表面電漿共振系統之相位擷取與分析

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姓名

顏嘉宏(Jya-hong Yan) 查詢紙本館藏

畢業系所

光電科學與工程學系

論文名稱

表面電漿共振系統之相位擷取與分析
(Phase Acquisition and Data Analysis for a Surface-Plasmon-Resonance System)

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摘要(中)

本研究以相位移相干涉術(Phase-Shifting Interferometry)結合表面電漿共振(Surface Plasmon Resonance)技術，由CCD擷取影像，配合區間積分資料擷取(Integrated-Bucket data acquisition)的方法，進行相位的檢測。由光路的設計與時域的相位重建分別達到系統的穩定性和動態能力。本系統由實驗可得相位解析度為0.4度，系統的折射率解析度為7.8 × 10^-6 RIU (Refraction Index Unit)。本系統具有即時、高靈敏、高解析度、免標定、大量平行篩檢等優點，預計可運用於微生物分子鍵結反應分析(biomolecular interaction analysis, BIA)的量測領域上，如抗原與抗體之交互作用、蛋白質分子的非特定吸附或DNA雜交等。

摘要(英)

A dynamic surface-plasmon-resonance imaging sensor was developed in this research. Phase-shifting interferometry with integrated-bucket data acquisition is employed to perform phase-image detection with a photodiode and a single CCD. System stability and dynamic capability were achieved through optical configuration design and temporal phase-extraction algorithm respectively. The resolution of phase detection was 0.4 degree, and the measurement sensitivity of refractive index was 7.8 × 10^-6 RIU (Refractive Index Unit). This system is capable of real-time measurements with high sensitivity, resolution, and throughput. It is anticipated to find applications in lable-free screening of biomolecular interactions, such as antibody-antigen interaction, nonspecific protein binding, and DNA hybridization.

關鍵字(中)

★ 表面電漿共振

關鍵字(英)

★ surface plasmon resonance

論文目次

摘要 I
Abstract II
致謝 III
目錄 V
圖目錄 VIII
表目錄 XIII
第一章緒論 1
1-1 前言 1
1-2 文獻回顧 2
1-3研究動機 5
1-4 論文架構 6
第二章金屬的介電函數 8
2-1 介電函數 8
2-2 金屬介電函數的表示式 11
第三章 SPR理論介紹 14
3-1 基本受激態介紹 14
3-1-1 金屬塊材電漿子-極化光子 15
3-1-2 表面電漿子極化光子 17
3-1-3 表面電漿共振原理 18
3-2 SPR 產生方式 21
3-3 衰逝波 23
3-4 SPR傳播性質 25
3-5 層狀介質系統之反射係數 28
3-5-1 兩層介質系統之反射係數 28
3-5-2三層介質系統之反射係數 31
3-6 本質與放射性阻尼(Internal and Radiation Damping) 34
3-7 SPR 光強度特性 38
3-7-1厚度關係 38
3-7-2 波長關係 39
3-7-3 待測物折射率關係 39
3-8 SPR 相位特性 40
3-8-1 厚度關係 41
3-8-2 待測物折射率關係 43
第四章光學干涉與相移術 44
4-1 光學干涉基本原理 44
4-2 相移干涉術 46
4-2-1 五步相移法 48
4-2-2 相位的跳躍與解纏繞 50
4-3 動態相移干涉術 55
第五章實驗系統設計與架構 63
5-1 SPR 相位影像系統設計 63
5-2 系統架構 70
5-3 感測片的設計 74
5-4 機構設計 76
5-5程式設計 81
第六章實驗結果與分析 85
6-1 實驗的準備 85
6-2 實驗一 P極化光與S極化光的量測 89
6-3 實驗二系統穩定性量測 90
6-4 實驗三金膜表面粗糙度的量測 92
6-5 實驗四不同鹽水折射率量測 94
6-6 實驗五金膜陣列的量測 97
6-7 系統解析度分析 98
6-8 理論值與實驗值的比較 99
第七章結論與未來展望 102
參考文獻 103

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指導教授

李正中、陳怡君
(Cheng-chung Lee、Yi-chun Chen)

審核日期

2009-7-21

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