頻域近紅外光擴散光學斷層掃描系統之校正應用於假體量測

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姓名

張格寧(Ge-ning Zhang) 查詢紙本館藏

畢業系所

機械工程學系

論文名稱

頻域近紅外光擴散光學斷層掃描系統之校正應用於假體量測
(Calibrated Frequency-domain NIR Diffuse Optical Tomography for Tissue-mimicking Phantoms)

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摘要(中)

近紅外光擴散光學斷層掃瞄是一種非侵入式且無輻射性的新型生醫影像技術，主要提供組織內光學係數分佈的功能性影像。本論文的研究目的為發展頻域近紅外光擴散光學斷層掃瞄系統及數據校正方法，以期能為臨床上的腫瘤診斷提供有用之工具。量測系統為一單臂式旋轉機構用以擷取調變光穿過組織後的光強度及相位資訊。擷取的資料在進行影像重建之前必須經過適當的校正。我們使用的校正方式是以已知光學係數之均質假體做為基準，將量測與模擬結果作比較，藉此估算量測系統造成的資訊偏移。經由雙積分球系統量測假體材料(人造脂質,India ink)的光學係數在不同濃度下的線性變化，並求得製作所需真實光學係數之假體之配方。我們針對校正後之數據相對於模擬數據的誤差進行分析。結果顯示使用不同均質假體做為校正基準校正後之量測數據與模擬數據間會有不同程度的誤差。非均質假體之影像重建結果亦將在本論文中呈現並討論目前系統的量測極限。

摘要(英)

Near-infrared diffuse optical tomography is a new non-invasive and non-radiation biomedical imaging technique that provides functional image of optical properties distribution within objective tissues. The purpose of this thesis is to develop frequency-domain (FD) NIR-DOT system and the corresponding calibration method. We expected that FD NIR-DOT would become a useful tool for clinical tumor diagnosis. FD NIR-DOT measurement system is constructed based on a single-armed rotating scanning device. Intensity and phase delay information of intensity modulated light propagates through the objective tissue are acquired. For image reconstruction, acquired data (intensity and phase delay) must be calibrated properly in order to eliminate systematic offsets. We introduced a calibration method involving one complete characterized homogeneous phantom measurement and forward simulation. Double integrating sphere system was applied to determine absorption coefficient and reduced scattering coefficient of different concentrations of tissue-mimicking phantom contents (fat emulsions and India ink). According to the linear relationship between optical properties and concentration of phantom contents, phantoms with exact optical properties can be prepared. We analyzed the relative error between the calibrated data and the computed ones. Reconstructed images of two heterogeneous phantom cases are demonstrated that reveal the limitation of the current NIR-DOT imaging system.

關鍵字(中)

★ 醫學造影
★ 近紅外光光譜
★ 擴散光學斷層掃描

關鍵字(英)

★ Medical imaging
★ Near-infrared spectroscopy
★ Diffuse optical tomography

論文目次

摘要 i
Abstract ii
誌謝 iii
Contents iv
List of Figures vi
List of Tables ix
Chapter 1 Introduction 1
1.1 Motivation 1
1.2 Literature Review 3
1.3 Overview of Thesis 5
Chapter 2 Background Knowledge 7
2.1 Tissue Optics 7
2.1.1 Absorption 7
2.1.2 Scattering 8
2.1.3 Anisotropy 10
2.2 Optical Properties of Tissues 12
2.2.1 Water 12
2.2.2 Lipids 13
2.2.3 Hemoglobin 13
2.2.4 Normal Breast Tissue and Tumor 15
2.3 Geometries of NIR Methods 16
2.3.1 Single Point 16
2.3.2 Topography 16
2.3.3 Tomography 17
2.4 NIR-DOT Measuring Schemes 18
2.4.1 Continuous Wave 18
2.4.2 Time-domain 19
2.4.3 Frequency-domain 20
Chapter 3 Instrumentation and Method 21
3.1 Frequency-domain NIR-DOT System Setup 21
3.2 Instruments and Components 24
3.2.1 List of FD NIR-DOT Instruments and Components 24
3.2.2 Performance of Laser Diode 25
3.2.3 Characteristic of Photomultiplier Tube 26
3.2.4 Heterodyne Detection 28
3.3 Image Reconstruction 29
3.3.1 Diffusion Approximation 30
3.3.2 Forward Simulation 30
3.3.3 Inverse Solution 31
3.4 Calibration of Frequency-domain Measurement Data 33
Chapter 4 Phantom Study 35
4.1 Double Integrating Sphere Technique and IAD Method 35
4.1.1 Double Integrating Sphere Technique 35
4.1.2 Inverse Adding-doubling Method 36
4.2 Optical Properties of Fat Emulsions and India Ink 37
4.3 Preparation of Liquid Phantom 41
4.4 Discussion 43
Chapter 5 Phantom Measurements and Image Reconstruction 44
5.1 Homogeneous Phantom Measurements 44
5.1.1 FD Measurements of Homogeneous Phantom 44
5.1.2 Measured Data Calibration 47
5.2 Heterogeneous Phantom Measurement and Reconstructed Image 54
Chapter 6 Conclusions and Future Works 60
Reference 62
Appendix 67
A. Scattering Coefficients of Intralipid 10% and Lipovenoes 10% 67
B. Other Heterogeneous Cases 68
B.1 100mm Diameter Heterogeneous Phantom Case 1 68
B.2 100mm Heterogeneous Phantom Case 2 70

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指導教授

潘敏俊(Min-chun Pan)

審核日期

2010-1-21

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