博碩士論文 83246007 詳細資訊




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姓名 陳建宇(Chien-Yue Chen)  查詢紙本館藏   畢業系所 光電科學與工程學系
論文名稱 生醫訊號小波分析及疊紋量測系統
(Biomedical Signal Wavelet Analysis and the Moire Measurement System)
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摘要(中) 摘 要
生醫訊號的擷取與分析無論是對於生物科學研究或者是對於醫學臨床的需求上,都是必需且迫切需要更精密準確的技術以求突破。在本論文中,第二章我針對心率變異度、腦電圖、脈搏波三種常見的生醫訊號現有的測量及分析技術之方法與原理給予介紹。在第三章及第四章中,我以傅立葉頻譜分析在不同姿勢以及針灸刺激之下腦波的活動狀況。在姿勢影響腦波的研究中指出只有左腦的?波能量在坐姿時比臥姿時要上升,應與坐姿時交感神經活性上升有關。在針灸對腦波影響的研究中則指出,對左手外關穴施以深達1.5公分之深層針刺並測量顳顱區的腦電波時發現θ波被針灸刺激所誘發的效果最為顯著,且與中醫氣行經脈理論較為相符。在第五章中,首先介紹近年來的熱門分析技術小波變換,並在將之應用在心率變異度分析時,發現相鄰頻帶間能量漏洩導致重建訊號失真現象,並提出以最小平方差法將偏差值降至最低。第六章中,我針對末期孕婦在坐姿與仰臥姿下之心率變異度與自律神經活性之關係,利用第五章所提出的最佳母小波函數之離散小波多分辨分析法進行分析工作,得到與傳統人為切割頻域的分析法一致的結果,同時能更精確的洞悉末期孕婦在仰臥的情況下其交感神經調控的低頻能量也會下降,造成反應能力退化的情形。在第七章中,本論文利用疊紋精密光電量測系統,採陰影疊紋的方法,設計出一套光學式陰影疊紋脈診系統。並將此套系統應用在人體脈搏波的量測,與血氧濃度計比較之結果發現在脈搏的主頻率上可以獲得相當一致的結果。同時由於此疊紋脈搏量測系統可以進行表面多點量測記錄,我們同時測量寸關尺三的中醫師把脈的位置,試圖以影像分析技術建立三維的脈象圖。在第八章中,我們利用這樣的疊紋表面精密量測技術,提供一個簡單方便又非接觸式的痛覺量化的觀察法,可以將麻醉後老鼠受到刺激的的屈肌顫動忠實的記錄下來,並且透過影像處理(影片擷取分割、轉灰階、像素點讀取)跟傅立葉分析將痛覺產生的反應予以量化。本研究之結果,與傳統痛覺研究的方法進行比較,可以得出相同的結論。除此之外,還比傳統的方法更進一步的可以觀察老鼠的痛覺反應行為模式,透過頻譜的分析,更可以對有統計差異的頻峰解釋其反映的生理現象,對於痛覺的機制可以進行更深入且更客觀的研究。
摘要(英) non
關鍵字(中) ★ 疊紋
★ 小波分析
★ 生醫訊號
關鍵字(英) ★ biomedical signal
★ moire
★ wavelet analysis
論文目次 目 錄
摘要 I
目錄 II
表目錄 VI
圖目錄 VII
第一章 緒論 1
1.1 研究動機 1
1.2 常見的幾種生醫訊號簡介 5
1.2.1 心率變異度 5
1.2.2 腦電圖簡介 5
1.2.3 脈搏波簡介 7
1.3 訊號分析方法沿革 9
參考文獻 12
第二章 生醫訊號分析方法 14
2.1 研究設計 14
2.2常用生醫訊號分析法 14
2.2.1 心率變異度分析法 14
2.2.2 腦電圖訊號紀錄與分析 16
2.2.3 脈搏波訊號紀錄 18
2.3 數位訊號處理之基礎理論 20
2.4 生醫統計原理簡介 23
參考文獻 27
附表 29
附圖 30
第三章 左右腦波對稱性之研究與坐臥姿對腦波之影響 32
3.1 簡介 32
3.2 研究設計 33
3.3 實驗結果 34
3.4 討論 35
3.5 結論 36
參考文獻 38
附表 39
附圖 40
第四章 針刺左手外關穴腦波活動頻譜分析之研究 41
4.1 簡介 41
4.2 研究設計 42
4.3 實驗結果 43
4.4 討論 45
4.5 結論 47
參考文獻 48
附表
第五章 小波生醫訊號分析 55
5.1 小波分析理論 55
5.2 最佳母小波多分辨分析法 60
5.2.1 研究動機 60
5.2.2 假設 61
5.2.3 測試方法 62
5.2.4 發現能量漏洩問題 64
5.2.5 以最小平方差法找出最適當的母小波函數 65
5.2.6 結論 67
參考文獻 68
50
附圖 53
附表 70
附圖 72
第六章 坐臥姿對孕婦末期之心率變異度小波分析 76
6.1 簡介 76
6.2 研究設計 76
6.3 訊號分析的方法 77
6.4 實驗結果 78
6.5 討論 79
6.6 結論 81
參考文獻 83
附表 85
附圖 86
第七章 疊紋表面精密量測系統 88
7.1疊紋研究之歷史沿革 88
7.2 疊紋的基本原理 88
7.2.1 由Ronchi 光柵產生疊紋之數學模型 88
7.2.2 疊紋近似表示 91
7.2.3 陰影疊紋 93
7.3 疊紋脈搏量測系統 94
7.3.1 系統架設 94
7.3.2 表面量測流程與實驗設備 95
7.3.3 影像擷取與資料分析 96
7.4 系統偏差校正 96
7.4.1 影像灰階數校正 97
7.4.2 光源校正 97
7.4.3 系統架構之穩固性測試 99
7.5 實驗結果 99
7.6 結論 101
參考文獻 103
附圖 105
第八章 疊紋表面精密量測系統於痛覺量化之應用 120
8.1 簡介 120
8.2 實驗方法 120
8.2.1 福馬林測試 120
8.2.2 實驗架設 120
8.2.3 影像擷取與分析方法 121
8.3實驗結果 121
8.4 討論與結論 122
參考文獻 124
附圖 125
第九章 結論與未來展望 126
中英文名詞對照表 130
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[15] Chang RS, “ 3 Dimensional Moiré Datum Diagnostic Setup”, Patent No.09133166 (Taiwan).
[16] Chang RS, Chen CY, Chiu CL, “Measurement of Body Pulsing with Phase Moiré Imaging System”, Optics and Photonics TAIWAN ’99, pp. 1188-1190, 1999.
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[18] Post D, Han B, High Sensitivity Moiré Experimental Analysis for Mechanics and Materials, New York : Springer-Verlag, P.91-121, 1994.
[19] Chang RS, Chen CY, Lin CH, Liu YJ, Kuo CD, “Pulse Measurement based on Moiré Diagnostic System”, Applied Optics – Biomedical Optics, 2003. (revised on 18th March)
[20] Chang RS, Chen CY, Lin CH, Liu YJ, Kuo CD, “The Global Measurement of Dynamic Vibration of Acupoints by Moiré Technology”, Journal of Chinese Medical Association of Acupuncture, pp. 27-35, 2003. (published)
ch8
[1] Chang RS, Chen CY, Lin CH, Liu YJ, Kuo CD, “Pulse Measurement based on Moiré Diagnostic System”, Applied Optics – Biomedical Optics, 2003. (revised on 18th March)
[2] Chang RS, Chen CY, Lin CH, Liu YJ, Kuo CD, “The Global Measurement of Dynamic Vibration of Acupoints by Moiré Technology”, Journal of Chinese Medical Association of Acupuncture, pp. 27-35, 2003.
[3] Lin CH, Yeh LW, Chen CY, Chang RS, Chen WY, Chen JD, “Quantitatively Expression of Pain”, The 1st International Conference on Regenerative Medicine of the Nervous System, 3rd Session II, 30th Oct., 2003. (presented)
指導教授 郭正典、張榮森
(Cheng-Deng Kuo、Rong-Seng Chang)
審核日期 2004-7-14
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