非接觸式光學量測應用於生物醫學

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姓名

陳盈運(Ying-yun Chen) 查詢紙本館藏

畢業系所

光電科學與工程學系

論文名稱

非接觸式光學量測應用於生物醫學
(Non-Contact Optical Measurement Used in the Biomedical Field)

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摘要(中)

本論文主要是建立三種不同架構的非接觸式光學量測系統，並應
用於生物醫學量測，第一種為利用光學疊紋(Moiré)技術，自動化判
斷疊纹條纹的位置並記錄條紋變化的週期量，計算出待測物表面任一
位置的地形高度與其高度變化，此系統可以分析中醫脈象(the
conditions of pulse)，中醫脈象包括脈的位置(藉由影像處理疊紋圖案)、
脈的節律(藉由頻率)、脈的形狀(藉由疊紋圖案)和脈的強度(藉由震幅
強度)。
第二種為利用電容式麥克風量測手腕脈搏之脈音，將麥克風擷取
的信號做濾波處理，並傳送到電腦做快速傅立葉轉換(FFT)程式，轉
換為心跳頻率，本裝置遵從中醫的把脈方式，針對的寸、關、尺三處
分別以不同的把脈壓力，浮取(50mmHg)、中取(80mmHg)和沉取
(110mmHg)進行量測分析，以上兩種量測方式是針對中醫脈搏並分析
數據，使中醫得以量化。
第三種為利用雷射光學三角量測（laser optical triangulation）原理，
針對我們所選用的動物，透過注射數不同濃度福馬林試劑得到各種不
同刺激(空針注射、12% 福馬林注射、37%福馬林注射) 的頻率，實驗
結果為正相關的曲線，使痛覺可以被量化。

摘要(英)

This paper is to establish three different non-contact optical measurement
systems used in the biomedical field. The first system uses optical moiré to
automatically determine the location of moiré pattern, record the cycle of
pattern change and calculate the height and height change at any spot of a
test surface. This system can analyze the conditions of pulse which include
the location (image processing of moiré pattern), rhythm (via frequency),
shape (via moiré pattern) and strength of pulse (via amplitude).
The second system uses a condenser microphone to measure the pulse of
wrist. Signals captured by the microphone is filtered and transmitted to a
computer for a fast Fourier transform (FFT) to be converted into heart rate.
This device follows the practice of pulse reading in Chinese medicine and
applies three different pressures of 50mmHg, 80mmHg and 110mmHg at
wrist, guan and cubit. The two measurement methods above analyze and
quantify the pulse reading in Traditional Chinese Medicine.
The third system uses the concept of laser optical triangulation which
injects different concentrations of formalin reagent into animal to obtain
different frequencies of stimuli (empty injection, 12% formalin, 37%
formalin). The results show positive correlation, so that pain can be
quantified.

關鍵字(中)

★ 非接觸式
★ 疊紋
★ 脈象
★ 脈音
★ 痛覺

關鍵字(英)

★ Non-contact
★ moiré
★ pulse
★ pulse tone
★ pain

論文目次

iv
Content
摘要 ...................................................................................................................... i
Abstract .................................................................................................................ii
致謝 ..................................................................................................................... iii
Content ................................................................................................................. iv
List of Figures ........................................................................................................ vi
List of Tables ........................................................................................................ vii
......................................................... Chapter 1 Overview of Biomedical Measurement
............................................................................................................................. 1
1.1 Introduction of Biomedical Measurement ......................................................... 1
1.2 Research Motivation and Contributions ........................................................... 3
1.2.1 Moiré Technique and Auscultation for Pulse Measurement ......................................... 3
1.2.2 A Study on Optical Triangulation for Biological Pain Measurement ........................... 6
1.3 Dissertation Outline .......................................................................................... 7
...... Chapter 2 An Application of Automatized 3D Moiré Monitoring System in Pulse
Measurement ........................................................................................................ 8
2.1 Abstract ............................................................................................................ 8
2.2 Introduction ...................................................................................................... 9
2.3 Method ........................................................................................................... 12
2.3.1 Measurement Principle of Shadow Moiré .................................................................. 12
2.3.2 Drawing Terrain Feature Figure and Measuring Height Variations ............................ 14
2.3.3 The Automatized Calculation Program ....................................................................... 16
2.4 Moiré Monitor System .................................................................................... 18
2.4.1 System Structure ......................................................................................................... 18
2.4.2 Program Calculation Process ...................................................................................... 22
2.4.3 The Accuracy of Detection ......................................................................................... 24
2.5 Pulse Measurement Results ............................................................................ 27
2.5.1 Detecting the Height Variations Around the Right-Hand Guan Pulse ........................ 28
2.5.2 Pulse Waveform of Pulse Movements Monitor .......................................................... 29
2.5.3 Summary ..................................................................................................................... 31
...................................................Chapter 3 A Study of New Pulse Auscultation System
............................................................................................................................ 32
3.1 Abstract .......................................................................................................... 32
3.2 Introduction .................................................................................................... 33
3.3 New Pulse Auscultation System....................................................................... 35
3.4 Measuring Steps ............................................................................................. 44
3.5 Calibration and Errors Analysis ..................................................................... 45
3.6 Experimental Results ...................................................................................... 46
3.7 Summary ........................................................................................................ 54
............ Chapter 4 The Optical Measurement and Quantitative Analysis of Algesia in
Spodoptera litura Larva ....................................................................................... 56
4.1 Abstract .......................................................................................................... 56
4.2 Introduction .................................................................................................... 57
4.3 Methods and Materials ................................................................................... 58
4.3.1 Methods ...................................................................................................................... 58
4.3.2 Materials and Sample Preparation .............................................................................. 62
4.3.3 Experimental Methods and Procedures ...................................................................... 62
4.3.4 System Calibration and Error Analysis ....................................................................... 65
4.4 Experimental Results ...................................................................................... 67
4.5 Summary ........................................................................................................ 69
........................................................................ Chapter 5 Conclusion and Future Work
............................................................................................................................ 72
References ........................................................................................................... 75

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指導教授

張榮森(Rong-seng Chang)

審核日期

2015-7-13

推文