醫用近紅外光光電量測機構對模擬乳房與腫瘤之假體量測分析

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姓名

施易利(Yih-Lih Shih) 查詢紙本館藏

畢業系所

機械工程學系

論文名稱

醫用近紅外光光電量測機構對模擬乳房與腫瘤之假體量測分析
(NIR Electro-optical Measurement and Analysis for the Heterogeneous Intralipid Phantoms Imitating Breast Tumors)

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摘要(中)

擴散式近紅外光斷層掃描系統是新穎的醫學造影技術，此掃描系統的優點是它的安全性高，非侵入式的偵測特性。由於特定波段NIR 光源對於病變組織，因吸收及散射係數差異，而具有效的診斷能力，使其相較其它斷層掃描系統更能有效發現病變組織所在。本論文主要探討在一個高解析度的旋轉機構對人造假體做一個標的物和兩個標物的分析。針對標的物在不同因素下(包括標的物對假體中心偏移量，標的物和假體背景濃度對比度，標的物和假體相對的尺寸比)所造成的影響去做討論。分析所得結論，可用以預測使用此一斷層掃描系統在真實組織下進行量測時，可能的診斷極限，也可提供醫生使用此系統在醫療診斷上之瞭解。
研究中，當NIR 光源位置在絕對座標0 度時，對一個標的物的非均質人造假體進行探討。分析結果可以發現

摘要(英)

Near infrared (NIR) diffuse optical tomography (DOT) is a new medical imaging modality, the advantages are safe (longer wavelength) and non-radioactive, in spite of its low spatial resolution at the current phase. Due to the diagnostic potential of NIR,the abnormality of tissues in NIR light is to allow earlier detection rather than most other imaging modalities. This thesis describes the NIR Electro-optical measurement for Intralipid phantoms using our own developed NIR DOT scanning
instrument with highly spatially angular resolution, in order to investigate the
influence of different factors such as the off-boundary, the volume density (v.d.) of
inclusion, and the size ratio. The influence of each condition also can reveal the real
condition of biomedical tissue, and this information can offer the doctor for diagnosis.
This thesis discusses Intralipid phantoms which are the homogeneous background
with one inclusion or two inclusions.
For the homogeneous background with one inclusion and the source position at s0 , the contrast is large, the resolution of inclusion position is good but the resolution of inclusion size is bad. The off-boundary is small, the resolution of contrast and inclusion size are both good. The inclusion size is large, the resolution of contrast is good but the resolution of off-boundary is bad.
For the homogeneous background with two inclusions and the source position at s0 , the contrast (I0) is large; the resolution of inclusion position is good. The off-boundary (I0) is small confined to the non-directly detected inclusion (I4) with small v.d.; the resolution of contrast is good. The common conclusion for the homogeneous background with one inclusion and two inclusions can be obtained.
Those phenomena are similar in some condition, especially for source position at s0 and Sπ.
This thesis also simulates a power curve by using an exponential form. The light trajectory of model in this thesis was set as straight line, unlike the real trajectory. The outcome does not seem well. From this thesis, it can give a general concept about the influence of different factors. Furthermore, the original experimental data can be used as the input and the calibration of image reconstruction.

關鍵字(中)

★ 近紅外光
★ 假體

關鍵字(英)

★ Intralipid phantom
★ heterogeneous
★ NIR
★ DOT

論文目次

Contents
CHAPTER 1 INTRODUCTION…………………………………1
1.1 Motivation……………………………………………1
1.2 Literature Review…………………………………3
1.3 Overview of the Thesis…………………………10
CHAPTER 2 OPTICAL PROPERTY OF BIOMEDICAL TISSUE………………………………………………12
2.1 Optical Properties………………………………12
2.1.1 Absorption………………………………………13
2.1.2 Scattering………………………………………14
2.1.3 Anisotropy………………………………………15
2.1.4 Refractive index………………………………16
2.2 Optical Properties of Interesting Object…16
2.2.1 Water………………………………………………16
2.2.2 Fat…………………………………………………17
2.2.3 Oxygenated and Deoxygenated Hemoglobin…17
2.2.4 Breast Tissue……………………………………18
2.3 Propagation of Photons…………………………19
CHPATER 3 INSTRUMENTATION……………………………20
3.1 Source-detector Geometry………………………20
3.1.1 Single point……………………………………20
3.1.2 Topography………………………………………21
3.1.3 Tomography………………………………………21
3.2 Types of Measuring Instrument…………………22
3.2.1 Continuous wave…………………………………22
3.2.2 Time domain………………………………………23
3.2.3 Frequency domain………………………………24
3.3 Experimental Equipments and Phantom Materials…………………………………………………24
3.3.1 Equipment…………………………………………25
3.3.2 Container…………………………………………27
3.3.3 Intralipid phantom……………………………27
3.3.4 Ink…………………………………………………28
3.4 Eccentric and Centering ………………………29
CHAPTER 4 EX P E R I M E N T S AN D DI S C U S S I O N S: H O M O G E N E O U S BACKGROUN D WITH ONE I N C L U S I O N…………………………………32
4.1 Size Ratio of Background to Inclusion 10:1………………………………………………………33
4.2 Size Ratio of Background to Inclusion 15:1………………………………………………………34
4.3 Definition on Attenuation Depth, Attenuation Width and Resolution…………………………………36
4.4 Attenuation Depth and Width v.s. Off-boundary…………………………………………………38
4.4.1 Conditions based on the same v.d…………39
4.4.2 Conditions based on the same size ratio…42
4.5 Attenuation Depth and Width v.s. Inclusion v.d.………………………………………………………45
4.5.1 Conditions based on the same off-boundary…………………………………………………46
4.5.2 Conditions based on the same size ratio.……………………………………………………………49
4.6 Attenuation Depth and Width v.s. Size Ratio………………………………………………………52
4.6.1 Conditions based on the same v.d…………………………………………………………53
4.6.2 Conditions based on the same off-boundary…………………………………………………55
4.7 Concluding Remark…………………………………59
CHAPTER 5 EX P E R I M E N T S AN D DI S C U S S I O N S: H O M O G E N E O U S B A C K G R O U N D W I T H T W O I N C L U S I O N S…………63
5.1 Attenuation Depth and Width v.s. Off-boundary of I0…………………………………………64
5.1.1 Conditions based on the same v.d. of I4…………………………………………………………66
5.1.2 Conditions based on the same v.d. of I0…………………………………………………………68
5.2 Attenuation Depth and Width v.s. Inclusion v.d. of I0………………………………………………71
5.2.1 Conditions based on the same v.d. of I4…………………………………………………………72
5.2.2 Conditions based on the same Off-boundary of I0………………………………………………………74
5.3 Concluding Remark…………………………………77
CHAPTER 6 SIMULATION…………………………………82
CHAPTER 7 CONCLUSIONS…………………………………90
REFERENCE…………………………………………………93
APPENDIX…………………………………………………99

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指導教授

潘敏俊(Min-Chun Pan)

審核日期

2006-7-22

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