。新興污染物除了存在於環境
中，亦存在於我們的日常生活。此類新興污染物之存在主要都是經由不當的使用及排放
所造成，因此希望藉由此研究結果，有助於提升國人的環保意識，建立適當的使用及排
放標準，以減輕人類對環境所造成的負擔。摘要(英) In recent years, the development of new sensitive methods for detecting chemicals and
determining biological effects of emerging contaminants (ECs) has shifted attention of the
scientific community toward new undetected unregulated contaminants or those that had not
been considered as a risk. Notably, ECs, which are defined as newly identified or previously
unrecognized pollutants, primarily comprise products utilized in large quantities in everyday
life such as fluorescent whitening agents (FWAs), human and veterinary pharmaceuticals,
personal care products, surfactants and surfactant residues, plasticizers and various industrial
additives. However, little information of these chemicals is available, and it is difficult to
predict the impacts on ecobiological environment, public health and safety. The reason of a
lack of information for ECs is a lack of analytical methods for determining trace
concentrations. Analyzing ECs is extremely challenging, not only due to the diversity of
chemical properties of ECs, but also because of the typically low concentrations and matrix
complexities. Novel analytical methodologies for ECs containing different polarities and
functional groups are presented in this thesis that detected EC content in environmental
samples.
The first part of this thesis developed and validated a comprehensive method for
determining trace amounts of five ionic FWAs in environmental water samples. Various
solid-phase extraction cartridges were evaluated regarding recoveries, abundance and ion
suppression effect. The new Oasis WAX-SPE cartridge generates optimal sample extraction
results. Analytes were then identified and quantified by liquid chromatography/electrospray
ionization tandem mass spectrometry (LC-ESI-MS-MS) in negative ionization mode,
applying di-n-hexylammonium acetate (DHAA) as the ion-pairing reagent in mobile phases.
Qualification with the MS-MS spectral comparison would confirm the presence of FWAs,
and selectivity and sensitivity can be improved using product ion scan technique. Limits of
quantification (LOQs) were established at 4 – 18 ng/L in 50 mL water samples. Intrabatch
and interbatch precision at two concentration levels was also investigated. Precision for
these five FWAs, as indicated by relative standard deviation (RSD), was <13 and 11% for the
intra- and interbatch, respectively. Accuracy, expressed as mean recovery, was 68 – 97%.
The proposed method was finally applied to environmental water samples. The
concentrations of selected FWAs in water samples were n.d. – 1580 ng/L. Preliminary
results demonstrated that five FWAs existed in river water and wastewater treatment plant
(WWTP) effluent samples.
In the second part, the proposed method for trace determination of five FWAs in
environmental water samples was further applied to paper materials and infant clothing. The
FWAs were extracted from paper material and cloth samples using hot-water extraction;
aqueous extracts were then effectively extracted with the Oasis WAX-SPE cartridge. The
analytes were accurately determined by ion-pair chromatography combined with negative
LC-ESI-MS-MS. The LOQs were 0.2 – 0.9 ng/g in 2g samples. Recovery of the five
FWAs in spiked commercial samples was 42 – 95% and %RSD (n = 3) was 2 – 11%. The
proposed method was finally applied to commercial samples, and the preliminary results
revealed that concentration of FWAs was n.d. – 4.2 mg/g in napkins, n.d. –7.0 ng/g in tissues,
and n.d. – 118 mg/g in infant clothes. The results also indicated that two stilbene-type
disulfonates were predominant in FWAs detected in napkin and infant clothing samples.
Because the analyses of ionic substances were well-developed in the 1st and 2nd parts, the
investigation of the third part focused on the occurrence and levels of selected acidic and
neutral pharmaceutical residues in Taiwanese river and wastewater samples. These
pharmaceutical residues were extracted from water samples using Oasis HLB-SPE. The
analytes were then identified and quantified using LC-MS-MS at a flow-rate of 0.2 mL/min
with dual-polarity ESI. The LOQs were 0.5 – 20 ng/L for 250 mL water samples. The
selected analytes were detected at concentrations of <0.5 – 960 ng/L in WWTP effluent and
river water samples.
Finally, three complementary LC-MS ionization methods, ESI, atmospheric pressure
chemical ionization (APCI) and atmospheric pressure photoionization (APPI) were evaluated
regarding the ion suppression effect in real samples containing complex matrix and optimized
to identify five neutral estrogens in influent and effluent of WWTPs. Wastewater samples
were first subjected to SPE coupled with desalting extraction to eliminate matrix interference.
As the abundances of ESI and dopant-assisted APPI (DA-APPI) were better than APCI, both
ionization methods with LC-MS-MS were utilized to detect five estrogenic compounds to
evaluate the ion suppression effect and complement detection and quantification of estrogenic
compounds in complex wastewater samples. Average ion suppression factors for extracts
from the WWTP influent—analyzed using ESI and APPI—were 52 ± 5% and 27 ± 7%,
respectively. Sensitivity and ionization efficiency of the LC-ESI-MS-MS system decreased
dramatically when a complicated matrix existed in the WWTP influent sample. Estrogenic
compounds were detected in WWTP influent and effluent samples at concentrations of n.d. –
230 ng/L and n.d. – 28.5 ng/L, respectively. The lower detection limits obtained when using
ESI and the high matrix tolerance of the APPI method facilitated complete quantification of estrogenic compounds in extremely complex samples in a complementary manner.
The dissertation reveals that the ionization efficiency and limitations vary due to diverse
chemical properties and different functional groups of ECs as LC-MS is utilized. As
difficulties are encountered during method development, more investigations are needed to
ensure the quality of developed and optimized analyzing methods. The preliminary results
of this dissertation also demonstrate that these ECs present not only in environment, but also
in our daily life because of improper use and discharge. Since little information exists
regarding the occurrence of FWAs, pharmaceuticals and estrogenic compounds in aquatic
environments in Taiwan, this study is significant in that it provides information regarding the
contents and fate of selected ECs in Taiwanese environments. Moreover, this study
promotes environmental protection and conservation, and support pollution-control policies
and sustainable development in Taiwan.關鍵字(中) ★ 固相萃取法
★ 新興污染物
★ 液相層析串聯質譜技術關鍵字(英) ★ solid-phase extraction
★ emerging contaminants
★ water analysis
★ Liquid chromatography-tandem mass spectrometry論文目次 Abstract................................................................................................................................I
Abstract in Chinese............................................................................................................ IV
Table of contents ................................................................................................................ VI
List of figures ...................................................................................................................VIII
List of tables........................................................................................................................ X
Abbreviation .....................................................................................................................XII
Chapter 1 Introduction........................................................................................................ 1
1.1 Research motivation................................................................................................. 1
1.2 The cycle of emerging contaminants ........................................................................ 5
1.3 Methods for detecting emerging contaminants.......................................................... 7
1.5 The purposes of this study...................................................................................... 16
1.6 Thesis Overview..................................................................................................... 19
References ................................................................................................................... 21
Chapter 2 Determination of FWAs in environmental waters by solid-phase extraction
and ion pair liquid chromatography-tandem mass spectrometry ................................... 28
2.1 Introduction............................................................................................................ 28
2.2 Experimental Section ............................................................................................. 34
2.2.1 Chemicals and Reagents .............................................................................. 34
2.2.2 Sample collection ........................................................................................ 34
2.2.3 SPE Procedure............................................................................................. 35
2.2.4 Chromatographic Conditions ....................................................................... 37
2.2.5 Mass Spectrometry...................................................................................... 38
2.3 Results and Discussion........................................................................................... 39
2.3.1 Optimization of LC-MS-MS analysis........................................................... 39
2.3.2 Optimization of SPE.................................................................................... 41
2.3.3 Method Validation ....................................................................................... 43
2.3.4 Applications................................................................................................. 45
2.4 Summary................................................................................................................ 48
References ................................................................................................................... 49
Chapter 3 The contents of FWAs in paper materials and infant clothes ......................... 53
3.1 Introduction............................................................................................................ 53
3.2 Experimental.......................................................................................................... 55
3.2.1 Chemicals and Reagents .............................................................................. 55
3.2.2 Sample preparation...................................................................................... 55
3.2.3 HPLC-ESI-MS-MS analysis ........................................................................ 56
3.3 Results and Discussion........................................................................................... 57
3.3.1 Optimization of LC-MS-MS analysis........................................................... 57
3.3.2 Analytical performance................................................................................ 59
3.3.3 Applications................................................................................................. 61
3.4 Summary................................................................................................................ 64
References ................................................................................................................... 65
Chapter 4 Using liquid chromatography-ion trap mass spectrometry to determine
pharmaceutical residues in Taiwanese rivers and wastewaters ....................................... 66
4.1 Introduction............................................................................................................ 66
4.2 Experimental.......................................................................................................... 70
4.2.1 Chemicals and reagents................................................................................ 70
4.2.2 Sample collection ........................................................................................ 70
4.2.3 Sample extraction........................................................................................ 71
4.2.4 LC-MS-MS analysis .................................................................................... 72
4.3 Results and discussion............................................................................................ 74
4.3.1 Optimization of LC-MS-MS analysis........................................................... 74
4.3.2 Method validation........................................................................................ 77
4.3.3 Application.................................................................................................. 79
4.4 Summary................................................................................................................ 84
References ................................................................................................................... 85
Chapter 5 Determination of estrogenic compounds in wastewater using LC-MS-MS with
ESI and APPI following desalting extraction.................................................................... 90
5.1 Introduction............................................................................................................ 90
5.2 Experimental.......................................................................................................... 94
5.2.1 Reagents and chemicals ............................................................................... 94
5.2.2 Sample collection ........................................................................................ 94
5.2.3 Sample pretreatment .................................................................................... 94
5.2.4 LC-MS-MS analysis .................................................................................... 96
5.3 Results and discussion............................................................................................ 99
5.3.1 Optimization of LC-MS-MS parameters ...................................................... 99
5.3.2 Comparison of thee API interfaces............................................................. 101
5.3.3 Method validation...................................................................................... 104
5.3.4 Evaluation of ion suppression in API-MS-MS ........................................... 106
5.3.5 Application of LC-MS-MS methods to WWTP wastewater samples...........110
5.4 Summary...............................................................................................................113
References ..................................................................................................................114
Chapter 6 Conclusions..................................................................................................... 120參考文獻 [1] Field, J.A., Johnson, C.A., Rose, J.B., What is “emerging”? Environ. Sci. Technol. 2006,
40, 7105.
[2] Glassmeyer, S.T., The cycle of emerging contaminants, Water Resour. IMPACT, 2007,
9(3), 5-7.
[3] Daughton, C.G., Emerging pollutants, and communicating the science of environmental
chemistry and mass spectrometry: pharmaceuticals in the environment, J. Am. Soc. Mass
Spectrum. 2001, 12, 1067-1076.
[4] Richardson, S.D., Environmental mass spectrometry, Anal. Chem. 2000, 72, 4477-4496.
[5] Richardson, S.D., Environmental mass spectrometry: Emerging contaminants and
current issues, Anal. Chem. 2002, 74, 2719-2742.
[6] Richardson, S.D., Environmental mass spectrometry: Emerging contaminants and
current issues, Anal. Chem. 2004, 76, 3337-3364.
[7] Richardson, S.D., Environmental mass spectrometry: Emerging contaminants and
current issues, Anal. Chem. 2006, 78, 4021-4045.
[8] Richardson, S.D., Water analysis: Emerging contaminants and current issues, Anal.
Chem. 2003, 75, 2831-2857.
[9] Richardson, S.D., Water analysis: Emerging contaminants and current issues, Anal.
Chem. 2005, 77, 3807-3838.
[10] Richardson, S.D., Water analysis: Emerging contaminants and current issues, Anal.
Chem. 2007, 79, 4295-4324.
[11] Peck, A.M., Analytical methods for the determination of persistent ingredients of
personal care products in environmental matrices, Anal. Bioanal. Chem. 2006, 386,
907-939.
[12] USGS (U.S. Geological Survey), Toxics Substances Hydrology Program – Emerging
Contaminants in the Environment. http://toxics.usgs.gov/regional/emc/, accessed March
2007.
[13] Younos, T., Emerging threats to drinking water quality, Renew. Res. J., 2005, 23(2),
6-12.
[14] Kolpin, D.W., Furlong, E.T., Meyer, M.T., Thurman, E.M., Zaugg, S.D., Barber, L.B.,
Buxton, H.T., Pharmaceuticals, hormones, and other organic wastewater contaminants
in U.S. streams, 1999-2000 – A national reconnaissance, Environ. Sci. Technol. 2002,
36, 1202-1211.
[15] Ashton, D., Hilton, M., Thomas, K.V., Investigating the environmental transport of
human pharmaceuticals to streams in the United Kingdom, Sci. Total Environ., 2004,
333, 167-184.
[16] Bendz, D., Paxeus, N.A., Ginn, T.R., Loge, F.J., Occurrence and fate of
pharmaceutically active compounds in the environment, a case study: Hoje river in
Sweden, J. Hazard. Mater., 2005, 122, 195-204.
[17] Kim, S.D., Cho, J., Kim, I.S., Vanderford, B.J., Snyder, S.A., Occurrence and removal
of pharmaceuticals and endocrine disruptors in South Korean surface, drinking, and
waste waters, Water Res. 2007, 41, 1013-1021.
[18] Yeung, L. W. Y., So, M. K., Jiang, G., Taniyasu, S., Yamashita, N., Song, M., Wu, Y.; Li,
J., Giesy, J. P., Guruge, K. S., Lam, P. K. S, Perfluorooctanesulfonate and Related
Fluorochemicals in Human Blood Samples from China. Environ. Sci. Technol. 2006, 40,
715-720.
[19] La Guardia, M.J., Hale, R.C., Harvey, E., Bush, E.O., Mainor, T.M., Gaylor, M.O.,
Organic contaminants of emerging concern in land-applied sewage sludge (biosolids), J.
Res. Sci. Tech. 2004, 1, 111-122.
[20] Kinney, C.A., Furlong, E.T., Zaugg, S.D., Burkhardt, M.R., Werner, S.L., Cahill, J.D.,
Jorgensen, G.R., Survey of organic wastewater contaminants in biosolids destined for
land application, Environ. Sci. Technol. 2006, 40, 7207-7215.
[21] Harrison, E.Z., Oakes, S.R., Hysell, M., Hay, A., Organic chemicals in sewage sludges,
Sci. Total Environ., 2006, 367, 481-497.
[22] Ternes, T.A., Anderson, H., Gilberg, D., Bonerz, M., Determination of estrogens in
sludge and sediments by liquid extraction and GC/MS/MS, Anal. Chem. 2002, 74,
3498-3504.
[23] Pedersen, J.A., Yeager, M.A., Suffet, I.H., Xenobiotic organic compounds in runoff from
fields irrigated with treated wastewater, J. Agric. Food Chem. 2003, 51, 1360-1372.
[24] Pedersen, J.A., Soliman, M., Suffet, I.H., Human pharmaceuticals, hormones, and
personal care product ingredients in runoff from agricultural fields irrigated with treated
wastewater, J. Agric. Food Chem. 2005, 53, 1625-1632.
[25] Ferrer, I., Thurman, E.M., Liquid chromatography/time-of-flight/mass spectrometry
(LC/TOF/MS) for the analysis of emerging contaminants, Trends Anal. Chem. 2003, 22,
750-756.
[26] Daughton, C.G., Ternes, T.A., Pharmaceuticals and personal care products in the
environment: Agents of subtle change? Environ. Health Perspect. 1999, 107 (suppl 6) 907-938.
[27] López de Alda, M.J., Díaz-Cruz, S., Petrović, M., Barceló, D., Liquid chromatography–
(tandem) mass spectrometry of selected emerging pollutants (steroid sex hormones,
drugs and alkylphenolic surfactants) in the aquatic environment, J. Chromatogr. A 2003,
1000, 503-526.
[28] Glassmeyer, S.T., Furlong, E.T., Kolpin, D.W., Cahill, J.D., Zaugg, S.D., Werner, S.L.,
Meyer, M.T., Kryak, D.D., Transport of chemical and microbial compounds from known
wastewater discharges: Potential for use as indicators of human fecal contamination,
Environ. Sci. Technol. 2005, 39, 5157-5169.
[29] Li, C.T., Cheng, C.Y., Ding, W.H., Determination of alkylphenol residues in baby-food
purees by steam distillation extraction and gas chromatography–mass spectrometry.
Food Chem. Toxicol. 2008, 46, 803-807.
[30] Cheng, C.Y., Liu, L.L., Ding, W.H., Occurrence and seasonal variation of alkylphenols
in marine organisms from the coast of Taiwan. Chemosphere, 2006, 65, 2152-2159.
[31] Cheng, C.Y., Wu, C.Y., Wang, C.H., Ding, W.H., Determination and distribution
characteristics of degradation products of nonylphenol polyethoxylates in the rivers of
Taiwan. Chemosphere, 2006, 65, 2275-2281.
[32] Ding, W.H., Chiang, C.C., Derivatization procedures for the detection of estrogenic
chemicals by gas chromatography/mass spectrometry, Rapid Commun. Mass Spectrum.
2003, 17, 56-63.
[33] Richardson, S.D., Plewa, M.J., Wagner, E.D., Schoeny R., DeMarini, D.M., Occurrence,
genotoxicity, and carcinogenicity of regulated and emerging disinfection by-products in
drinking water: A review and roadmap for research, Mutat. Res.-Rev. Mutat. 2007, 636,
178-242.
[34] Shi, Y., Zhang, P., Wang, Y., Shi, J., Cai, Y., Mou, S., Jiang, G., Perchlorate in sewage
sludge, rice, bottled water and milk collected from different areas in China, Environ. Int.
2007, 33, 955-962.
[35] Richardson, S.D., Disinfection by-products and other emerging contaminants in
drinking water, Trends Anal. Chem. 2003, 22, 666-684.
[36] Petrović, M., Gonzalez, S., Barceló, D., Analysis and removal of emerging contaminants
in wastewater and drinking water, Trends Anal. Chem. 2003, 22, 685-696.
[37] Heberer, T., Occurrence, fate, and removal of pharmaceutical residues in the aquatic
environment: a review of recent research data, Toxicol. Lett. 2002, 131, 5-17.
[38] Roehl, R., Slingsby, R., Avdalovic, N., Jackson, P. E., Applications of ion chromatography with electrospray mass spectrometric detection to the determination of
environmental contaminants in water, J Chromatogr. A 2002, 956, 245-254.
[39] Drinking Water Contaminant Candidate List 3-Draft; Notice. USEPA, Federal Register:
Vol. 73, No. 35, 9627-9654. February 21, 2008. online available at
http://www.epa.gov/safewater/ccl/ccl3.html
[40] National Research Council. Hormonally active agents in the environmental. National
Academy Press: Washington, DC, 1999, 430pp.
[41] Jørgensen, S.E., Halling-Sørensen, B., Drugs in the environment, Chemosphere 2000, 40,
691-699.
[42] Hansen, P.-D., Risk assessment of emerging contaminants in aquatic systems, Trends
Anal. Chem. 2007, 26, 1095-1099.
[43] USEPA, Introduction to Emerging Contaminants, CWEA Specialty Conference -
Chemicals of Emerging Concern: Regulatory & Analytical Perspectives, Los Angeles ,
CA, United States, May 22, 2007 (2007), available at http://www.cwea.org/
conferences/2007/Chemicals/Intro_to_Emerging_Contaminants.pdf
[44] Ternes, T.A., Analytical methods for the determination of pharmaceuticals in aqueous
environmental samples, Trends Anal. Chem. 2001, 20, 419-434.
[45] Willoughby, R., Sheehan, E., Mitrovich, S., A global view of LC/MS: How to solve your
most challenging analytical problems (2nd ed.), Global View Publishing, Pittsburgh,
2002.
[46] Whitehouse, C.M., Dreyer, R.N., Yamashita, M., Fenn, J.B., Electrospray interface for
liquid chromatographs and mass spectrometers, Anal. Chem. 1985, 57, 675-679.
[47] Niessen, W.M.A., State-of-the-art in liquid chromatography–mass spectrometry, J.
Chromatogr. A 1999, 856, 179-197.
[48] Bruins, A.P., Covey, T.R., Henion, J.D., Ion spray interface for combined liquid
chromatography/atmospheric pressure ionization mass spectrometry, Anal. Chem. 1987,
59, 2642-2646.
[49] Banks, J.F., Quinn, Jr.J.P., Whitehouse, C.M., LC/ESI-MS determination of proteins
using conventional liquid chromatography and ultrasonically assisted electrospray, Anal.
Chem. 1994, 66, 3688-3695.
[50] Carroll, D.I., Dzidic, I., Stillwell, R.N., Haegele, K.D., Horning, E.C., Atmospheric
pressure ionization mass spectrometry. Corona discharge ion source for use in a liquid
chromatograph-mass spectrometer-computer analytical system, Anal. Chem. 1975, 47,
2369-2373.
[51] Thomson, B.A., Atmospheric pressure ionization and liquid chromatography/mass
spectrometry-together at last, J. Am. Soc. Mass Spectrom. 1998, 9, 187-193.
[52] Hayen, H., Karst, U., Strategies for the liquid chromatographic-mass spectrometric
analysis of non-polar compounds, J. Chromatogr. A 2003, 1000, 549-565.
[53] Robb, D.B., Covey, T.R., Bruins, A.P., Atmospheric pressure photoionization: An
ionization method for liquid chromatography-mass spectrometry, Anal. Chem. 2000, 72,
3653-3659.
[54] Raffaelli, A., Saba, A., Atmospheric pressure photoionization mass spectrometry, Mass
Spectrum. Rev. 2003, 22, 318-331.
[55] Hanold, K.A., Fischer, S.M., Cormia, P.H., Miller, C.E., Syage, J.A., Atmospheric
pressure photoionization. 1. General properties for LC/MS, Anal. Chem. 2004, 76,
2842-2851.
[56] Takino, M., Yamaguchi, K., Nakahara, T., Determination of carbamate pesticide residues
in vegetables and fruits by liquid chromatography-atmospheric pressure
photoionization-mass spectrometry and atmospheric pressure Chemical Ionization-Mass
Spectrometry, J. Agric. Food Chem. 2004, 52, 727-735.
[57] Cavaliere, C., Foglia, P., Pastorini, E., Samperi, R., Laganà, A., Liquid
chromatography/tandem mass spectrometric confirmatory method for determining
aflatoxin M1 in cow milk Comparison between electrospray and atmospheric pressure
photoionization sources, J Chromatogr. A 2006, 1101, 69-78.
[58] Leinonen, A., Kuuranne, T., Kostiainen, R., Liquid chromatography/mass spectrometry
in anabolic steroid analysis-optimization and comparison of three ionization techniques:
electrospray ionization, atmospheric pressure chemical ionization and atmospheric
pressure photoionization, J. Mass Spectrom. 2002, 37, 693-698.
[59] Cai, S.S., Syage, J.A., Comparison of Atmospheric Pressure Photoionization,
Atmospheric Pressure Chemical Ionization, and Electrospray Ionization Mass
Spectrometry for Analysis of Lipids, Anal. Chem. 2006, 78, 1191-1199.
[60] Syage, J.A., Mechanism of [M+H]+ formation in photoionization mass spectrometry, J.
Am. Soc. Mass Spectrom. 2004, 15, 1521-1533.
[61] Kauppila, T.J., Kotiaho, T., Kostiainen, R., Negative ion-atmospheric pressure
photoionzation-mass spectrometry, J. Am. Soc. Mass Spectrom. 2004, 15, 203-211.
[62] Kauppila, T.J., Bruins, A.P., Kostiainen, R., Effect of the solvent flow rate on the
ionization efficiency in atmospheric pressure photoionization-mass spectrometry, J. Am.
Soc. Mass Spectrom. 2005, 16, 1399-1407.
[63] Syage, J.A., Evans, M.D., Hanold, K.A., Photoionization mass spectrometry, Am. Lab.
2000, 32, 24-29.
[64] Kauppila, T.J., Kuuranne, T., Meurer, E.C., Eberlin, M.N., Kotiaho, T., Kostiainen, R.,
Atmospheric pressure photoionization mass spectrometry. Ionization mechanism and the
effect of solvent on the ionization of naphthalenes, Anal. Chem. 2002, 74, 5470–5479.
[65] Koster, G., Bruins, A. P., Mechanisms for ion formation in LC/MS by atmospheric
pressure photo-ionization (APPI). Proceedings of the 49th ASMS Conference on Mass
Spectrometry and Allied Topics; Chicago, IL, May, 2001.
[66] Hunter, E.P., Lias, S.G., Evaluated gas phase basicities and proton affinities of molecules:
An update, J. Phys. Chem. Ref. Data, 1998, 27, 413-656.
[67] NIST Chemistry WebBook, NIST Standard Reference Database Number 69, June 2005,
National Institute of Standards and Technology, Gaithersburg, MD 20899-1070, USA,
available at http://webbook.nist.gov/chemistry/
[68] Niessen, W.M.A., Progress in liquid chromatography–mass spectrometry
instrumentation and its impact on high-throughput screening, J. Chromatogr. A 2003,
1000, 413-436.
[69] Lim, C.-K., Lord, G., Current developments in LC-MS for pharmaceutical analysis, Biol.
Pharm. Bull. 2002, 5, 547-557.
[70] Brönstrup, M., High-throughput mass spectrometry for compound characterization in
drug discovery, Top Curr. Chem. 2003, 225, 283-302.
[71] Lee, H., Pharmaceutical applications of liquid chromatography coupled with mass
spectrometry (LC/MS), J. Liq. Chromatogr. R. T. 2005, 28, 1161-1202.
[72] Zwiener, C., Frimmel, F.H., LC-MS analysis in the aquatic environment and in water
treatment-a critical review. Part I: Instrumentation and general aspects of analysis and
detection, Anal. Bioanal. Chem. 2004, 378, 851-861.
[73] SciFinder Scholar 2006, The values calculated using advanced chemistry development
(ACD) software for Solaris, American Chemical Society, Washington, DC, 2006.
[74] Kebarle, P., Tang, L., From ions in solution to ions in the gas phase, Anal Chem. 1993,
65, 972A-986A.
[75] Buhrman, D.L., Price, P.I. Rudewicz, P.J., Quantitation of SR 27417 in human plasma
using electrospray liquid chromatography-tandem mass spectrometry: A study of ion
suppression, J. Am. Soc. Mass Spectrom. 1996, 7, 1099-1105.
[76] Jessome, L.L., Volmer, D.A., Ion suppression: a major concern in mass spectrometry,LC GC N. Am. 2006, 24, 498-510.
[77] Nelson, M.D., Dolan, J.W., Ion suppression in LC-MS-MS: a case study, LC GC Eur.
2002, 15, 73-79.
[78] Chen, H.C., Wang, S.P., Ding, W.H., Determination of fluorescent whitening agents in
environmental waters by solid- phase extraction and ion pair liquid
chromatography-tandem mass spectrometry. J. Chromatogr. A 2006, 1102, 135-142.
[79] Chen, H.C. and Ding, W.H., Hot-water and solid-phase extraction of fluorescent
whitening agents in paper materials and infant clothes followed by unequivocal
determination with ion-pair chromatography- tandem mass spectrometry. J. Chromatogr.
A 2006, 1108, 202-207.
[80] Chen, H.C., Wang. P.L., Ding, W.H., Using liquid chromatography–ion trap mass
spectrometry to determine pharmaceutical residues in Taiwanese rivers and wastewaters.
Chemosphere 2008, 72, 863-869.指導教授 丁望賢(Wang-Hsien Ding) 審核日期 2008-6-30 推文 plurk
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