組織工程用三維支架之製程路徑規劃

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姓名

吳瑞祥(Jui-Hsiang Wu) 查詢紙本館藏

畢業系所

機械工程學系

論文名稱

組織工程用三維支架之製程路徑規劃
(The process of the path planning of the three dimension scaffold for tissue engineering)

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摘要(中)

組織工程支架提供細胞貼附和生長環境，結合所需的調控因子和生物反應器可以誘使細胞分化與組織再生，而支架的三維結構會影響細胞的遷移、培養液的流動，所以支架結構設計與製作方式是否良好對細胞在支架內部的培養成效有相當的影響。支架的三維結構可以藉由電腦輔助設計出理想的支架模型或從電腦斷層掃瞄影像重建並擷取所需的區域。
本研究主要在發展一套製作支架的軟體，包含支架與支撐路徑規劃及加工機器控制介面，並針對路徑線段端點懸空的問題提出解決方案，以使支架製作品質更趨完善。在支架路徑規劃方面，就模型切層輪廓與路徑線段做交集運算，求出支架路徑線段端點，再判斷支架路徑線段端點是否懸空。假如端點懸空，則須把端點投影到下一層切面上，並從下一層支架路徑線段中找離端點最近的點替代之，以避免材料的累積。又為了節省模型製作的時間，路徑線段端點會被依序連結幾個連續路徑。在另一方面，任一層的支撐區域面積是將該層以上的支架材料區域聯集與該層的支架面積輪廓做差集求出，而支撐路徑線段的端點位置是由該層以上的各層支架路徑線段端點投影在該層支撐區域上，再經分類後求出。最後再判斷支撐跟支架路徑線段是否會發生碰撞，假如發生碰撞需修改支撐路徑線段端點。由耳朵模型的模擬實驗中得知本研究的方法確實能夠改善支架的製作品質。

摘要(英)

The scaffold for tissue engineering provides cell adhesion and growing environment. Combining regulatory factor and bio-reactor can induce cell differentiation and tissue regeneration. The three dimensional structure of the scaffold affects cell migration and the flow of medium. Therefore the structure design and fabrication method of scaffolds have great influence for cell culture inside the scaffold. The structure of the scaffold can be designed by applying computer-aided design or generated from CT image model.
This research is to develop a software program to fabricate scaffold models, including the planning of scaffold and supporter path and the control interface of the processing machine, and to solve suspending problems of path points of scaffolds so that the quality of scaffolds can be improved. In the path planning of scaffolds, the path points are derived by finding the intersection points of the slice contour and paths and then judged if they are suspended in the air. If any path point is suspended, it will be replaced by the path point on the next lower layer, which is closest to the projection of the path point on the next lower layer, so that material will not accumulate. Also, the path pints will be connected sequentially to form several continuous paths to save fabrication time. On the other hand, the supporter area of each layer is derived by finding the difference between its scaffold area and the union of the scaffold areas of all layers above this layer. The path points of the supporter area are determined by analyzing and categorizing those of the scaffold areas above this layer. Finally, the supporter paths will be judged whether they are collided with the scaffold paths. If a collision happens, the position of the supporter path point will be modified. The path planning simulation experiment using an ear model shows that the proposed method is definitely able to improve the production quality of scaffolds.

關鍵字(中)

★ 支架
★ 快速成型
★ 組織工程

關鍵字(英)

★ Scaffolds
★ Tissue Engineering
★ Rapid Prototyping

論文目次

摘要 I
Abstract II
致謝 III
目錄 IV
表目錄 VII
圖目錄 VIII
第1章序論 1
1-1 研究動機與目的 1
1-2 文獻回顧 2
1-2-1 快速成型系統簡介 2
1-2-2 切層理論簡介 6
1-3 研究方法與簡介 7
1-4 章節瀏覽 9
第2章研究理論與方法 10
2-1 切層流程圖 10
2-2 模型建構 10
2-3 模型切層 14
2-4 支架路徑規劃 16
2-4-1 建構連續路徑 17
2-4-2 修正懸空路徑點 23
2-4-3 判斷連接線段是否重複 32
2-4-4 判斷連接線段是否懸空太長 33
2-5 支撐路徑規劃 33
2-5-1 求各層支撐區域 35
2-5-2 支架路徑線段投影並分類 41
2-5-3 判斷個別區域的路徑線段方向 43
2-5-4 簡化支撐路徑線段 44
2-5-5 建構連續路徑 45
2-5-6 判斷支撐跟支架是否碰撞 46
2-5-7 輸出支撐路徑線段端點 52
第3章軟體界面說明 53
3-1 軟體操作介紹 53
3-1-1 選單功能介紹 54
3-1-2 串列通訊參數設定 56
3-1-3 平台控制 57
第4章實驗結果與討論 58
4-1 支架路徑 58
4-1-1 4D結構修正懸空路徑點前跟修正後的支架路徑比較 59
4-1-2 2D結構修正懸空路徑點前跟修正後的支架路徑比較 64
4-1-3 2D跟4D修正懸空路徑點後的路徑誤差值比較 70
4-1-4 原始模型跟4D支架路徑比較 73
4-2 支撐路徑 74
第5章結果與未來展望 77
參考文獻 79

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指導教授

曾清秀(Ching-Shiow Teseng)

審核日期

2008-1-23

推文