博碩士論文 965301024 詳細資訊




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姓名 彭康榮(Kang-Jung Peng)  查詢紙本館藏   畢業系所 電機工程學系在職專班
論文名稱 使用田口法於指叉式電容性生物感測器的最佳化設計之二維電場模擬
(Two-dimensional Electric-field Simulation for Optimal Design of Interdigitated Capacitive Biosensor by Taguchi Method)
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摘要(中) 本研究期待設計出一套具有最大電容特性及最佳靈敏度的指叉式電容生物感測器之範本。本研究利用先進設計系統(Advanced Design System)軟體進行二維電場模擬及使用田口實驗設計分析法,可獲得指叉式電容感測器之最佳電極幾何參數設計和各電極參數與電容效應之比重關係。針對指叉式電容生物感測器,本研究所設計出的最佳電極之各幾何參數,分別為電極寬度 = 1200 μm、電極間距 = 0.01 μm、電極厚度 = 500 μm以及電極交叉長度 = 10000 μm,其整體電容效應遠大於一般文獻上之指叉式電容生物感測器,約為795.17倍;各電極參數與電容效應之比重關係為電極寬度(31.65%) > 電極間距(26.154%) > 電極厚度(23.154%) > 電極交叉長度(19.039%)。考慮以現今製程技術實現之容易度,將電極寬度與電極間距設定為一般文獻常用值10 μm,而電極厚度及電極交叉長度仍遵循本研又究所得到的最佳參數設計。在設計上遷就製程技術現實所得到的電容效應雖然只是採用最佳電極參數尺寸之設計的5.53分之一,但卻是未採用最佳化設計者的142.96倍。對於生物待測物(例如DNA cylinder、Protein G及MDA231 Cell等)的靈敏度方面,遷就製程技術所設計出的感測器與最佳化設計的表現相近。故本研究的結論建議使用遷就現有製程之最佳電極參數尺寸來設計電容性生物感測器,以利於使用現今製程來實現並提高偵測的靈敏度。
摘要(英) The goal of this research is to develop an interdigitated capacitive biosensor with maximum capacitive response and highest sensitivity. This research concentrated on two-dimensional electric-filed simulation using ADS (Advanced Design System) to analyze and understand the capacitive response of interdigitated biosensors. Furthermore, Taguchi method was employed to find the optimal electrode geometric parameters. The optimal geometric parameters of interdigitated capacitive biosensor thus determined were: electrode width = 1200 μm, electrode spacing = 0.01 μm, electrode thickness = 500 μm, and overlapping length = 10000 μm. The capacitance of this optimal design was 795.17 times as big as that of an interdigitated capacitive biosensor with ordinary geometric parameters. The capacitance of an interdigitated biosensor is determined collectively by its geometric parameters. According to the results by Taguchi method, the relevant parameters and their weights of influences were: electrode width (31.65%), electrode spacing (26.154%), electrode thickness (23.154%), and overlapping length (19.039%). A suboptimal design was proposed to meet the current process limitation. The electrode width and spacing were both changed to 10um, whereas the electrode thickness and overlapping length followed the optimal geometric design. The resultant capacitance was reduced to 1/5.53 times as big as that of the optimal design. Nevertheless, it was still 142.96 times as big as that with the ordinary geometric parameters. For detection of DNA, protein, cell, et. al., by biosensors of suboptimal geometry design, the sensitivity doubled that of the ordinary design and was commensurate to that of the optimal design. Hence, the suboptimal design represents a good choice for capacitive biosensors to attain high sensitivity
under current process limitation.
關鍵字(中) ★ 田口設計分析法
★ 電容效應
★ 指叉式電極
關鍵字(英) ★ Taguchi's method
★ Capacitance
★ Interdigitated electrode
論文目次 中文摘要................................................................................................... I
英文摘要................................................................................................... II
誌謝........................................................................................................... IV
目錄........................................................................................................... V
圖目錄....................................................................................................... IX
表目錄....................................................................................................... XIV
第一章 緒論............................................................................................. 1
1-1 前言.................................................................................................... 1
1-2 生物感測器介紹................................................................................ 2
1-2-1 生物感測器的定義與其發展歷史回顧................................. 2
1-2-2 生物感測器類型與設計......................................................... 5
1-3 電化學生物感測器之電容特性........................................................ 12
1-3-1 不同等效電路的介紹............................................................. 12
1-3-2 電雙層架構與理論................................................................. 15
1-3-3 介電電容原理推導................................................................. 19
1-4 電容式生物感測器之簡介................................................................ 26
1-4-1電容生物感測器應用範圍...................................................... 26
1-4-2 常見電容式感測器之電極型式介紹.................................... 34
1-4-3 指叉式電容感測器之介紹與幾何參數之文獻回顧............ 37
第二章 研究動機與目的......................................................................... 50
2-1 研究動機............................................................................................ 50
2-2 研究目標............................................................................................ 52
第三章 設計最佳指叉式電容生物感測器............................................. 54
3-1 設計指叉式電容生物感測器之幾何參數範圍................................ 54
3-1-1 定義指叉式電極參數及設定幾何參數之分析範圍............ 54
3-1-2實驗目的................................................................................. 54
3-1-3 設定電極寬度對於指叉式電容生物感測器之分析範圍.... 56
3-1-3-1 實驗方法................................................................. 56
3-1-3-2 擴大研究電極寬度對於電容大小之影響............. 57
3-1-4 設定電極間距對於指叉式電容生物感測器之分析範圍.... 58
3-1-4-1 實驗方法................................................................. 58
3-1-4-2 擴大研究電極間距對於電容大小之影響............. 59
3-1-5 設定電極厚度對於指叉式電容生物感測器之分析範圍.... 60
3-1-5-1 實驗方法................................................................. 60
3-1-5-2 擴大研究電極厚度對於電容大小之影響............. 61
3-1-6 設定電極交叉長度對於指叉式電容生物感測器之分析範圍
.................................................................................................................. 62
3-1-6-1 實驗方法................................................................ 62
3-1-6-2 擴大研究電極交叉長度對於電容大小之影響.... 63
3-1-7 ADS模擬軟體之簡介與設計步驟........................................ 64
3-1-7-1 ADS模擬軟體之簡介............................................. 64
3-1-7-2 ADS軟體模擬之設計步驟..................................... 67
3-2 指叉式電容感測器進行最佳化分析............................................... 72
3-2-1實驗背景................................................................................. 72
3-2-2實驗目的................................................................................. 74
3-2-3實驗方法與步驟..................................................................... 74
3-2-4田口設計分析實驗................................................................. 82
第四章 實驗結果與討論......................................................................... 86
4-1指叉式電極之單一幾何參數與電容大小之設計範圍.................... 86
4-1-1 指叉式電極寬度與電容大小之實驗結果............................ 86
4-1-2 指叉式電極間距與電容大小之實驗結果............................ 89
4-1-3 指叉式電極厚度與電容大小之實驗結果............................ 91
4-1-4 指叉式電極交叉長度與電容大小之實驗結果.................... 94
4-1-5 指叉式電極幾何參數之設計範圍與討論............................ 96
4-2指叉式電容感測器最佳化分析結果與討論.................................... 103
4-2-1田口分析法之因子效應分析與最佳化預測......................... 103
4-2-2指叉式電容感測器進行最佳化之分析討論......................... 107
4-3 考慮現有製程設計之討論............................................................... 111
4-4 加上生物待測物之靈敏度比較....................................................... 113
4-4-1實驗方法................................................................................. 113
4-4-2 實驗結果................................................................................ 114
4-5 指叉式電容性生物感測器用於實際應用之分析比較................... 120
4-5-1實驗方法................................................................................. 121
4-5-2 實驗結果................................................................................ 122
第五章 結論與未來展望......................................................................... 127
5-1 結論.................................................................................................... 127
5-2 未來展望............................................................................................ 129
參考文獻................................................................................................... 130
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指導教授 蔡章仁(Jang-Zern Tsai) 審核日期 2011-8-26
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