合成外差式生化感測器之研究

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姓名

王柏欽(Boching Wang) 查詢紙本館藏

畢業系所

光電科學與工程學系

論文名稱

合成外差式生化感測器之研究
(Research of Surface Plasmon Resonance Biosensor Combined with Synthetic Heterodyne Signal Process Technique)

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摘要(中)

本研究目的在於，以表面電漿共振生化感測器為基礎，設計一套高感度、低雜訊及高解析度之正交干涉生化感測系統。
這套新穎的系統可維持原本表面電漿共振裝置之高靈敏度以及高解析度，採用分佈式回饋雷射二極體(DFBLD)為光源，採用正交干涉光路，合成外差式的訊號處理，載波過濾低頻雜訊，可得線性的高訊雜比(signal to noise)相位差訊號。

摘要(英)

The purpose of this research is to design a high-sensitivity, high resolution and low noise system of a surface plasmon resonance (SPR) biosensor.
In this paper, a Distributed Feed-back Bragg laser diode (DFBLD)was used as a light source, and quadrature interferometry technique was also used to setup the optical system. A synthetic heterodyne signal process was then developed to deal with the signal data.
In this novel system, it preserves the advantages of high sensitivity and high resolution quality of SPR biosensor. A high signal to noise(S/N) ratio and linear data of phase difference were obtained by signal processing to filter the low frequency noise.

關鍵字(中)

★ 合成外差式訊號處理
★ 生物感測器
★ 生化感測器
★ 表面電漿共振

關鍵字(英)

★ surface plasmon resonance
★ synthetic heterodyne signal process
★ biochemical sensor
★ biosensor

論文目次

目錄
中文摘要----------------------------------------------------------Ⅰ
英文摘要----------------------------------------------------------Ⅱ
誌謝--------------------------------------------------------------Ⅲ
目錄--------------------------------------------------------------Ⅳ
圖目錄------------------------------------------------------------Ⅴ
第一章緒論
1-1 前言-----------------------------------------------------------1
1-2研究動機--------------------------------------------------------2
1-3研究目的--------------------------------------------------------4
第二章理論探討
2-1表面電漿共振原理------------------------------------------------5
2-2干涉原理------------------------------------------------------ 12
2-2-1麥克森干涉術---------------------------------------------12
2-2-2 正交干涉技術--------------------------------------------14
2-3 合成外差式訊號處理技術----------------------------------------17
2-4 呂薩加圖的相位差測量------------------------------------------19
第三章實驗設計
3-1 系統架構的動機------------------------------------------------22
3-2 雷射光源的選擇------------------------------------------------23
3-3 SPR裝置的設置------------------------------------------------24
3-4 系統光路架構--------------------------------------------------27
3-5 合成外差式之信號處理------------------------------------------30
第四章結果與討論
4-1 SPR裝置的測量------------------------------------------------31
4-2 實驗數據及訊號處理-------------------------------------------32
4-3 信號處理的軟體模擬-------------------------------------------33
第五章結論與建議
5-1 結論---------------------------------------------------------36
5-2 建議---------------------------------------------------------37
參考書目----------------------------------------------------------39

參考文獻

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指導教授

張堯盛、張榮森
(Yau-Sheng Chang、Rong-Seng Chang)

審核日期

2006-7-20

推文